New insights into the architecture of the islet of Langerhans: a focused cross-species assessment

Human Islet Morphology Revisited

(2015) Susan Bonner-Weir et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Thinking bedside at the bench: the NOD mouse model of T1DM

(2015) James C. Reed et al.   Nature Reviews Endocrinology

Neural control of the endocrine pancreas

(2014) Rayner Rodriguez-Diaz et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Control of Insulin Secretion by Cholinergic Signaling in the Human Pancreatic Islet

(2014) J. Molina et al.   DIABETES

Betatrophin Versus Bitter-Trophin and the Elephant in the Room: Time for a New Normal in  -Cell Regeneration Research

(2014) A. F. Stewart   DIABETES

GABA Promotes Human  -Cell Proliferation and Modulates Glucose Homeostasis

(2014) I. Purwana et al.   DIABETES

β-Cell Failure in Type 2 Diabetes: Postulated Mechanisms and Prospects for Prevention and Treatment

(2014) Philippe A. Halban et al.   DIABETES CARE

Autocrine activation of P2Y1 receptors couples Ca2+ influx to Ca2+ release in human pancreatic beta cells

(2014) Shara Khan et al.   DIABETOLOGIA

The regulation of pre- and post-maturational plasticity of mammalian islet cell mass

(2014) Teresa Mezza et al.   DIABETOLOGIA

Association of proinflammatory cytokines and islet resident leucocytes with islet dysfunction in type 2 diabetes

(2014) Matthew J. Butcher et al.   DIABETOLOGIA

The dark side of islet vasculature

(2014) Peter In’t Veld et al.   DIABETOLOGIA

Islet Remodeling in Female Mice with Spontaneous Autoimmune and Streptozotocin-Induced Diabetes

(2014) Annette Plesner et al.   PLoS One

Young capillary vessels rejuvenate aged pancreatic islets

(2014) Joana Almaça et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resident Macrophages Mediate Islet Amyloid Polypeptide–Induced Islet IL-1β Production and β-Cell Dysfunction

(2013) Clara Y. Westwell-Roper et al.   DIABETES

Insulin Resistance Alters Islet Morphology in Nondiabetic Humans

(2013) T. Mezza et al.   DIABETES

 -Aminobutyric Acid Regulates Both the Survival and Replication of Human  -Cells

(2013) J. Tian et al.   DIABETES

Resveratrol Prevents  -Cell Dedifferentiation in Nonhuman Primates Given a High-Fat/High-Sugar Diet

(2013) J. L. Fiori et al.   DIABETES

Pancreatic Islet Vasculature Adapts to Insulin Resistance Through Dilation and Not Angiogenesis

(2013) C. Dai et al.   DIABETES

GLP-1 Effects on Islets: Hormonal, Neuronal, or Paracrine?

(2013) M. Y. Donath et al.   DIABETES CARE

Are we overestimating the loss of beta cells in type 2 diabetes?

(2013) Lorella Marselli et al.   DIABETOLOGIA

Predominance of β-Cell Neogenesis Rather Than Replication in Humans With an Impaired Glucose Tolerance and Newly Diagnosed Diabetes

(2013) S. Yoneda et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Minireview: Intraislet Regulation of Insulin Secretion in Humans

(2013) Guy A. Rutter et al.   MOLECULAR ENDOCRINOLOGY

Quantitative Analysis of Pancreatic Polypeptide Cell Distribution in the Human Pancreas

(2013) Xiaojun Wang et al.   PLoS One

Regional Differences in Islet Distribution in the Human Pancreas - Preferential Beta-Cell Loss in the Head Region in Patients with Type 2 Diabetes

(2013) Xiaojun Wang et al.   PLoS One

Reporter islets in the eye reveal the plasticity of the endocrine pancreas

(2013) E. Ilegems et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Connectivity in Islets of Langerhans from Mouse Pancreas Tissue Slices

(2013) Andraž Stožer et al.   PLoS Computational Biology

Taurine supplementation prevents morpho-physiological alterations in high-fat diet mice pancreatic β-cells

(2012) Rosane Aparecida Ribeiro et al.   AMINO ACIDS

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

Vascular Endothelial Growth Factor-Mediated Islet Hypervascularization and Inflammation Contribute to Progressive Reduction of  -Cell Mass

(2012) J. Agudo et al.   DIABETES

γ-Aminobutyric acid (GABA) signalling in human pancreatic islets is altered in type 2 diabetes

(2012) J. Taneera et al.   DIABETOLOGIA

Superior beta cell proliferation, function and gene expression in a subpopulation of rat islets identified by high blood perfusion

(2012) J. Lau et al.   DIABETOLOGIA

Impact of obesity severity and duration on pancreatic β- and α-cell dynamics in normoglycemic non-human primates

(2012) R Guardado-Mendoza et al.   INTERNATIONAL JOURNAL OF OBESITY

Formation of a Human β-Cell Population within Pancreatic Islets Is Set Early in Life

(2012) Brigid E. Gregg et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Regeneration of Pancreatic Non-β Endocrine Cells in Adult Mice following a Single Diabetes-Inducing Dose of Streptozotocin

(2012) Yanqing Zhang et al.   PLoS One

Glucagon regulates its own synthesis by autocrine signaling

(2012) B. Leibiger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Noninvasive in vivo model demonstrating the effects of autonomic innervation on pancreatic islet function

(2012) R. Rodriguez-Diaz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Islet amyloid polypeptide in pancreatic islets from type 2 diabetic subjects

(2012) Tatsuo Tomita   Islets

Quantification of islet size and architecture

(2012) German Kilimnik et al.   Islets

Non-invasive in vivo imaging of pancreatic β-cell function and survival - a perspective

(2011) I. B. Leibiger et al.   Acta Physiologica

β-Cell Loss and β-Cell Apoptosis in Human Type 2 Diabetes Are Related to Islet Amyloid Deposition

(2011) Catherine A. Jurgens et al.   AMERICAN JOURNAL OF PATHOLOGY

Bace2 Is a β Cell-Enriched Protease that Regulates Pancreatic β Cell Function and Mass

(2011) Daria Esterházy et al.   Cell Metabolism

Innervation Patterns of Autonomic Axons in the Human Endocrine Pancreas

(2011) Rayner Rodriguez-Diaz et al.   Cell Metabolism

Glucose and Inflammation Control Islet Vascular Density and β-Cell Function in NOD Mice

(2011) Eitan M. Akirav et al.   DIABETES

A Low-Oxygenated Subpopulation of Pancreatic Islets Constitutes a Functional Reserve of Endocrine Cells

(2011) R. Olsson et al.   DIABETES

Physiologic action of glucagon on liver glucose metabolism

(2011) C. J. Ramnanan et al.   DIABETES OBESITY & METABOLISM

Pancreatic alpha cell mass in European subjects with type 2 diabetes

(2011) J. C. Henquin et al.   DIABETOLOGIA

Endocrine cells and blood vessels work in tandem to generate hormone pulses

(2011) Marie Schaeffer et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Reduction of plasma membrane glutamate transport potentiates insulin but not glucagon secretion in pancreatic islet cells

(2011) Nicole Feldmann et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Alpha cells secrete acetylcholine as a non-neuronal paracrine signal priming beta cell function in humans

(2011) Rayner Rodriguez-Diaz et al.   NATURE MEDICINE

Islet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus

(2011) Per Westermark et al.   PHYSIOLOGICAL REVIEWS

High-resolution, noninvasive longitudinal live imaging of immune responses

(2011) M. H. Abdulreda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GABA exerts protective and regenerative effects on islet beta cells and reverses diabetes

(2011) N. Soltani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glucose-dependent blood flow dynamics in murine pancreatic islets in vivo

(2010) Lara R. Nyman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Somatostatin and its receptors from fish to mammals

(2010) Manuel D. Gahete et al.   Annals of the New York Academy of Sciences

 -Aminobutyric Acid (GABA) Is an Autocrine Excitatory Transmitter in Human Pancreatic  -Cells

(2010) M. Braun et al.   DIABETES

Unique Arrangement of  - and  -Cells in Human Islets of Langerhans

(2010) D. Bosco et al.   DIABETES

Glucose-responsive beta cells in islets isolated from a patient with long-standing type 1 diabetes mellitus

(2010) J. N. Walker et al.   DIABETOLOGIA

Evidence of increased islet cell proliferation in patients with recent-onset type 1 diabetes

(2010) A. Willcox et al.   DIABETOLOGIA

ATP-gated P2X3 receptors constitute a positive autocrine signal for insulin release in the human pancreatic   cell

(2010) M. C. Jacques-Silva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Paracrinology of islets and the paracrinopathy of diabetes

(2010) R. H. Unger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The insulin secretory granule as a signaling hub

(2010) Jakob Suckale et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Islet architecture: A comparative study

(2010) Abraham Kim et al.   Islets

Evolutionary origins of the purinergic signalling system

(2009) G. Burnstock et al.   Acta Physiologica

Insulin Signaling in α Cells Modulates Glucagon Secretion In Vivo

(2009) Dan Kawamori et al.   Cell Metabolism

β-cell development and turnover during prenatal life in humans

(2009) Juris J Meier et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Characterization of β-Cell Mass and Insulin Resistance in Diet-induced Obese and Diet-resistant Rats

(2009) Sarah J. Paulsen et al.   Obesity

Pancreatic islet amyloidosis,  -cell apoptosis, and  -cell proliferation are determinants of islet remodeling in type-2 diabetic baboons

(2009) R. Guardado-Mendoza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Native pancreatic α-cell adaptation in streptozotocin-induced diabetic primates: importance for pig islet xenotransplantation

(2009) Denis Dufrane et al.   XENOTRANSPLANTATION

Glutamate Is a Positive Autocrine Signal for Glucagon Release

(2008) Over Cabrera et al.   Cell Metabolism

Somatostatin Secreted by Islet  -Cells Fulfills Multiple Roles as a Paracrine Regulator of Islet Function

(2008) A. C. Hauge-Evans et al.   DIABETES

Pancreatic β-cell mass in European subjects with type 2 diabetes

(2008) J. Rahier et al.   DIABETES OBESITY & METABOLISM

Ghrelin-producing epsilon cells in the developing and adult human pancreas

(2008) K. M. Andralojc et al.   DIABETOLOGIA

Blood vessels of human islets of Langerhans are surrounded by a double basement membrane

(2008) I. Virtanen et al.   DIABETOLOGIA

Noninvasive in vivo imaging of pancreatic islet cell biology

(2008) Stephan Speier et al.   NATURE MEDICINE

GABAA receptors: Subtypes provide diversity of function and pharmacology

(2008) Richard W. Olsen et al.   NEUROPHARMACOLOGY