Metformin exhibits preventive and therapeutic efficacy against experimental cystic echinococcosis

Metformin for chemoprevention of metachronous colorectal adenoma or polyps in post-polypectomy patients without diabetes: a multicentre double-blind, placebo-controlled, randomised phase 3 trial

(2016) Takuma Higurashi et al.   LANCET ONCOLOGY

Atorvastatin and metformin administration modulates experimental Trichinella spiralis infection

(2016) Ahmad A. Othman et al.   PARASITOLOGY INTERNATIONAL

Potential Anti-cancer Drugs Commonly Used for Other Indications

(2015) Veronika Hanusova et al.   CURRENT CANCER DRUG TARGETS

The expression dynamics of transforming growth factor-β/Smad signaling in the liver fibrosis experimentally caused by Clonorchis sinensis

(2015) Chao Yan et al.   Parasites & Vectors

Evolutionary Analysis and Classification of OATs, OCTs, OCTNs, and Other SLC22 Transporters: Structure-Function Implications and Analysis of Sequence Motifs

(2015) Christopher Zhu et al.   PLoS One

Recent advances in Echinococcus genomics and stem cell research

(2015) U. Koziol et al.   VETERINARY PARASITOLOGY

In Vitro Anti-Echinococcal and Metabolic Effects of Metformin Involve Activation of AMP-Activated Protein Kinase in Larval Stages of Echinococcus granulosus

(2015) Julia A. Loos et al.   PLoS One

In VitroandIn VivoEffects of Tamoxifen against Larval Stage Echinococcus granulosus

(2014) María Celeste Nicolao et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Albendazolesulphoxide concentrations in plasma and hydatid cyst and prediction of parasitological and clinical outcomes in patients with liver hydatidosis caused by Echinococcus granulosus

(2014) Tomislava Skuhala et al.   CROATIAN MEDICAL JOURNAL

Identification and pharmacological induction of autophagy in the larval stages of Echinococcus granulosus: an active catabolic process in calcareous corpuscles

(2014) Julia A. Loos et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Metformin—mode of action and clinical implications for diabetes and cancer

(2014) Ida Pernicova et al.   Nature Reviews Endocrinology

Validation of Suitable Reference Genes for Expression Normalization in Echinococcus spp. Larval Stages

(2014) Sergio Martin Espínola et al.   PLoS One

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

(2014) William W Wheaton et al.   eLife

Metformin and cancer

(2013) Christos V. Rizos et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

(2013) Russell A. Miller et al.   NATURE

The genomes of four tapeworm species reveal adaptations to parasitism

(2013) Isheng J. Tsai et al.   NATURE

The genome of the hydatid tapeworm Echinococcus granulosus

(2013) Huajun Zheng et al.   NATURE GENETICS

P-glycoprotein expression and pharmacological modulation in larval stages of Echinococcus granulosus

(2013) María Celeste Nicolao et al.   PARASITOLOGY INTERNATIONAL

AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In Vivo

(2012) Brandon Faubert et al.   Cell Metabolism

Human cystic echinococcosis: epidemiologic, zoonotic, clinical, diagnostic and therapeutic aspects

(2012) Shyamapada Mandal et al.   Asian Pacific Journal of Tropical Medicine

A Transcriptomic Analysis of Echinococcus granulosus Larval Stages: Implications for Parasite Biology and Host Adaptation

(2012) John Parkinson et al.   PLoS Neglected Tropical Diseases

Comparative Performances of Flubendazole and Albendazole in Cystic Echinococcosis:Ex VivoActivity, Plasma/Cyst Disposition, and Efficacy in Infected Mice

(2011) Laura Ceballos et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Clinical Pharmacokinetics of Metformin

(2011) Garry G. Graham et al.   CLINICAL PHARMACOKINETICS

Cellular and molecular mechanisms of metformin: an overview

(2011) Benoit Viollet et al.   CLINICAL SCIENCE

Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status

(2011) X. Stephenne et al.   DIABETOLOGIA

Metformin inhibits melanoma development through autophagy and apoptosis mechanisms

(2011) T Tomic et al.   Cell Death & Disease

Role of human placental apical membrane transporters in the efflux of glyburide, rosiglitazone, and metformin

(2010) Sarah J. Hemauer et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

The LKB1/AMPK signaling pathway has tumor suppressor activity in acute myeloid leukemia through the repression of mTOR-dependent oncogenic mRNA translation

(2010) A. S. Green et al.   BLOOD

Metformin inhibits P-glycoprotein expression via the NF-κB pathway and CRE transcriptional activity through AMPK activation

(2010) Hyung Gyun Kim et al.   BRITISH JOURNAL OF PHARMACOLOGY

Chemoprophylactic Activity of Flubendazole in Cystic Echinococcosis

(2010) Laura Ceballos et al.   CHEMOTHERAPY

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

(2010) Marc Foretz et al.   JOURNAL OF CLINICAL INVESTIGATION

Metformin in Cancer Therapy: A New Perspective for an Old Antidiabetic Drug?

(2010) I. Ben Sahra et al.   MOLECULAR CANCER THERAPEUTICS

Metformin suppresses azoxymethane-induced colorectal aberrant crypt foci by activating AMP-activated protein kinase

(2010) Kunihiro Hosono et al.   MOLECULAR CARCINOGENESIS

Xenobiotic, Bile Acid, and Cholesterol Transporters: Function and Regulation

(2010) C. D. Klaassen et al.   PHARMACOLOGICAL REVIEWS

LKB1 and AMP-activated protein kinase control of mTOR signalling and growth

(2009) R. J. Shaw   Acta Physiologica

Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans

(2009) Enrico Brunetti et al.   ACTA TROPICA

Metformin Selectively Targets Cancer Stem Cells, and Acts Together with Chemotherapy to Block Tumor Growth and Prolong Remission

(2009) H. A. Hirsch et al.   CANCER RESEARCH

Benzimidazoles for the treatment of cystic and alveolar echinococcosis: what is the consensus?

(2009) Dominique Angèle Vuitton   Expert Review of Anti-Infective Therapy

Spectrophotometric method for analysis of metformin hydrochloride

(2009) G Mubeen et al.   INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES

Identification of functional FKB protein in Echinococcus granulosus: Its involvement in the protoscolicidal action of rapamycin derivates and in calcium homeostasis

(2009) Andrea C. Cumino et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Flubendazole in cystic echinococcosis therapy: Pharmaco-parasitological evaluation in mice

(2009) Laura Ceballos et al.   PARASITOLOGY INTERNATIONAL

Echinococcosis: a review

(2008) Pedro Moro et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Albendazole treatment in cystic echinococcosis: pharmacokinetics and clinical efficacy of two different aqueous formulations

(2008) Laura Ceballos et al.   PARASITOLOGY RESEARCH