Coenzyme depletion by members of the aerolysin family of pore-forming toxins leads to diminished ATP levels and cell death

An aerolysin-like enterotoxin from Vibrio splendidus may be involved in intestinal tract damage and mortalities in turbot, Scophthalmus maximus (L.), and cod, Gadus morhua L., larvae

(2012) H L Macpherson et al.   JOURNAL OF FISH DISEASES

Pore-forming toxins induce multiple cellular responses promoting survival

(2011) Manuel R. Gonzalez et al.   CELLULAR MICROBIOLOGY

Helicobacter pylori VacA Induces Programmed Necrosis in Gastric Epithelial Cells

(2011) Jana N. Radin et al.   INFECTION AND IMMUNITY

Structure of the Food-Poisoning Clostridium perfringens Enterotoxin Reveals Similarity to the Aerolysin-Like Pore-Forming Toxins

(2011) David C. Briggs et al.   JOURNAL OF MOLECULAR BIOLOGY

Gene-Trap Mutagenesis Identifies Mammalian Genes Contributing to Intoxication by Clostridium perfringens ε-Toxin

(2011) Susan E. Ivie et al.   PLoS One

Extending the Aerolysin Family: From Bacteria to Vertebrates

(2011) Pawel Szczesny et al.   PLoS One

Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome

(2011) Z. J. Reitman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polymer Partitioning and Ion Selectivity Suggest Asymmetrical Shape for the Membrane Pore Formed by Epsilon Toxin

(2010) Ekaterina M. Nestorovich et al.   BIOPHYSICAL JOURNAL

Complex Contribution of Cyclophilin D to Ca2+-induced Permeability Transition in Brain Mitochondria, with Relation to the Bioenergetic State

(2010) Judit Doczi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NAD+ Depletion Is Necessary and Sufficient forPoly(ADP-Ribose) Polymerase-1-Mediated Neuronal Death

(2010) C. C. Alano et al.   JOURNAL OF NEUROSCIENCE

Identification of Small Molecule Inhibitors of Clostridium perfringens ε-Toxin Cytotoxicity Using a Cell-Based High-Throughput Screen

(2010) Michelle Lewis et al.   Toxins

Integrated, Nontargeted Ultrahigh Performance Liquid Chromatography/Electrospray Ionization Tandem Mass Spectrometry Platform for the Identification and Relative Quantification of the Small-Molecule Complement of Biological Systems

(2009) Anne M. Evans et al.   ANALYTICAL CHEMISTRY

Dominant-negative Inhibitors of theClostridium perfringensϵ-Toxin

(2009) Teal M. Pelish et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

 -Hemolysin from Escherichia coli uses endogenous amplification through P2X receptor activation to induce hemolysis

(2009) M. Skals et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clostridium septicum alpha-toxin forms pores and induces rapid cell necrosis

(2009) Oliver Knapp et al.   TOXICON

Programmed Cellular Necrosis Mediated by the Pore-Forming α-Toxin from Clostridium septicum

(2009) Catherine L. Kennedy et al.   PLoS Pathogens

Cellular NAD Replenishment Confers Marked Neuroprotection Against Ischemic Cell Death

(2008) Suping Wang et al.   STROKE