Thioredoxin-Interacting Protein (TXNIP) in Cerebrovascular and Neurodegenerative Diseases: Regulation and Implication

Nrf2 inhibits NLRP3 inflammasome activation through regulating Trx1/TXNIP complex in cerebral ischemia reperfusion injury

(2018) Yanghao Hou et al.   BEHAVIOURAL BRAIN RESEARCH

Mangiferin suppresses endoplasmic reticulum stress in perivascular adipose tissue and prevents insulin resistance in the endothelium

(2017) Xiaoshan Xu et al.   EUROPEAN JOURNAL OF NUTRITION

Vascular endothelial cells senescence is associated with NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation via reactive oxygen species (ROS)/thioredoxin-interacting protein (TXNIP) pathway

(2017) Yanlin Yin et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Thioredoxin-Interacting Protein Mediates Apoptosis in Early Brain Injury after Subarachnoid Haemorrhage

(2017) Qing Zhao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Thioredoxin-interacting protein links endoplasmic reticulum stress to inflammatory brain injury and apoptosis after subarachnoid haemorrhage

(2017) Qing Zhao et al.   Journal of Neuroinflammation

TXNIP overexpression suppresses proliferation and induces apoptosis in SMMC7221 cells through ROS generation and MAPK pathway activation

(2017) Jian Li et al.   ONCOLOGY REPORTS

Xanthohumol ameliorates lipopolysaccharide (LPS)-induced acute lung injury via induction of AMPK/GSK3β-Nrf2 signal axis

(2017) Hongming Lv et al.   Redox Biology

Trimethylamine N-oxide induces inflammation and endothelial dysfunction in human umbilical vein endothelial cells via activating ROS-TXNIP-NLRP3 inflammasome

(2016) Xiaolei Sun et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hyperbaric Oxygen Preconditioning Attenuates Hemorrhagic Transformation Through Reactive Oxygen Species/Thioredoxin-Interacting Protein/Nod-Like Receptor Protein 3 Pathway in Hyperglycemic Middle Cerebral Artery Occlusion Rats

(2016) Zhen-Ni Guo et al.   CRITICAL CARE MEDICINE

Activation of the TXNIP/NLRP3 inflammasome pathway contributes to inflammation in diabetic retinopathy: a novel inhibitory effect of minocycline

(2016) Wei Chen et al.   INFLAMMATION RESEARCH

Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammation

(2016) Ángel Chamorro et al.   LANCET NEUROLOGY

Telmisartan ameliorates oxidative stress and subarachnoid haemorrhage-induced cerebral vasospasm

(2016) Fatih Erdi et al.   NEUROLOGICAL RESEARCH

Quercetin attenuates tau hyperphosphorylation and improves cognitive disorder via suppression of ER stress in a manner dependent on AMPK pathway

(2016) Junjun Chen et al.   Journal of Functional Foods

Alterations of the thioredoxin system during subarachnoid hemorrhage-induced cerebral vasospasm

(2015) B. Kaya et al.   ACTA NEUROCHIRURGICA

The edaravone and 3-n-butylphthalide ring-opening derivative 10b effectively attenuates cerebral ischemia injury in rats

(2015) Kai Hua et al.   ACTA PHARMACOLOGICA SINICA

The decrease in histone methyltransferase EZH2 in response to fluid shear stress alters endothelial gene expression and promotes quiescence

(2015) Monika Maleszewska et al.   ANGIOGENESIS

Redox Regulation of NLRP3 Inflammasomes: ROS as Trigger or Effector?

(2015) Justine M. Abais et al.   ANTIOXIDANTS & REDOX SIGNALING

Reactive Oxygen Species-Induced TXNIP Drives Fructose-Mediated Hepatic Inflammation and Lipid Accumulation Through NLRP3 Inflammasome Activation

(2015) Xian Zhang et al.   ANTIOXIDANTS & REDOX SIGNALING

Txnip ablation reduces vascular smooth muscle cell inflammation and ameliorates atherosclerosis in apolipoprotein E knockout mice

(2015) Chang Hyun Byon et al.   ATHEROSCLEROSIS

Salidroside ameliorates cognitive impairment in a d-galactose-induced rat model of Alzheimer’s disease

(2015) Jin Gao et al.   BEHAVIOURAL BRAIN RESEARCH

Retrospective analysis of the relationship between elevated plasma levels of TXNIP and carotid intima-media thickness in subjects with impaired glucose tolerance and early Type 2 diabetes mellitus

(2015) Yongcai Zhao et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Epigenome-wide association study identifiesTXNIPgene associated with type 2 diabetes mellitus and sustained hyperglycemia

(2015) Carolina Soriano-Tárraga et al.   HUMAN MOLECULAR GENETICS

Foam cell-derived 4-hydroxynonenal induces endothelial cell senescence in a TXNIP-dependent manner

(2015) Yael Riahi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Lentinan exerts synergistic apoptotic effects with paclitaxel in A549 cellsviaactivating ROS-TXNIP-NLRP3 inflammasome

(2015) Wei Liu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Astragaloside IV and cycloastragenol are equally effective in inhibition of endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation in the endothelium

(2015) Yan Zhao et al.   JOURNAL OF ETHNOPHARMACOLOGY

Pharmacological activation of AMPK prevents Drp1-mediated mitochondrial fission and alleviates endoplasmic reticulum stress-associated endothelial dysfunction

(2015) Jia Li et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Activation of the NLRP3 Inflammasome in Association with Calcium Oxalate Crystal Induced Reactive Oxygen Species in Kidneys

(2015) Sunil Joshi et al.   JOURNAL OF UROLOGY

Resveratrol Decreases TXNIP mRNA and Protein Nuclear Expressions With an Arterial Function Improvement in Old Mice

(2015) Tatiana Bedarida et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013

(2015) Theo Vos et al.   LANCET

Mangiferin inhibits endoplasmic reticulum stress-associated thioredoxin-interacting protein/NLRP3 inflammasome activation with regulation of AMPK in endothelial cells

(2015) Junna Song et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

New Insight Into Metformin Action: Regulation of ChREBP and FOXO1 Activities in Endothelial Cells

(2015) Xiaoyu Li et al.   MOLECULAR ENDOCRINOLOGY

Global neurotrauma research challenges and opportunities

(2015) Andrés M. Rubiano et al.   NATURE

Immune attack: the role of inflammation in Alzheimer disease

(2015) Frank L. Heppner et al.   NATURE REVIEWS NEUROSCIENCE

Umbelliferone ameliorates cerebral ischemia–reperfusion injury via upregulating the PPAR gamma expression and suppressing TXNIP/NLRP3 inflammasome

(2015) Xiangxiang Wang et al.   NEUROSCIENCE LETTERS

Interrelation of Oxidative Stress and Inflammation in Neurodegenerative Disease: Role of TNF

(2015) Roman Fischer et al.   Oxidative Medicine and Cellular Longevity

Ilexgenin A inhibits endoplasmic reticulum stress and ameliorates endothelial dysfunction via suppression of TXNIP/NLRP3 inflammasome activation in an AMPK dependent manner

(2015) Yi Li et al.   PHARMACOLOGICAL RESEARCH

Curcumin attenuates glutamate neurotoxicity in the hippocampus by suppression of ER stress-associated TXNIP/NLRP3 inflammasome activation in a manner dependent on AMPK

(2015) Ying Li et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

A New Strategy for Preventive and Functional Therapeutic Methods for Dementia—Approach Using Natural Products—

(2015) Yasushi Ohizumi   YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN

NADPH Oxidase-Induced NALP3 Inflammasome Activation Is Driven by Thioredoxin-Interacting Protein Which Contributes to Podocyte Injury in Hyperglycemia

(2015) Pan Gao et al.   Journal of Diabetes Research

The Role of Oxidative Stress in Neurodegenerative Diseases

(2015) Geon Ha Kim et al.   Experimental Neurobiology

Thioredoxin-Interacting Protein Is a Biomechanical Regulator of Src Activity

(2014) Oded N. Spindel et al.   CIRCULATION RESEARCH

Quercetin, luteolin and epigallocatechin gallate alleviate TXNIP and NLRP3-mediated inflammation and apoptosis with regulation of AMPK in endothelial cells

(2014) Jianjun Wu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

RNA and β-Hemolysin of Group BStreptococcusInduce Interleukin-1β (IL-1β) by Activating NLRP3 Inflammasomes in Mouse Macrophages

(2014) Rahul Gupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quercetin inhibits AMPK/TXNIP activation and reduces inflammatory lesions to improve insulin signaling defect in the hypothalamus of high fructose-fed rats

(2014) Qing-Yu Zhang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Thioredoxin interacting protein (TXNIP) is a novel tumor suppressor in thyroid cancer

(2014) Jennifer A Morrison et al.   Molecular Cancer

Thioredoxin-Interacting Protein: a Novel Target for Neuroprotection in Experimental Thromboembolic Stroke in Mice

(2014) Tauheed Ishrat et al.   MOLECULAR NEUROBIOLOGY

Molecular Mechanisms of Curcumin on Diabetes-Induced Endothelial Dysfunctions: Txnip, ICAM-1, and NOX2 Expressions

(2014) Natchaya Wongeakin et al.   Biomed Research International

Thioredoxin/Txnip: Redoxisome, as a Redox Switch for the Pathogenesis of Diseases

(2014) Eiji Yoshihara et al.   Frontiers in Immunology

Thioredoxin-Interacting Protein Expression Is Required for VEGF-Mediated Angiogenic Signal in Endothelial Cells

(2013) Mohammed A. Abdelsaid et al.   ANTIOXIDANTS & REDOX SIGNALING

Thioredoxin-Interacting Protein Mediates Sustained VEGFR2 Signaling in Endothelial Cells Required for Angiogenesis

(2013) Shin-Young Park et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Quercetin and allopurinol reduce liver thioredoxin-interacting protein to alleviate inflammation and lipid accumulation in diabetic rats

(2013) Wei Wang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Deletion of thioredoxin-interacting protein preserves retinal neuronal function by preventing inflammation and vascular injury

(2013) M F El-Azab et al.   BRITISH JOURNAL OF PHARMACOLOGY

Rosuvastatin Alleviates Diabetic Cardiomyopathy by Inhibiting NLRP3 Inflammasome and MAPK Pathways in a Type 2 Diabetes Rat Model

(2013) Beibei Luo et al.   CARDIOVASCULAR DRUGS AND THERAPY

A Critical Role for Thioredoxin-Interacting Protein in Diabetes-Related Impairment of Angiogenesis

(2013) L. L. Dunn et al.   DIABETES

Thioredoxin-interacting protein is required for endothelial NLRP3 inflammasome activation and cell death in a rat model of high-fat diet

(2013) Islam N. Mohamed et al.   DIABETOLOGIA

Critical role of TXNIP in oxidative stress, DNA damage and retinal pericyte apoptosis under high glucose: Implications for diabetic retinopathy

(2013) Takhellambam S. Devi et al.   EXPERIMENTAL CELL RESEARCH

The State of US Health, 1990-2010

(2013) Christopher J. L. Murray   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

FOXO1 Competes with Carbohydrate Response Element-binding Protein (ChREBP) and Inhibits Thioredoxin-interacting Protein (TXNIP) Transcription in Pancreatic Beta Cells

(2013) Carly Kibbe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMPK-Dependent Degradation of TXNIP upon Energy Stress Leads to Enhanced Glucose Uptake via GLUT1

(2013) Ning Wu et al.   MOLECULAR CELL

The current and projected economic burden of Parkinson's disease in the United States

(2013) Stacey L. Kowal et al.   MOVEMENT DISORDERS

Thioredoxin-interacting protein regulates insulin transcription through microRNA-204

(2013) Guanlan Xu et al.   NATURE MEDICINE

NLRP3 Controls Trypanosoma cruzi Infection through a Caspase-1-Dependent IL-1R-Independent NO Production

(2013) Virginia M. Gonçalves et al.   PLoS Neglected Tropical Diseases

TXNIP Deficiency Exacerbates Endotoxic Shock via the Induction of Excessive Nitric Oxide Synthesis

(2013) Young-Jun Park et al.   PLoS Pathogens

Thioredoxin-Interacting Protein Mediates Nuclear–to–Plasma Membrane Communication

(2012) Oded N. Spindel et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

TRIF Licenses Caspase-11-Dependent NLRP3 Inflammasome Activation by Gram-Negative Bacteria

(2012) Vijay A.K. Rathinam et al.   CELL

Thioredoxin-Interacting Protein Mediates ER Stress-Induced β Cell Death through Initiation of the Inflammasome

(2012) Christine M. Oslowski et al.   Cell Metabolism

IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress

(2012) Alana G. Lerner et al.   Cell Metabolism

Thioredoxin Interacting Protein Promotes Endothelial Cell Inflammation in Response to Disturbed Flow by Increasing Leukocyte Adhesion and Repressing Kruppel-Like Factor 2

(2012) Xiao-Qun Wang et al.   CIRCULATION RESEARCH

Preventing  -Cell Loss and Diabetes With Calcium Channel Blockers

(2012) G. Xu et al.   DIABETES

Involvement of thioredoxin-interacting protein (TXNIP) in glucocorticoid-mediated beta cell death

(2012) E. Reich et al.   DIABETOLOGIA

TXNIP Links Innate Host Defense Mechanisms to Oxidative Stress and Inflammation in Retinal Muller Glia under Chronic Hyperglycemia: Implications for Diabetic Retinopathy

(2012) Takhellambam S. Devi et al.   Experimental Diabetes Research

Hypoxia-inducible factors and their roles in energy metabolism

(2012) Nobuhito Goda et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Activation of the NLRP3 Inflammasome by Group B Streptococci

(2012) A. Costa et al.   JOURNAL OF IMMUNOLOGY

Roles of thioredoxin binding protein (TXNIP) in oxidative stress, apoptosis and cancer

(2012) Jianbiao Zhou et al.   MITOCHONDRION

Induction of thioredoxin-interacting protein is mediated by oxidative stress, calcium, and glucose after brain injury in mice

(2012) Gab Seok Kim et al.   NEUROBIOLOGY OF DISEASE

Amino-Functionalized Polystyrene Nanoparticles Activate the NLRP3 Inflammasome in Human Macrophages

(2011) Oleg Lunov et al.   ACS Nano

TXNIP, the major player in insulin resistance, is early over-expressed in the brain of the 5XFAD Alzheimer's mice model and is induced by Aβ in vitro: Emerging role of TXNIP and inflammation in Alzheimer's Disease progression

(2011) Tiphany Gouget et al.   Alzheimers & Dementia

Thioredoxin-Interacting Protein Mediates TRX1 Translocation to the Plasma Membrane in Response to Tumor Necrosis Factor-α

(2011) Cameron World et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The histone methyltransferase inhibitor, DZNep, up-regulates TXNIP, increases ROS production, and targets leukemia cells in AML

(2011) J. Zhou et al.   BLOOD

Thioredoxin interacting protein is a novel mediator of retinal inflammation and neurotoxicity

(2011) Mohammed MH Al-Gayyar et al.   BRITISH JOURNAL OF PHARMACOLOGY

Basic Calcium Phosphate Crystals Induce Monocyte/Macrophage IL-1  Secretion through the NLRP3 Inflammasome In Vitro

(2011) B. Pazar et al.   JOURNAL OF IMMUNOLOGY

AMP-Activated Protein Kinase (AMPK) Mediates Nutrient Regulation of Thioredoxin-Interacting Protein (TXNIP) in Pancreatic Beta-Cells

(2011) Maayan Shaked et al.   PLoS One

The Emerging Role of the Thioredoxin System in Angiogenesis

(2010) Louise L. Dunn et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Effect of endothelial cell proliferation on atherogenesis: A role of p21Sdi/Cip/Waf1 in monocyte adhesion to endothelial cells

(2010) Hiyo Obikane et al.   ATHEROSCLEROSIS

trans-Resveratrol downregulates Txnip overexpression occurring during liver ischemia-reperfusion

(2010) Valérie Nivet-Antoine et al.   BIOCHIMIE

Synaptic NMDAR activity suppresses FOXO1 expression via a cis-acting FOXO binding site: FOXO1 is a FOXO target gene

(2010) Bashayer Mubarak et al.   Channels

Respiration-dependent H2O2Removal in Brain Mitochondria via the Thioredoxin/Peroxiredoxin System

(2010) Derek A. Drechsel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of β blockers and calcium-channel blockers on within-individual variability in blood pressure and risk of stroke

(2010) Peter M Rothwell et al.   LANCET NEUROLOGY

Mitochondrial dysfunction: A potential link between neuroinflammation and neurodegeneration?

(2010) Maarten E. Witte et al.   MITOCHONDRION

High glucose condition upregulated Txnip expression level in rat mesangial cells through ROS/MEK/MAPK pathway

(2010) Shaohong Fang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Inhibition of TXNIP expression in vivo blocks early pathologies of diabetic retinopathy

(2010) L Perrone et al.   Cell Death & Disease

Diabetes induces and calcium channel blockers prevent cardiac expression of proapoptotic thioredoxin-interacting protein

(2009) Junqin Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Up-regulation of thioredoxin interacting protein (Txnip) by p38 MAPK and FOXO1 contributes to the impaired thioredoxin activity and increased ROS in glucose-treated endothelial cells

(2009) Xiaonan Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

KLF2-induced actin shear fibers control both alignment to flow and JNK signaling in vascular endothelium

(2009) R. A. Boon et al.   BLOOD

Inflammation in ischaemic brain injury: Current advances and future perspectives

(2009) Weiliang Xia et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Lack of TXNIP Protects Against Mitochondria-Mediated Apoptosis but Not Against Fatty Acid-Induced ER Stress-Mediated  -Cell Death

(2009) J. Chen et al.   DIABETES

The NLRP3 Inflammasome Mediates In Vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNA

(2009) Irving C. Allen et al.   IMMUNITY

Intracellular Shuttling and Mitochondrial Function of Thioredoxin-interacting Protein

(2009) Geetu Saxena et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thioredoxin interacting protein (TXNIP) induces inflammation through chromatin modification in retinal capillary endothelial cells under diabetic conditions

(2009) Lorena Perrone et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Expression and regulation of vitamin D3upregulated protein 1 (VDUP1) is conserved in mammalian and insect brain

(2009) Mark C. Levendusky et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Expression, Localization, and Function of the Thioredoxin System in Diabetic Nephropathy

(2009) A. Advani et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Identification of Thioredoxin-Interacting Protein 1 as a Hypoxia-Inducible Factor 1α-Induced Gene in Pancreatic Cancer

(2009) Amanda F. Baker et al.   PANCREAS

Hypoxic reprogramming

(2008) Daniel P Kelly   NATURE GENETICS

A Combination of Genomic Approaches Reveals the Role of FOXO1a in Regulating an Oxidative Stress Response Pathway

(2008) Paola de Candia et al.   PLoS One