Foam cell-derived 4-hydroxynonenal induces endothelial cell senescence in a TXNIP-dependent manner

4-Hydroxy-2-Nonenal Enhances Tissue Factor Activity in Human Monocytic Cells via p38 Mitogen-Activated Protein Kinase Activation-Dependent Phosphatidylserine Exposure

(2013) Rit Vatsyayan et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cell death and diseases related to oxidative stress:4-hydroxynonenal (HNE) in the balance

(2013) S Dalleau et al.   CELL DEATH AND DIFFERENTIATION

Signaling properties of 4-hydroxyalkenals formed by lipid peroxidation in diabetes

(2013) Guy Cohen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Reactive aldehydes – second messengers of free radicals in diabetes mellitus

(2013) M. Jaganjac et al.   FREE RADICAL RESEARCH

Physiology and Pathophysiology of Carnosine

(2013) Alexander A. Boldyrev et al.   PHYSIOLOGICAL REVIEWS

The lipid peroxidation product 4-hydroxy-2-nonenal: Advances in chemistry and analysis

(2013) Corinne M. Spickett   Redox Biology

Effects of 4-hydroxynonenal on vascular endothelial and smooth muscle cell redox signaling and function in health and disease

(2013) Sarah J. Chapple et al.   Redox Biology

The Thioredoxin System as a Therapeutic Target in Human Health and Disease

(2012) Dler Faieeq Darweesh Mahmood et al.   ANTIOXIDANTS & REDOX SIGNALING

Thioredoxin-1 Promotes Anti-Inflammatory Macrophages of the M2 Phenotype and Antagonizes Atherosclerosis

(2012) Khadija El Hadri et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Thioredoxin Interacting Protein Promotes Endothelial Cell Inflammation in Response to Disturbed Flow by Increasing Leukocyte Adhesion and Repressing Kruppel-Like Factor 2

(2012) Xiao-Qun Wang et al.   CIRCULATION RESEARCH

Azelaic acid reduced senescence-like phenotype in photo-irradiated human dermal fibroblasts: possible implication of PPARγ

(2012) Stefania Briganti et al.   EXPERIMENTAL DERMATOLOGY

Lipid Peroxidation Product 4-Hydroxy-trans-2-nonenal Causes Endothelial Activation by Inducing Endoplasmic Reticulum Stress

(2012) Elena Vladykovskaya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Lipid Peroxidation and PPAR-δ in Amplifying Glucose-Stimulated Insulin Secretion

(2011) Guy Cohen et al.   DIABETES

Hydroxyalkenals and oxidized phospholipids modulation of endothelial cytoskeleton, focal adhesion and adherens junction proteins in regulating endothelial barrier function

(2011) Peter V. Usatyuk et al.   MICROVASCULAR RESEARCH

Effects of Disturbed Flow on Vascular Endothelium: Pathophysiological Basis and Clinical Perspectives

(2011) Jeng-Jiann Chiu et al.   PHYSIOLOGICAL REVIEWS

AMP-Activated Protein Kinase (AMPK) Mediates Nutrient Regulation of Thioredoxin-Interacting Protein (TXNIP) in Pancreatic Beta-Cells

(2011) Maayan Shaked et al.   PLoS One

Lipid peroxidation of poly-unsaturated fatty acids in normal and obese adipose tissues

(2011) G. Cohen et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Signaling and cytotoxic functions of 4-hydroxyalkenals

(2010) Yael Riahi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The Emerging Role of the Thioredoxin System in Angiogenesis

(2010) Louise L. Dunn et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The Natural Protective Mechanism Against Hyperglycemia in Vascular Endothelial Cells: Roles of the Lipid Peroxidation Product 4-Hydroxydodecadienal and Peroxisome Proliferator-Activated Receptor  

(2010) Y. Riahi et al.   DIABETES

Mechanisms of Vascular Aging: New Perspectives

(2010) Z. Ungvari et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Endoplasmic reticulum stress and atherosclerosis

(2010) Gökhan S Hotamisligil   NATURE MEDICINE

Thioredoxin-1 and Endothelial Cell Aging: Role in Cardiovascular Diseases

(2009) Joachim Altschmied et al.   ANTIOXIDANTS & REDOX SIGNALING

Up-regulation of thioredoxin interacting protein (Txnip) by p38 MAPK and FOXO1 contributes to the impaired thioredoxin activity and increased ROS in glucose-treated endothelial cells

(2009) Xiaonan Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Stress-induced premature senescence of endothelial cells: a perilous state between recovery and point of no return

(2009) Michael S Goligorsky et al.   CURRENT OPINION IN HEMATOLOGY

Stereochemical Configuration of 4-Hydroxy-2-nonenal-Cysteine Adducts and Their Stereoselective Formation in a Redox-regulated Protein

(2009) Chika Wakita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of irreversibly glycated LDL in human vascular smooth muscle cells: lipid loading, oxidative and inflammatory stress

(2009) Anca V. Sima et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Vascular endothelial responses to altered shear stress: Pathologic implications for atherosclerosis

(2008) Jeng-Jiann Chiu et al.   ANNALS OF MEDICINE

Cilostazol Inhibits Oxidative Stress–Induced Premature Senescence Via Upregulation of Sirt1 in Human Endothelial Cells

(2008) Hidetaka Ota et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Endothelial dysfunction and diabetes: roles of hyperglycemia, impaired insulin signaling and obesity

(2008) Wineke Bakker et al.   CELL AND TISSUE RESEARCH

Vascular endothelial senescence: from mechanisms to pathophysiology

(2008) Jorge D. Erusalimsky   JOURNAL OF APPLIED PHYSIOLOGY

Nitric oxide and endothelial cellular senescence

(2008) Toshio Hayashi et al.   PHARMACOLOGY & THERAPEUTICS

4-Hydroxynonenal: A membrane lipid oxidation product of medicinal interest

(2007) G. Poli et al.   MEDICINAL RESEARCH REVIEWS

Identification and Characterization of a Selective Peroxisome Proliferator-Activated Receptor β/δ (NR1C2) Antagonist

(2007) Barry G. Shearer et al.   MOLECULAR ENDOCRINOLOGY