Novel factors modulating human β-cell proliferation

SerpinB1 Promotes Pancreatic β Cell Proliferation

(2016) Abdelfattah El Ouaamari et al.   Cell Metabolism

Reprogrammed Stomach Tissue as a Renewable Source of Functional β Cells for Blood Glucose Regulation

(2016) Chaiyaboot Ariyachet et al.   Cell Stem Cell

Inhibition of DYRK1A Stimulates Human β-Cell Proliferation

(2016) Ercument Dirice et al.   DIABETES

Inhibition of TGF-β Signaling Promotes Human Pancreatic β-Cell Replication

(2016) Sangeeta Dhawan et al.   DIABETES

Glucose Induces Mouse β-Cell Proliferation via IRS2, MTOR, and Cyclin D2 but Not the Insulin Receptor

(2016) Rachel E. Stamateris et al.   DIABETES

Evidence of β-Cell Dedifferentiation in Human Type 2 Diabetes

(2016) Francesca Cinti et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Osteoprotegerin and Denosumab Stimulate Human Beta Cell Proliferation through Inhibition of the Receptor Activator of NF-κB Ligand Pathway

(2015) Nagesha Guthalu Kondegowda et al.   Cell Metabolism

Vascularized and Complex Organ Buds from Diverse Tissues via Mesenchymal Cell-Driven Condensation

(2015) Takanori Takebe et al.   Cell Stem Cell

Augmented Stat5 Signaling Bypasses Multiple Impediments to Lactogen-Mediated Proliferation in Human β-Cells

(2015) Hainan Chen et al.   DIABETES

Human β-Cell Proliferation and Intracellular Signaling: Part 3

(2015) Andrew F. Stewart et al.   DIABETES

WS6 induces both alpha and beta cell proliferation without affecting differentiation or viability

(2015) Brian P. Boerner et al.   ENDOCRINE JOURNAL

Co-transplantation of Human Pancreatic Islets With Post-migratory Neural Crest Stem Cells Increases β-Cell Proliferation and Vascular And Neural Regrowth

(2015) Liza Grapensparr et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Compensatory Islet Response to Insulin Resistance Revealed by Quantitative Proteomics

(2015) Abdelfattah El Ouaamari et al.   JOURNAL OF PROTEOME RESEARCH

A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication

(2015) Peng Wang et al.   NATURE MEDICINE

Diabetes mellitus—advances and challenges in human β-cell proliferation

(2015) Peng Wang et al.   Nature Reviews Endocrinology

DYRK1A in neurodegeneration and cancer: Molecular basis and clinical implications

(2015) Ramzi Abbassi et al.   PHARMACOLOGY & THERAPEUTICS

Inhibition of DYRK1A and GSK3B induces human β-cell proliferation

(2015) Weijun Shen et al.   Nature Communications

The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells

(2015) Bernard Khor et al.   eLife

Harmine Lengthens Circadian Period of the Mammalian Molecular Clock in the Suprachiasmatic Nucleus

(2014) Daisuke Kondoh et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Computational & experimental evaluation of the structure/activity relationship of β-carbolines as DYRK1A inhibitors

(2014) Binia Drung et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Dyrk1A induces pancreatic β cell mass expansion and improves glucose tolerance

(2014) Latif Rachdi et al.   CELL CYCLE

Insulin Resistance Compensation: Not Just a Matter of  -Cells?

(2014) E. Montanya   DIABETES

GABA Promotes Human  -Cell Proliferation and Modulates Glucose Homeostasis

(2014) I. Purwana et al.   DIABETES

Human  -Cell Proliferation and Intracellular Signaling Part 2: Still Driving in the Dark Without a Road Map

(2014) E. Bernal-Mizrachi et al.   DIABETES

Summary of the Keystone Islet Workshop (April 2014): The Increasing Demand for Human Islet Availability in Diabetes Research

(2014) R. N. Kulkarni et al.   DIABETES

Dyrk1a haploinsufficiency induces diabetes in mice through decreased pancreatic beta cell mass

(2014) Latif Rachdi et al.   DIABETOLOGIA

Diabetes researchers fear worsening access to human islets

(2014) Shraddha Chakradhar   NATURE MEDICINE

Biology of the RANKL–RANK–OPG System in Immunity, Bone, and Beyond

(2014) Matthew C. Walsh et al.   Frontiers in Immunology

Type 2 Diabetes and Congenital Hyperinsulinism Cause DNA Double-Strand Breaks and p53 Activity in β Cells

(2013) Sharona Tornovsky-Babeay et al.   Cell Metabolism

Soluble Factors Secreted by T Cells Promote  -Cell Proliferation

(2013) E. Dirice et al.   DIABETES

Insulin Resistance Alters Islet Morphology in Nondiabetic Humans

(2013) T. Mezza et al.   DIABETES

Glucokinase Activation Ameliorates ER Stress-Induced Apoptosis in Pancreatic  -Cells

(2013) J. Shirakawa et al.   DIABETES

Systemic Regulation of the Age-Related Decline of Pancreatic β-Cell Replication

(2013) Seth J. Salpeter et al.   DIABETES

TGF-β Superfamily Member Nodal Stimulates Human β-Cell Proliferation While Maintaining Cellular Viability

(2013) Brian P. Boerner et al.   ENDOCRINOLOGY

Small-Molecule Inducer of β Cell Proliferation Identified by High-Throughput Screening

(2013) Weijun Shen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Liver-Derived Systemic Factors Drive β Cell Hyperplasia in Insulin-Resistant States

(2013) Abdelfattah El Ouaamari et al.   Cell Reports

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

Neonatal β Cell Development in Mice and Humans Is Regulated by Calcineurin/NFAT

(2012) William R. Goodyer et al.   DEVELOPMENTAL CELL

Loss of HGF/c-Met Signaling in Pancreatic β-Cells Leads to Incomplete Maternal β-Cell Adaptation and Gestational Diabetes Mellitus

(2012) Cem Demirci et al.   DIABETES

Human  -Cell Proliferation and Intracellular Signaling: Driving in the Dark Without a Road Map

(2012) R. N. Kulkarni et al.   DIABETES

Discovery of Novel Potent and Highly Selective Glycogen Synthase Kinase-3β (GSK3β) Inhibitors for Alzheimer’s Disease: Design, Synthesis, and Characterization of Pyrazines

(2012) Stefan Berg et al.   JOURNAL OF MEDICINAL CHEMISTRY

Generation of functional insulin-producing cells in the gut by Foxo1 ablation

(2012) Chutima Talchai et al.   NATURE GENETICS

Adenosine kinase inhibition selectively promotes rodent and porcine islet  -cell replication

(2012) J. P. Annes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specific Glucose-Induced Control of Insulin Receptor Substrate-2 Expression Is Mediated via Ca 2+ -Dependent Calcineurin/NFAT Signaling in Primary Pancreatic Islet β-Cells

(2011) Damien Demozay et al.   DIABETES

Synthesis and evaluation of β-carboline derivatives as potential monoamine oxidase inhibitors

(2010) J. Reniers et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Mitochondrial dysfunction and biotransformation of β-carboline alkaloids, harmine and harmaline, on isolated rat hepatocytes

(2010) Yoshio Nakagawa et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Conditional ablation of Gsk-3β in islet beta cells results in expanded mass and resistance to fat feeding-induced diabetes in mice

(2010) Y. Liu et al.   DIABETOLOGIA

Serotonin regulates pancreatic beta cell mass during pregnancy

(2010) Hail Kim et al.   NATURE MEDICINE

Large Islets, Beta-Cell Proliferation, and a Glucokinase Mutation

(2010) Sameer Kassem et al.   NEW ENGLAND JOURNAL OF MEDICINE

Gestational Diabetes Mellitus Resulting From Impaired  -Cell Compensation in the Absence of FoxM1, a Novel Downstream Effector of Placental Lactogen

(2009) H. Zhang et al.   DIABETES

The Transcriptional Response of the Islet to Pregnancy in Mice

(2009) Sebastian Rieck et al.   MOLECULAR ENDOCRINOLOGY

Identification of small-molecule inducers of pancreatic  -cell expansion

(2009) W. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expansion of β-cell mass in response to pregnancy

(2009) Sebastian Rieck et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Glycogen Synthase Kinase-3 and Mammalian Target of Rapamycin Pathways Contribute to DNA Synthesis, Cell Cycle Progression, and Proliferation in Human Islets

(2008) H. Liu et al.   DIABETES

Exendin-4 Stimulation of Cyclin A2 in  -Cell Proliferation

(2008) W.-J. Song et al.   DIABETES

Mice with beta cell overexpression of glycogen synthase kinase-3β have reduced beta cell mass and proliferation

(2008) Z. Liu et al.   DIABETOLOGIA

Genetic Deficiency of Glycogen Synthase Kinase-3β Corrects Diabetes in Mouse Models of Insulin Resistance

(2008) Katsuya Tanabe et al.   PLOS BIOLOGY