(Re)generating Human Beta Cells: Status, Pitfalls, and Perspectives

Artemether Does Not Turn α Cells into β Cells

(2018) Talitha van der Meulen et al.   Cell Metabolism

Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2

(2017) Nuria Cerdá-Esteban et al.   Nature Communications

Activation of the Wnt/β-catenin pathway in pancreatic beta cells during the compensatory islet hyperplasia in prediabetic mice

(2016) D.A. Maschio et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SerpinB1 Promotes Pancreatic β Cell Proliferation

(2016) Abdelfattah El Ouaamari et al.   Cell Metabolism

PKCζ Is Essential for Pancreatic β-Cell Replication During Insulin Resistance by Regulating mTOR and Cyclin-D2

(2016) Jayalakshmi Lakshmipathi et al.   DIABETES

Inhibition of DYRK1A Stimulates Human β-Cell Proliferation

(2016) Ercument Dirice et al.   DIABETES

Glucose Induces Mouse β-Cell Proliferation via IRS2, MTOR, and Cyclin D2 but Not the Insulin Receptor

(2016) Rachel E. Stamateris et al.   DIABETES

Phase 3 Trial of Transplantation of Human Islets in Type 1 Diabetes Complicated by Severe Hypoglycemia

(2016) Bernhard J. Hering et al.   DIABETES CARE

Novel factors modulating human β-cell proliferation

(2016) J. Shirakawa et al.   DIABETES OBESITY & METABOLISM

Extreme obesity induces massive beta cell expansion in mice through self-renewal and does not alter the beta cell lineage

(2016) Aaron R. Cox et al.   DIABETOLOGIA

FoxO1 Plays an Important Role in Regulating β-Cell Compensation for Insulin Resistance in Male Mice

(2016) Ting Zhang et al.   ENDOCRINOLOGY

Effects of Obesity and Diabetes on α- and β-Cell Mass in Surgically Resected Human Pancreas

(2016) Jun Inaishi et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Sfrp5mediates glucose-induced proliferation in rat pancreatic β-cells

(2016) Binbin Guan et al.   JOURNAL OF ENDOCRINOLOGY

Generation of Functional Beta-Like Cells from Human Exocrine Pancreas

(2016) Maria J. Lima et al.   PLoS One

Human pancreatic beta-like cells converted from fibroblasts

(2016) Saiyong Zhu et al.   Nature Communications

Generation of stem cell-derived β-cells from patients with type 1 diabetes

(2016) Jeffrey R. Millman et al.   Nature Communications

Adipose- and muscle-derived Wnts trigger pancreatic β-cell adaptation to systemic insulin resistance

(2016) Kamil Kozinski et al.   Scientific Reports

Resolving Discrepant Findings on ANGPTL8 in β-Cell Proliferation: A Collaborative Approach to Resolving the Betatrophin Controversy

(2016) Aaron R. Cox et al.   PLoS One

Pregnancy Hyperglycemia in Prolactin Receptor Mutant, but Not Prolactin Mutant, Mice and Feeding-Responsive Regulation of Placental Lactogen Genes Implies Placental Control of Maternal Glucose Homeostasis1

(2015) Saara M. Rawn et al.   BIOLOGY OF REPRODUCTION

Osteoprotegerin and Denosumab Stimulate Human Beta Cell Proliferation through Inhibition of the Receptor Activator of NF-κB Ligand Pathway

(2015) Nagesha Guthalu Kondegowda et al.   Cell Metabolism

Human pancreas development

(2015) R. E. Jennings et al.   DEVELOPMENT

Augmented Stat5 Signaling Bypasses Multiple Impediments to Lactogen-Mediated Proliferation in Human β-Cells

(2015) Hainan Chen et al.   DIABETES

Induction of the ChREBPβ Isoform Is Essential for Glucose-Stimulated β-Cell Proliferation

(2015) Pili Zhang et al.   DIABETES

New insights into the architecture of the islet of Langerhans: a focused cross-species assessment

(2015) Rafael Arrojo e Drigo et al.   DIABETOLOGIA

Controlled induction of human pancreatic progenitors produces functional beta-like cells in vitro

(2015) H. A. Russ et al.   EMBO JOURNAL

Insulin demand regulates β cell number via the unfolded protein response

(2015) Rohit B. Sharma et al.   JOURNAL OF CLINICAL INVESTIGATION

TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors

(2015) Inês Cebola et al.   NATURE CELL BIOLOGY

A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication

(2015) Peng Wang et al.   NATURE MEDICINE

Diabetes mellitus—advances and challenges in human β-cell proliferation

(2015) Peng Wang et al.   Nature Reviews Endocrinology

Ex Vivo Expansion and Differentiation of Human and Mouse Fetal Pancreatic Progenitors Are Modulated by Epidermal Growth Factor

(2015) Paola Bonfanti et al.   STEM CELLS AND DEVELOPMENT

Inhibition of DYRK1A and GSK3B induces human β-cell proliferation

(2015) Weijun Shen et al.   Nature Communications

A human beta cell line with drug inducible excision of immortalizing transgenes

(2015) Marion Benazra et al.   Molecular Metabolism

Prolactin Receptors and Placental Lactogen Drive Male Mouse Pancreatic Islets to Pregnancy-Related mRNA Changes

(2015) Lotte Goyvaerts et al.   PLoS One

Novel GATA6 Mutations in Patients with Pancreatic Agenesis and Congenital Heart Malformations

(2015) Christina S. Chao et al.   PLoS One

Generation of Functional Human Pancreatic β Cells In Vitro

(2014) Felicia W. Pagliuca et al.   CELL

Perspectives on the Activities of ANGPTL8/Betatrophin

(2014) Peng Yi et al.   CELL

ANGPTL8/Betatrophin Does Not Control Pancreatic Beta Cell Expansion

(2014) Viktoria Gusarova et al.   CELL

Reprogramming of human pancreatic exocrine cells to β-like cells

(2014) M Lemper et al.   CELL DEATH AND DIFFERENTIATION

Analysis of Transcription Factors Key for Mouse Pancreatic Development Establishes NKX2-2 and MNX1 Mutations as Causes of Neonatal Diabetes in Man

(2014) Sarah E. Flanagan et al.   Cell Metabolism

Reduced Ki67 Staining in the Postmortem State Calls Into Question Past Conclusions About the Lack of Turnover of Adult Human β-Cells

(2014) Brooke A. Sullivan et al.   DIABETES

Betatrophin Versus Bitter-Trophin and the Elephant in the Room: Time for a New Normal in  -Cell Regeneration Research

(2014) A. F. Stewart   DIABETES

Human  -Cell Proliferation and Intracellular Signaling Part 2: Still Driving in the Dark Without a Road Map

(2014) E. Bernal-Mizrachi et al.   DIABETES

GATA4 Mutations Are a Cause of Neonatal and Childhood-Onset Diabetes

(2014) C. Shaw-Smith et al.   DIABETES

Menin determines K-RAS proliferative outputs in endocrine cells

(2014) Chester E. Chamberlain et al.   JOURNAL OF CLINICAL INVESTIGATION

Development of a conditionally immortalized human pancreatic β cell line

(2014) Raphaël Scharfmann et al.   JOURNAL OF CLINICAL INVESTIGATION

Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers

(2014) Simona Chera et al.   NATURE

Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells

(2014) Alireza Rezania et al.   NATURE BIOTECHNOLOGY

Role of Endogenous GLP-1 and GIP in Beta Cell Compensatory Responses to Insulin Resistance and Cellular Stress

(2014) Srividya Vasu et al.   PLoS One

Contribution of a Non-β-Cell Source to β-Cell Mass during Pregnancy

(2014) Chiara Toselli et al.   PLoS One

Redifferentiation of Adult Human β Cells Expanded In Vitro by Inhibition of the WNT Pathway

(2014) Ayelet Lenz et al.   PLoS One

Differentiated human stem cells resemble fetal, not adult, β cells

(2014) Sinisa Hrvatin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell therapy for type 1 diabetes

(2014) K. R. Muir et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

Revealing transcription factors during human pancreatic β cell development

(2014) Elizabeth Conrad et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Pancreas development in humans

(2014) Fong Cheng Pan et al.   Current Opinion in Endocrinology Diabetes and Obesity

Increased Circulating Betatrophin Concentrations in Patients with Type 2 Diabetes

(2014) Daniel Espes et al.   International Journal of Endocrinology

The window period of NEUROGENIN3 during human gestation

(2014) Rachel J Salisbury et al.   Islets

Islet β cell mass in diabetes and how it relates to function, birth, and death

(2013) Gordon C. Weir et al.   Annals of the New York Academy of Sciences

RETRACTED: Betatrophin: A Hormone that Controls Pancreatic β Cell Proliferation

(2013) Peng Yi et al.   CELL

Epigenomic Analysis of Multilineage Differentiation of Human Embryonic Stem Cells

(2013) Wei Xie et al.   CELL

Argonaute2 Mediates Compensatory Expansion of the Pancreatic β Cell

(2013) Sudhir G. Tattikota et al.   Cell Metabolism

Toward the Development of a Global Induced Pluripotent Stem Cell Library

(2013) Marc Turner et al.   Cell Stem Cell

Adult Duct-Lining Cells Can Reprogram into β-like Cells Able to Counter Repeated Cycles of Toxin-Induced Diabetes

(2013) Keith Al-Hasani et al.   DEVELOPMENTAL CELL

Suppression of Epithelial-to-Mesenchymal Transitioning Enhances Ex Vivo Reprogramming of Human Exocrine Pancreatic Tissue Toward Functional Insulin-Producing β-Like Cells

(2013) Maria João Lima et al.   DIABETES

Elevated Mouse Hepatic Betatrophin Expression Does Not Increase Human  -Cell Replication in the Transplant Setting

(2013) Y. Jiao et al.   DIABETES

Hepatocyte Growth Factor/c-Met Signaling Is Required for  -Cell Regeneration

(2013) J. C. Alvarez-Perez et al.   DIABETES

Conversion of Mature Human  -Cells Into Glucagon-Producing  -Cells

(2013) H. S. Spijker et al.   DIABETES

Development of the Human Pancreas From Foregut to Endocrine Commitment

(2013) R. E. Jennings et al.   DIABETES

Transcription factor gene MNX1 is a novel cause of permanent neonatal diabetes in a consanguineous family

(2013) A. Bonnefond et al.   DIABETES & METABOLISM

BiallelicPDX1(insulin promoter factor 1) mutations causing neonatal diabetes without exocrine pancreatic insufficiency

(2013) E. De Franco et al.   DIABETIC MEDICINE

Increased circulating levels of betatrophin in individuals with long-standing type 1 diabetes

(2013) Daniel Espes et al.   DIABETOLOGIA

Downregulation of Sfrp5 promotes beta cell proliferation during obesity in the rat

(2013) Sandra A. Rebuffat et al.   DIABETOLOGIA

Identification of particular groups of microRNAs that positively or negatively impact on beta cell function in obese models of type 2 diabetes

(2013) Valeria Nesca et al.   DIABETOLOGIA

Anonymous sources: where do adult β cells come from?

(2013) Michael S. German   JOURNAL OF CLINICAL INVESTIGATION

No evidence for β cell neogenesis in murine adult pancreas

(2013) Xiangwei Xiao et al.   JOURNAL OF CLINICAL INVESTIGATION

Epigenomic plasticity enables human pancreatic α to β cell reprogramming

(2013) Nuria C. Bramswig et al.   JOURNAL OF CLINICAL INVESTIGATION

Small-Molecule Inducer of β Cell Proliferation Identified by High-Throughput Screening

(2013) Weijun Shen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nutrient Sensing, Metabolism, and Cell Growth Control

(2013) Hai-Xin Yuan et al.   MOLECULAR CELL

Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice

(2013) Luc Baeyens et al.   NATURE BIOTECHNOLOGY

Recessive mutations in a distal PTF1A enhancer cause isolated pancreatic agenesis

(2013) Michael N Weedon et al.   NATURE GENETICS

Mechanisms of Diabetic Complications

(2013) Josephine M. Forbes et al.   PHYSIOLOGICAL REVIEWS

Serotonin regulates glucose-stimulated insulin secretion from pancreatic   cells during pregnancy

(2013) M. Ohara-Imaizumi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of polyhormonal insulin-producing cells derived in vitro from human embryonic stem cells

(2013) Jennifer E. Bruin et al.   Stem Cell Research

Enrichment of human embryonic stem cell-derived NKX6.1-expressing pancreatic progenitor cells accelerates the maturation of insulin-secreting cells in vivo

(2013) Alireza Rezania et al.   STEM CELLS

The Inactivation of Arx in Pancreatic α-Cells Triggers Their Neogenesis and Conversion into Functional β-Like Cells

(2013) Monica Courtney et al.   PLoS Genetics

Potent Induction Immunotherapy Promotes Long-Term Insulin Independence After Islet Transplantation in Type 1 Diabetes

(2012) M. D. Bellin et al.   AMERICAN JOURNAL OF TRANSPLANTATION

In vitro Generation of Functional Insulin-producing Cells from Lipoaspirated Human Adipose Tissue-derived Stem Cells

(2012) Mohamad Lizan Mohamad Buang et al.   ARCHIVES OF MEDICAL RESEARCH

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

Differentiation of Human Adipose Tissue-Derived Stem Cells into Aggregates of Insulin-Producing Cells through the Overexpression of Pancreatic and Duodenal Homeobox Gene-1

(2012) Jiyeon Lee et al.   CELL TRANSPLANTATION

ChREBP Mediates Glucose-Stimulated Pancreatic  -Cell Proliferation

(2012) M. R. Metukuri et al.   DIABETES

Maturation of Human Embryonic Stem Cell-Derived Pancreatic Progenitors Into Functional Islets Capable of Treating Pre-existing Diabetes in Mice

(2012) A. Rezania et al.   DIABETES

 -Cell Mass and Turnover in Humans: Effects of obesity and aging

(2012) Y. Saisho et al.   DIABETES CARE

Hepatocyte Growth Factor Plays a Key Role in Insulin Resistance-Associated Compensatory Mechanisms

(2012) Tiago G. Araújo et al.   ENDOCRINOLOGY

Redifferentiation of Expanded Human Pancreatic β-Cell-derived Cells by Inhibition of the NOTCH Pathway

(2012) Yael Bar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Formation of a Human β-Cell Population within Pancreatic Islets Is Set Early in Life

(2012) Brigid E. Gregg et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

MicroRNAs contribute to compensatory β cell expansion during pregnancy and obesity

(2012) Cécile Jacovetti et al.   JOURNAL OF CLINICAL INVESTIGATION

GW8510 Increases Insulin Expression in Pancreatic Alpha Cells through Activation of p53 Transcriptional Activity

(2012) Dina Fomina-Yadlin et al.   PLoS One

Crosstalk between the developing pancreas and its blood vessels: An evolving dialog

(2012) Alethia Villasenor et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Reference Maps of Human ES and iPS Cell Variation Enable High-Throughput Characterization of Pluripotent Cell Lines

(2011) Christoph Bock et al.   CELL

Control of Pancreatic β Cell Regeneration by Glucose Metabolism

(2011) Shay Porat et al.   Cell Metabolism

The Adult Mouse and Human Pancreas Contain Rare Multipotent Stem Cells that Express Insulin

(2011) Simon R. Smukler et al.   Cell Stem Cell

Combination Therapy with a Dipeptidyl Peptidase-4 Inhibitor and a Proton Pump Inhibitor Induces β-Cell Neogenesis from Adult Human Pancreatic Duct Cells Implanted in Immunodeficient Mice

(2011) Wilma L. Suarez-Pinzon et al.   CELL TRANSPLANTATION

Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas

(2011) J. L. Kopp et al.   DEVELOPMENT

Lineage tracing reveals the dynamic contribution of Hes1+ cells to the developing and adult pancreas

(2011) D. Kopinke et al.   DEVELOPMENT

Pancreas organogenesis: From bud to plexus to gland

(2011) Fong Cheng Pan et al.   DEVELOPMENTAL DYNAMICS

Specific Glucose-Induced Control of Insulin Receptor Substrate-2 Expression Is Mediated via Ca 2+ -Dependent Calcineurin/NFAT Signaling in Primary Pancreatic Islet β-Cells

(2011) Damien Demozay et al.   DIABETES

Autologous Umbilical Cord Blood Transfusion in Young Children With Type 1 Diabetes Fails to Preserve C-Peptide

(2011) M. J. Haller et al.   DIABETES CARE

Longevity of human islet α- and β-cells

(2011) M. Cnop et al.   DIABETES OBESITY & METABOLISM

The functional and molecular characterisation of human embryonic stem cell-derived insulin-positive cells compared with adult pancreatic beta cells

(2011) C. L. Basford et al.   DIABETOLOGIA

Immunohistochemical characterisation of cells co-producing insulin and glucagon in the developing human pancreas

(2011) M. J. Riedel et al.   DIABETOLOGIA

miRNAs control insulin content in pancreatic β-cells via downregulation of transcriptional repressors

(2011) Tal Melkman-Zehavi et al.   EMBO JOURNAL

Loss of Foxd3 Results in Decreased β-Cell Proliferation and Glucose Intolerance During Pregnancy

(2011) Jennifer L. Plank et al.   ENDOCRINOLOGY

Participation of Akt, Menin, and p21 in Pregnancy-Induced β-Cell Proliferation

(2011) Elizabeth Hughes et al.   ENDOCRINOLOGY

Guards and Culprits in the Endoplasmic Reticulum: Glucolipotoxicity andβ-Cell Failure in Type II Diabetes

(2011) Udayakumar Karunakaran et al.   Experimental Diabetes Research

A genetically engineered human pancreatic β cell line exhibiting glucose-inducible insulin secretion

(2011) Philippe Ravassard et al.   JOURNAL OF CLINICAL INVESTIGATION

Type 2 diabetes across generations: from pathophysiology to prevention and management

(2011) Christopher J Nolan et al.   LANCET

GATA6 haploinsufficiency causes pancreatic agenesis in humans

(2011) Hana Lango Allen et al.   NATURE GENETICS

Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration

(2011) Chris Jopling et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Islet-Like Cell Aggregates Generated from Human Adipose Tissue Derived Stem Cells Ameliorate Experimental Diabetes in Mice

(2011) Vikash Chandra et al.   PLoS One

Insulin-Producing Cells Generated from Dedifferentiated Human Pancreatic Beta Cells Expanded In Vitro

(2011) Holger A. Russ et al.   PLoS One

Ectopic PDX-1 Expression Directly Reprograms Human Keratinocytes along Pancreatic Insulin-Producing Cells Fate

(2011) Michal Mauda-Havakuk et al.   PLoS One

Kinetics and genomic profiling of adult human and mouse β-cell maturation

(2011) Marta Szabat et al.   Islets

Non-β-cell progenitors of β-cells in pregnant mice

(2011) Sylvie Abouna et al.   Organogenesis

Developmental Stages in Human Embryos: Revised and New Measurements

(2010) Ronan O’Rahilly et al.   CELLS TISSUES ORGANS

Human bone marrow-derived mesenchymal cells differentiate and mature into endocrine pancreatic lineage in vivo

(2010) Smruti M. Phadnis et al.   CYTOTHERAPY

Glucose and aging control the quiescence period that follows pancreatic beta cell replication

(2010) S. J. Salpeter et al.   DEVELOPMENT

Disruption of Hepatocyte Growth Factor/c-Met Signaling Enhances Pancreatic  -Cell Death and Accelerates the Onset of Diabetes

(2010) J. Mellado-Gil et al.   DIABETES

 -Cell Replication Is Increased in Donor Organs From Young Patients After Prolonged Life Support

(2010) P. I. Veld et al.   DIABETES

Homozygous Mutations in NEUROD1 Are Responsible for a Novel Syndrome of Permanent Neonatal Diabetes and Neurological Abnormalities

(2010) O. Rubio-Cabezas et al.   DIABETES

 -Cell Growth and Regeneration: Replication Is Only Part of the Story

(2010) S. Bonner-Weir et al.   DIABETES

Regeneration of insulin production by autologous bone marrow blood autotransplantation in patients with type 1 diabetes

(2010) E. Esmatjes et al.   DIABETOLOGIA

Glucose stimulates human beta cell replication in vivo in islets transplanted into NOD–severe combined immunodeficiency (SCID) mice

(2010) H. E. Levitt et al.   DIABETOLOGIA

Placental lactogens induce serotonin biosynthesis in a subset of mouse beta cells during pregnancy

(2010) A. Schraenen et al.   DIABETOLOGIA

Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancy

(2010) A. E. Butler et al.   DIABETOLOGIA

β-Cell Mass Dynamics and Islet Cell Plasticity in Human Type 2 Diabetes

(2010) Stephen C. Hanley et al.   ENDOCRINOLOGY

Novel GLIS3 mutations demonstrate an extended multisystem phenotype

(2010) P Dimitri et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Significant Human β-Cell Turnover Is Limited to the First Three Decades of Life as Determined byin VivoThymidine Analog Incorporation and Radiocarbon Dating

(2010) S. Perl et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Regulation of pancreatic islet gene expression in mouse islets by pregnancy

(2010) B T Layden et al.   JOURNAL OF ENDOCRINOLOGY

Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss

(2010) Fabrizio Thorel et al.   NATURE

Rfx6 directs islet formation and insulin production in mice and humans

(2010) Stuart B. Smith et al.   NATURE

Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine

(2010) Kenichiro Furuyama et al.   NATURE GENETICS

Serotonin regulates pancreatic beta cell mass during pregnancy

(2010) Hail Kim et al.   NATURE MEDICINE

Large Islets, Beta-Cell Proliferation, and a Glucokinase Mutation

(2010) Sameer Kassem et al.   NEW ENGLAND JOURNAL OF MEDICINE

Adipose Tissue Derived Stem Cells for Regeneration and Differentiation into Insulin-Producing Cells

(2010) Song Cheol Kim et al.   Current Stem Cell Research & Therapy

The Ectopic Expression of Pax4 in the Mouse Pancreas Converts Progenitor Cells into α and Subsequently β Cells

(2009) Patrick Collombat et al.   CELL

Pancreatic Exocrine Duct Cells Give Rise to Insulin-Producing β Cells during Embryogenesis but Not after Birth

(2009) Myriam Solar et al.   DEVELOPMENTAL CELL

Gestational Diabetes Mellitus Resulting From Impaired  -Cell Compensation in the Absence of FoxM1, a Novel Downstream Effector of Placental Lactogen

(2009) H. Zhang et al.   DIABETES

The long lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulation

(2009) M. Cnop et al.   DIABETOLOGIA

β-cell development and turnover during prenatal life in humans

(2009) Juris J Meier et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

C-Peptide Levels and Insulin Independence Following Autologous Nonmyeloablative Hematopoietic Stem Cell Transplantation in Newly Diagnosed Type 1 Diabetes Mellitus

(2009) Carlos E. B. Couri   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Transdifferentiation of human adipose tissue-derived stromal cells into insulin-producing clusters

(2009) Hanayuki Okura et al.   JOURNAL OF ARTIFICIAL ORGANS

Exendin-4 Promotes Liver Cell Proliferation and Enhances thePDX-1-induced Liver to Pancreas Transdifferentiation Process

(2009) Vered Aviv et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endocrine Cell Clustering During Human Pancreas Development

(2009) Jongmin Jeon et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Type 2 diabetes mellitus after gestational diabetes: a systematic review and meta-analysis

(2009) Leanne Bellamy et al.   LANCET

Glucose Effects on Beta-Cell Growth and Survival Require Activation of Insulin Receptors and Insulin Receptor Substrate 2

(2009) A. Assmann et al.   MOLECULAR AND CELLULAR BIOLOGY

The Transcriptional Response of the Islet to Pregnancy in Mice

(2009) Sebastian Rieck et al.   MOLECULAR ENDOCRINOLOGY

Generation of pluripotent stem cells from patients with type 1 diabetes

(2009) R. Maehr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

miR-375 maintains normal pancreatic  - and  -cell mass

(2009) M. N. Poy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expansion of β-cell mass in response to pregnancy

(2009) Sebastian Rieck et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Combination Therapy with Glucagon-Like Peptide-1 and Gastrin Induces β-Cell Neogenesis from Pancreatic Duct Cells in Human Islets Transplanted in Immunodeficient Diabetic Mice

(2008) Wilma L. Suarez-Pinzon et al.   CELL TRANSPLANTATION

Biphasic Ngn3 expression in the developing pancreas

(2008) Alethia Villasenor et al.   DEVELOPMENTAL DYNAMICS

Transcriptional dynamics of endodermal organ formation

(2008) Richard I. Sherwood et al.   DEVELOPMENTAL DYNAMICS

 -Cell Replication Is the Primary Mechanism Subserving the Postnatal Expansion of  -Cell Mass in Humans

(2008) J. J. Meier et al.   DIABETES

In Vitro Proliferation of Cells Derived From Adult Human  -Cells Revealed By Cell-Lineage Tracing

(2008) H. A. Russ et al.   DIABETES

Crucial role of insulin receptor substrate-2 in compensatory β-cell hyperplasia in response to high fat diet-induced insulin resistance

(2008) I. Takamoto et al.   DIABETES OBESITY & METABOLISM

Pancreatic β-cell mass in European subjects with type 2 diabetes

(2008) J. Rahier et al.   DIABETES OBESITY & METABOLISM

Transcription factor expression in the developing human fetal endocrine pancreas

(2008) B. M. Lyttle et al.   DIABETOLOGIA

Maturation of Adult β-Cells Revealed Using aPdx1/InsulinDual-Reporter Lentivirus

(2008) Marta Szabat et al.   ENDOCRINOLOGY

Prolactin Receptor Is Required for Normal Glucose Homeostasis and Modulation of β-Cell Mass during Pregnancy

(2008) Carol Huang et al.   ENDOCRINOLOGY

Increased pancreatic islet mass is accompanied by activation of the insulin receptor substrate-2/serine-threonine kinase pathway and augmented cyclin D2 protein levels in insulin-resistant rats

(2008) Alex Rafacho et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Slow and steady is the key to β-cell replication

(2008) Kristen Brennand et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

In vivo reprogramming of adult pancreatic exocrine cells to β-cells

(2008) Qiao Zhou et al.   NATURE

Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo

(2008) Evert Kroon et al.   NATURE BIOTECHNOLOGY

Placental Growth Hormone-Related Proteins and Prolactin-Related Proteins

(2007) D. Haig   PLACENTA