YAP triggers the Wnt/β-catenin signalling pathway and promotes enterocyte self-renewal, regeneration and tumorigenesis after DSS-induced injury

Wnt signaling regulates hepatobiliary repair following cholestatic liver injury in mice

(2016) Hirohisa Okabe et al.   HEPATOLOGY

Inflammatory networks underlying colorectal cancer

(2016) Audrey Lasry et al.   NATURE IMMUNOLOGY

The intestinal epithelial barrier: a therapeutic target?

(2016) Matthew A. Odenwald et al.   Nature Reviews Gastroenterology & Hepatology

Hippo Pathway Regulation of Gastrointestinal Tissues

(2015) Fa-Xing Yu et al.   Annual Review of Physiology

ERG Activates the YAP1 Transcriptional Program and Induces the Development of Age-Related Prostate Tumors

(2015) Liem T. Nguyen et al.   CANCER CELL

Alternative Wnt Signaling Activates YAP/TAZ

(2015) Hyun Woo Park et al.   CELL

Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer

(2015) Fa-Xing Yu et al.   CELL

Kremen1 and Dickkopf1 control cell survival in a Wnt-independent manner

(2015) F Causeret et al.   CELL DEATH AND DIFFERENTIATION

The Hippo/YAP pathway interacts with EGFR signaling and HPV oncoproteins to regulate cervical cancer progression

(2015) Chunbo He et al.   EMBO Molecular Medicine

YAP promotes proliferation, chemoresistance, and angiogenesis in human cholangiocarcinoma through TEAD transcription factors

(2015) Patricia Marti et al.   HEPATOLOGY

Yap-dependent reprogramming of Lgr5+ stem cells drives intestinal regeneration and cancer

(2015) Alex Gregorieff et al.   NATURE

A gp130–Src–YAP module links inflammation to epithelial regeneration

(2015) Koji Taniguchi et al.   NATURE

Increased TEAD4 expression and nuclear localization in colorectal cancer promote epithelial–mesenchymal transition and metastasis in a YAP-independent manner

(2015) Y Liu et al.   ONCOGENE

Dynamic alterations in Hippo signaling pathway and YAP activation during liver regeneration

(2014) James L. Grijalva et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

YAP/TAZ Incorporation in the β-Catenin Destruction Complex Orchestrates the Wnt Response

(2014) Luca Azzolin et al.   CELL

Hippo Pathway Activity Influences Liver Cell Fate

(2014) Dean Yimlamai et al.   CELL

Activation of β-Catenin and Yap1 in Human Hepatoblastoma and Induction of Hepatocarcinogenesis in Mice

(2014) Junyan Tao et al.   GASTROENTEROLOGY

IL-6-Dependent Mucosal Protection Prevents Establishment of a Microbial Niche for Attaching/Effacing Lesion-Forming Enteric Bacterial Pathogens

(2014) S. M. Dann et al.   JOURNAL OF IMMUNOLOGY

Identification of Gene Expression Changes from Colitis to CRC in the Mouse CAC Model

(2014) Xin Li et al.   PLoS One

Lgr5+ Stem Cells Are Indispensable for Radiation-Induced Intestinal Regeneration

(2013) Ciara Metcalfe et al.   Cell Stem Cell

Yes-Associated Protein Up-regulates Jagged-1 and Activates the NOTCH Pathway in Human Hepatocellular Carcinoma

(2013) Darjus Felix Tschaharganeh et al.   GASTROENTEROLOGY

Recent advances in inflammatory bowel disease: mucosal immune cells in intestinal inflammation

(2013) M Zaeem Cader et al.   GUT

The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment

(2013) Randy Johnson et al.   NATURE REVIEWS DRUG DISCOVERY

Organ repair and regeneration: An overview

(2012) Joëlle A. Baddour et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

A Critical Role for the Wnt Effector Tcf4 in Adult Intestinal Homeostatic Self-Renewal

(2012) J. H. van Es et al.   MOLECULAR AND CELLULAR BIOLOGY

Wnt signalling and its role in stem cell-driven intestinal regeneration and hyperplasia

(2011) J. B. Cordero et al.   Acta Physiologica

Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease

(2011) R. M. Gadaleta et al.   GUT

Constitutive intestinal NF-κB does not trigger destructive inflammation unless accompanied by MAPK activation

(2011) Monica Guma et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance

(2011) D. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hippo Pathway Inhibits Wnt Signaling to Restrain Cardiomyocyte Proliferation and Heart Size

(2011) T. Heallen et al.   SCIENCE

Disparate Cellular Basis of Improved Liver Repair in β-Catenin-Overexpressing Mice After Long-Term Exposure to 3,5-Diethoxycarbonyl-1,4-Dihydrocollidine

(2010) Michael D. Thompson et al.   AMERICAN JOURNAL OF PATHOLOGY

The Hippo Pathway Regulates Wnt/β-Catenin Signaling

(2010) Xaralabos Varelas et al.   DEVELOPMENTAL CELL

The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program

(2010) J. Cai et al.   GENES & DEVELOPMENT

A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF -TRCP

(2010) B. Zhao et al.   GENES & DEVELOPMENT

Intestinal growth factors: Potential use in the treatment of inflammatory bowel disease and their role in mucosal healing

(2010) Kumar Krishnan et al.   INFLAMMATORY BOWEL DISEASES

gp130-Mediated Stat3 Activation in Enterocytes Regulates Cell Survival and Cell-Cycle Progression during Colitis-Associated Tumorigenesis

(2009) Julia Bollrath et al.   CANCER CELL

IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer

(2009) Sergei Grivennikov et al.   CANCER CELL

Disease-related expression of the IL6/STAT3/SOCS3 signalling pathway in ulcerative colitis and ulcerative colitis-related carcinogenesis

(2009) Y. Li et al.   GUT

Clinical implications of mucosal healing for the management of IBD

(2009) Guillaume Pineton de Chambrun et al.   Nature Reviews Gastroenterology & Hepatology

Galectin-2 and -4, but not Galectin-1, promote intestinal epithelial wound healing in vitro through a TGF-beta-independent mechanism

(2008) Daniela Paclik et al.   INFLAMMATORY BOWEL DISEASES

Epithelial restitution and wound healing in inflammatory bowel disease

(2008) Andreas Sturm et al.   WORLD JOURNAL OF GASTROENTEROLOGY