Targeting Echinococcus multilocularis Stem Cells by Inhibition of the Polo-Like Kinase EmPlk1

The unique stem cell sysem of the immortal larva of the human parasite Echinococcus multilocularis

(2014) Uriel Koziol et al.   EvoDevo

Targeting prostate cancer cell lines with polo-like kinase 1 inhibitors as a single agent and in combination with histone deacetylase inhibitors

(2013) Michel D. Wissing et al.   FASEB JOURNAL

The genomes of four tapeworm species reveal adaptations to parasitism

(2013) Isheng J. Tsai et al.   NATURE

Subcutaneous Infection Model Facilitates Treatment Assessment of Secondary Alveolar Echinococcosis in Mice

(2013) Tatiana Küster et al.   PLoS Neglected Tropical Diseases

A randomised phase II trial of the Polo-like kinase inhibitor BI 2536 in chemo-naïve patients with unresectable exocrine adenocarcinoma of the pancreas – a study within the Central European Society Anticancer Drug Research (CESAR) collaborative network

(2012) K Mross et al.   BRITISH JOURNAL OF CANCER

A Phase I Open-Label Dose-Escalation Study of Intravenous BI 2536 Together With Pemetrexed in Previously Treated Patients With Non–Small-Cell Lung Cancer

(2012) Peter M. Ellis et al.   Clinical Lung Cancer

Phase i study of the Plk1 inhibitor BI 2536 administered intravenously on three consecutive days in advanced solid tumours

(2012) A. Frost et al.   Current Oncology

In vitro efficacy of the anticancer drug imatinib on Echinococcus multilocularis larvae

(2012) Sarah Hemer et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

SmSak, the Second Polo-Like Kinase of the Helminth Parasite Schistosoma mansoni: Conserved and Unexpected Roles in Meiosis

(2012) Thavy Long et al.   PLoS One

A Comparative Transcriptomic Analysis Reveals Conserved Features of Stem Cell Pluripotency in Planarians and Mammals

(2012) Roselyne M. Labbé et al.   STEM CELLS

Switching Polo-like kinase-1 on and off in time and space

(2012) Wytse Bruinsma et al.   TRENDS IN BIOCHEMICAL SCIENCES

Schistosoma mansoni polo-like kinases and their function in control of mitosis and parasite reproduction

(2011) Colette Dissous et al.   ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS

A critical balance between Cyclin B synthesis and Myt1 activity controls meiosis entry in Xenopus oocytes

(2011) M. Gaffre et al.   DEVELOPMENT

PLK1 as an oncology target: current status and future potential

(2011) Campbell McInnes et al.   DRUG DISCOVERY TODAY

SMART 7: recent updates to the protein domain annotation resource

(2011) I. Letunic et al.   NUCLEIC ACIDS RESEARCH

Cestode genomics - progress and prospects for advancing basic and applied aspects of flatworm biology

(2011) P. D. OLSON et al.   PARASITE IMMUNOLOGY

Clinical features and treatment of alveolar echinococcosis

(2010) Peter Kern   CURRENT OPINION IN INFECTIOUS DISEASES

Multicentric parallel phase II trial of the polo-like kinase 1 inhibitor BI 2536 in patients with advanced head and neck cancer, breast cancer, ovarian cancer, soft tissue sarcoma and melanoma. The first protocol of the European Organization for Research and Treatment of Cancer (EORTC) Network Of Core Institutes (NOCI)

(2010) Patrick Schöffski et al.   EUROPEAN JOURNAL OF CANCER

Schistosoma mansoni Polo-like kinase 1: A mitotic kinase with key functions in parasite reproduction☆

(2010) Thavy Long et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

The role of evolutionarily conserved signalling systems in Echinococcus multilocularis development and host–parasite interaction

(2010) Klaus Brehm   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Echinococcus multilocularis primary cells: Improved isolation, small-scale cultivation and RNA interference

(2010) Markus Spiliotis et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy

(2010) Klaus Strebhardt   NATURE REVIEWS DRUG DISCOVERY

Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans

(2009) Enrico Brunetti et al.   ACTA TROPICA

BI 6727, A Polo-like Kinase Inhibitor with Improved Pharmacokinetic Profile and Broad Antitumor Activity

(2009) D. Rudolph et al.   CLINICAL CANCER RESEARCH

Molecular characterisation of MEK1/2- and MKK3/6-like mitogen-activated protein kinase kinases (MAPKK) from the fox tapeworm Echinococcus multilocularis

(2009) Verena Gelmedin et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Echinococcus multilocularis as an experimental model in stem cell research and molecular host-parasite interaction

(2009) K. BREHM   PARASITOLOGY

Echinococcus metacestodes as laboratory models for the screening of drugs against cestodes and trematodes

(2009) A. HEMPHILL et al.   PARASITOLOGY

Characterization and inhibition of a p38-like mitogen-activated protein kinase (MAPK) from Echinococcus multilocularis: Antiparasitic activities of p38 MAPK inhibitors

(2008) Verena Gelmedin et al.   BIOCHEMICAL PHARMACOLOGY

Phase I Dose Escalation and Pharmacokinetic Study of BI 2536, a Novel Polo-Like Kinase 1 Inhibitor, in Patients With Advanced Solid Tumors

(2008) Klaus Mross et al.   JOURNAL OF CLINICAL ONCOLOGY

Transient transfection of Echinococcus multilocularis primary cells and complete in vitro regeneration of metacestode vesicles

(2007) Markus Spiliotis et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY