A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication

Dyrk1A induces pancreatic β cell mass expansion and improves glucose tolerance

(2014) Latif Rachdi et al.   CELL CYCLE

Human CDC2-Like Kinase 1 (CLK1): A Novel Target for Alzheimer’s Disease

(2014) Princi Jain et al.   CURRENT DRUG TARGETS

GABA Promotes Human  -Cell Proliferation and Modulates Glucose Homeostasis

(2014) I. Purwana et al.   DIABETES

Human  -Cell Proliferation and Intracellular Signaling Part 2: Still Driving in the Dark Without a Road Map

(2014) E. Bernal-Mizrachi et al.   DIABETES

Dyrk1a haploinsufficiency induces diabetes in mice through decreased pancreatic beta cell mass

(2014) Latif Rachdi et al.   DIABETOLOGIA

Menin determines K-RAS proliferative outputs in endocrine cells

(2014) Chester E. Chamberlain et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepatocyte Growth Factor/c-Met Signaling Is Required for  -Cell Regeneration

(2013) J. C. Alvarez-Perez et al.   DIABETES

Mechanism of dual specificity kinase activity of DYRK1A

(2013) Agnes Walte et al.   FEBS Journal

Cell-type, allelic, and genetic signatures in the human pancreatic beta cell transcriptome

(2013) A. C. Nica et al.   GENOME RESEARCH

Small-Molecule Inducer of β Cell Proliferation Identified by High-Throughput Screening

(2013) Weijun Shen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Neonatal β Cell Development in Mice and Humans Is Regulated by Calcineurin/NFAT

(2012) William R. Goodyer et al.   DEVELOPMENTAL CELL

ChREBP Mediates Glucose-Stimulated Pancreatic  -Cell Proliferation

(2012) M. R. Metukuri et al.   DIABETES

Human  -Cell Proliferation and Intracellular Signaling: Driving in the Dark Without a Road Map

(2012) R. N. Kulkarni et al.   DIABETES

 -Cell Mass and Turnover in Humans: Effects of obesity and aging

(2012) Y. Saisho et al.   DIABETES CARE

Formation of a Human β-Cell Population within Pancreatic Islets Is Set Early in Life

(2012) Brigid E. Gregg et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Selectivity, Cocrystal Structures, and Neuroprotective Properties of Leucettines, a Family of Protein Kinase Inhibitors Derived from the Marine Sponge Alkaloid Leucettamine B

(2012) Tania Tahtouh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Developments in harmine pharmacology — Implications for ayahuasca use and drug-dependence treatment

(2012) Daniel I. Brierley et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Specific Glucose-Induced Control of Insulin Receptor Substrate-2 Expression Is Mediated via Ca 2+ -Dependent Calcineurin/NFAT Signaling in Primary Pancreatic Islet β-Cells

(2011) Damien Demozay et al.   DIABETES

cMyc Is a Principal Upstream Driver of β-Cell Proliferation in Rat Insulinoma Cell Lines and Is an Effective Mediator of Human β-Cell Replication

(2011) Esra Karslioglu et al.   MOLECULAR ENDOCRINOLOGY

Cell cycle control of β-cell replication in the prenatal and postnatal human pancreas

(2010) Christina U. Köhler et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Induction of Human β-Cell Proliferation and Engraftment Using a Single G1/S Regulatory Molecule, cdk6

(2010) Nathalie M. Fiaschi-Taesch et al.   DIABETES

Activation, regulation, and inhibition of DYRK1A

(2010) Walter Becker et al.   FEBS Journal

Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A

(2010) Yasushi Ogawa et al.   Nature Communications

The ups and downs of Myc biology

(2009) Laura Soucek et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Survey of the Human Pancreatic  -Cell G1/S Proteome Reveals a Potential Therapeutic Role for Cdk-6 and Cyclin D1 in Enhancing Human  -Cell Replication and Function In Vivo

(2009) N. Fiaschi-Taesch et al.   DIABETES

Identification of small-molecule inducers of pancreatic  -cell expansion

(2009) W. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lessons From the First Comprehensive Molecular Characterization of Cell Cycle Control in Rodent Insulinoma Cell Lines

(2008) I. Cozar-Castellano et al.   DIABETES

Hepatocyte Growth Factor Enhances Engraftment and Function of Nonhuman Primate Islets

(2008) N. M. Fiaschi-Taesch et al.   DIABETES

 -Cell Replication Is the Primary Mechanism Subserving the Postnatal Expansion of  -Cell Mass in Humans

(2008) J. J. Meier et al.   DIABETES