Mechanisms of Action and Cell Death Associated with Clostridium perfringens Toxins

Expansion of the Clostridium perfringens toxin-based typing scheme

(2018) Julian I. Rood et al.   ANAEROBE

Evidence that Clostridium perfringens Enterotoxin-Induced Intestinal Damage and Enterotoxemic Death in Mice Can Occur Independently of Intestinal Caspase-3 Activation

(2018) John C. Freedman et al.   INFECTION AND IMMUNITY

Structural pierce into molecular mechanism underlying Clostridium perfringens Epsilon toxin function

(2017) Saeed Khalili et al.   TOXICON

Cellular Entry of Clostridium perfringens Iota-Toxin and Clostridium botulinum C2 Toxin

(2017) Masaya Takehara et al.   Toxins

The Potential Therapeutic Agent Mepacrine Protects Caco-2 Cells against Clostridium perfringens Enterotoxin Action

(2017) John C. Freedman et al.   mSphere

New insights into Clostridium perfringens epsilon toxin activation and action on the brain during enterotoxemia

(2016) John C. Freedman et al.   ANAEROBE

The pathogenesis of necrotic enteritis in chickens: what we know and what we need to know: a review

(2016) John F. Prescott et al.   AVIAN PATHOLOGY

NetB and necrotic enteritis: the hole movable story

(2016) Julian I. Rood et al.   AVIAN PATHOLOGY

Pore-forming activity of clostridial binary toxins

(2016) O. Knapp et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Role of pannexin 1 in Clostridium perfringens beta-toxin-caused cell death

(2016) Soshi Seike et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Oligomer formation of Clostridium perfringens epsilon-toxin is induced by activation of neutral sphingomyelinase

(2016) Teruhisa Takagishi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Clostridium perfringens α-Toxin Impairs Lipid Raft Integrity in Neutrophils

(2016) Masaya Takehara et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Clostridium perfringens Enterotoxin: Action, Genetics, and Translational Applications

(2016) John Freedman et al.   Toxins

Clostridium perfringens α-Toxin Impairs Innate Immunity via Inhibition of Neutrophil Differentiation

(2016) Masaya Takehara et al.   Scientific Reports

Role of P2X7 receptor in Clostridium perfringens beta-toxin-mediated cellular injury

(2015) Masahiro Nagahama et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Novel receptors for bacterial protein toxins

(2015) Gudula Schmidt et al.   CURRENT OPINION IN MICROBIOLOGY

Death in the fast lane: what's next for necroptosis?

(2015) Andrew Oberst   FEBS Journal

Identification and Characterization of Clostridium perfringens Beta Toxin Variants with Differing Trypsin Sensitivity andIn VitroCytotoxicity Activity

(2015) James R. Theoret et al.   INFECTION AND IMMUNITY

Clostridium perfringens α-toxin interaction with red cells and model membranes

(2015) S. A. Jewell et al.   Soft Matter

The Myelin and Lymphocyte Protein MAL Is Required for Binding and Activity of Clostridium perfringens ε-Toxin

(2015) Kareem Rashid Rumah et al.   PLoS Pathogens

Binding Studies on Isolated Porcine Small Intestinal Mucosa and in vitro Toxicity Studies Reveal Lack of Effect of C. perfringens Beta-Toxin on the Porcine Intestinal Epithelium

(2015) Simone Roos et al.   Toxins

Recent Insights into Clostridium perfringens Beta-Toxin

(2015) Masahiro Nagahama et al.   Toxins

Membrane-Binding Mechanism of Clostridium perfringens Alpha-Toxin

(2015) Masataka Oda et al.   Toxins

Clostridial pore-forming toxins: Powerful virulence factors

(2014) Michel R. Popoff   ANAEROBE

Pannexin channels and their links to human disease

(2014) Silvia Penuela et al.   BIOCHEMICAL JOURNAL

RIP kinases: key decision makers in cell death and innate immunity

(2014) F Humphries et al.   CELL DEATH AND DIFFERENTIATION

Epsilon toxin fromClostridium perfringensacts on oligodendrocytes without forming pores, and causes demyelination

(2014) Laetitia Wioland et al.   CELLULAR MICROBIOLOGY

Towards an understanding of the role of Clostridium perfringens toxins in human and animal disease

(2014) Francisco A Uzal et al.   Future Microbiology

Clostridium perfringens Type A Enterotoxin Damages the Rabbit Colon

(2014) J. P. Garcia et al.   INFECTION AND IMMUNITY

Die another way – non-apoptotic mechanisms of cell death

(2014) Stephen W. G. Tait et al.   JOURNAL OF CELL SCIENCE

Correction: Identification of Novel Pathogenicity Loci in Clostridium perfringens Strains That Cause Avian Necrotic Enteritis

(2014) Dion Lepp et al.   PLoS One

Clostridium perfringens Phospholipase C Induced ROS Production and Cytotoxicity Require PKC, MEK1 and NFκB Activation

(2014) Laura Monturiol-Gross et al.   PLoS One

Comparative Neuropathology of Ovine Enterotoxemia Produced by Clostridium perfringens Type D Wild-Type Strain CN1020 and Its Genetically Modified Derivatives

(2014) J. P. Garcia et al.   VETERINARY PATHOLOGY

Proteolytic Processing and Activation of Clostridium perfringens Epsilon Toxin by Caprine Small Intestinal Contents

(2014) J. C. Freedman et al.   mBio

Internalization ofClostridium perfringensα-toxin leads to ERK activation and is involved on its cytotoxic effect

(2013) Laura Monturiol-Gross et al.   CELLULAR MICROBIOLOGY

Epsilon Toxin Is Essential for the Virulence of Clostridium perfringens Type D Infection in Sheep, Goats, and Mice

(2013) J. P. Garcia et al.   INFECTION AND IMMUNITY

The p38 MAPK and JNK Pathways Protect Host Cells against Clostridium perfringens Beta-Toxin

(2013) Masahiro Nagahama et al.   INFECTION AND IMMUNITY

The pathology of enterotoxemia by Clostridium perfringens type C in calves

(2013) Jorge P. Garcia et al.   JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION

Clostridium perfringens Beta-Toxin Induces Necrostatin-Inhibitable, Calpain-Dependent Necrosis in Primary Porcine Endothelial Cells

(2013) Delphine Autheman et al.   PLoS One

Attack of the nervous system by Clostridium perfringens Epsilon toxin: From disease to mode of action on neural cells

(2013) Laetitia Wioland et al.   TOXICON

Structural and Functional Analysis of the Pore-Forming Toxin NetB from Clostridium perfringens

(2013) X.-X. Yan et al.   mBio

Human Claudin-8 and -14 Are Receptors Capable of Conveying the Cytotoxic Effects of Clostridium perfringens Enterotoxin

(2013) A. Shrestha et al.   mBio

Identification of a lambda toxin-negative Clostridium perfringens strain that processes and activates epsilon prototoxin intracellularly

(2012) Justine M. Harkness et al.   ANAEROBE

Autophagy, Apoptosis, Mitoptosis and Necrosis: Interdependence Between Those Pathways and Effects on Cancer

(2012) Wiem Chaabane et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Regulation of ATP production by mitochondrial Ca2+

(2012) Andrei I. Tarasov et al.   CELL CALCIUM

Intracellular Trafficking of Clostridium perfringens Iota-Toxin b

(2012) Masahiro Nagahama et al.   INFECTION AND IMMUNITY

Clostridium perfringensAlpha-toxin Recognizes the GM1a-TrkA Complex

(2012) Masataka Oda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Architecture and Functional Analysis of NetB, a Pore-forming Toxin fromClostridium perfringens

(2012) Christos G. Savva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coenzyme depletion by members of the aerolysin family of pore-forming toxins leads to diminished ATP levels and cell death

(2012) Christine M. Fennessey et al.   Molecular BioSystems

Sequence of Two Plasmids from Clostridium perfringens Chicken Necrotic Enteritis Isolates and Comparison with C. perfringens Conjugative Plasmids

(2012) Valeria R. Parreira et al.   PLoS One

CD44 Promotes Intoxication by the Clostridial Iota-Family Toxins

(2012) Darran J. Wigelsworth et al.   PLoS One

The effect of Clostridium perfringens type C strain CN3685 and its isogenic beta toxin null mutant in goats

(2012) J.P. Garcia et al.   VETERINARY MICROBIOLOGY

Endothelial Binding of Beta Toxin to Small Intestinal Mucosal Endothelial Cells in Early Stages of Experimentally Induced Clostridium Perfringens Type C Enteritis in Pigs

(2012) V. L. Schumacher et al.   VETERINARY PATHOLOGY

Calcium and cell death mechanisms: A perspective from the cell death community

(2011) Boris Zhivotovsky et al.   CELL CALCIUM

Molecular basis of toxicity of Clostridium perfringens epsilon toxin

(2011) Monika Bokori-Brown et al.   FEBS Journal

Epsilon toxin: a fascinating pore-forming toxin

(2011) Michel R. Popoff   FEBS Journal

Clostridium perfringens Iota-Toxin b Induces Rapid Cell Necrosis

(2011) Masahiro Nagahama et al.   INFECTION AND IMMUNITY

Development and Application of a Mouse Intestinal Loop Model To Study theIn VivoAction of Clostridium perfringens Enterotoxin

(2011) Justin A. Caserta et al.   INFECTION AND IMMUNITY

Cell death and infection: A double-edged sword for host and pathogen survival

(2011) Hiroshi Ashida et al.   JOURNAL OF CELL BIOLOGY

Structures, Biosynthesis, and Functions of Gangliosides-an Overview

(2011) Robert K. Yu et al.   Journal of Oleo Science

Diagnosis of Clostridium Perfringens Intestinal Infections in Sheep and Goats

(2011) Francisco A. Uzal et al.   JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION

Gene-Trap Mutagenesis Identifies Mammalian Genes Contributing to Intoxication by Clostridium perfringens ε-Toxin

(2011) Susan E. Ivie et al.   PLoS One

Identification of Novel Clostridium perfringens Type E Strains That Carry an Iota Toxin Plasmid with a Functional Enterotoxin Gene

(2011) Kazuaki Miyamoto et al.   PLoS One

Evidence for a Prepore Stage in the Action of Clostridium perfringens Epsilon Toxin

(2011) Susan L. Robertson et al.   PLoS One

Necrotic Enteritis-Derived Clostridium perfringens Strain with Three Closely Related Independently Conjugative Toxin and Antibiotic Resistance Plasmids

(2011) T. L. Bannam et al.   mBio

Sialidases Affect the Host Cell Adherence and Epsilon Toxin-Induced Cytotoxicity of Clostridium perfringens Type D Strain CN3718

(2011) Jihong Li et al.   PLoS Pathogens

Regulation of apoptosis-associated lysosomal membrane permeabilization

(2010) Ann-Charlotte Johansson et al.   APOPTOSIS

Manipulation of Host Cell Death Pathways during Microbial Infections

(2010) Mohamed Lamkanfi et al.   Cell Host & Microbe

Endocytosis and toxicity of clostridial binary toxins depend on a clathrin-independent pathway regulated by Rho-GDI

(2010) Maryse Gibert et al.   CELLULAR MICROBIOLOGY

Rapid Cytopathic Effects of Clostridium perfringens Beta-Toxin on Porcine Endothelial Cells

(2010) C. Gurtner et al.   INFECTION AND IMMUNITY

Characterization of Toxin Plasmids in Clostridium perfringens Type C Isolates

(2010) A. Gurjar et al.   INFECTION AND IMMUNITY

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Organization of the cpe Locus in CPE-Positive Clostridium perfringens Type C and D Isolates

(2010) Jihong Li et al.   PLoS One

Clostridium perfringens Epsilon Toxin Targets Granule Cells in the Mouse Cerebellum and Stimulates Glutamate Release

(2010) Etienne Lonchamp et al.   PLoS One

The Long-Lived Nature of Clostridium perfringens Iota Toxin in Mammalian Cells Induces Delayed Apoptosis

(2009) H. Hilger et al.   INFECTION AND IMMUNITY

Characterization of Virulence Plasmid Diversity among Clostridium perfringens Type B Isolates

(2009) S. Sayeed et al.   INFECTION AND IMMUNITY

Development and Application of New Mouse Models To Study the Pathogenesis of Clostridium perfringens Type C Enterotoxemias

(2009) F. A. Uzal et al.   INFECTION AND IMMUNITY

Clostridium perfringens  -toxin binding to vascular endothelial cells in a human case of enteritis necroticans

(2009) J. Miclard et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Clostridium perfringens Epsilon Toxin Increases the Small Intestinal Permeability in Mice and Rats

(2009) Jorge Goldstein et al.   PLoS One

Clostridium perfringens beta-toxin targets endothelial cells in necrotizing enteritis in piglets

(2009) J. Miclard et al.   VETERINARY MICROBIOLOGY

Clinicopathologic Features of Experimental Clostridium perfringens Type D Enterotoxemia in Cattle

(2009) E. J. F. Filho et al.   VETERINARY PATHOLOGY

Association between avian necrotic enteritis andClostridium perfringensstrains expressing NetB toxin

(2009) Anthony L. Keyburn et al.   VETERINARY RESEARCH

Clostridium perfringens Iota-Toxin: Structure and Function

(2009) Jun Sakurai et al.   Toxins

Domain mapping of a claudin-4 modulator, the C-terminal region of C-terminal fragment of Clostridium perfringens enterotoxin, by site-directed mutagenesis

(2008) Azusa Takahashi et al.   BIOCHEMICAL PHARMACOLOGY

Involvement of tumour necrosis factor-α in Clostridium perfringensβ-toxin-induced plasma extravasation in mice

(2008) M Nagahama et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effects of Clostridium perfringens Beta-Toxin on the Rabbit Small Intestine and Colon

(2008) J. E. Vidal et al.   INFECTION AND IMMUNITY

The relationship between the metabolism of sphingomyelin species and the hemolysis of sheep erythrocytes induced byClostridium perfringensα-toxin

(2008) Masataka Oda et al.   JOURNAL OF LIPID RESEARCH

Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis

(2008) P Pinton et al.   ONCOGENE

Structural basis of actin recognition and arginine ADP-ribosylation by Clostridium perfringens  -toxin

(2008) H. Tsuge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sub-clinical necrotic enteritis in broiler chickens: Novel etiological consideration based on ultra-structural and molecular changes in the intestinal tissue

(2008) A.A. Olkowski et al.   RESEARCH IN VETERINARY SCIENCE

Binding of ɛ-toxin from Clostridium perfringens in the nervous system

(2008) Jonatan Dorca-Arévalo et al.   VETERINARY MICROBIOLOGY

Aquaporin-4 in Acute Cerebral Edema Produced by Clostridium perfringens Type D Epsilon Toxin

(2008) J. W. Finnie et al.   VETERINARY PATHOLOGY