Macroautophagy and Chaperone-Mediated Autophagy in Heart Failure: The Known and the Unknown

Sestrin 1 ameliorates cardiac hypertrophy via autophagy activation

(2017) Ruicong Xue et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Autophagic dysregulation in doxorubicin cardiomyopathy

(2017) Jordan J. Bartlett et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

DDiT4L promotes autophagy and inhibits pathological cardiac hypertrophy in response to stress

(2017) Bridget Simonson et al.   Science Signaling

DDiT4L promotes autophagy and inhibits pathological cardiac hypertrophy in response to stress

(2017) Bridget Simonson et al.   Science Signaling

Mir30c Is Involved in Diabetic Cardiomyopathy through Regulation of Cardiac Autophagy via BECN1

(2017) Chen Chen et al.   Molecular Therapy-Nucleic Acids

Metformin Triggers Autophagy to Attenuate Drug-Induced Apoptosis in NSCLC Cells, with Minor Effects on Tumors of Diabetic Patients

(2017) Zhiguang Xiao et al.   NEOPLASIA

UVRAG Deficiency Exacerbates Doxorubicin-Induced Cardiotoxicity

(2017) Lin An et al.   Scientific Reports

The role of autophagy in cardiac hypertrophy

(2016) Lanfang Li et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

p62 links the autophagy pathway and the ubiqutin–proteasome system upon ubiquitinated protein degradation

(2016) Wei Jing Liu et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Type-2 diabetes increases autophagy in the human heart through promotion of Beclin-1 mediated pathway

(2016) Pujika Emani Munasinghe et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Basal autophagy protects cardiomyocytes from doxorubicin-induced toxicity

(2016) Marcela Pizarro et al.   TOXICOLOGY

Astragalus polysaccharide restores autophagic flux and improves cardiomyocyte function in doxorubicin-induced cardiotoxicity

(2016) Yuan Cao et al.   Oncotarget

Autophagy protects cardiomyocytes from the myocardial ischaemia-reperfusion injury through the clearance of CLP36

(2016) Shiguo Li et al.   Open Biology

Myocardial autophagic energy stress responses—macroautophagy, mitophagy, and glycophagy

(2015) Lea M. D. Delbridge et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Autophagic adaptations in diabetic cardiomyopathy differ between type 1 and type 2 diabetes

(2015) Hiromitsu Kanamori et al.   Autophagy

SAR405, a PIK3C3/Vps34 inhibitor that prevents autophagy and synergizes with MTOR inhibition in tumor cells

(2015) Benoit Pasquier   Autophagy

Heart Disease and Stroke Statistics—2016 Update

(2015) Dariush Mozaffarian et al.   CIRCULATION

Resistance of Dynamin-related Protein 1 Oligomers to Disassembly Impairs Mitophagy, Resulting in Myocardial Inflammation and Heart Failure

(2015) Thomas J. Cahill et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacologic agents targeting autophagy

(2015) Helin Vakifahmetoglu-Norberg et al.   JOURNAL OF CLINICAL INVESTIGATION

Atg13 Is Essential for Autophagy and Cardiac Development in Mice

(2015) Takeshi Kaizuka et al.   MOLECULAR AND CELLULAR BIOLOGY

mTORC1 Phosphorylates UVRAG to Negatively Regulate Autophagosome and Endosome Maturation

(2015) Young-Mi Kim et al.   MOLECULAR CELL

Targeting mitochondria metabolism for cancer therapy

(2015) Samuel E Weinberg et al.   Nature Chemical Biology

Cardiac-specific overexpression of metallothionein attenuates myocardial remodeling and contractile dysfunction in l-NAME-induced experimental hypertension: Role of autophagy regulation

(2015) Lifang Yang et al.   TOXICOLOGY LETTERS

Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation

(2015) Tomokazu Murakawa et al.   Nature Communications

Protein misfolding and cardiac disease: Establishing cause and effect

(2014) J. Scott Pattison et al.   Autophagy

A method to measure cardiac autophagic flux in vivo

(2014) Eri Iwai-Kanai et al.   Autophagy

To be or not to be? Examples of incorrect identification of autophagic compartments in conventional transmission electron microscopy of mammalian cells

(2014) Eeva-Liisa Eskelinen   Autophagy

Exchange protein directly activated by cAMP 1 promotes autophagy during cardiomyocyte hypertrophy

(2014) Anne-Coline Laurent et al.   CARDIOVASCULAR RESEARCH

Deficient Chaperone-Mediated Autophagy in Liver Leads to Metabolic Dysregulation

(2014) Jaime L. Schneider et al.   Cell Metabolism

Danon Disease

(2014) Ryan S. D’souza et al.   Circulation-Heart Failure

Parkin‐independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brain

(2014) Yusuke Kageyama et al.   EMBO JOURNAL

Mice with cardiac-restricted overexpression of Myozap are sensitized to biomechanical stress and develop a protein-aggregate-associated cardiomyopathy

(2014) Derk Frank et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mitochondrial Dysfunctions in Neurodegenerative Diseases: Relevance to Alzheimer’s Disease

(2014) Jana Hroudová et al.   Biomed Research International

DAP-kinase and autophagy

(2013) Vered Levin-Salomon et al.   APOPTOSIS

Cardiovascular autophagy

(2013) Sergio Lavandero et al.   Autophagy

Dissecting the role of the Atg12–Atg5-Atg16 complex during autophagosome formation

(2013) Marta Walczak et al.   Autophagy

Regulation of PIK3C3/VPS34 complexes by MTOR in nutrient stress-induced autophagy

(2013) Hai-Xin Yuan et al.   Autophagy

Proteostasis and neurodegeneration: The roles of proteasomal degradation and autophagy

(2013) Keiji Tanaka et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cardiomyocyte ryanodine receptor degradation by chaperone-mediated autophagy

(2013) Zully Pedrozo et al.   CARDIOVASCULAR RESEARCH

‘Ryanopathy’: causes and manifestations of RyR2 dysfunction in heart failure

(2013) Andriy E. Belevych et al.   CARDIOVASCULAR RESEARCH

Differential Regulation of Distinct Vps34 Complexes by AMPK in Nutrient Stress and Autophagy

(2013) Joungmok Kim et al.   CELL

Chaperone-mediated autophagy: roles in disease and aging

(2013) Ana Maria Cuervo et al.   CELL RESEARCH

Two ubiquitin-like conjugation systems that mediate membrane formation during autophagy

(2013) Hitoshi Nakatogawa   Essays in Biochemistry

Diminished Autophagy Limits Cardiac Injury in Mouse Models of Type 1 Diabetes

(2013) Xianmin Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin receptor substrate signaling suppresses neonatal autophagy in the heart

(2013) Christian Riehle et al.   JOURNAL OF CLINICAL INVESTIGATION

Enhanced autophagy ameliorates cardiac proteinopathy

(2013) Md. Shenuarin Bhuiyan et al.   JOURNAL OF CLINICAL INVESTIGATION

Proteasomal and lysosomal protein degradation and heart disease

(2013) Xuejun Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The interplay between autophagy and apoptosis in the diabetic heart

(2013) Changhan Ouyang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The role of autophagy in doxorubicin-induced cardiotoxicity

(2013) Amie J. Dirks-Naylor   LIFE SCIENCES

Identification of a candidate therapeutic autophagy-inducing peptide

(2013) Sanae Shoji-Kawata et al.   NATURE

Interplay of LRRK2 with chaperone-mediated autophagy

(2013) Samantha J Orenstein et al.   NATURE NEUROSCIENCE

Proteotoxicity and Cardiac Dysfunction — Alzheimer's Disease of the Heart?

(2013) Monte S. Willis et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cytosolic p53 inhibits Parkin-mediated mitophagy and promotes mitochondrial dysfunction in the mouse heart

(2013) Atsushi Hoshino et al.   Nature Communications

Cathepsin‐L Ameliorates Cardiac Hypertrophy Through Activation of the Autophagy–Lysosomal Dependent Protein Processing Pathways

(2013) Mei Sun et al.   Journal of the American Heart Association

Mitophagy: mechanisms, pathophysiological roles, and analysis

(2012) Wen-Xing Ding et al.   BIOLOGICAL CHEMISTRY

Prior starvation mitigates acute doxorubicin cardiotoxicity through restoration of autophagy in affected cardiomyocytes

(2012) Tomonori Kawaguchi et al.   CARDIOVASCULAR RESEARCH

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Impaired Autophagosome Clearance Contributes to Cardiomyocyte Death in Ischemia/Reperfusion Injury

(2012) Xiucui Ma et al.   CIRCULATION

Danon disease caused by two novel mutations of the LAMP2 gene: implications for two ends of the clinical spectrum

(2012) Daojun Hong et al.   CLINICAL NEUROPATHOLOGY

Mitochondrial dysfunction in heart failure

(2012) Mariana G. Rosca et al.   HEART FAILURE REVIEWS

Parkin Protein Deficiency Exacerbates Cardiac Injury and Reduces Survival following Myocardial Infarction

(2012) Dieter A. Kubli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PINK1- and Parkin-mediated mitophagy at a glance

(2012) Seok Min Jin et al.   JOURNAL OF CELL SCIENCE

Chaperone-mediated autophagy: a unique way to enter the lysosome world

(2012) Susmita Kaushik et al.   TRENDS IN CELL BIOLOGY

Mitochondrial Quality Control Mediated by PINK1 and Parkin: Links to Parkinsonism

(2012) D. Narendra et al.   Cold Spring Harbor Perspectives in Biology

Characterization of macroautophagic flux in vivo using a leupeptin-based assay

(2011) Jeffrey Haspel et al.   Autophagy

The role of autophagy emerging in postinfarction cardiac remodelling

(2011) Hiromitsu Kanamori et al.   CARDIOVASCULAR RESEARCH

PKD is a kinase of Vps34 that mediates ROS-induced autophagy downstream of DAPk

(2011) A Eisenberg-Lerner et al.   CELL DEATH AND DIFFERENTIATION

The Beclin 1 network regulates autophagy and apoptosis

(2011) R Kang et al.   CELL DEATH AND DIFFERENTIATION

Microautophagy: lesser-known self-eating

(2011) Wen-wen Li et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Autophagy and p62 in Cardiac Proteinopathy

(2011) Qingwen Zheng et al.   CIRCULATION RESEARCH

Atg7 Induces Basal Autophagy and Rescues Autophagic Deficiency in CryAB R120G Cardiomyocytes

(2011) J. Scott Pattison et al.   CIRCULATION RESEARCH

Broad activation of the ubiquitin–proteasome system by Parkin is critical for mitophagy

(2011) Nickie C. Chan et al.   HUMAN MOLECULAR GENETICS

Caloric Restriction Mimetic 2-Deoxyglucose Antagonizes Doxorubicin-induced Cardiomyocyte Death by Multiple Mechanisms

(2011) Kai Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin Mediates Proteasome-dependent Protein Degradation and Rupture of the Outer Mitochondrial Membrane

(2011) Saori R. Yoshii et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STAT1 deficiency in the heart protects against myocardial infarction by enhancing autophagy

(2011) J. McCormick et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Autophagy as a therapeutic target in cardiovascular disease

(2011) Andriy Nemchenko et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Complex Inhibitory Effects of Nitric Oxide on Autophagy

(2011) Sovan Sarkar et al.   MOLECULAR CELL

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Ischemia and reperfusion—from mechanism to translation

(2011) Holger K Eltzschig et al.   NATURE MEDICINE

PTEN-inducible kinase 1 (PINK1)/Park6 is indispensable for normal heart function

(2011) F. Billia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK

(2011) L. Shang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chaperone-Mediated Autophagy Is Required for Tumor Growth

(2011) M. Kon et al.   Science Translational Medicine

A photoconvertible fluorescent reporter to track chaperone-mediated autophagy

(2011) Hiroshi Koga et al.   Nature Communications

Atg8: an autophagy-related ubiquitin-like protein family

(2011) Tomer Shpilka et al.   GENOME BIOLOGY

Current Status of Dual Renin Angiotensin Aldosterone System Blockade for the Treatment of Cardiovascular Diseases

(2010) Steven G. Chrysant   AMERICAN JOURNAL OF CARDIOLOGY

Oxidative Stress Stimulates Autophagic Flux During Ischemia/Reperfusion

(2010) Nirmala Hariharan et al.   ANTIOXIDANTS & REDOX SIGNALING

Quantitation of "autophagic flux" in mature skeletal muscle

(2010) Jeong-Sun Ju et al.   Autophagy

VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD

(2010) Emilie Tresse et al.   Autophagy

Renin-angiotensin-aldosterone system blockade for cardiovascular diseases: current status

(2010) Terry KW Ma et al.   BRITISH JOURNAL OF PHARMACOLOGY

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

Chaperone-mediated autophagy: machinery, regulation and biological consequences

(2010) Wenming Li et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Ubiquitin Proteasome Dysfunction in Human Hypertrophic and Dilated Cardiomyopathies

(2010) Jaime M. Predmore et al.   CIRCULATION

Myocardial Ischemic Preconditioning Preserves Postischemic Function of the 26S Proteasome Through Diminished Oxidative Damage to 19S Regulatory Particle Subunits

(2010) Andras Divald et al.   CIRCULATION RESEARCH

Manipulation of Death Pathways in Desmin-Related Cardiomyopathy

(2010) Alina Maloyan et al.   CIRCULATION RESEARCH

Nix Is Critical to Two Distinct Phases of Mitophagy, Reactive Oxygen Species-mediated Autophagy Induction and Parkin-Ubiquitin-p62-mediated Mitochondrial Priming

(2010) Wen-Xing Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy: assays and artifacts

(2010) Sandra Barth et al.   JOURNAL OF PATHOLOGY

Identification of Regulators of Chaperone-Mediated Autophagy

(2010) Urmi Bandyopadhyay et al.   MOLECULAR CELL

Autophagy is defective in collagen VI muscular dystrophies and its reactivation rescues myofiber degeneration

(2010) Paolo Grumati et al.   NATURE MEDICINE

Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells

(2010) D.-F. Suen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy Induced by Ischemic Preconditioning is Essential for Cardioprotection

(2010) Chengqun Huang et al.   Journal of Cardiovascular Translational Research

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities

(2009) William I. Sivitz et al.   ANTIOXIDANTS & REDOX SIGNALING

Phosphorylation of Beclin 1 by DAP-kinase promotes autophagy by weakening its interactions with Bcl-2 and Bcl-XL

(2009) Einat Zalckvar et al.   Autophagy

Nutrient-dependent regulation of autophagy through the target of rapamycin pathway: Figure 1

(2009) Yu-Yun Chang et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

IF1, the endogenous regulator of the F1Fo-ATPsynthase, defines mitochondrial volume fraction in HeLa cells by regulating autophagy

(2009) Michelangelo Campanella et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Doxorubicin Cardiomyopathy

(2009) Kanu Chatterjee et al.   CARDIOLOGY

Ischaemic preconditioning improves proteasomal activity and increases the degradation of  PKC during reperfusion

(2009) E. N. Churchill et al.   CARDIOVASCULAR RESEARCH

Atg32 Is a Mitochondrial Protein that Confers Selectivity during Mitophagy

(2009) Tomotake Kanki et al.   DEVELOPMENTAL CELL

Mitochondria-Anchored Receptor Atg32 Mediates Degradation of Mitochondria via Selective Autophagy

(2009) Koji Okamoto et al.   DEVELOPMENTAL CELL

DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy

(2009) Einat Zalckvar et al.   EMBO REPORTS

Degradation of regulator of calcineurin 1 (RCAN1) is mediated by both chaperone-mediated autophagy and ubiquitin proteasome pathways

(2009) Heng Liu et al.   FASEB JOURNAL

Glutathione Participates in the Regulation of Mitophagy in Yeast

(2009) Maika Deffieu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcription Factor GATA4 Inhibits Doxorubicin-induced Autophagy and Cardiomyocyte Death

(2009) Satoru Kobayashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy

(2009) Ian G. Ganley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mapping the Phosphorylation Sites of Ulk1

(2009) Frank C. Dorsey et al.   JOURNAL OF PROTEOME RESEARCH

ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

(2009) Chang Hwa Jung et al.   MOLECULAR BIOLOGY OF THE CELL

Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1–phosphatidylinositol-3-kinase complex

(2009) Yun Zhong et al.   NATURE CELL BIOLOGY

Dynamics and diversity in autophagy mechanisms: lessons from yeast

(2009) Hitoshi Nakatogawa et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

(2009) C. Vives-Bauza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Neuronal Survival Factor MEF2D by Chaperone-Mediated Autophagy

(2009) Q. Yang et al.   SCIENCE

Chaperone-mediated autophagy: selectivity pays off

(2009) Ana Maria Cuervo   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Principles of lysosomal membrane degradation

(2008) Heike Schulze et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Autophagy in the cardiovascular system

(2008) Guido R.Y. De Meyer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Elevated p53 expression is associated with dysregulation of the ubiquitin-proteasome system in dilated cardiomyopathy

(2008) E. J. Birks et al.   CARDIOVASCULAR RESEARCH

Autophagy in Load-Induced Heart Disease

(2008) Beverly A. Rothermel et al.   CIRCULATION RESEARCH

miR-133 and miR-30 Regulate Connective Tissue Growth Factor

(2008) Rudy F. Duisters et al.   CIRCULATION RESEARCH

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells

(2008) Taichi Hara et al.   JOURNAL OF CELL BIOLOGY

Cardioprotection by adaptation to ischaemia augments autophagy in association with BAG-1 protein

(2008) Narasimman Gurusamy et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The Chaperone-Mediated Autophagy Receptor Organizes in Dynamic Protein Complexes at the Lysosomal Membrane

(2008) U. Bandyopadhyay et al.   MOLECULAR AND CELLULAR BIOLOGY

Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking

(2008) Chengyu Liang et al.   NATURE CELL BIOLOGY

Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function

(2008) Cong Zhang et al.   NATURE MEDICINE

Autophagy is an adaptive response in desmin-related cardiomyopathy

(2008) P. Tannous et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy and aging: keeping that old broom working

(2008) Ana Maria Cuervo   TRENDS IN GENETICS