MST kinases in development and disease

Brahma regulates the Hippo pathway activity through forming complex with Yki–Sd and regulating the transcription of Crumbs

(2015) Ye Zhu et al.   CELLULAR SIGNALLING

NDR Functions as a Physiological YAP1 Kinase in the Intestinal Epithelium

(2015) Lei Zhang et al.   CURRENT BIOLOGY

The Spectrin cytoskeleton regulates the Hippo signalling pathway

(2015) G. C. Fletcher et al.   EMBO JOURNAL

A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis

(2015) Toshiro Moroishi et al.   GENES & DEVELOPMENT

β-Spectrin Regulates the Hippo Signaling Pathway and Modulates the Basal Actin Network

(2015) Kenneth Kin Lam Wong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cost-benefit analysis of the mechanisms that enable migrating cells to sustain motility upon changes in matrix environments

(2015) M. Tozluoglu et al.   Journal of the Royal Society Interface

Hippo Pathway Gene Mutations in Malignant Mesothelioma: Revealed by RNA and Targeted Exon Sequencing

(2015) Akihiko Miyanaga et al.   Journal of Thoracic Oncology

CCM-3/STRIPAK promotes seamless tube extension through endocytic recycling

(2015) Benjamin Lant et al.   Nature Communications

mTORC2 Regulates Cardiac Response to Stress by Inhibiting MST1

(2015) Sebastiano Sciarretta et al.   Cell Reports

Hippo-Independent Activation of YAP by the GNAQ Uveal Melanoma Oncogene through a Trio-Regulated Rho GTPase Signaling Circuitry

(2014) Xiaodong Feng et al.   CANCER CELL

Hippo Coactivator YAP1 Upregulates SOX9 and Endows Esophageal Cancer Cells with Stem-like Properties

(2014) S. Song et al.   CANCER RESEARCH

Cytoskeletal Tension Inhibits Hippo Signaling through an Ajuba-Warts Complex

(2014) Cordelia Rauskolb et al.   CELL

Tumor-propagating cells and Yap/Taz activity contribute to lung tumor progression and metastasis

(2014) A. N. Lau et al.   EMBO JOURNAL

Cross Talk between NDR Kinase Pathways Coordinates Cytokinesis with Cell Separation in Schizosaccharomyces pombe

(2014) Sneha Gupta et al.   EUKARYOTIC CELL

Analysis of S. pombe SIN protein association to the SPB reveals two genetically separable states of the SIN

(2014) P. Wachowicz et al.   JOURNAL OF CELL SCIENCE

STRIPAK components determine mode of cancer cell migration and metastasis

(2014) Chris D. Madsen et al.   NATURE CELL BIOLOGY

MST3 Kinase Phosphorylates TAO1/2 to Enable Myosin Va Function in Promoting Spine Synapse Development

(2014) Sila K. Ultanir et al.   NEURON

Genetic Deletion of Mst1 Alters T Cell Function and Protects against Autoimmunity

(2014) Konstantin V. Salojin et al.   PLoS One

Structural insights into the activation of MST3 by MO25

(2013) Youcef Mehellou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structural and Thermodynamic Characterization of Nore1-SARAH: A Small, Helical Module Important in Signal Transduction Networks

(2013) Cihan Makbul et al.   BIOCHEMISTRY

Spatial Organization of Hippo Signaling at the Plasma Membrane Mediated by the Tumor Suppressor Merlin/NF2

(2013) Feng Yin et al.   CELL

Cumulative Haploinsufficiency and Triplosensitivity Drive Aneuploidy Patterns and Shape the Cancer Genome

(2013) Teresa Davoli et al.   CELL

A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors

(2013) Mariaceleste Aragona et al.   CELL

Mask Is Required for the Activity of the Hippo Pathway Effector Yki/YAP

(2013) Leticia Sansores-Garcia et al.   CURRENT BIOLOGY

Mask Proteins Are Cofactors of Yorkie/YAP in the Hippo Pathway

(2013) Clara M. Sidor et al.   CURRENT BIOLOGY

The Hippo Pathway Member Nf2 Is Required for Inner Cell Mass Specification

(2013) Katie Cockburn et al.   CURRENT BIOLOGY

Polarity-Dependent Distribution of Angiomotin Localizes Hippo Signaling in Preimplantation Embryos

(2013) Yoshikazu Hirate et al.   CURRENT BIOLOGY

Identification of SIN Pathway Targets Reveals Mechanisms of Crosstalk between NDR Kinase Pathways

(2013) Sneha Gupta et al.   CURRENT BIOLOGY

Bantam is essential for Drosophila intestinal stem cell proliferation in response to Hippo signaling

(2013) Hongling Huang et al.   DEVELOPMENTAL BIOLOGY

Focal Defects in Single-Celled Tubes Mutant for Cerebral Cavernous Malformation 3, GCKIII, or NSF2

(2013) Yanjun Song et al.   DEVELOPMENTAL CELL

The Hippo Effector Yorkie Controls Normal Tissue Growth by Antagonizing Scalloped-Mediated Default Repression

(2013) Laura M. Koontz et al.   DEVELOPMENTAL CELL

Differential proliferation rates generate patterns of mechanical tension that orient tissue growth

(2013) Yanlan Mao et al.   EMBO JOURNAL

Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation

(2013) F.-X. Yu et al.   GENES & DEVELOPMENT

The Tumor Suppressor Mst1 Promotes Changes in the Cellular Redox State by Phosphorylation and Inactivation of Peroxiredoxin-1 Protein

(2013) Sonali Jalan Rawat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Hippo pathway polarizes the actin cytoskeleton during collective migration ofDrosophilaborder cells

(2013) Eliana P. Lucas et al.   JOURNAL OF CELL BIOLOGY

YAP and TAZ Regulate Skin Wound Healing

(2013) Min-Jung Lee et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

(2013) Fernando Calvo et al.   NATURE CELL BIOLOGY

Cell Cycle Regulated Interaction of a Yeast Hippo Kinase and Its Activator MO25/Hym1

(2013) Jonathan Hsu et al.   PLoS One

Ajuba Family Proteins Link JNK to Hippo Signaling

(2013) G. Sun et al.   Science Signaling

Angiomotin prevents pluripotent lineage differentiation in mouse embryos via Hippo pathway-dependent and -independent mechanisms

(2013) Chuen Yan Leung et al.   Nature Communications

Brahma is essential for Drosophila intestinal stem cell proliferation and regulated by Hippo signaling

(2013) Yunyun Jin et al.   eLife

A novel non-canonical mechanism of regulation of MST3 (mammalian Sterile20-related kinase 3)

(2012) Stephen J. Fuller et al.   BIOCHEMICAL JOURNAL

The phenotype of human STK4 deficiency

(2012) H. Abdollahpour et al.   BLOOD

Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling

(2012) Fa-Xing Yu et al.   CELL

Homeodomain-Interacting Protein Kinase Regulates Yorkie Activity to Promote Tissue Growth

(2012) Joanna Chen et al.   CURRENT BIOLOGY

Homeodomain-Interacting Protein Kinase Regulates Hippo Pathway-Dependent Tissue Growth

(2012) Carole L.C. Poon et al.   CURRENT BIOLOGY

The Cell Adhesion Molecule Echinoid Functions as a Tumor Suppressor and Upstream Regulator of the Hippo Signaling Pathway

(2012) Tao Yue et al.   DEVELOPMENTAL CELL

Salt-inducible kinases regulate growth through the Hippo signalling pathway in Drosophila

(2012) Michael C. Wehr et al.   NATURE CELL BIOLOGY

Rap2A links intestinal cell polarity to brush border formation

(2012) Martijn Gloerich et al.   NATURE CELL BIOLOGY

Scribble Acts in the Drosophila Fat-Hippo Pathway to Regulate Warts Activity

(2012) Shilpi Verghese et al.   PLoS One

A Screen for Round Egg Mutants in Drosophila Identifies Tricornered, Furry, and Misshapen as Regulators of Egg Chamber Elongation

(2012) Sally Horne-Badovinac et al.   G3-Genes Genomes Genetics

MST1 mutations in autosomal recessive primary immunodeficiency characterized by defective naive T-cell survival

(2011) N. T. Nehme et al.   BLOOD

Yap1 Acts Downstream of α-Catenin to Control Epidermal Proliferation

(2011) Karin Schlegelmilch et al.   CELL

Wbp2 cooperates with Yorkie to drive tissue growth downstream of the Salvador–Warts–Hippo pathway

(2011) X Zhang et al.   CELL DEATH AND DIFFERENTIATION

Mitotic Exit Control: A Space and Time Odyssey

(2011) Marisa Segal   CURRENT BIOLOGY

SIN-Inhibitory Phosphatase Complex Promotes Cdc11p Dephosphorylation and Propagates SIN Asymmetry in Fission Yeast

(2011) N. Sadananda Singh et al.   CURRENT BIOLOGY

Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila

(2011) B. G. Fernandez et al.   DEVELOPMENT

Tao-1 Phosphorylates Hippo/MST Kinases to Regulate the Hippo-Salvador-Warts Tumor Suppressor Pathway

(2011) Julian C. Boggiano et al.   DEVELOPMENTAL CELL

MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases

(2011) Beatrice M Filippi et al.   EMBO JOURNAL

Cdc15 integrates Tem1 GTPase-mediated spatial signals with Polo kinase-mediated temporal cues to activate mitotic exit

(2011) J. M. Rock et al.   GENES & DEVELOPMENT

Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein

(2011) B. Zhao et al.   GENES & DEVELOPMENT

Genome-wide methylation profiling in Crohnʼs disease identifies altered epigenetic regulation of key host defense mechanisms including the Th17 pathway

(2011) Elaine R. Nimmo et al.   INFLAMMATORY BOWEL DISEASES

Structure-Function Analysis of Core STRIPAK Proteins

(2011) Michelle J. Kean et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance

(2011) D. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Zyxin Links Fat Signaling to the Hippo Pathway

(2011) Cordelia Rauskolb et al.   PLOS BIOLOGY

Lgl, aPKC, and Crumbs Regulate the Salvador/Warts/Hippo Pathway through Two Distinct Mechanisms

(2010) Nicola A. Grzeschik et al.   CURRENT BIOLOGY

The Merlin/NF2 Tumor Suppressor Functions through the YAP Oncoprotein to Regulate Tissue Homeostasis in Mammals

(2010) Nailing Zhang et al.   DEVELOPMENTAL CELL

The WW Domain Protein Kibra Acts Upstream of Hippo in Drosophila

(2010) Roland Baumgartner et al.   DEVELOPMENTAL CELL

Evidence for a Growth-Stabilizing Regulatory Feedback Mechanism between Myc and Yorkie, the Drosophila Homolog of Yap

(2010) Ricardo M. Neto-Silva et al.   DEVELOPMENTAL CELL

Kibra Is a Regulator of the Salvador/Warts/Hippo Signaling Network

(2010) Alice Genevet et al.   DEVELOPMENTAL CELL

The Ste20 kinase misshapen is essential for the invasive behaviour of ovarian epithelial cells in Drosophila

(2010) Laura Cobreros-Reguera et al.   EMBO REPORTS

The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program

(2010) J. Cai et al.   GENES & DEVELOPMENT

A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF -TRCP

(2010) B. Zhao et al.   GENES & DEVELOPMENT

Distinct and overlapping genetic loci in crohnʼs disease and ulcerative colitis: Correlations with pathogenesis

(2010) Matti Waterman et al.   INFLAMMATORY BOWEL DISEASES

Fission Yeast Germinal Center (GC) Kinase Ppk11 Interacts with Pmo25 and Plays an Auxiliary Role in Concert with the Morphogenesis Orb6 Network (MOR) in Cell Morphogenesis

(2010) Tetsuya Goshima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CCM3 signaling through sterile 20–like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations

(2010) Xiangjian Zheng et al.   JOURNAL OF CLINICAL INVESTIGATION

Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity

(2010) Rebecca A. Stockton et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Combined Functional Genomic and Proteomic Approaches Identify a PP2A Complex as a Negative Regulator of Hippo Signaling

(2010) Paulo S. Ribeiro et al.   MOLECULAR CELL

WW domain-mediated interaction with Wbp2 is important for the oncogenic property of TAZ

(2010) S W Chan et al.   ONCOGENE

The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded

(2010) C. Ling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The apical-basal cell polarity determinant Crumbs regulates Hippo signaling in Drosophila

(2010) C.-L. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression

(2010) H. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver

(2010) L. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Hippo-Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis

(2010) K.-P. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of the tumor suppressor RASSF2 in regulation of MST1 kinase activity

(2009) Hoogeun Song et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mst1 and Mst2 Maintain Hepatocyte Quiescence and Suppress Hepatocellular Carcinoma Development through Inactivation of the Yap1 Oncogene

(2009) Dawang Zhou et al.   CANCER CELL

Phosphorylation-independent repression of Yorkie in Fat-Hippo signaling

(2009) Hyangyee Oh et al.   DEVELOPMENTAL BIOLOGY

The Hippo Signaling Pathway Components Lats and Yap Pattern Tead4 Activity to Distinguish Mouse Trophectoderm from Inner Cell Mass

(2009) Noriyuki Nishioka et al.   DEVELOPMENTAL CELL

Mst4 and Ezrin Induce Brush Borders Downstream of the Lkb1/Strad/Mo25 Polarization Complex

(2009) Jean Paul ten Klooster et al.   DEVELOPMENTAL CELL

Mst1 controls lymphocyte trafficking and interstitial motility within lymph nodes

(2009) Koko Katagiri et al.   EMBO JOURNAL

MST Kinases Monitor Actin Cytoskeletal Integrity and Signal via c-Jun N-Terminal Kinase Stress-Activated Kinase To Regulate p21Waf1/Cip1 Stability

(2009) R. M. Densham et al.   MOLECULAR AND CELLULAR BIOLOGY

Mutations in the C-terminus of the conserved NDR kinase, Cbk1p of Saccharomyces cerevisiae, make the protein independent of upstream activators

(2009) Cristina Panozzo et al.   MOLECULAR GENETICS AND GENOMICS

An integrated workflow for charting the human interaction proteome: insights into the PP2A system

(2009) Timo Glatter et al.   Molecular Systems Biology

In vivo analysis of Yorkie phosphorylation sites

(2009) H Oh et al.   ONCOGENE

The Germinal Center Kinase GCK-1 Is a Negative Regulator of MAP Kinase Activation and Apoptosis in the C. elegans Germline

(2009) Katherine R. Schouest et al.   PLoS One

Scribble participates in Hippo signaling and is required for normal zebrafish pronephros development

(2009) K. Skouloudaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An overview of the fission yeast septation initiation network (SIN): Figure 1

(2008) Andrea Krapp et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

SCALLOPED Interacts with YORKIE, the Nuclear Effector of the Hippo Tumor-Suppressor Pathway in Drosophila

(2008) Youlian Goulev et al.   CURRENT BIOLOGY

In vivo regulation of Yorkie phosphorylation and localization

(2008) H. Oh et al.   DEVELOPMENT

The TEAD/TEF Family Protein Scalloped Mediates Transcriptional Output of the Hippo Growth-Regulatory Pathway

(2008) Shian Wu et al.   DEVELOPMENTAL CELL

The TEAD/TEF Family of Transcription Factor Scalloped Mediates Hippo Signaling in Organ Size Control

(2008) Lei Zhang et al.   DEVELOPMENTAL CELL

A crucial role of WW45 in developing epithelial tissues in the mouse

(2008) Joo-Hyeon Lee et al.   EMBO JOURNAL

A PP2A Phosphatase High Density Interaction Network Identifies a Novel Striatin-interacting Phosphatase and Kinase Complex Linked to the Cerebral Cavernous Malformation 3 (CCM3) Protein

(2008) Marilyn Goudreault et al.   MOLECULAR & CELLULAR PROTEOMICS

The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naive T cells

(2008) D. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The NDR/LATS Family Kinase Cbk1 Directly Controls Transcriptional Asymmetry

(2008) Emily Mazanka et al.   PLOS BIOLOGY