The role of autophagy in cardiac hypertrophy

Mitochondrial dynamics, mitophagy and cardiovascular disease

(2016) César Vásquez-Trincado et al.   JOURNAL OF PHYSIOLOGY-LONDON

Recent progress in research on molecular mechanisms of autophagy in the heart

(2015) Yasuhiro Maejima et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Targeted deletion of PTEN in cardiomyocytes renders cardiac contractile dysfunction through interruption of Pink1–AMPK signaling and autophagy

(2015) Nathan D. Roe et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Antioxidant catalase rescues against high fat diet-induced cardiac dysfunction via an IKKβ-AMPK-dependent regulation of autophagy

(2015) Lei Liang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Doxycycline ameliorates aggregation of collagen and atrial natriuretic peptide in murine post-infarction heart

(2015) Hongjun Zhu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

mTOR: a pharmacologic target for autophagy regulation

(2015) Young Chul Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Apoptosis, autophagy, necroptosis, and cancer metastasis

(2015) Zhenyi Su et al.   Molecular Cancer

AMPK: energy sensor and survival mechanism in the ischemic heart

(2015) Dake Qi et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Redox regulated peroxisome homeostasis

(2015) Xiaofeng Wang et al.   Redox Biology

A static pressure sensitive receptor APJ promote H9c2 cardiomyocyte hypertrophy via PI3K-autophagy pathway

(2014) Feng Xie et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Aliskiren ameliorates pressure overload-induced heart hypertrophy and fibrosis in mice

(2014) Li-qing Weng et al.   ACTA PHARMACOLOGICA SINICA

Clearance of misfolded and aggregated proteins by aggrephagy and implications for aggregation diseases

(2014) Juha M.T. Hyttinen et al.   AGEING RESEARCH REVIEWS

AMPK inhibits cardiac hypertrophy by promoting autophagy via mTORC1

(2014) Yanh Li et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

The autophagic roles of Rab small GTPases and their upstream regulators

(2014) Zsuzsanna Szatmári et al.   Autophagy

REDD1 attenuates cardiac hypertrophy via enhancing autophagy

(2014) Chen Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pharmacological regulators of autophagy and their link with modulators of lupus disease

(2014) Frédéric Gros et al.   BRITISH JOURNAL OF PHARMACOLOGY

Metabolic Control of Autophagy

(2014) Lorenzo Galluzzi et al.   CELL

MicroRNA-221 inhibits autophagy and promotes heart failure by modulating the p27/CDK2/mTOR axis

(2014) M Su et al.   CELL DEATH AND DIFFERENTIATION

Key autophagic targets and relevant small-molecule compounds in cancer therapy

(2014) X.-P Tong et al.   CELL PROLIFERATION

Adiponectin receptor 1 overexpression reduces lipid accumulation and hypertrophy in the heart of diet-induced obese mice – possible involvement of oxidative stress and autophagy

(2014) I-Pin Chou et al.   ENDOCRINE RESEARCH

Berberine improves pressure overload-induced cardiac hypertrophy and dysfunction through enhanced autophagy

(2014) Ming-Hui Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Increased autophagy reduces endoplasmic reticulum stress after neonatal hypoxia–ischemia: Role of protein synthesis and autophagic pathways

(2014) Silvia Carloni et al.   EXPERIMENTAL NEUROLOGY

Valsartan Regulates Myocardial Autophagy and Mitochondrial Turnover in Experimental Hypertension

(2014) Xin Zhang et al.   HYPERTENSION

Increased Reactive Oxygen Species, Metabolic Maladaptation, and Autophagy Contribute to Pulmonary Arterial Hypertension–Induced Ventricular Hypertrophy and Diastolic Heart Failure

(2014) Dhawjbahadur K. Rawat et al.   HYPERTENSION

Ubiquitylation by the Ltn1 E3 ligase protects 60S ribosomes from starvation-induced selective autophagy

(2014) Batool Ossareh-Nazari et al.   JOURNAL OF CELL BIOLOGY

Mechanical Stress Triggers Cardiomyocyte Autophagy through Angiotensin II Type 1 Receptor-Mediated p38MAP Kinase Independently of Angiotensin II

(2014) Li Lin et al.   PLoS One

FOXO transcription factors: key regulators of cellular quality control

(2014) Ashley E. Webb et al.   TRENDS IN BIOCHEMICAL SCIENCES

Emerging role of selective autophagy in human diseases

(2014) Kenji Mizumura et al.   Frontiers in Pharmacology

Why should autophagic flux be assessed?

(2013) Xiao-jie Zhang et al.   ACTA PHARMACOLOGICA SINICA

Chronic alcohol consumption disrupts myocardial protein balance and function in aged, but not adult, female F344 rats

(2013) Charles H. Lang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

MTOR overactivation and interrupted autophagy flux in obese hearts

(2013) Yingmei Zhang et al.   Autophagy

Cardiovascular autophagy

(2013) Sergio Lavandero et al.   Autophagy

Cold stress accentuates pressure overload-induced cardiac hypertrophy and contractile dysfunction: Role of TRPV1/AMPK-mediated autophagy

(2013) Songhe Lu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Autophagy-mediated degradation is necessary for regression of cardiac hypertrophy during ventricular unloading

(2013) Jota Oyabu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Adiponectin knockout accentuates high fat diet-induced obesity and cardiac dysfunction: Role of autophagy

(2013) Rui Guo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Cardiomyocyte ryanodine receptor degradation by chaperone-mediated autophagy

(2013) Zully Pedrozo et al.   CARDIOVASCULAR RESEARCH

Carboxyl terminus of Hsp70-interacting protein (CHIP) is required to modulate cardiac hypertrophy and attenuate autophagy during exercise

(2013) Monte S. Willis et al.   CELL BIOCHEMISTRY AND FUNCTION

Chloroquine Prevents Progression of Experimental Pulmonary Hypertension via Inhibition of Autophagy and Lysosomal Bone Morphogenetic Protein Type II Receptor Degradation

(2013) Lu Long et al.   CIRCULATION RESEARCH

Mitochondrial Contagion Induced by Parkin Deficiency in Drosophila Hearts and Its Containment by Suppressing Mitofusin

(2013) Poonam Bhandari et al.   CIRCULATION RESEARCH

Phosphoinositide 3-kinases as accelerators and brakes of autophagy

(2013) Fergal O′Farrell et al.   FEBS Journal

Macrophage Migration Inhibitory Factor Deletion Exacerbates Pressure Overload–Induced Cardiac Hypertrophy Through Mitigating Autophagy

(2013) Xihui Xu et al.   HYPERTENSION

Enhanced autophagy ameliorates cardiac proteinopathy

(2013) Md. Shenuarin Bhuiyan et al.   JOURNAL OF CLINICAL INVESTIGATION

miR-30a downregulation aggravates pressure overload-induced cardiomyocyte hypertrophy

(2013) Xuesong Yin et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Mechanism and Physiological Significance of Growth Factor-Related Autophagy

(2013) Terytty Yang Li et al.   PHYSIOLOGY

Autophagy Plays an Essential Role in Mediating Regression of Hypertrophy during Unloading of the Heart

(2013) Nirmala Hariharan et al.   PLoS One

MiR-30-Regulated Autophagy Mediates Angiotensin II-Induced Myocardial Hypertrophy

(2013) Wei Pan et al.   PLoS One

Intermedin Suppresses Pressure Overload Cardiac Hypertrophy through Activation of Autophagy

(2013) HuaLi Chen et al.   PLoS One

Myocardial Injection of Apelin-Overexpressing Bone Marrow Cells Improves Cardiac Repair via Upregulation of Sirt3 after Myocardial Infarction

(2013) Lanfang Li et al.   PLoS One

Anti-Remodeling Effects of Rapamycin in Experimental Heart Failure: Dose Response and Interaction with Angiotensin Receptor Blockade

(2013) Kalkidan Bishu et al.   PLoS One

Cathepsin‐L Ameliorates Cardiac Hypertrophy Through Activation of the Autophagy–Lysosomal Dependent Protein Processing Pathways

(2013) Mei Sun et al.   Journal of the American Heart Association

Apelin-13 increases myocardial progenitor cells and improves repair postmyocardial infarction

(2012) Lanfang Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Facilitated ethanol metabolism promotes cardiomyocyte contractile dysfunction through autophagy in murine hearts

(2012) Rui Guo et al.   Autophagy

MicroRNAs in autophagy and their emerging roles in crosstalk with apoptosis

(2012) Jianzhen Xu et al.   Autophagy

Ubiquitination and selective autophagy

(2012) S Shaid et al.   CELL DEATH AND DIFFERENTIATION

Mitochondria and Mitophagy

(2012) Dieter A. Kubli et al.   CIRCULATION RESEARCH

Striking a Balance: Autophagy, Apoptosis, and Necrosis in a Normal and Failing Heart

(2012) Wajihah Mughal et al.   CURRENT HYPERTENSION REPORTS

Cardiomyocyte autophagy: metabolic profit and loss

(2012) Zhao V. Wang et al.   HEART FAILURE REVIEWS

Autophagy: an affair of the heart

(2012) Roberta A. Gottlieb et al.   HEART FAILURE REVIEWS

Autophagy in the Heart

(2012) Erika Y. Wang et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Cardiac Autophagy

(2012) Oktay F. Rifki et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

(2012) Takafumi Oka et al.   NATURE

Involvement of Autophagy in Cardiac Remodeling in Transgenic Mice with Cardiac Specific Over-Expression of Human Programmed Cell Death 5

(2012) Lin An et al.   PLoS One

JNK modulates FOXO3a for the expression of the mitochondrial death and mitophagy marker BNIP3 in pathological hypertrophy and in heart failure

(2012) A H Chaanine et al.   Cell Death & Disease

The miRNA-212/132 family regulates both cardiac hypertrophy and cardiomyocyte autophagy

(2012) Ahmet Ucar et al.   Nature Communications

Decreased metalloprotease 9 induction, cardiac fibrosis, and higher autophagy after pressure overload in mice lacking the transcriptional regulator p8

(2011) Serban P. Georgescu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Autophagy mechanism of right ventricular remodeling in murine model of pulmonary artery constriction

(2011) Natia Qipshidze et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Microautophagy in mammalian cells: Revisiting a 40-year-old conundrum

(2011) Dalibor Mijaljica et al.   Autophagy

Chronic akt activation accentuates aging-induced cardiac hypertrophy and myocardial contractile dysfunction: role of autophagy

(2011) Yinan Hua et al.   BASIC RESEARCH IN CARDIOLOGY

SNARE Proteins Are Required for Macroautophagy

(2011) Usha Nair et al.   CELL

Autophagy in the Cellular Energetic Balance

(2011) Rajat Singh et al.   Cell Metabolism

Unmasking the janus faces of autophagy in obesity-associated insulin resistance and cardiac dysfunction

(2011) Xihui Xu et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Tuning flux: autophagy as a target of heart disease therapy

(2011) Min Xie et al.   CURRENT OPINION IN CARDIOLOGY

Autophagy as a therapeutic target in cardiovascular disease

(2011) Andriy Nemchenko et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Lysosomal positioning coordinates cellular nutrient responses

(2011) Viktor I. Korolchuk et al.   NATURE CELL BIOLOGY

Histone deacetylase (HDAC) inhibitors attenuate cardiac hypertrophy by suppressing autophagy

(2011) D. J. Cao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy During Cardiac Stress: Joys and Frustrations of Autophagy

(2010) Roberta A. Gottlieb et al.   Annual Review of Physiology

The IP3 receptor–mitochondria connection in apoptosis and autophagy

(2010) Jean-Paul Decuypere et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Impaired turnover of autophagolysosomes in cathepsin L deficiency

(2010) Julia Dennemärker et al.   BIOLOGICAL CHEMISTRY

Left ventricular hypertrophy: An overlooked cardiovascular risk factor

(2010) M. A. BAUML et al.   CLEVELAND CLINIC JOURNAL OF MEDICINE

Chaperone-mediated autophagy in protein quality control

(2010) Esperanza Arias et al.   CURRENT OPINION IN CELL BIOLOGY

Molecular mechanism and physiological role of pexophagy

(2010) Ravi Manjithaya et al.   FEBS LETTERS

The regulation of autophagy - unanswered questions

(2010) Y. Chen et al.   JOURNAL OF CELL SCIENCE

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Autophagy in mammalian development and differentiation

(2010) Noboru Mizushima et al.   NATURE CELL BIOLOGY

Eaten alive: a history of macroautophagy

(2010) Zhifen Yang et al.   NATURE CELL BIOLOGY

Autophagy, Redox Signaling, and Ventricular Remodeling

(2009) Narasimman Gurusamy et al.   ANTIOXIDANTS & REDOX SIGNALING

Autophagy is required for preconditioning by the adenosine A1 receptor-selective agonist CCPA

(2009) Smadar Yitzhaki et al.   BASIC RESEARCH IN CARDIOLOGY

Loss of cardioprotection with ageing

(2009) K. Boengler et al.   CARDIOVASCULAR RESEARCH

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Mammalian autophagy: core molecular machinery and signaling regulation

(2009) Zhifen Yang et al.   CURRENT OPINION IN CELL BIOLOGY

Mammalian Target of Rapamycin Is a Critical Regulator of Cardiac Hypertrophy in Spontaneously Hypertensive Rats

(2009) Will Soesanto et al.   HYPERTENSION

Autophagy in transition from hypertrophic cardiomyopathy to heart failure

(2009) A. Fidzianska et al.   Microscopy

Beneficial Effects of Mammalian Target of Rapamycin Inhibition on Left Ventricular Remodeling After Myocardial Infarction

(2009) Sebastian J. Buss et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Adiponectin Protects Against Angiotensin II–Induced Cardiac Fibrosis Through Activation of PPAR-α

(2008) Koichi Fujita et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Autophagy in Load-Induced Heart Disease

(2008) Beverly A. Rothermel et al.   CIRCULATION RESEARCH

Autophagy: a target for therapeutic interventions in myocardial pathophysiology

(2008) Antonis Halapas et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Histone deacetylase inhibition reduces myocardial ischemia-reperfusion injury in mice

(2008) Anne Granger et al.   FASEB JOURNAL

Apelin-induced vascular smooth muscle cell proliferation: the regulation of cyclin D1

(2008) Feng Li   Frontiers in Bioscience-Landmark

Autophagy–physiology and pathophysiology

(2008) Yasuo Uchiyama et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Cardioprotection by Ischemic Postconditioning Is Lost in Aged and STAT3-Deficient Mice

(2007) Kerstin Boengler et al.   CIRCULATION RESEARCH