Article
Agriculture, Dairy & Animal Science
D. Goo, U. D. Gadde, W. K. Kim, C. G. Gay, E. W. Porta, S. W. Jones, S. Walker, H. S. Lillehoj
Summary: This study presents a passive immunization technology using hyperimmune egg yolk immunoglobulin Y (IgY) to protect against Necrotic enteritis (NE) caused by Clostridium perfringens in poultry. The protective effects of the IgYs were evaluated in commercial broilers, and it was found that the dietary mixture containing antibodies provided protection against NE through passive immunization.
Article
Pharmacology & Pharmacy
Pin Gong, Peipei Wang, Sihui Pi, Yuxi Guo, Shuya Pei, Wenjuan Yang, Xiangna Chang, Lan Wang, Fuxin Chen
Summary: This study found that proanthocyanidins from grape seed have protective effects against Cd-induced diabetic nephropathy, possibly through regulating oxidative-antioxidative status, metal-binding ability, and oxidative stress-related signaling pathways.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Environmental Sciences
Won-Young Lee, Hyun-Jung Park
Summary: T-2 toxin induces reproductive toxicity and germ cell damage. It reduces testicular germ cell number and downregulates their corresponding markers, but increases Sertoli cell markers and steroidogenic enzyme expression. T-2 toxin also decreases cell viability, increases apoptosis, and triggers ROS-mediated JNK/p38-MAPK signaling pathway, leading to mitochondrial dysfunction and apoptotic cell death in germ cells.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Plant Sciences
Ah-Won Kwak, Jin Woo Park, Seung-On Lee, Jin-Young Lee, Ji-hye Seo, Goo Yoon, Mee-Hyun Lee, Joon-Seok Choi, Jung-Hyun Shim
Summary: This study found that Isolinderalactone (ILL) can exert its anticancer effect in colorectal cancer (CRC) cells sensitive and resistant to oxaliplatin (Ox) by inducing ROS-mediated apoptosis through JNK/p38 MAPK signaling pathways. This provides a new insight into therapeutic strategies targeting drug-resistant CRC.
Article
Cell Biology
Xi Chen, Weijie Ma, Ye Yao, Qi Zhang, Jinghua Li, Xiaoling Wu, Chengjie Mei, Xiang Jiang, Yiran Chen, Ganggang Wang, Kunlei Wang, Yingyi Liu, Yonghua Guo, Zhisu Liu, Yufeng Yuan
Summary: The study identified SDPR as a tumor suppressor in HCC by promoting apoptosis through the activation of the ASK1-JNK/p38 MAPK signaling pathways. This inhibits tumor growth and migration by enhancing cell apoptosis.
CELL DEATH & DISEASE
(2021)
Article
Biotechnology & Applied Microbiology
Mohammad Ali Shamshirgaran, Mehdi Golchin, Elham Mohammadi
Summary: In this study, a recombinant Lactobacillus casei strain expressing the NetB protein of Clostridium perfringens was used as a probiotic-based vector vaccine to immunize broiler chickens against necrotic enteritis. The vaccinated birds showed significant protection against the disease and developed strong antibody responses. This study suggests that a probiotic-based vector vaccine could be a promising candidate for controlling necrotic enteritis in broiler chickens.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yongzhu Zhang, Liqing Yin, Jiajia Dong, Xiudong Xia
Summary: Isoflavones, derived from soybeans, have shown potential neuroprotective effects by increasing cell viability, decreasing reactive oxygen species levels, inhibiting apoptosis, and regulating the cell cycle. They activate Nrf2 protein, inhibit p38 MAPK and AKT-mTOR pathways, and compete with Keap1, suggesting isoflavones could be a potent neuroprotective phytochemical in soybeans and their products.
Article
Immunology
Walaa Yehia Abdelzaher, Seham A. Abdel-Gaber, Michael Atef Fawzy, Abdel Hamid Sayed Abo Bakr Ali, Mina Ezzat Attya, Ayman Geddawy
Summary: Atorvastatin may protect against cyclophosphamide-induced thyroid injury by regulating the JNK/ERK/p38-MAPK signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Julia Bruggisser, Ioan Iacovache, Samuel C. Musson, Matteo T. Degiacomi, Horst Posthaus, Benoit Zuber
Summary: This study describes the structure of Clostridium perfringens beta-toxin (CPB) and its formation of an octameric pore complex with unique structural features. The research also identifies CPB as a member of a new subclass of the hemolysin-like family. Additionally, the study demonstrates that the structure of the pore can be modified without affecting its pore-forming ability, making it attractive for macromolecule sensing and nanotechnology. The cryo-electron microscopy structure of the CPB octameric pore will contribute to future developments in nanotechnology and basic research.
Article
Biochemistry & Molecular Biology
Yang Liu, Jing Liang, Jian-Wei Li, Li-Hua Xing, Fen-Xin Li, Na Wang, Yu-Jing Wu, Yu-Ze Ma, Zhao-Rui Xing, Xue Jiang, Xin-Yue Zhang, Zheng-Xuan Lei, Xiao Wang, Shui-Xing Yu
Summary: Clostridium perfringens is an important pathogen that causes dangerous infections, but its clearance mechanism from the host is poorly understood. In this study, the formation of extracellular traps (ETs) by phagocytes was found to play a beneficial role in killing and clearing C. perfringens bacteria.
Article
Food Science & Technology
Masahiro Nagahama, Keiko Kobayashi, Masaya Takehara
Summary: The study found that lysosomal proteases cathepsin B and L facilitate the internalization of iota-toxin by activating ASMase, indicating their role in the cytotoxicity caused by the toxin.
Article
Cell Biology
Ling Liu, Yihao Xing, Mengyao Cao, Jinglei Xu, Jingjing Chen
Summary: JS-K induces apoptosis in hepatocellular carcinoma cells by activating JNK and p38 MAPK and inhibiting the Raf/MEK/ERK signaling pathway.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Baocheng Xie, Zhanwei Zeng, Shiyi Liao, Chenhui Zhou, Longhuo Wu, Daohua Xu
Summary: Kaempferol exhibits beneficial effects on osteogenic differentiation and counteracts the inhibitory activity of dexamethasone by activating JNK and p38-MAPK signaling pathways, improving bone mineralization. This potential makes it a promising candidate for developing new drugs for treating glucocorticoid-induced osteoporosis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Chenhong Lin, Huiqin He, John J. Kim, Xia Zheng, Zhihui Huang, Ning Dai
Summary: Upregulation of AQP8 and AQP3, as well as translocation of AQP8, were observed in colon tissues of patients with functional constipation. The Jun N-terminal kinase and p38 mitogen-activated protein kinase signaling pathways were found to be involved in the regulation of AQP8 in response to changes in osmotic pressure.
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Michael A. Fawzy, Sherif A. Maher, Sally M. Bakkar, Mahmoud A. El-Rehany, Moustafa Fathy
Summary: This study demonstrated the protective effect of pantoprazole on renal ischemia/reperfusion injury in rats for the first time, by suppressing apoptosis, reducing pro-inflammatory cytokines levels, and impacting intracellular signaling pathways. Moreover, multiple doses of pantoprazole showed a greater therapeutic effect than a single dose.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Soshi Seike, Masaya Takehara, Keiko Kobayashi, Masahiro Nagahama
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2016)
Article
Pharmacology & Pharmacy
Masaya Takehara, Teruhisa Takagishi, Soshi Seike, Kyohei Oishi, Yoshino Fujihara, Kazuaki Miyamoto, Keiko Kobayashi, Masahiro Nagahama
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2016)
Review
Food Science & Technology
Masaya Takehara, Teruhisa Takagishi, Soshi Seike, Masataka Oda, Yoshihiko Sakaguchi, Junzo Hisatsune, Sadayuki Ochi, Keiko Kobayashi, Masahiro Nagahama
Article
Biochemistry & Molecular Biology
Soshi Seike, Masaya Takehara, Teruhisa Takagishi, Kazuaki Miyamoto, Keiko Kobayashi, Masahiro Nagahama
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2018)
Article
Multidisciplinary Sciences
Soshi Seike, Kazuaki Miyamoto, Keiko Kobayashi, Masaya Takehara, Masahiro Nagahama
Article
Multidisciplinary Sciences
Hidetomo Kobayashi, Tadamune Otsubo, Fumiteru Teraoka, Kiyoshi Ikeda, Soshi Seike, Eizo Takahashi, Keinosuke Okamoto, Toru Yoshida, Hideaki Tsuge, Hiroyasu Yamanaka
Article
Multidisciplinary Sciences
Teruhisa Takagishi, Masaya Takehara, Soshi Seike, Kazuaki Miyamoto, Keiko Kobayashi, Masahiro Nagahama
SCIENTIFIC REPORTS
(2017)
Article
Food Science & Technology
Soshi Seike, Masaya Takehara, Keiko Kobayashi, Masahiro Nagahama
Article
Multidisciplinary Sciences
Hidetomo Kobayashi, Soshi Seike, Masafumi Yamaguchi, Mitsunobu Ueda, Eizo Takahashi, Keinosuke Okamoto, Hiroyasu Yamanaka
Article
Food Science & Technology
Masahiro Nagahama, Soshi Seike, Sadayuki Ochi, Keiko Kobayashi, Masaya Takehara
Article
Microbiology
Soshi Seike, Hidetomo Kobayashi, Mitsunobu Ueda, Eizo Takahashi, Keinosuke Okamoto, Hiroyasu Yamanaka
Summary: This study is the first to examine the in vitro formation and components of the biofilm of several Aeromonas clinical and environmental strains, revealing that the biofilms contain polysaccharides, extracellular nucleic acids, and proteins. Among these components, some proteins in the Aeromonas biofilms may affect biofilm formation. Furthermore, the release of outer membrane vesicles by Aeromonas strains was found to be closely related to biofilm formation.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Immunology
Mitsunobu Ueda, Hidetomo Kobayashi, Soshi Seike, Eizo Takahashi, Keinosuke Okamoto, Hiroyasu Yamanaka
Summary: Aeromonas sobria, a Gram-negative pathogen causing food-borne illness, opportunistically leads to severe extraintestinal diseases in immunocompromised patients and the elderly. It can disrupt the barrier function of the intestinal epithelium by destroying tight junctions, potentially aiding the invasion of pathogens into deep sites in the human body.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biology
Masaya Takehara, Soshi Seike, Yuuta Sonobe, Hiroto Bandou, Saki Yokoyama, Teruhisa Takagishi, Kazuaki Miyamoto, Keiko Kobayashi, Masahiro Nagahama
COMMUNICATIONS BIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Masaya Takehara, Soshi Seike, Teruhisa Takagishi, Keiko Kobayashi, Masahiro Nagahama
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2017)
Article
Immunology
Masahiro Nagahama, Masaya Takehara, Teruhisa Takagishi, Soshi Seike, Kazuaki Miyamoto, Keiko Kobayashi
INFECTION AND IMMUNITY
(2017)