Comprehensive Review in Current Developments of Benzimidazole-Based Medicinal Chemistry

Synthesis, characterization and antimicrobial activity of 1,3,4-oxadiazole bearing 1H-benzimidazole derivatives

(2017) Salahuddin et al.   Arabian Journal of Chemistry

Synthesis and in-silico molecular docking simulation of 3-chloro-4-substituted-1-(2-(1H-benzimidazol-2-yl)phenyl))-azetidin-2-ones as novel analgesic anti-inflammatory agent

(2016) Santosh S. Chhajed et al.   Arabian Journal of Chemistry

Synthesis and Biological Evaluation of Some 1,2-Disubstituted Benzimidazole Derivatives as New Potential Anticancer Agents

(2013) Leyla Yurttaş et al.   ARCHIV DER PHARMAZIE

Microwave-Assisted Synthesis and Biological Evaluation of Some Benzimidazole Derivatives Containing a 1,2,4-Triazol Ring

(2013) Emre Menteşe et al.   ARCHIV DER PHARMAZIE

Design and synthesis of novel benzimidazole derivatives as phosphodiesterase 10A inhibitors with reduced CYP1A2 inhibition

(2013) Wataru Hamaguchi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and biological evaluation of novel styryl benzimidazole derivatives as probes for imaging of neurofibrillary tangles in Alzheimer’s disease

(2013) Kenji Matsumura et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis, biological activity and molecular modeling studies on 1H-benzimidazole derivatives as acetylcholinesterase inhibitors

(2013) Ayşe Selcen Alpan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Molecular docking guided structure based design of symmetrical N,N′-disubstituted urea/thiourea as HIV-1 gp120–CD4 binding inhibitors

(2013) Sree Kanth Sivan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Syntheses and biological evaluation of 1-heteroaryl-2-aryl-1 H -benzimidazole derivatives as c-Jun N-terminal kinase inhibitors with neuroprotective effects

(2013) Mi-hyun Kim et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis, biological evaluation and molecular modeling of substituted 2-aminobenzimidazoles as novel inhibitors of acetylcholinesterase and butyrylcholinesterase

(2013) Jinmei Zhu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Selective inhibition of heme oxygenase-2 activity by analogs of 1-(4-chlorobenzyl)-2-(pyrrolidin-1-ylmethyl)-1H-benzimidazole (clemizole): Exploration of the effects of substituents at the N-1 position

(2013) Jason Z. Vlahakis et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis and pharmacological evaluation of omeprazole-like agents with anti-inflammatory activity

(2013) Ahmed O.H. El-Nezhawy et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties

(2013) Mathieu Bibian et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and biological analysis of benzazol-2-yl piperazine sulfonamides as 11β-hydroxysteroid dehydrogenase 1 inhibitors

(2013) Sandra Hofer et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and antiprotozoal activity of novel 2-{[2-(1H-imidazol-1-yl)ethyl]sulfanyl}-1H-benzimidazole derivatives

(2013) Jaime Pérez-Villanueva et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of 2-((1H-benzo[d]imidazol-1-yl)methyl)-4H-pyrido[1,2-a]pyrimidin-4-ones as novel PKM2 activators

(2013) Chuangxing Guo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and cytotoxic activities of novel hybrid 2-phenyl-3-alkylbenzofuran and imidazole/triazole compounds

(2013) Wen Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Regioselective synthesis of isoxazole–mercaptobenzimidazole hybrids and their in vivo analgesic and anti-inflammatory activity studies

(2013) Shravankumar Kankala et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Benzimidazole-carboxamides as potent and bioavailable stearoyl-CoA desaturase (SCD1) inhibitors from ligand-based virtual screening and chemical optimization

(2013) Hans Matter et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis, single crystal and antitumor activities of benzimidazole–quinazoline hybrids

(2013) Alka Sharma et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis, antioxidant, and antimicrobial evaluation of some 2-arylbenzimidazole derivatives

(2013) Binhua Zhou et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design and synthesis of positional isomers of 5 and 6-bromo-1-[(phenyl)sulfonyl]-2-[(4-nitrophenoxy)methyl]-1H-benzimidazoles as possible antimicrobial and antitubercular agents

(2013) P. Karuvalam Ranjith et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and antiprotozoal activity of nitazoxanide–N-methylbenzimidazole hybrids

(2013) Olivia Soria-Arteche et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of new conjugated coumarin–benzimidazole hybrids and their anticancer activity

(2013) Kamaldeep Paul et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Identification of novel HDAC inhibitors through cell based screening and their evaluation as potential anticancer agents

(2013) Tong Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Recognition of HIV-TAR RNA using neomycin–benzimidazole conjugates

(2013) Nihar Ranjan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, synthesis, quantum chemical studies and biological activity evaluation of pyrazole–benzimidazole derivatives as potent Aurora A/B kinase inhibitors

(2013) Youguang Zheng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Potent MCH-1 receptor antagonists from cis-1,4-diaminocyclohexane-derived indane analogs

(2013) Yimin Qian et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and biological evaluation of aminobenzimidazole derivatives with a phenylcyclohexyl acetic acid group as anti-obesity and anti-diabetic agents

(2013) Hyun Jung Kwak et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis, characterization, and molecular docking analysis of novel benzimidazole derivatives as cholinesterase inhibitors

(2013) Yeong Keng Yoon et al.   BIOORGANIC CHEMISTRY

One step synthesis of pyrido[1,2-a]benzimidazole derivatives of aryloxypyrazole and their antimicrobial evaluation

(2013) Hardik H. Jardosh et al.   CHINESE CHEMICAL LETTERS

Design, synthesis and antimicrobial evaluation of novel benzimidazole type of Fluconazole analogues and their synergistic effects with Chloromycin, Norfloxacin and Fluconazole

(2013) Hui-Zhen Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of novel hybrid compounds of imidazole scaffold-based 2-benzylbenzofuran as potent anticancer agents

(2013) Xue-Quan Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, in vitro antiplatelet activity and molecular modelling studies of 10-substituted 2-(1-piperazinyl)pyrimido[1,2- a ]benzimidazol-4(10 H )-ones

(2013) Mario Di Braccio et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Rational design, synthesis and QSAR study of vasorelaxant active 3-pyridinecarbonitriles incorporating 1H-benzimidazol-2-yl function

(2013) Zeinab M. Nofal et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and antiproliferative properties of some new 5-substituted-2-iminobenzimidazole derivatives

(2013) Anelia Ts. Mavrova et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Nonpeptidic angiotensin II AT1 receptor antagonists derived from 6-substituted aminocarbonyl and acylamino benzimidazoles

(2013) Jun Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and antitumor activities of novel dibenzo[b,d]furan–imidazole hybrid compounds

(2013) Lan-Xiang Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Microwave assisted synthesis of dihydrobenzo[4,5]imidazo[1,2-a]pyrimidin-4-ones; synthesis, in vitro antimicrobial and anticancer activities of novel coumarin substituted dihydrobenzo[4,5]imidazo[1,2-a]pyrimidin-4-ones

(2013) Kallimeledoddi B. Puttaraju et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Coumarins hinged directly on benzimidazoles and their ribofuranosides to inhibit hepatitis C virus

(2013) Shwu-Chen Tsay et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of a benzimidazole series of ADAMTS-5 (aggrecanase-2) inhibitors by scaffold hopping

(2013) Shinya Sogame et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Organometallic benzimidazoles: Synthesis, characterization and antimalarial activity

(2013) Patricia Toro et al.   INORGANIC CHEMISTRY COMMUNICATIONS

Discovery of Potent, Selective Chymase Inhibitors via Fragment Linking Strategies

(2013) Steven J. Taylor et al.   JOURNAL OF MEDICINAL CHEMISTRY

Anti-inflammatory Effects of Extracellular Cyclosporins Are Exclusively Mediated by CD147

(2013) Miroslav Malesevic et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and in vitro Antibacterial Activity of 5-Halogenomethylsulfonyl- Benzimidazole and Benzotriazole Derivatives

(2013) Zbigniew Ochal et al.   Medicinal Chemistry

Synthesis and biological evaluation of benzo[d]imidazolyl chromeno[2,3-d]pyrimidinones

(2013) Anisetti Ravindernath et al.   MEDICINAL CHEMISTRY RESEARCH

A rational design, synthesis, characterization, and antihypertensive activities of some new substituted benzimidazoles

(2013) Anurekha Jain et al.   MEDICINAL CHEMISTRY RESEARCH

Design and One-Pot and Microwave-Assisted Synthesis of 2-Amino/5-Aryl-1,3,4-oxadiazoles Bearing a Benzimidazole Moiety as Antioxidants

(2012) İlgar Kerimov et al.   ARCHIV DER PHARMAZIE

Optimization and structure–activity relationships of a series of potent inhibitors of methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase as novel antimicrobial agents

(2012) Nag S. Kumar et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and docking studies of novel antitumor benzimidazoles

(2012) Mohamed A. Omar et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Identification of novel benzimidazole derivatives as inhibitors of leukotriene biosynthesis by virtual screening targeting 5-lipoxygenase-activating protein (FLAP)

(2012) Erden Banoglu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The therapeutic journey of benzimidazoles: A review

(2012) Yogita Bansal et al.   BIOORGANIC & MEDICINAL CHEMISTRY

2-Phenylamino-6-cyano-1H-benzimidazole-based isoform selective casein kinase 1 gamma (CK1γ) inhibitors

(2012) Zihao Hua et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, synthesis and identification of novel benzimidazole derivatives as highly potent NPY Y5 receptor antagonists with attractive in vitro ADME profiles

(2012) Yuusuke Tamura et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and evaluation of 2-[2-(phenylthiomethyl)-1H-benzo[d] imidazol-1-yl)acetohydrazide derivatives as antitumor agents

(2012) Ting Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Benzoheterocyclic amodiaquine analogues with potent antiplasmodial activity: Synthesis and pharmacological evaluation

(2012) Dennis S.B. Ongarora et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Newly synthesized bis-benzimidazole derivatives exerting anti-tumor activity through induction of apoptosis and autophagy

(2012) Xiu-Jun Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Inhibition of HIV-1 capsid assembly: Optimization of the antiviral potency by site selective modifications at N1, C2 and C16 of a 5-(5-furan-2-yl-pyrazol-1-yl)-1H-benzimidazole scaffold

(2012) Martin Tremblay et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Benzimidazole bearing oxadiazole and triazolo-thiadiazoles nucleus: Design and synthesis as anticancer agents

(2012) Asif Husain et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and anti-angiogenic activity of benzothiazole, benzimidazole containing phthalimide derivatives

(2012) Shunmugam Nagarajan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and Potent In vitro Activity of Novel 1H-Benzimidazoles as Anti-MRSA Agents

(2012) Hacer Karataş et al.   Chemical Biology & Drug Design

Synthesis and biological evaluation of novel benzimidazole derivatives and their binding behavior with bovine serum albumin

(2012) Shao-Lin Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

5-Acetyl-2-arylbenzimidazoles as antiviral agents. Part 4

(2012) Gabriella Vitale et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

2-Anilino-4-(benzimidazol-2-yl)pyrimidines – A multikinase inhibitor scaffold with antiproliferative activity toward cancer cell lines

(2012) Renate Determann et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of benzimidazolyl-1,3,4-oxadiazol-2ylthio-N-phenyl (benzothiazolyl) acetamides as antibacterial, antifungal and antituberculosis agents

(2012) Rahul V. Patel et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, characterization and antimicrobial studies of some new quinoline incorporated benzimidazole derivatives

(2012) B. Garudachari et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, antitumor activity and SAR study of novel [1,2,4]triazino[4,5-a]benzimidazole derivatives

(2012) Hala Bakr El-Nassan   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of benzimidazoles bearing oxadiazole nucleus as anticancer agents

(2012) Mohd Rashid et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Benzimidazole clubbed with triazolo-thiadiazoles and triazolo-thiadiazines: New anticancer agents

(2012) Asif Husain et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Oxidative and nitrosative stress in the maintenance of myocardial function

(2012) Yixuan Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Design and Synthesis of a Novel Series of Bicyclic Heterocycles As Potent γ-Secretase Modulators

(2012) Francois Bischoff et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fragment-Based Design of Symmetrical Bis-benzimidazoles as Selective Inhibitors of the Trimethoprim-Resistant, Type II R67 Dihydrofolate Reductase

(2012) Dominic Bastien et al.   JOURNAL OF MEDICINAL CHEMISTRY

Potent and Highly Selective Benzimidazole Inhibitors of PI3-Kinase Delta

(2012) Jeremy M. Murray et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Discovery and Optimization of a Novel Class of Potent, Selective, and Orally Bioavailable Anaplastic Lymphoma Kinase (ALK) Inhibitors with Potential Utility for the Treatment of Cancer

(2012) Richard T. Lewis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design and synthesis of positional isomers of 1-alkyl-2-trifluoromethyl-5 or 6-substituted benzimidazoles and their antimicrobial activity

(2012) G. Sathaiah et al.   MEDICINAL CHEMISTRY RESEARCH

Anti-microbial benzimidazole derivatives: synthesis and in vitro biological evaluation

(2012) Love Kumar Soni et al.   MEDICINAL CHEMISTRY RESEARCH

Design, synthesis, and biological evaluation of new 4-thiazolidinone derivatives substituted with benzimidazole ring as potential chemotherapeutic agents

(2012) Georgina N. Masoud et al.   MEDICINAL CHEMISTRY RESEARCH

Synthesis and Anti-inflammatory Evaluation of Novel Benzimidazole and Imidazopyridine Derivatives

(2012) Gaozhi Chen et al.   ACS Medicinal Chemistry Letters

Identification of a novel resistance mutation for benzimidazole inhibitors of the HCV RNA-dependent RNA polymerase

(2011) Leen Delang et al.   ANTIVIRAL RESEARCH

Synthesis of 2-Mercaptobenzimidazole Derivatives as Potential Anti-microbial and Cytotoxic Agents

(2011) Kallappa M. Hosamani et al.   ARCHIV DER PHARMAZIE

Synthesis and biological evaluation of benzimidazole-5-carbohydrazide derivatives as antimalarial, cytotoxic and antitubercular agents

(2011) José Camacho et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Bis(oxyphenylene)benzimidazoles: A novel class of anti-Plasmodium falciparum agents

(2011) Annie Mayence et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A reverse method for diversity introduction of benzimidazole to synthesize H+/K+-ATP enzyme inhibitors

(2011) Yu Yan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Inhibition of the helicase activity of the HCV NS3 protein by symmetrical dimeric bis-benzimidazoles

(2011) Vera L. Tunitskaya et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and pharmacological evaluation of novel benzoylazole-based PPAR α/γ activators

(2011) Kantaro Ushiroda et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of a new class of potent prolylcarboxypeptidase inhibitors derived from alanine

(2011) Zhicai Wu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and biological evaluation of benzo[d]imidazole derivatives as potential anti-cancer agents

(2011) Hamad M. Alkahtani et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

New benzimidazole derivatives as antiplasmodial agents and plasmepsin inhibitors: Synthesis and analysis of structure–activity relationships

(2011) Zafar Saied Saify et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Derivatives of Benzimidazol-2-ylquinoline and Benzimidazol-2-ylisoquinoline as Selective A1 Adenosine Receptor Antagonists with Stimulant Activity on Human Colon Motility

(2011) Barbara Cosimelli et al.   ChemMedChem

Pyrido[1,2-a]benzimidazole-Based Agents Active Against Tuberculosis (TB), Multidrug-Resistant (MDR) TB and Extensively Drug-Resistant (XDR) TB

(2011) Marco Pieroni et al.   ChemMedChem

Synthesis, spectroscopic characterization and antiproliferative evaluation in vitro of novel Schiff bases related to benzimidazoles

(2011) Marijana Hranjec et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) of some benzimidazole derivatives with trichomonicidal activity

(2011) Jaime Pérez-Villanueva et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, characterization and cytotoxicity of some novel 1,3-disubstituted-2,3-dihydro-2-iminobenzimidazoles

(2011) Anelia Ts. Mavrova et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, characterization of some benzazoles bearing pyridine moiety: Search for novel anticancer agents

(2011) Heba S.A. Elzahabi   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of novel 1,2,5-trisubstituted benzimidazoles as potential antitumor agents

(2011) Rodrigo Abonia et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and bioevaluation of novel 3,4,5-trimethoxybenzylbenzimidazole derivatives that inhibit Helicobacter pylori-induced pathogenesis in human gastric epithelial cells

(2011) Chih-Shiang Chang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Oxidases and peroxidases in cardiovascular and lung disease: New concepts in reactive oxygen species signaling

(2011) Imad Al Ghouleh et al.   FREE RADICAL BIOLOGY AND MEDICINE

Novel 4,4-Disubstituted Piperidine-Based C–C Chemokine Receptor-5 Inhibitors with High Potency against Human Immunodeficiency Virus-1 and an Improved human Ether-a-go-go Related Gene (hERG) Profile

(2011) Wieslaw M. Kazmierski et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel 1,3-Dipropyl-8-(3-benzimidazol-2-yl-methoxy-1-methylpyrazol-5-yl)xanthines as Potent and Selective A2B Adenosine Receptor Antagonists

(2011) Pier Giovanni Baraldi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and antimicrobial activities of a new class of 6-arylbenzimidazo[1,2-c]quinazolines

(2011) Rondla Rohini et al.   JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY

Synthesis of potential anticancer derivatives of pyrido[1,2-a]benzimidazoles

(2011) Hanan M. Refaat   MEDICINAL CHEMISTRY RESEARCH

Antimicrobial screening of novel synthesized benzimidazole nucleus containing 4-oxo-thiazolidine derivatives

(2011) N. C. Desai et al.   MEDICINAL CHEMISTRY RESEARCH

First synthesis of an aziridinyl fused pyrrolo[1,2-a]benzimidazole and toxicity evaluation towards normal and breast cancer cell lines

(2011) Sarah Bonham et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Optimization of Potent Inhibitors of P. falciparum Dihydroorotate Dehydrogenase for the Treatment of Malaria

(2011) Renato T. Skerlj et al.   ACS Medicinal Chemistry Letters

Synthesis, antimicrobial and cytotoxic activity of novel azetidine-2-one derivatives of 1H-benzimidazole

(2011) Malleshappa Noolvi et al.   Arabian Journal of Chemistry

Design, synthesis and biological evaluation of some novel benzimidazole derivatives for their potential anticonvulsant activity

(2010) Priyal Jain et al.   ARCHIVES OF PHARMACAL RESEARCH

Design and synthesis of novel benzimidazole derivatives as inhibitors of hepatitis B virus

(2010) Yu Luo et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: Design, synthesis, and structure–activity relationships

(2010) Shigeo Hayashi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Novel 1,3-dihydro-benzimidazol-2-ones and their analogues as potent non-nucleoside HIV-1 reverse transcriptase inhibitors

(2010) Anna-Maria Monforte et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Antiviral activity of benzimidazole derivatives. II. Antiviral activity of 2-phenylbenzimidazole derivatives

(2010) Michele Tonelli et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis, vasorelaxant activity and antihypertensive effect of benzo[d]imidazole derivatives

(2010) Gabriel Navarrete-Vázquez et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Benzimidazole Thumb Pocket I finger-loop inhibitors of HCV NS5B polymerase: Improved drug-like properties through C-2 SAR in three sub-series

(2010) Pierre L. Beaulieu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel N-substituted benzimidazole CXCR4 antagonists as potential anti-HIV agents

(2010) John F. Miller et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and SAR of novel isoquinoline CXCR4 antagonists with potent anti-HIV activity

(2010) John F. Miller et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of a novel tricyclic 1,2,3,4,4a,5,6,10b-octahydro-1,10-phenanthroline ring system and CXCR4 antagonists with potent activity against HIV-1

(2010) John G. Catalano et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and SAR of novel CXCR4 antagonists that are potent inhibitors of T tropic (X4) HIV-1 replication

(2010) Renato Skerlj et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

2-Phenyl-5-(pyrrolidin-1-yl)-1-(3,4,5-trimethoxybenzyl)-1H-benzimidazole, a benzimidazole derivative, inhibits growth of human prostate cancer cells by affecting tubulin and c-Jun N-terminal kinase

(2010) Wei-Ling Chang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inflammation 2010: New Adventures of an Old Flame

(2010) Ruslan Medzhitov   CELL

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Synthesis and Antimicrobial Activity of Some Novel 4-(1H-Benz[d]imidazol-2yl)-1,3-thiazol-2-amines

(2010) Vanga Malla Reddy et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Synthesis and Antibacterial Activity of Some Novel 6-(1H-Benz[d]imidazol-2-yl)-8-(5-nitro-2-furyl)-3-(4-pyridyl)-7,8-dihydro[1,2,4]triazolo[3,4-b][1,3,4]thiadiazepines

(2010) Vanga Malla Reddy et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Design, Synthesis and Biological Evaluation of Novel Inhibitors ofTrypanosoma bruceiPteridine Reductase 1

(2010) Daniel Spinks et al.   ChemMedChem

Synthesis and bioactivity of a novel series of 3,6-disubstituted 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles

(2010) Ying Jun Li et al.   CHINESE CHEMICAL LETTERS

Evolving epidemiology of hepatitis C virus

(2010) D. Lavanchy   CLINICAL MICROBIOLOGY AND INFECTION

Cell cycle disruption and apoptotic activity of 3-aminothiazolo[3,2-a]benzimidazole-2-carbonitrile and its homologues

(2010) Abdelwareth A.O. Sarhan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Benzimidazole derivatives related to 2,3-acrylonitriles, benzimidazo[1,2-a]quinolines and fluorenes: Synthesis, antitumor evaluation in vitro and crystal structure determination

(2010) Marijana Hranjec et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and toxicity towards normal and cancer cell lines of benzimidazolequinones containing fused aromatic rings and 2-aromatic ring substituents

(2010) Eoin Moriarty et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel benzimidazole–pyrimidine conjugates as potent antitumor agents

(2010) Heba T. Abdel-Mohsen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The influence of the aziridinyl substituent of benzimidazoles and benzimidazolequinones on toxicity towards normal and Fanconi anaemia cells

(2010) Karen Fahey et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological activity of 2-(trifluoromethyl)-1H-benzimidazole derivatives against some protozoa and Trichinella spiralis

(2010) Francisco Hernández-Luis et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Post Groebke–Blackburn multicomponent protocol: Synthesis of new polyfunctional imidazo[1,2-a]pyridine and imidazo[1,2-a]pyrimidine derivatives as potential antimicrobial agents

(2010) Taleb H. Al-Tel et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and pharmacological evaluation of novel 5-substituted-1-(phenylsulfonyl)-2-methylbenzimidazole derivatives as anti-inflammatory and analgesic agents

(2010) Monika Gaba et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological activities of novel amine-derived bis-azoles as potential antibacterial and antifungal agents

(2010) Bo Fang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

In-vivo analgesic and anti-inflammatory activities of newly synthesized benzimidazole derivatives

(2010) Kavitha C.S. Achar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Antimicrobial activity and a SAR study of some novel benzimidazole derivatives bearing hydrazone moiety

(2010) Yusuf Özkay et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and anticancer activity of some novel 2-substituted benzimidazole derivatives

(2010) Hanan M. Refaat   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Derivatives of benzimidazole pharmacophore: Synthesis, anticonvulsant, antidiabetic and DNA cleavage studies

(2010) Ramya V. Shingalapur et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and in vitro cytotoxic evaluation of some thiazolylbenzimidazole derivatives

(2010) Yu Luo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Microwave supported synthesis of some novel 1,3-Diarylpyrazino[1,2-a]benzimidazole derivatives and investigation of their anticancer activities

(2010) Seref Demirayak et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Oxidative stress, inflammation, and cancer: How are they linked?

(2010) Simone Reuter et al.   FREE RADICAL BIOLOGY AND MEDICINE

Neuroprotective strategies involving ROS in Alzheimer disease

(2010) Magali Dumont et al.   FREE RADICAL BIOLOGY AND MEDICINE

Benzimidazol-2-ylidene Gold(I) Complexes Are Thioredoxin Reductase Inhibitors with Multiple Antitumor Properties

(2010) Riccardo Rubbiani et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Novel Small Molecule Orally Bioavailable C−X−C Chemokine Receptor 4 Antagonists That Are Potent Inhibitors of T-Tropic (X4) HIV-1 Replication

(2010) Renato T. Skerlj et al.   JOURNAL OF MEDICINAL CHEMISTRY

An Imidazopiperidine Series of CCR5 Antagonists for the Treatment of HIV: The Discovery ofN-{(1S)-1-(3-Fluorophenyl)-3-[(3-endo)-3-(5-isobutyryl-2-methyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl}acetamide (PF-232798)

(2010) Paul A. Stupple et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel Trisubstituted Benzimidazoles, TargetingMtbFtsZ, as a New Class of Antitubercular Agents

(2010) Kunal Kumar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Microwave-assisted synthesis of some new tetrazolo[1,5-a]quinoline-based benzimidazoles catalyzed by p-TsOH and investigation of their antimicrobial activity

(2010) Divyesh C. Mungra et al.   MEDICINAL CHEMISTRY RESEARCH

N-Hydroxy-1,2-disubstituted-1H-benzimidazol-5-yl acrylamides as novel histone deacetylase inhibitors: Design, synthesis, SAR studies, and in vivo antitumor activity

(2009) Haishan Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of benzimidazole-diamide finger loop (Thumb Pocket I) allosteric inhibitors of HCV NS5B polymerase: Implementing parallel synthesis for rapid linker optimization

(2009) Sylvie Goulet et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

New Therapies for Hepatitis C Virus Infection

(2009) Vincent Soriano et al.   CLINICAL INFECTIOUS DISEASES

Synthesis and evaluation of in vitro anti-microbial and anti-tubercular activity of 2-styryl benzimidazoles

(2009) Ramya V. Shingalapur et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and antitubercular screening of imidazole derivatives☆

(2009) Jyoti Pandey et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, physicochemical properties and antimicrobial activity of some new benzimidazole derivatives

(2009) K.F. Ansari et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Studies towards the identification of putative bioactive conformation of potent vasodilator arylidene N-acylhydrazone derivatives

(2009) Arthur E. Kümmerle et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Recent advances in the development of NS5B polymerase inhibitors for the treatment of hepatitis C virus infection

(2009) Pierre L Beaulieu   EXPERT OPINION ON THERAPEUTIC PATENTS

Alkaloids as potential anti-tubercular agents

(2009) Navneet Kishore et al.   FITOTERAPIA

Microwave assisted, one-pot synthesis of 5-nitro- 2-aryl substituted-1H-benzimidazole libraries: Screeningin vitrofor antimicrobial activity

(2009) Kallappa Mahadevappa Hosamani et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Synthesis, antimicrobial and antiviral activity of substituted benzimidazoles

(2009) Deepika Sharma et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Hepatitis C virus genotype 1b as a risk factor for hepatocellular carcinoma development: A meta-analysis

(2009) Sara Raimondi et al.   JOURNAL OF HEPATOLOGY

Synthesis, characterization, and antimicrobial activities of clubbed [1,2,4]-oxadiazoles with fluorobenzimidazoles

(2009) Ganesh R. Jadhav et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Synthesis and Evaluation of a New Generation of Orally Efficacious Benzimidazole-Based Poly(ADP-ribose) Polymerase-1 (PARP-1) Inhibitors as Anticancer Agents

(2009) Yunsong Tong et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure of HIV-1 nonnucleoside reverse transcriptase inhibitors derivatives of N-benzyl-benzimidazole with different substituents in position 4

(2009) Natasza E. Ziółkowska et al.   JOURNAL OF MOLECULAR STRUCTURE

Design, Synthesis and Anti-HIV Integrase Evaluation of 4-Oxo-4H-quinolizine-3-carboxylic Acid Derivatives

(2009) Yi-Sheng Xu et al.   MOLECULES

Synthesis and Antimicrobial Activity of Some Novel 2-[4-(Substituted Piperazin-/Piperidin-1-ylcarbonyl)phenyl]-1H-benzimidazole Derivatives

(2008) Canan Kus et al.   ARCHIV DER PHARMAZIE

Synthesis and analgesic/anti-inflammatory evaluation of fused heterocyclic ring systems incorporating phenylsulfonyl moiety

(2008) Mohamed R. Shaaban et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Novel N1-substituted 1,3-dihydro-2H-benzimidazol-2-ones as potent non-nucleoside reverse transcriptase inhibitors

(2008) Anna-Maria Monforte et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structure-based design and synthesis of benzimidazole derivatives as dipeptidyl peptidase IV inhibitors

(2008) Michael B. Wallace et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Balancing oral exposure with Cyp3A4 inhibition in benzimidazole-based IGF-IR inhibitors

(2008) Kurt Zimmermann et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Clubbed [1,2,3] triazoles by fluorine benzimidazole: A novel approach to H37Rv inhibitors as a potential treatment for tuberculosis

(2008) Charansingh Gill et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, synthesis and in vitro antiprotozoal activity of benzimidazole-pentamidine hybrids

(2008) Héctor Torres-Gómez et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

First synthesis of N-[(aziridin-2-yl)methyl]benzimidazolequinone and analysis of toxicity towards normal and Fanconi anemia cells

(2008) Liz O’Donovan et al.   CHEMICAL COMMUNICATIONS

Non-Nucleoside Inhibitors of NS5B Polymerase Binding to Allosteric Sites: 3DQSAR and Molecular Docking Studies

(2008) Hongyu Cao et al.   CURRENT MEDICINAL CHEMISTRY

SAR study of clubbed [1,2,4]-triazolyl with fluorobenzimidazoles as antimicrobial and antituberculosis agents

(2008) Ganesh Rajaram Jadhav et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and antinociceptive activities of some pyrazoline derivatives

(2008) Zafer Asim Kaplancikli et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, pharmacological screening, quantum chemical and in vitro permeability studies of N-Mannich bases of benzimidazoles through bovine cornea

(2008) E. Philip Jesudason et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and antiparasitic and antifungal evaluation of 2′-arylsubstituted-1H,1′H-[2,5′]bisbenzimidazolyl-5-carboxamidines

(2008) Mehmet Alp et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery and Evaluation of 4-(2-(4-chloro-1H-pyrazol-1-yl)ethylamino)-3-(6-(1-(3-fluoropropyl)piperidin-4-yl)-4-methyl-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one (BMS-695735), an Orally Efficacious Inhibitor of Insulin-like Growth Factor-1 Receptor Kinase with Broad Spectrum in Vivo Antitumor Activity

(2008) Upender Velaparthi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Structure−Activity Relationships and in Vivo Characterization of 4-Amino-3-benzimidazol-2-ylhydroquinolin-2-ones: A Novel Class of Receptor Tyrosine Kinase Inhibitors

(2008) Paul A. Renhowe et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Exploding Field of the HCV Polymerase Non-Nucleoside Inhibitors: Summary of a First Generation Compounds

(2008) Enzo Tramontano   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Current Status of COX-2 Inhibitors

(2008) Palwinder Singh et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Maraviroc for Previously Treated Patients with R5 HIV-1 Infection

(2008) Roy M. Gulick et al.   NEW ENGLAND JOURNAL OF MEDICINE

Synthesis of new benzimidazole–coumarin conjugates as anti-hepatitis C virus agents

(2007) Jih Ru Hwu et al.   ANTIVIRAL RESEARCH

Synthesis, anti-bacterial, anti-asthmatic and anti-diabetic activities of novel N-substituted-2-(4-phenylethynyl-phenyl)-1H-benzimidazoles and N-substituted 2[4-(4,4-dimethyl-thiochroman-6-yl-ethynyl)-phenyl)-1H-benzimidazoles

(2007) Ramanatham Vinodkumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY