Article
Infectious Diseases
Carola Buscemi, Cristiana Randazzo, Paolo Buscemi, Rosalia Caldarella, Martina Lombardo, Silvio Buscemi
Summary: Cystic echinococcosis is a zoonotic disease caused by ingesting food or water contaminated with Echinococcus eggs. We report a case of a 64-year-old male patient with disseminated abdominal cystic echinococcosis, who received long-term treatment with albendazole and showed significant disease regression.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2023)
Review
Parasitology
Adriano Casulli, Alessandro Massolo, Urmas Saarma, Gerald Umhang, Federica Santolamazza, Azzurra Santoro
Summary: This study fills a knowledge gap by providing a quantitative measure of molecularly identified species and genotypes causing human cystic echinococcosis. The study identifies geographical hotspots of different Echinococcus granulosus species causing the disease and highlights data gaps.
PARASITES & VECTORS
(2022)
Article
Veterinary Sciences
Jadoon Khan, Nosheen Basharat, Salman Khan, Syed Muhammad Jamal, Sadeeq Ur Rahman, Aamer Ali Shah, Sanaullah Khan, Rehman Ali, Shahid Niaz Khan, Ijaz Ali
Summary: The study revealed a 17% prevalence of cystic echinococcosis in livestock in the Malakand division of Pakistan, with liver and lungs being the most affected organs. The infection was primarily caused by Echinococcus granulosus sensu stricto, with Echinococcus ortleppi and Echinococcus equinus also present in buffaloes.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Review
Veterinary Sciences
Ian David Woolsey, Andrea L. Miller
Summary: Echinococcus spp. have a global distribution and are of significance to human and veterinary professionals. Infections can lead to different diseases, including cystic echinococcosis and alveolar echinococcosis.
RESEARCH IN VETERINARY SCIENCE
(2021)
Article
Parasitology
Francesca Porcu, Cinzia Cantacessi, Giorgia Dessi, Maria Francesca Sini, Fahad Ahmed, Lia Cavallo, Francesca Nonnis, Katherine Gibson, Cecilia Varcasia, Gaelle Joanny, Antonio Scala, Claudia Tamponi, Antonio Varcasia
Summary: The use of edutainment approaches, digital educational tools, and participatory teaching methods can enhance students' understanding of cystic echinococcosis and its prevention. The study results highlight the effectiveness of these methods in health education.
PARASITES & VECTORS
(2022)
Article
Immunology
Nosheen Basharat, Jadoon Khan, Irfan Ullah, Aamer Ali Shah, Ijaz Ali
Summary: In this study, the molecular characterization of human echinococcosis in the southern Punjab region of Pakistan was conducted. The majority of human infections were caused by E. granulosus s.s., followed by E. multilocularis and E. canadensis. Genotypic characterization among both human and livestock populations is needed to explore the genetic diversity of echinococcosis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Veterinary Sciences
Shahid Niaz Khan, Rehman Ali, Sanaullah Khan, Sadia Norin, Muhammad Rooman, Noor Ul Akbar, Taj Ali Khan, Sumbal Haleem, Murad Ali Khan, Ijaz Ali
Summary: The study found an overall prevalence of 9% of cystic echinococcosis among examined animals. Hydatid cyst infection was highest in buffaloes (12%), followed by sheep (10%), cows (9%), and goats (5.1%). The infection rate was highest in Lakki Marwat district (10%), followed by Bannu district (9%) and Karak district (7%). Female animals were more likely to be infected with CE (11.6%) than male animals (5.3%) (p = 0.001).
BMC VETERINARY RESEARCH
(2021)
Article
Parasitology
Erastus Mulinge, Eberhard Zeyhle, Cecilia Mbae, Lucy Gitau, Timothy Kaburu, Japhet Magambo, Ute Mackenstedt, Thomas Romig, Peter Kern, Marion Wassermann
Summary: Cystic echinococcosis is common in humans and animals in eastern Africa. This study reports the frequency of different Echinococcus species in donkeys, with E. equinus being the most prevalent. This is the first report of Echinococcus spp. in donkeys from sub-Saharan Africa, and the first confirmation of E. equinus in East Africa. Donkeys have a limited role in the transmission of E. granulosus s. s., E. canadensis (G6/7) and E. ortleppi.
Article
Immunology
Xiaofeng Jiang, Xiaofan Zhang, Nan Jiang, Yeting Sun, Teng Li, Jing Zhang, Yujuan Shen, Jianping Cao
Summary: By performing single-cell RNA sequencing, this study characterized immune and endothelial cells in liver samples of mice at different stages of Echinococcus granulosus infection. They identified an SPP1(+) macrophage subset with immunosuppressive and pro-angiogenic functions, and revealed its key regulators and interactions with endothelial cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Ihsan Ullah, Sadia Sattar, Ijaz Ali, Arshad Farid, Amin Ullah, Refaat A. A. Eid, Mohamed Samir A. Zaki, Muhammad Alaa Eldeen, Iftikhar Ahmed, Irfan Ullah
Summary: Cystic echinococcosis (CE), or hydatid cyst disease (HCD), is highly endemic in Baluchistan, Pakistan, but no previous studies have been conducted in this region. This study collected and analyzed 23 human hydatid cyst samples, revealing the presence of multiple genotypes, with G1 and G3 being the most prevalent and the first report of G6/G7 in Baluchistan.
Article
Parasitology
Leonardo Uchiumi, Guillermo Mujica, Daniel Araya, Juan Carlos Salvitti, Mariano Sobrino, Sergio Moguillansky, Alejandro Solari, Patricia Blanco, Fabiana Barrera, Janete Lamunier, Marcos Arezo, Marcos Seleiman, Zaida E. Yadon, Francesca Tamarozzi, Adriano Casulli, Edmundo Larrieu
Summary: This study investigated the prevalence and risk factors of human cystic echinococcosis in Norquinco and Ramos Mexia, Argentina. Results suggest a link between infection acquired since childhood and constant exposure throughout life, especially in rural areas.
PARASITES & VECTORS
(2021)
Article
Parasitology
S. Orsten, I. Baysal, S. Yabanoglu-Ciftci, T. Ciftci, A. Azizova, D. Akinci, Y. Akyon, O. Akhan
Summary: This study investigated altered cellular pathways in cystic echinococcosis (CE) by comparing miRNA profiles of CE patients with controls, revealing downregulation of several miRNAs associated with cell proliferation, apoptosis, cell-cell interactions, and cell cycle regulation in CE patients. Further research in this direction may help elucidate the pathogenesis of human CE and its connection to other pathologies.
JOURNAL OF HELMINTHOLOGY
(2021)
Article
Chemistry, Medicinal
Bei Chen, Mingzhi Yan, Huijing Gao, Qin Ma, Lihua Li, Guodong Lue, Yuehong Gong, Limei Wen, Shaoquan Xu, Jianhua Wang, Jun Zhao
Summary: In this study, the effects of 7 harmine derivatives on Echinococcus granulosus s.s. were evaluated. It was found that H-2-168 and DH-004 exhibited significant antiparasitic effects and satisfactory therapeutic outcomes in vivo. These compounds induced DNA damage in E. granulosus s.s., which may contribute to their therapeutic effects. Overall, H-2-168 and DH-004 are highly effective candidate compounds with low toxicity for the treatment of CE.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Review
Parasitology
Solomon Ngutor Karshima, Musa Isiyaku Ahmed, Nuhu Bala Adamu, Abdullahi Alhaji Magaji, Musa Zakariah, Konto Mohammed
Summary: Echinococcosis and Echinococcus granulosus infections are prevalent among humans and dogs in Africa. A holistic control approach targeting humans, livestock, dogs, and the environment is recommended to reduce disease transmission.
PARASITES & VECTORS
(2022)
Article
Biotechnology & Applied Microbiology
Yanping Zhao, Quzhen Gongsang, Jingkai Ji, Junhua Li, Fahai Qi, Jiandong Li, Gezhen Qiangba, Wangmu Danzeng, Fang Chen, Hongcheng Zhou, Huasang, Jiefang Yin, Na Pei, Jiandan Xie, Huimin Cai, Asan, Huasheng Pang, Jingzhong Li, Weijun Chen, Bin Li
Summary: The study identified Eg cfDNA in plasma of CE patients through high-throughput sequencing, which significantly increased in concentration and fragment length after treatment, indicating its potential as a marker for monitoring CE treatment.
Article
Parasitology
J. Fabbri, M. C. Elissondo
JOURNAL OF HELMINTHOLOGY
(2019)
Article
Pharmacology & Pharmacy
Juan Aparicio-Blanco, Victor Sebastian, Jean P. Benoit, Ana I. Torres-Suarez
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2019)
Article
Pharmacology & Pharmacy
Giovanna Lollo, Kevin Matha, Martina Bocchiardo, Jerome Bejaud, Ilaria Marigo, Angelique Virgone-Carlotta, Thomas Dehoux, Charlotte Riviere, Jean-Paul Rieu, Stephanie Briancon, Thomas Perrier, Olivier Meyer, Jean-Pierre Benoit
JOURNAL OF DRUG TARGETING
(2019)
Article
Oncology
Laura Pinton, Elena Masetto, Marina Vettore, Samantha Solito, Sara Magri, Marta D'Andolfi, Paola Del Bianco, Giovanna Lollo, Jean-Pierre Benoit, Hideho Okada, Aaron Diaz, Alessandro Della Puppa, Susanna Mandruzzato
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2019)
Article
Biotechnology & Applied Microbiology
Gabriela Ullio-Gamboa, Kenea C. Udobi, Sophie Dezard, Marla K. Perna, Keila N. Miles, Narciso Costa, Frederic Taran, Alain Pruvost, Jean-Pierre Benoit, Matthew R. Skelton, Pascale de Lonlay, Aloise Mabondzo
Article
Pharmacology & Pharmacy
M. L. Formica, G. V. Ullio Gamboa, L. Tartara, J. D. Luna, J. P. Benoit, S. D. Palma
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2020)
Article
Multidisciplinary Sciences
Ana Cadete, Ana Olivera, Magnus Besev, Pradeep K. Dhal, Lidia Goncalves, Antonio J. Almeida, Guillaume Bastiat, Jean-Pierre Benoit, Maria de la Fuente, Marcos Garcia-Fuentes, Maria Jose Alonso, Dolores Torres
SCIENTIFIC REPORTS
(2019)
Article
Parasitology
Julia Fabbri, Juan Pablo Espinosa, Patricia Eugenia Pensel, Sandra Karina Medici, Gabriela Ullio Gamboa, Jean Pierre Benoit, Maria Celina Elissondo
Article
Biotechnology & Applied Microbiology
Laura Pinton, Sara Magri, Elena Masetto, Marina Vettore, Ilaria Schibuola, Vincenzo Ingangi, Ilaria Marigo, Kevin Matha, Jean-Pierre Benoit, Alessandro Della Puppa, Vincenzo Bronte, Giovanna Lollo, Susanna Mandruzzato
JOURNAL OF NANOBIOTECHNOLOGY
(2020)
Article
Pharmacology & Pharmacy
Kevin Matha, Giovanna Lollo, Giuseppe Taurino, Renaud Respaud, Ilaria Marigo, Molood Shariati, Ovidio Bussolati, An Vermeulen, Katrien Remaut, Jean-Pierre Benoit
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2020)
Article
Parasitology
Julia Fabbri, Patricia Eugenia Pensel, Clara Maria Albani, Lurdes Milagros Lopez, Analia Simonazzi, Jose Maria Bermudez, Santiago Daniel Palma, Maria Celina Elissondo
Article
Nanoscience & Nanotechnology
Molood Shariati, Giovanna Lollo, Kevin Matha, Benedicte Descamps, Christian Vanhove, Leen Van de Sande, Wouter Willaert, Lieve Balcaen, Frank Vanhaecke, Jean-Pierre Benoit, Wim Ceelen, Stefaan C. De Smedt, Katrien Remaut
ACS APPLIED MATERIALS & INTERFACES
(2020)
Review
Pharmacology & Pharmacy
Kevin Matha, Brice Calvignac, Jean-Pierre Gangneux, Jean-Pierre Benoit
Summary: Visceral leishmaniasis is a neglected disease in many countries, but nanomedicine has shown success in treating it, particularly with liposomal amphotericin B's remarkable cure rates. However, developing more efficient strategies like targeting functionalization, oral formulations, or combined therapies face numerous obstacles and raise many questions.
EXPERT OPINION ON DRUG DELIVERY
(2021)
Article
Infectious Diseases
Hugo R. Vaca, Ana M. Celentano, Maria Agustina Toscanini, Tino Heimburg, Ehab Ghazy, Patrik Zeyen, Alexander-Thomas Hauser, Guilherme Oliveira, Maria C. Elissondo, Manfred Jung, Wolfgang Sippl, Federico Camicia, Mara Cecilia Rosenzvit
Summary: The study evaluated the anthelmintic profile of HDAC inhibitors on the model cestode Mesocestoides vogae, identifying entinostat, TH65, and TH92 as promising candidates with potent anthelmintic effects. Pairwise drug combinations of these inhibitors and albendazole showed positive interaction in anthelmintic effects, indicating a potential for developing new cestocidal compounds based on HDAC inhibition.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Parasitology
Gabriela Martinez Moura Tavares, Hannar Angelica de Melo Alverga, Estela Moraes Felix, Giovana de Oliveira Dichman, Gabriel Monteiro Pinheiro, Yara Juliano, Priscila Paruci, Dennis Minoru Fujita, Lucas Melo Neves, Marina Tiemi Shio, Luiz Henrique da Silva Nali
Summary: This study investigated the frequency of N. gonorrhoeae infection in women in a poor area of São Paulo and found that most of the strains detected showed resistance to one or more antimicrobials.
Article
Parasitology
Qian Yao, Ying-Ying Fan, Shuang Huang, Gui-Rong Hu, Jun-Ke Song, Xin Yang, Guang-Hui Zhao
Summary: This study found that the expression of miR-4521 was upregulated during C. parvum infection, and this upregulation was related to the TLR/NF-kappa B signal pathway. Additionally, miR-4521 promoted the propagation of C. parvum in HCT-8 cells by regulating BCL2-mediated cell apoptosis through targeting foxm1.
Article
Parasitology
Cho Naing, Maxine A. Whittaker, Wong Siew Tung, Htar Aung, Joon Wah Mak
Summary: This study aimed to estimate the prevalence of zoonotic brugian filariasis in animals and compare it with the prevalence in humans in the same area. The findings suggest that cats, dogs, and leaf-eating monkeys may serve as potential reservoirs for human brugian filariasis.
Review
Parasitology
Raissa Nogueira de Brito, Susan Tanner, Julie Velasquez Runk, Juliana Hoyos
Summary: This study conducted a scoping review to identify major research themes and knowledge gaps in the social science literature on leishmaniases or Chagas disease. The findings showed that research in this field mainly focuses on the sociocultural, economic, historical, and political dimensions of the diseases. Future research should pay more attention to how social institutions and economic factors shape disease education, control measures, healthcare access, and quality of life of affected individuals.
Article
Parasitology
Minghao Zheng, Mengyao Zhang, Hao Li, Shipo Wu, Yuee Zhao, Jinlong Zhang, Yunyue Zhou, Mohamed Boie Jalloh, Kun Zhang, Lina Chen, Zhiqiang Mi, Yong Cui, Lihua Hou
Summary: Rapid and convenient detection of Plasmodium falciparum, the deadliest malaria parasite in Africa, is crucial for malaria eradication efforts in medical resource-limited settings. A CRISPR-based diagnostic method that can detect P. falciparum without nucleic acid extraction was developed and showed high sensitivity and consistency with qPCR test. It can also detect artemisinin-resistant strains and other laboratory-cultured strains. This method has great potential for clinical testing and large-scale community screening in Africa and other regions.
Article
Parasitology
Fabian Correa-Morales, Cassandra Gonzalez-Acosta, David Ibarra-Ojeda, Miguel Moreno-Garcia
Summary: Since 2002, West Nile Virus (WNV) has been reported in 18 states in Mexico. This paper discusses the proposed hypotheses for the absence of WNV outbreaks in Latin America and provides a context-specific explanation for Mexico.
Article
Parasitology
Umberto Molini, Lauren M. Coetzee, Vernon Christians, Maria Y. Hemberger, Bernard Chiwome, Maria Amukwaya, Siegfried Khaiseb, Giovanni Cattoli, William G. Dundon, Giovanni Franzo
Summary: Porcine circovirus 3 (PCV-3) has been reported globally since its first identification in 2015. Limited data on PCV-3 in Africa led to a study in Namibia, which found a high prevalence of PCV-3 in backyard piggeries, but not in commercial farms with higher biosecurity measures. The source of viral introduction and factors such as semen importation, feeding backyard pigs with human food waste, pig exchanges, and wildlife movements may be involved in the dispersal of PCV-3 within Namibia. Further studies are needed to understand the epidemiology and impact of PCV-3 on pig productivity and wildlife health.
Article
Parasitology
Chutchai Piewbang, Panida Poonsin, Pattiya Lohavicharn, Panitnan Punyathi, Sawang Kesdangsakonwut, Tanit Kasantikul, Somporn Techangamsuwan
Summary: This study provides insights into the pathology of natural SARS-CoV-2 infection in dogs, revealing severe damage to the lungs and involvement of multiple organs. The findings suggest the potential utility of dogs as a model for studying SARS-CoV-2 infection in humans, highlighting the need for further investigation.
Article
Parasitology
Julian Avila-Jimenez, Juan David Gutierrez, Mariano Altamiranda-Saavedra
Summary: Leishmaniasis is a parasitic disease transmitted to humans by sandfly vectors and vertebrate hosts. This study used ecological niche modeling to investigate the potential distribution of host and vector species associated with cutaneous leishmaniasis transmission, revealing different distribution patterns under varying climatic conditions.
Article
Parasitology
Luis A. Gomez-Puerta, Juan Olazabal, Santiago Paredes, Juan Lopez, Miguel Anampa, Angelica Mondragon, Ana Vargas-Calla, Hugo Castillo
Summary: This study reports the first detection of Candidatus M. haemolamae infection in vicunas from the Pampa Galeras National Reserve in Peru, using molecular diagnosis. Tick-infested vicunas had a higher likelihood of being infected with Candidatus M. haemolamae compared to tick-free vicunas. Gender and age were not associated with infection.
Article
Parasitology
Berlin Londono-Renteria, Zakaria Seidu, Helena Lamptey, Michael F. Ofori, Lars Hviid, Mary Lopez-Perez
Summary: Heterozygous carriers of HbAS and HbAC have a reduced risk of severe malaria, but not immunity against Plasmodium falciparum infection. Antibody levels against gSG6-P1 peptide in Anopheles mosquito saliva can serve as a serological biomarker for exposure to Plasmodium infection. This study highlights the importance of studying the role of hemoglobinopathies in malaria transmission for improving control interventions.
Article
Parasitology
Imane Belbacha, Meryem El Azzouzi, Rajae Bensghir, Kamal Filali Marhoum, Khadija Hajjout, El Mir Elharti, Khalid Sadki, Hicham Oumzil
Summary: This study investigates the association of three SNPs in the APOBEC3G gene with disease outcomes in Moroccan HIV-1 infected patients. The rs2294367 CG genotype is strongly associated with protection against HIV-1 infection, particularly in older individuals.
Article
Parasitology
Tan Luong, Do Kien Tran, Anh Hung Pham, Thi Thu-Ha Hoang, Van Khang Pham, Quang Thai Pham, Thi Mai Hung Tran, Minh Hoa Luong, Thanh Long Pham, Jason K. Blackburn
Summary: This study examined the epidemiology of anthrax in Lai Chau province, Vietnam, using historical data. Spatial clusters of human and livestock anthrax were identified, and the characteristics of the disease were described. The study found that there were distinct differences between the high-risk areas for human and livestock anthrax, and most human cases occurred during specific seasons. Additionally, the decrease in livestock anthrax vaccine coverage was associated with an increase in disease incidence.
Article
Parasitology
Jin-tao Chen, Jian-bo Zhan, Ming-chao Zhu, Kai-ji Li, Man-qing Liu, Bin Hu, Kun Cai, Hai-rong Xiong, Shu-liang Chen, Wei-long Tan, Liang-jun Chen, Wei Hou
Summary: This study investigated the prevalence and variation of orthohantavirus in rodents and humans in Hubei province, China. It identified the diversity of orthohantaviruses circulating in the region, with the HV004-like subtype being the main genotype in rodents and patients. This highlights the importance of continued attention and research on orthohantaviruses, especially newly identified strains.