Progress in the pharmacological treatment of human cystic and alveolar echinococcosis: Compounds and therapeutic targets

Enantiomers of triclabendazole sulfoxide: Analytical and semipreparative HPLC separation, absolute configuration assignment, and transformation into sodium salt

(2017) Rosella Ferretti et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

The sodium salt of the enantiomers of ricobendazole: Preparation, solubility and chiroptical properties

(2017) Roberto Cirilli et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Development of a movement-based in vitro screening assay for the identification of new anti-cestodal compounds

(2017) Dominic Ritler et al.   PLoS Neglected Tropical Diseases

Metformin exhibits preventive and therapeutic efficacy against experimental cystic echinococcosis

(2017) Julia A. Loos et al.   PLoS Neglected Tropical Diseases

Cystic and alveolar echinococcosis: Successes and continuing challenges

(2017) Christine M. Budke et al.   PLoS Neglected Tropical Diseases

In vitro effectiveness of Curcuma longa and Zingiber officinale extracts on Echinococcus protoscoleces

(2017) Esam Almalki et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Bortezomib initiates endoplasmic reticulum stress, elicits autophagy and death in Echinococcus granulosus larval stage

(2017) María Celeste Nicolao et al.   PLoS One

In vitro and in vivo efficacy of carvacrol against Echinococcus granulosus

(2016) Julia Fabbri et al.   ACTA TROPICA

Protoscolicidal effects of chenodeoxycholic acid on protoscoleces of Echinococcus granulosus

(2016) Hongjuan Shi et al.   EXPERIMENTAL PARASITOLOGY

In Vitro Scolicidal Effects of Salvadora persica Root Extract against Protoscolices of Echinococcus granulosus

(2016) Abdel-Azeem S. Abdel-Baki et al.   KOREAN JOURNAL OF PARASITOLOGY

In vitro effect of sodium arsenite on Echinococcus granulosus protoscoleces

(2016) Guoqiang Xing et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Scolicidal and apoptotic activities of albendazole sulfoxide and albendazole sulfoxide-loaded PLGA-PEG as a novel nanopolymeric particle against Echinococcus granulosus protoscoleces

(2016) Marziyeh Naseri et al.   PARASITOLOGY RESEARCH

Efficacy of osthole for Echinococcus granulosus in vitro and Echinococcus multilocularis in vivo

(2016) Miaomiao Yuan et al.   VETERINARY PARASITOLOGY

Antihydatic and immunomodulatory effects of Punica granatum peel aqueous extract in a murine model of echinococcosis

(2016) Moussa Labsi et al.   Asian Pacific Journal of Tropical Medicine

In vitro anti-hydatic and immunomodulatory effects of ginger and [6]-gingerol

(2016) Manel Amri et al.   Asian Pacific Journal of Tropical Medicine

Screening of the Open Source Malaria Box Reveals an Early Lead Compound for the Treatment of Alveolar Echinococcosis

(2016) Britta Stadelmann et al.   PLoS Neglected Tropical Diseases

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond

(2016) Wesley C. Van Voorhis et al.   PLoS Pathogens

Combined flubendazole-nitazoxanide treatment of cystic echinococcosis: Pharmacokinetic and efficacy assessment in mice

(2015) Ceballos Laura et al.   ACTA TROPICA

Cystic echinococcosis therapy: Albendazole-loaded lipid nanocapsules enhance the oral bioavailability and efficacy in experimentally infected mice

(2015) Patricia E. Pensel et al.   ACTA TROPICA

Optimization of fluoride-containing bioactive glasses as a novel scolicidal agent adjunct to hydatid surgery

(2015) Ali Rostami et al.   ACTA TROPICA

Oral treatments of Echinococcus multilocularis-infected mice with the antimalarial drug mefloquine that potentially interacts with parasite ferritin and cystatin

(2015) Tatiana Küster et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Chemical composition, protoscolicidal effects and acute toxicity ofPistacia atlanticaDesf. fruit extract

(2015) Hossein Mahmoudvand et al.   NATURAL PRODUCT RESEARCH

In vivo activity of albendazole in combination with thymol against Echinococcus multilocularis

(2015) Clara María Albani et al.   VETERINARY PARASITOLOGY

Scolicidal activity of biosynthesized silver nanoparticles against Echinococcus granulosus protoscolices

(2015) Mohammad Taghi Rahimi et al.   International Journal of Surgery

Efficacy of Albendazole-Chitosan Microsphere-based Treatment for Alveolar Echinococcosis in Mice

(2015) Maitiseyiti Abulaihaiti et al.   PLoS Neglected Tropical Diseases

In Vitro Anti-Echinococcal and Metabolic Effects of Metformin Involve Activation of AMP-Activated Protein Kinase in Larval Stages of Echinococcus granulosus

(2015) Julia A. Loos et al.   PLoS One

In vitro effect of 5-fluorouracil and paclitaxel on Echinococcus granulosus larvae and cells

(2014) P.E. Pensel et al.   ACTA TROPICA

Efficacy of albendazole in combination with thymol against Echinococcus multilocularis protoscoleces and metacestodes

(2014) Albani Clara María et al.   ACTA TROPICA

Safety of the Combined Use of Praziquantel and Albendazole in the Treatment of Human Hydatid Disease

(2014) Lucía Alvela-Suárez et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

In VitroandIn VivoEffects of Tamoxifen against Larval Stage Echinococcus granulosus

(2014) María Celeste Nicolao et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In VivoStudy of the Efficacy of the Aromatic Water of Zataria multiflora on Hydatid Cysts

(2014) Mohammad Moazeni et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Is the Adjuvant Albendazole Treatment Really Needed with PAIR in the Management of Liver Hydatid Cysts? A Prospective, Randomized Trial with Short-Term Follow-Up Results

(2014) Okan Akhan et al.   CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY

Comprehensive Review in Current Developments of Benzimidazole-Based Medicinal Chemistry

(2014) Rangappa S. Keri et al.   Chemical Biology & Drug Design

Albendazolesulphoxide concentrations in plasma and hydatid cyst and prediction of parasitological and clinical outcomes in patients with liver hydatidosis caused by Echinococcus granulosus

(2014) Tomislava Skuhala et al.   CROATIAN MEDICAL JOURNAL

Acceptance of standardized ultrasound classification, use of albendazole, and long-term follow-up in clinical management of cystic echinococcosis

(2014) Francesca Tamarozzi et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Activities of fenbendazole in comparison with albendazole against Echinococcus multilocularis metacestodes in vitro and in a murine infection model

(2014) Tatiana Küster et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Unraveling the impact of hydroxylation on interactions of bile acid cationic lipids with model membranes by in-depth calorimetry studies

(2014) Manish Singh et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Preventive and therapeutic effects of Zataria multiflora methanolic extract on hydatid cyst: An in vivo study

(2014) Mohammad Moazeni et al.   VETERINARY PARASITOLOGY

Enhanced chemoprophylactic and clinical efficacy of albendazole formulated as solid dispersions in experimental cystic echinococcosis

(2014) Patricia E. Pensel et al.   VETERINARY PARASITOLOGY

Scolicidal effects of biogenic selenium nanoparticles against protoscolices of hydatid cysts

(2014) Hossein Mahmoudvand et al.   International Journal of Surgery

The unique stem cell sysem of the immortal larva of the human parasite Echinococcus multilocularis

(2014) Uriel Koziol et al.   EvoDevo

Targeting Echinococcus multilocularis Stem Cells by Inhibition of the Polo-Like Kinase EmPlk1

(2014) Andreas Schubert et al.   PLoS Neglected Tropical Diseases

Profound Activity of the Anti-cancer Drug Bortezomib against Echinococcus multilocularis Metacestodes Identifies the Proteasome as a Novel Drug Target for Cestodes

(2014) Britta Stadelmann et al.   PLoS Neglected Tropical Diseases

Long-term outcomes of intraoperative and perioperative albendazole treatment in hepatic hydatidosis: single center experience

(2014) Kagan Karabulut et al.   Annals of Surgical Treatment and Research

A pharmacology-based comparison of the activity of albendazole and flubendazole against Echinococcus granulosus metacestode in sheep

(2013) L. Ceballos et al.   ACTA TROPICA

Development of a cell line from Echinococcus granulosus germinal layer

(2013) Clara María Albani et al.   ACTA TROPICA

CYP2J2 and CYP2C19 Are the Major Enzymes Responsible for Metabolism of Albendazole and Fenbendazole in Human Liver Microsomes and Recombinant P450 Assay Systems

(2013) Zhexue Wu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In VitroandIn VivoActivities of Dicationic Diguanidino Compounds against Echinococcus multilocularis Metacestodes

(2013) Tatiana Küster et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In vivo evaluation of the efficacy of albendazole sulfoxide and albendazole sulfoxide loaded solid lipid nanoparticles against hydatid cyst

(2013) Sara Ahmadnia et al.   EXPERIMENTAL PARASITOLOGY

Time-course and accumulation of triclabendazole and its metabolites in bile, liver tissues and flukes collected from treated sheep

(2013) Laura Moreno et al.   EXPERIMENTAL PARASITOLOGY

Amino ozonides exhibit in vitro activity against Echinococcus multilocularis metacestodes

(2013) Tatiana Küster et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Novel albendazole-chitosan nanoparticles for intestinal absorption enhancement and hepatic targeting improvement in rats

(2013) Yang Liu et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

Comparison of the Protoscolocidal Effectiveness of Hypertonic Saline, Povidone—Iodine and Albendazole Solutions in an Experimental Lung Hydatid Cyst Model

(2013) T Durgun Yetim et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Antimicrobial selenium nanoparticle coatings on polymeric medical devices

(2013) Phong A Tran et al.   NANOTECHNOLOGY

The genomes of four tapeworm species reveal adaptations to parasitism

(2013) Isheng J. Tsai et al.   NATURE

The genome of the hydatid tapeworm Echinococcus granulosus

(2013) Huajun Zheng et al.   NATURE GENETICS

Progressive alveolar echinococcosis after discontinuation of anthelmintic therapy

(2013) Michael Meilinger et al.   Parasites & Vectors

In vitro efficacy of triclabendazole and clorsulon against the larval stage of Echinococcus multilocularis

(2013) David Richter et al.   PARASITOLOGY RESEARCH

Chemotherapy in alveolar echinococcosis of multi-organs: what’s the role?

(2013) Haitao Li et al.   PARASITOLOGY RESEARCH

In-vitro scolicidal activity of Mallotus philippinensis (Lam.) Muell Arg. fruit glandular hair extract against hydatid cyst Echinococcus granulosus

(2013) Mayank Gangwar et al.   Asian Pacific Journal of Tropical Medicine

Anticestodal Activity of EndophyticPestalotiopsissp. on Protoscoleces of Hydatid CystEchinococcus granulosus

(2013) Vijay C. Verma et al.   Biomed Research International

Alveolar echinococcosis: evaluation of therapeutic strategies

(2013) Dominique A Vuitton et al.   Expert Opinion on Orphan Drugs

Could thymol have effectiveness on scolices and germinal layer of hydatid cysts?

(2012) María C. Elissondo et al.   ACTA TROPICA

The Anthelmintic Triclabendazole and Its Metabolites Inhibit the Membrane Transporter ABCG2/BCRP

(2012) Borja Barrera et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In Vitro Analysis of Albendazole Sulfoxide Enantiomers Shows that (+)-(R)-Albendazole Sulfoxide Is the Active Enantiomer against Taenia solium

(2012) A. Paredes et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In vitro efficacy of the anticancer drug imatinib on Echinococcus multilocularis larvae

(2012) Sarah Hemer et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Can albendazole be the only treatment for cardiac echinococcosis with multiple organ involvement?

(2012) M. Koubâa et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

A New Promising Application for Highly Cytotoxic Metal Compounds: η6-Areneruthenium(II) Phosphite Complexes for the Treatment of Alveolar Echinococcosis

(2012) Tatiana Küster et al.   JOURNAL OF MEDICINAL CHEMISTRY

Enhanced bioavailability and cysticidal effect of three mebendazole-oil preparations in mice infected with secondary cysts of Echinococcus granulosus

(2012) Cong-shan Liu et al.   PARASITOLOGY RESEARCH

In vitro and in vivo treatments of Echinococcus granulosus with Huaier aqueous extract and albendazole liposome

(2012) Hailong Lv et al.   PARASITOLOGY RESEARCH

Long-Term Albendazole Effectiveness for Hepatic Cystic Echinococcosis

(2011) Jorge Luis Salinas et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Evaluation of Nitazoxanide for the Treatment of Disseminated Cystic Echinococcosis: Report of Five Cases and Literature Review

(2011) José A. Pérez-Molina et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

In VitroEfficacy of Dicationic Compounds and Mefloquine Enantiomers against Echinococcus multilocularis Metacestodes

(2011) Britta Stadelmann et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Comparative Performances of Flubendazole and Albendazole in Cystic Echinococcosis:Ex VivoActivity, Plasma/Cyst Disposition, and Efficacy in Infected Mice

(2011) Laura Ceballos et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mitochondrial fumarate reductase as a target of chemotherapy: From parasites to cancer cells

(2011) Chika Sakai et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

In vitro assessment of praziquantel and a novel nanomaterial against protoscoleces of Echinococcus granulosus

(2011) S. De et al.   JOURNAL OF HELMINTHOLOGY

In Vitro Effects of Some Herbs Used in Egyptian Traditional Medicine on Viability of Protoscolices of Hydatid Cysts

(2011) Doaa A. Yones et al.   KOREAN JOURNAL OF PARASITOLOGY

Anthelmintic effect of Mentha spp. essential oils on Echinococcus granulosus protoscoleces and metacestodes

(2011) Marina A. Maggiore et al.   PARASITOLOGY RESEARCH

An insect growth inhibitor – lufenuron – enhances albendazole activity against hydatid cyst

(2011) Martín Breijo et al.   VETERINARY PARASITOLOGY

In vitro lethal effect of ajowan (Trachyspermum ammi L.) essential oil on hydatid cyst protoscoleces

(2011) Mohammad Moazeni et al.   VETERINARY PARASITOLOGY

Combined albendazole and amphotericin B against Echinococcus multilocularis in vitro

(2010) Stefan Reuter et al.   ACTA TROPICA

In VitroandIn VivoEfficacies of Mefloquine-Based Treatment against Alveolar Echinococcosis

(2010) Tatiana Küster et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Chemoprophylactic Activity of Flubendazole in Cystic Echinococcosis

(2010) Laura Ceballos et al.   CHEMOTHERAPY

Toxicity of the antimalarial artemisinin and its dervatives

(2010) Thomas Efferth et al.   CRITICAL REVIEWS IN TOXICOLOGY

Clinical features and treatment of alveolar echinococcosis

(2010) Peter Kern   CURRENT OPINION IN INFECTIOUS DISEASES

Use of natural antimicrobials to increase antibiotic susceptibility of drug resistant bacteria

(2010) Kavitha Palaniappan et al.   INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY

Application of an in vitro drug screening assay based on the release of phosphoglucose isomerase to determine the structure-activity relationship of thiazolides against Echinococcus multilocularis metacestodes

(2010) B. Stadelmann et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Effects of in vitro exposure of Echinococcus multilocularis metacestodes to cytostatic drugs on in vivo growth and proliferation of the parasite

(2010) Cora Hübner et al.   PARASITOLOGY RESEARCH

In vitro Effectiveness of Garlic (Allium sativum) Extract on Scolices of Hydatid Cyst

(2010) Mohammad Moazeni et al.   WORLD JOURNAL OF SURGERY

Evaluation of Oxfendazole, Praziquantel and Albendazole against Cystic Echinococcosis: A Randomized Clinical Trial in Naturally Infected Sheep

(2010) Cesar M. Gavidia et al.   PLoS Neglected Tropical Diseases

Praziquantel: Neglected drug? Ineffective treatment? Or therapeutic choice in cystic hydatid disease?

(2009) J.M. Bygott et al.   ACTA TROPICA

Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans

(2009) Enrico Brunetti et al.   ACTA TROPICA

Intra-Cystic Drug Concentration of Albendazole Sulphoxide in Patients with Echinococcus granulosus Cysts

(2009) Mesküre Capan et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Limitations of amphotericin B and nitazoxanide in the treatment of alveolar echinococcosis

(2009) D. Tappe et al.   ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY

A systematic review of the anticancer properties of berberine, a natural product from Chinese herbs

(2009) Yiyi Sun et al.   ANTI-CANCER DRUGS

Benzimidazoles for the treatment of cystic and alveolar echinococcosis: what is the consensus?

(2009) Dominique Angèle Vuitton   Expert Review of Anti-Infective Therapy

Alveolar and cystic echinococcosis: towards novel chemotherapeutical treatment options

(2009) A. Hemphill et al.   JOURNAL OF HELMINTHOLOGY

Echinococcus metacestodes as laboratory models for the screening of drugs against cestodes and trematodes

(2009) A. HEMPHILL et al.   PARASITOLOGY

Flubendazole interferes with a wide spectrum of cell homeostatic mechanisms in Echinococcus granulosus protoscoleces

(2009) Andrea C. Cumino et al.   PARASITOLOGY INTERNATIONAL

Flubendazole in cystic echinococcosis therapy: Pharmaco-parasitological evaluation in mice

(2009) Laura Ceballos et al.   PARASITOLOGY INTERNATIONAL

Flubendazole and ivermectin in vitro combination therapy produces a marked effect on Echinococcus granulosus protoscoleces and metacestodes

(2009) M. Celina Elissondo et al.   PARASITOLOGY RESEARCH

Enantiomeric behaviour of albendazole and fenbendazole sulfoxides in domestic animals: Pharmacological implications

(2009) Bettencourt P.S. Capece et al.   VETERINARY JOURNAL

Efficacy of Chlorhexidine Gluconate During Surgery for Hydatid Cyst

(2009) Omer Topcu et al.   WORLD JOURNAL OF SURGERY

Treatment Response of Cystic Echinococcosis to Benzimidazoles: A Systematic Review

(2009) Marija Stojkovic et al.   PLoS Neglected Tropical Diseases

In Vitro and In Vivo Treatments of Echinococcus Protoscoleces and Metacestodes with Artemisinin and Artemisinin Derivatives

(2008) M. Spicher et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Hepatic and extra-hepatic metabolic pathways involved in flubendazole biotransformation in sheep

(2008) Laura Maté et al.   BIOCHEMICAL PHARMACOLOGY

Characterization and inhibition of a p38-like mitogen-activated protein kinase (MAPK) from Echinococcus multilocularis: Antiparasitic activities of p38 MAPK inhibitors

(2008) Verena Gelmedin et al.   BIOCHEMICAL PHARMACOLOGY

Recent advances in the in vitro cultivation and genetic manipulation of Echinococcus multilocularis metacestodes and germinal cells

(2008) Klaus Brehm et al.   EXPERIMENTAL PARASITOLOGY

In vitro and in vivo effects of 2-methoxyestradiol, either alone or combined with albendazole, against Echinococcus metacestodes

(2008) Martin Spicher et al.   EXPERIMENTAL PARASITOLOGY

Echinococcosis: a review

(2008) Pedro Moro et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Thioureides of 2-(phenoxymethyl)benzoic acid 4-R substituted: A novel class of anti-parasitic compounds

(2008) Joachim Müller et al.   PARASITOLOGY INTERNATIONAL

Use of albendazole sulfoxide, albendazole sulfone, and combined solutions as scolicidal agents on hydatid cysts (in vitro study)

(2008) Gokhan Adas et al.   WORLD JOURNAL OF GASTROENTEROLOGY