Pancreas organogenesis: From bud to plexus to gland

Genetic inducible fate mapping in larval zebrafish reveals origins of adult insulin-producing  -cells

(2011) Y. Wang et al.   DEVELOPMENT

Lineage tracing reveals the dynamic contribution of Hes1+ cells to the developing and adult pancreas

(2011) D. Kopinke et al.   DEVELOPMENT

Pancreatic β Cells Require NeuroD to Achieve and Maintain Functional Maturity

(2010) Chunyan Gu et al.   Cell Metabolism

Glucose and aging control the quiescence period that follows pancreatic beta cell replication

(2010) S. J. Salpeter et al.   DEVELOPMENT

Adult pancreatic acinar cells give rise to ducts but not endocrine cells in response to growth factor signaling

(2010) S. A. Blaine et al.   DEVELOPMENT

Epithelial dynamics of pancreatic branching morphogenesis

(2010) A. Villasenor et al.   DEVELOPMENT

Nkx6 Transcription Factors and Ptf1a Function as Antagonistic Lineage Determinants in Multipotent Pancreatic Progenitors

(2010) Ashleigh E. Schaffer et al.   DEVELOPMENTAL CELL

Hedgehog Signaling in Pancreas Epithelium Regulates Embryonic Organ Formation and Adult  -Cell Function

(2010) J. Lau et al.   DIABETES

MafA and MafB Regulate Genes Critical to  -Cells in a Unique Temporal Manner

(2010) I. Artner et al.   DIABETES

Mesenchymal Bone Morphogenetic Protein Signaling Is Required for Normal Pancreas Development

(2010) Jonas Ahnfelt-Rønne et al.   DIABETES

 -Cell Growth and Regeneration: Replication Is Only Part of the Story

(2010) S. Bonner-Weir et al.   DIABETES

Replacement of Rbpj With Rbpjl in the PTF1 Complex Controls the Final Maturation of Pancreatic Acinar Cells

(2010) Toshihiko Masui et al.   GASTROENTEROLOGY

Control of hair follicle cell fate by underlying mesenchyme through a CSL-Wnt5a-FoxN1 regulatory axis

(2010) B. Hu et al.   GENES & DEVELOPMENT

N-cadherin is dispensable for pancreas development but required for β-cell granule turnover

(2010) Jenny K. Johansson et al.   GENESIS

Derepression of Polycomb targets during pancreatic organogenesis allows insulin-producing beta-cells to adopt a neural gene activity program

(2010) J. van Arensbergen et al.   GENOME RESEARCH

In vitro expression of NGN3 identifies RAB3B as the predominant Ras-associated GTP-binding protein 3 family member in human islets

(2010) Karen Piper Hanley et al.   JOURNAL OF ENDOCRINOLOGY

Foxa1 and Foxa2 Maintain the Metabolic and Secretory Features of the Mature β-Cell

(2010) Nan Gao et al.   MOLECULAR ENDOCRINOLOGY

Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss

(2010) Fabrizio Thorel et al.   NATURE

Rfx6 directs islet formation and insulin production in mice and humans

(2010) Stuart B. Smith et al.   NATURE

Pancreatic β-Cell Neogenesis by Direct Conversion from Mature α-Cells

(2010) Cheng-Ho Chung et al.   STEM CELLS

Signaling from Axon Guidance Receptors

(2010) G. J. Bashaw et al.   Cold Spring Harbor Perspectives in Biology

Eph Receptors and Ephrin Ligands: Important Players in Angiogenesis and Tumor Angiogenesis

(2010) Birgit Mosch et al.   Journal of Oncology

On the diabetic menu: Zebrafish as a model for pancreas development and function

(2009) Mary D. Kinkel et al.   BIOESSAYS

Rac1 regulates pancreatic islet morphogenesis

(2009) Thomas U Greiner et al.   BMC DEVELOPMENTAL BIOLOGY

The Ectopic Expression of Pax4 in the Mouse Pancreas Converts Progenitor Cells into α and Subsequently β Cells

(2009) Patrick Collombat et al.   CELL

Cdc42-Mediated Tubulogenesis Controls Cell Specification

(2009) Gokul Kesavan et al.   CELL

Nanoscale engineering of biomimetic surfaces: cues from the extracellular matrix

(2009) Klaus von der Mark et al.   CELL AND TISSUE RESEARCH

Rfx6 is an Ngn3-dependent winged helix transcription factor required for pancreatic islet cell development

(2009) Josselin Soyer et al.   DEVELOPMENT

Pancreatic neurogenin 3-expressing cells are unipotent islet precursors

(2009) R. Desgraz et al.   DEVELOPMENT

Neurog3 gene dosage regulates allocation of endocrine and exocrine cell fates in the developing mouse pancreas

(2009) Sui Wang et al.   DEVELOPMENTAL BIOLOGY

Sox17 Regulates Organ Lineage Segregation of Ventral Foregut Progenitor Cells

(2009) Jason R. Spence et al.   DEVELOPMENTAL CELL

Pancreatic Exocrine Duct Cells Give Rise to Insulin-Producing β Cells during Embryogenesis but Not after Birth

(2009) Myriam Solar et al.   DEVELOPMENTAL CELL

Islet-1 is Required for the Maturation, Proliferation, and Survival of the Endocrine Pancreas

(2009) A. Du et al.   DIABETES

Dre recombinase, like Cre, is a highly efficient site-specific recombinase in E. coli, mammalian cells and mice

(2009) K. Anastassiadis et al.   Disease Models & Mechanisms

Presenilins, Notch dose control the fate of pancreatic endocrine progenitors during a narrow developmental window

(2009) C. Cras-Meneur et al.   GENES & DEVELOPMENT

Bmi-1 regulates the Ink4a/Arf locus to control pancreatic  -cell proliferation

(2009) S. Dhawan et al.   GENES & DEVELOPMENT

Dual fluorescent protein reporters for studying cell behaviors in vivo

(2009) M. David Stewart et al.   GENESIS

Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity

(2009) Dana S. Wall et al.   JOURNAL OF CELL BIOLOGY

Endocrine Cell Clustering During Human Pancreas Development

(2009) Jongmin Jeon et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Multiple, temporal-specific roles for HNF6 in pancreatic endocrine and ductal differentiation

(2009) Hongjie Zhang et al.   MECHANISMS OF DEVELOPMENT

Notch-responsive cells initiate the secondary transition in larval zebrafish pancreas

(2009) Michael J. Parsons et al.   MECHANISMS OF DEVELOPMENT

Connective Tissue Growth Factor (CTGF) Inactivation Leads to Defects in Islet Cell Lineage Allocation and β-Cell Proliferation during Embryogenesis

(2009) Laura A. Crawford et al.   MOLECULAR ENDOCRINOLOGY

Chemicals turn human embryonic stem cells towards beta cells

(2009) Yu-Ping Yang et al.   Nature Chemical Biology

Retinoic Acid Signaling Organizes Endodermal Organ Specification along the Entire Antero-Posterior Axis

(2009) Elke Bayha et al.   PLoS One

Islet Formation during the Neonatal Development in Mice

(2009) Kevin Miller et al.   PLoS One

Cyp26 enzymes function in endoderm to regulate pancreatic field size

(2009) M. D. Kinkel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function

(2009) S. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Isolation and characterization of centroacinar/terminal ductal progenitor cells in adult mouse pancreas

(2009) M. Rovira et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic Signaling Network for the Specification of Embryonic Pancreas and Liver Progenitors

(2009) E. Wandzioch et al.   SCIENCE

Guidance from above: common cues direct distinct signaling outcomes in vascular and neural patterning

(2009) Maria V. Gelfand et al.   TRENDS IN CELL BIOLOGY

β Cells Can Be Generated from Endogenous Progenitors in Injured Adult Mouse Pancreas

(2008) Xiaobo Xu et al.   CELL

Cdx4 is required in the endoderm to localize the pancreas and limit  -cell number

(2008) M. D. Kinkel et al.   DEVELOPMENT

Conditional ablation of Notch signaling in pancreatic development

(2008) H. Nakhai et al.   DEVELOPMENT

Conditional inactivation of Myc impairs development of the exocrine pancreas

(2008) H. Nakhai et al.   DEVELOPMENT

Organ-specific requirements for Hdac1 in liver and pancreas formation

(2008) Emily S. Noël et al.   DEVELOPMENTAL BIOLOGY

pdx-1 function is specifically required in embryonic β cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis

(2008) Maureen Gannon et al.   DEVELOPMENTAL BIOLOGY

Pdx-1 and Ptf1a concurrently determine fate specification of pancreatic multipotent progenitor cells

(2008) Jared S. Burlison et al.   DEVELOPMENTAL BIOLOGY

Developmental biology of the pancreas: A comprehensive review

(2008) George K. Gittes   DEVELOPMENTAL BIOLOGY

Intra-Endodermal Interactions Are Required for Pancreatic β Cell Induction

(2008) Won-Suk Chung et al.   DEVELOPMENTAL CELL

Transcriptional dynamics of endodermal organ formation

(2008) Richard I. Sherwood et al.   DEVELOPMENTAL DYNAMICS

 -Cell Proliferation, but Not Neogenesis, Following 60% Partial Pancreatectomy Is Impaired in the Absence of FoxM1

(2008) A. Ackermann Misfeldt et al.   DIABETES

Reduction of Ptf1a Gene Dosage Causes Pancreatic Hypoplasia and Diabetes in Mice

(2008) A. Fukuda et al.   DIABETES

Mist1 Regulates Pancreatic Acinar Cell Proliferation Through p21CIP1/WAF1

(2008) Di Jia et al.   GASTROENTEROLOGY

Sfrp5 coordinates foregut specification and morphogenesis by antagonizing both canonical and noncanonical Wnt11 signaling

(2008) Y. Li et al.   GENES & DEVELOPMENT

On the origin of the   cell

(2008) J. M. Oliver-Krasinski et al.   GENES & DEVELOPMENT

Graded levels of Ptf1a differentially regulate endocrine and exocrine fates in the developing pancreas

(2008) P. D. S. Dong et al.   GENES & DEVELOPMENT

Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development

(2008) N. Gao et al.   GENES & DEVELOPMENT

MafA and MafB RegulatePdx1Transcription through the Area II Control Region in Pancreatic β Cells

(2008) Amanda M. Vanhoose et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone Deacetylase Inhibitors Modify Pancreatic Cell Fate Determination and Amplify Endocrine Progenitors

(2008) C. Haumaitre et al.   MOLECULAR AND CELLULAR BIOLOGY

In vivo reprogramming of adult pancreatic exocrine cells to β-cells

(2008) Qiao Zhou et al.   NATURE

The branching programme of mouse lung development

(2008) Ross J. Metzger et al.   NATURE

Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo

(2008) Evert Kroon et al.   NATURE BIOTECHNOLOGY

Retinoic Acid Promotes the Generation of Pancreatic Endocrine Progenitor Cells and Their Further Differentiation into β-Cells

(2008) Maria Öström et al.   PLoS One

Beta Cells within Single Human Islets Originate from Multiple Progenitors

(2008) Raphaël Scharfmann et al.   PLoS One

The Gata5 target, TGIF2, defines the pancreatic region by modulating BMP signals within the endoderm

(2007) F. M. Spagnoli et al.   DEVELOPMENT