DAP-kinase and autophagy

The DAPK family: a structure–function analysis

(2013) Ruth Shiloh et al.   APOPTOSIS

The DAP-kinase interactome

(2013) Shani Bialik et al.   APOPTOSIS

The ULK1 complex

(2013) Pui-Mun Wong et al.   Autophagy

Obatoclax (GX15-070) triggers necroptosis by promoting the assembly of the necrosome on autophagosomal membranes

(2013) F Basit et al.   CELL DEATH AND DIFFERENTIATION

Biology and trafficking of ATG9 and ATG16L1, two proteins that regulate autophagosome formation

(2013) Eszter Zavodszky et al.   FEBS LETTERS

Life in the balance – a mechanistic view of the crosstalk between autophagy and apoptosis

(2013) Assaf D. Rubinstein et al.   JOURNAL OF CELL SCIENCE

The role of membrane-trafficking small GTPases in the regulation of autophagy

(2013) C. F. Bento et al.   JOURNAL OF CELL SCIENCE

The ubiquitin ligase Mindbomb 1 coordinates gastrointestinal secretory cell maturation

(2013) Benjamin J. Capoccia et al.   JOURNAL OF CLINICAL INVESTIGATION

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

(2013) Ryan C. Russell et al.   NATURE CELL BIOLOGY

Amino acid signalling upstream of mTOR

(2013) Jenna L. Jewell et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1

(2013) L. Bar-Peled et al.   SCIENCE

Connections between SNAREs and autophagy

(2013) Kevin Moreau et al.   TRENDS IN BIOCHEMICAL SCIENCES

Identification of ROCK1 kinase as a critical regulator of Beclin1-mediated autophagy during metabolic stress

(2013) Aditi U. Gurkar et al.   Nature Communications

DAPK plays an important role in panobinostat-induced autophagy and commits cells to apoptosis under autophagy deficient conditions

(2012) Muktheshwar Gandesiri et al.   APOPTOSIS

Endocytosis and autophagy: Shared machinery for degradation

(2012) Christopher A. Lamb et al.   BIOESSAYS

Autophagy modulation as a potential therapeutic target for diverse diseases

(2012) David C. Rubinsztein et al.   NATURE REVIEWS DRUG DISCOVERY

Biogenesis and Cargo Selectivity of Autophagosomes

(2011) Hilla Weidberg et al.   Annual Review of Biochemistry

Induction of autophagy in hepatocellular carcinoma cells by SB203580 requires activation of AMPK and DAPK but not p38 MAPK

(2011) Haitao Zhang et al.   APOPTOSIS

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13

(2011) Junli Liu et al.   CELL

PKD is a kinase of Vps34 that mediates ROS-induced autophagy downstream of DAPk

(2011) A Eisenberg-Lerner et al.   CELL DEATH AND DIFFERENTIATION

Cell death by autophagy: facts and apparent artefacts

(2011) D Denton et al.   CELL DEATH AND DIFFERENTIATION

DAPK activates MARK1/2 to regulate microtubule assembly, neuronal differentiation and tau toxicity

(2011) P-R Wu et al.   CELL DEATH AND DIFFERENTIATION

PM02734 (Elisidepsin) Induces Caspase-Independent Cell Death Associated with Features of Autophagy, Inhibition of the Akt/mTOR Signaling Pathway, and Activation of Death-Associated Protein Kinase

(2011) Yi-He Ling et al.   CLINICAL CANCER RESEARCH

Myosin drives autophagy in a pathway linking Atg1 to Atg9

(2011) Shani Bialik et al.   EMBO JOURNAL

GTP binding to the ROC domain of DAP-kinase regulates its function through intramolecular signalling

(2011) Rodrigo Carlessi et al.   EMBO REPORTS

Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks

(2011) S. Alers et al.   MOLECULAR AND CELLULAR BIOLOGY

Death-associated protein kinase increases glycolytic rate through binding and activation of pyruvate kinase

(2011) I Mor et al.   ONCOGENE

Postfertilization Autophagy of Sperm Organelles Prevents Paternal Mitochondrial DNA Transmission

(2011) S. Al Rawi et al.   SCIENCE

DAPK1 Interaction with NMDA Receptor NR2B Subunits Mediates Brain Damage in Stroke

(2010) Weihong Tu et al.   CELL

Role of autophagy in suppression of inflammation and cancer

(2010) Eileen White et al.   CURRENT OPINION IN CELL BIOLOGY

Atg1-mediated myosin II activation regulates autophagosome formation during starvation-induced autophagy

(2010) Hong-Wen Tang et al.   EMBO JOURNAL

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

Protein Phosphatase 2A (PP2A) Holoenzymes Regulate Death-associated Protein Kinase (DAPK) in Ceramide-induced Anoikis

(2010) Ryan C. Widau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy

(2010) Sabrina Di Bartolomeo et al.   JOURNAL OF CELL BIOLOGY

Endogenous HMGB1 regulates autophagy

(2010) Daolin Tang et al.   JOURNAL OF CELL BIOLOGY

The Dependence Receptor UNC5H2/B Triggers Apoptosis via PP2A-Mediated Dephosphorylation of DAP Kinase

(2010) Céline Guenebeaud et al.   MOLECULAR CELL

Autophagy in mammalian development and differentiation

(2010) Noboru Mizushima et al.   NATURE CELL BIOLOGY

The origin of the autophagosomal membrane

(2010) Sharon A. Tooze et al.   NATURE CELL BIOLOGY

Phosphorylation of Beclin 1 by DAP-kinase promotes autophagy by weakening its interactions with Bcl-2 and Bcl-XL

(2009) Einat Zalckvar et al.   Autophagy

Autophagy Suppresses Tumorigenesis through Elimination of p62

(2009) Robin Mathew et al.   CELL

Vesicular trafficking and autophagosome formation

(2009) A Longatti et al.   CELL DEATH AND DIFFERENTIATION

Membrane trafficking events that partake in autophagy

(2009) Andrea Orsi et al.   CURRENT OPINION IN CELL BIOLOGY

Mammalian autophagy: core molecular machinery and signaling regulation

(2009) Zhifen Yang et al.   CURRENT OPINION IN CELL BIOLOGY

DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy

(2009) Einat Zalckvar et al.   EMBO REPORTS

DAP-kinase is a mediator of endoplasmic reticulum stress-induced caspase activation and autophagic cell death

(2008) D Gozuacik et al.   CELL DEATH AND DIFFERENTIATION

Peptide Combinatorial Libraries Identify TSC2 as a Death-associated Protein Kinase (DAPK) Death Domain-binding Protein and Reveal a Stimulatory Role for DAPK in mTORC1 Signaling

(2008) Craig Stevens et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DAPK-1 Binding to a Linear Peptide Motif in MAP1B Stimulates Autophagy and Membrane Blebbing

(2008) Ben Harrison et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of JNK1-dependent Bcl-2 Phosphorylation in Ceramide-induced Macroautophagy

(2008) Sophie Pattingre et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy

(2008) Yongjie Wei et al.   MOLECULAR CELL