Article
Pharmacology & Pharmacy
Kancheng He, Jinhua Wang, Yihong Zhou, Zihao Huang, Nengqing Xie, Yawei Li, Huating Hu, Zhaoyin Chen, Yuanqiao He, Yuxin Tang
Summary: This study explored the pharmacological mechanism of ICA-II in bladder cancer by identifying its potential targets and signaling pathways through bioinformatics analysis and molecular docking. Experimental results demonstrated that ICA-II inhibited bladder cancer cell proliferation by blocking the cell cycle and showed therapeutic effects on bladder cancer in both cell and animal experiments.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Fei Xu, Qiaolan Wu, Lei Li, Jie Gong, Ran Huo, Wenqiang Cui
Summary: Icariside II, an active flavonoid extracted from Epimedii, possesses multiple biological and pharmacological properties, including anti-inflammatory, anticancer, and anti-osteoporotic effects. It has been shown to induce apoptosis, inhibit proliferation, cell cycle arrest, trigger autophagy, reduce cellular metabolism, and inhibit cancer metastasis and angiogenesis in various cancers. Additionally, it has a synergistic effect with chemotherapeutic drugs, although strategies to improve its therapeutic effects are being developed due to its poor solubility and permeability.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Gui Chen, Zheng Cao, Zunji Shi, Hehua Lei, Chuan Chen, Peihong Yuan, Fang Wu, Caixiang Liu, Manyuan Dong, Yuchen Song, Jinlin Zhou, Yujing Lu, Limin Zhang
Summary: Recent studies show that icariside I, a novel anticancer agent, inhibits melanoma growth by modulating gut microbiota and host immunity, improving microbiota community structure and levels of microbiota-derived metabolites, leading to immune regulation and potential development as an anticancer drug.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Food Science & Technology
Dan Yan, Qian Wu, Xiuchun Li, Qian Chen, Caihong Huang, Jiaoyue Hu, Zuguo Liu
Summary: Ischemic retinopathies (IRs) are a common vision-threatening disease. Current treatments have limitations, so alternative treatments like Icariside II (IRS) are being explored. In a retinopathy model, IRS effectively inhibited abnormal angiogenesis and retinal hemorrhage. This was potentially mediated by regulating specific proteins involved in the pathological angiogenic process.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Endocrinology & Metabolism
Ani Chi, Bicheng Yang, Xiaohui Cao, Zhenqing Wang, Hanchao Liu, Hao Dai, Chunhua Deng, Min Zhang
Summary: This study aimed to investigate the therapeutic potential of Icariside II (ICA II) on testicular torsion. The results showed that ICA II alleviated testicular damage by mitigating spermatogenic cell injury and improving testosterone production.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Food Science & Technology
Wei Jiang, Kaixi Ding, Rensong Yue, Ming Lei
Summary: Diabetes mellitus is a global health issue and Epimedium has therapeutic effects in treating it. Icariin, a major component of Epimedium, improves pancreatic function and insulin resistance, and has preventive and therapeutic effects on diabetic complications. Further research is needed despite positive preclinical evidence.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Pharmacology & Pharmacy
Jianmei Gao, Congjian Ma, Dianya Xia, Nana Chen, Jianyong Zhang, Fan Xu, Fei Li, Yuqi He, Qihai Gong
Summary: This study demonstrates that ICS II preconditioning provides neuroprotection against ischaemic stroke by enhancing Nrf2 activity, which alleviates brain injury and promotes long-term recovery.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Rodica Olar, Catalin Maxim, Mihaela Badea, Mihaela Bacalum, Mina Raileanu, Speranta Avram, Natasa Celan Korosin, Teodora Burlanescu, Arpad Mihai Rostas
Summary: The study investigated copper complexes Cu(N-N)(bzac)(X)center dot nH(2)O, and found that the complexes containing 1,10-phenanthroline exhibited anti-melanoma activity and had favorable drug-likeness and ADME properties. These complexes also showed potential as targets for antitumor molecules and could be promising for melanoma alternative treatment.
Article
Biochemistry & Molecular Biology
Ioana Stejerean-Todoran, Katharina Zimmermann, Christine S. Gibhardt, Adina Vultur, Christian Ickes, Batool Shannan, Zurine Bonilla del Rio, Anna Wolling, Sabrina Cappello, Hsu-Min Sung, Magdalena Shumanska, Xin Zhang, Maithily Nanadikar, Muhammad U. Latif, Anna Wittek, Felix Lange, Andrea Waters, Patricia Brafford, Jorg Wilting, Henning Urlaub, Dorthe M. Katschinski, Peter Rehling, Christof Lenz, Stefan Jakobs, Volker Ellenrieder, Alexander Roesch, Michael P. Schon, Meenhard Herlyn, Hedwig Stanisz, Ivan Bogeski
Summary: MCUA expression correlates with melanoma patient survival and MCUA knockdown suppresses melanoma cell growth and stimulates migration and invasion. Knockdown of MCUA reduces tumor volumes but promotes lung metastases.
Article
Cell Biology
Dongjian Han, Bo Wang, Xinyue Cui, Weiwei He, Yi Zhang, Qingjiao Jiang, Fuhang Wang, Zhiyu Liu, Deliang Shen
Summary: This study demonstrates that ICS II treatment can alleviate pressure overload-induced cardiac hypertrophy, protect heart function, reduce apoptosis and oxidative stress, as well as inhibit excessive autophagy in the heart and cardiomyocytes. Activation of the SIRT3-AMPK pathway plays a role in this protective effect.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Multidisciplinary Sciences
Wenpeng Song, Yiming Yuan, Xiaohui Tan, Yangyang Gu, Jianyu Zeng, Weidong Song, Zhongcheng Xin, Dong Fang, Ruili Guan
Summary: This study investigated the effect and mechanism of Icariside II on the rapid phosphorylation of eNOS. The results demonstrated that Icariside II can promote cell proliferation and nitric oxide release, and regulate the phosphorylation of eNOS through multiple signaling pathways.
Article
Chemistry, Multidisciplinary
Liping Su, Jinghong Xian, Shiqin Fu, Yuhan Zhu, Hongzhi Cao, Zhihui Feng, Yupeng Tian, Xiaohe Tian
Summary: This study investigated the mechanisms of two terpyridyl Zn(ii) complexes with different alkyl chain lengths in regulating ROS production, mitochondrial signaling, and ultrastructural variations. The results showed that both complexes could enter live cells and accumulate in mitochondria, and the complex with higher ROS productivity could downregulate the caspase signaling pathway.
Article
Pharmacology & Pharmacy
Yang-Yang Gu, Xiao-Hui Tan, Wen-Peng Song, Wei-Dong Song, Yi-Ming Yuan, Zhong-Cheng Xin, Jia-Dong Wang, Dong Fang, Rui-Li Guan
Summary: This study found that ICA II can alleviate PA-induced endothelial dysfunction in HUVECs through the SRPK1-Akt-eNOS signaling pathway and restore cell viability.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Lior Levy, Tzila Davidov, Krishna K. Kolluri, Avraham Fridman, Stasia Krishtul, Sam M. Janes, Marcelle Machluf
Summary: Utilizing immunotherapeutic-nano-ghosts (iNGs) for cancer cell therapy combines the advantages of mesenchymal stem cell (MSC) therapy and T cell immunotherapy, providing a powerful and effective treatment for malignant diseases.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Plant Sciences
Rui Yu, Youfeng Zhou, Shufeng Shi, Xue Wang, Shuaishuai Huang, Yu Ren
Summary: The flavonoid Icariside II (ICS II) has been found to inhibit the proliferation, migration, and invasion of renal cell carcinoma (RCC) cells. This study demonstrated that ICS II induces a form of cell death called ferroptosis in RCC cells, which is accompanied by increased levels of Fe2+, MDA, and ROS, as well as decreased levels of GSH. The underlying mechanism involves the downregulation of GPX4 and the upregulation of miR-324-3p, which directly targets GPX4.
Article
Plant Sciences
Ying-Jie Chen, Jia-Ying Wu, Yu-Yi Deng, Ying Wu, Xiao-Qi Wang, Amy Sze-man Li, Lut Yi Wong, Xiu-Qiong Fu, Zhi-Ling Yu, Chun Liang
Summary: Rg3-plus-ART overcomes sorafenib resistance by inhibiting Src/STAT3 signaling and modulating ROS/STAT3 signaling.
JOURNAL OF GINSENG RESEARCH
(2022)
Review
Cell Biology
Shan He, Jinhua Xu, Jinfeng Wu
Summary: Vitiligo is a chronic autoimmune skin disorder characterized by depigmented patches and destruction of melanocytes. Oxidative stress, as a key factor, leads to melanocyte loss by altering the redox status and impairing the defense mechanism. There is a connection between oxidative stress and autoimmunity in vitiligo, with chemokines playing a role in disease progression.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Pharmacology & Pharmacy
Yu-Xi Liu, Bo-Wen Xu, Xiao-Di Niu, Ying-Jie Chen, Xiu-Qiong Fu, Xiao-Qi Wang, Cheng-Le Yin, Ji-Yao Chou, Jun-Kui Li, Jia-Ying Wu, Jing-Xuan Bai, Ying Wu, Sze-Man Li, Zhi-Ling Yu
Summary: This study demonstrates that Dioscin exerts anti-melanoma effects by inhibiting Src/STAT3 signaling-mediated angiogenesis. Mechanistic studies revealed that Dioscin inhibits activation of Src and STAT3, and decreases secretion of pro-angiogenic cytokines from melanoma cells. This research provides a pharmacological basis for developing Dioscin as an anti-melanoma agent.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Ting Li, Xiuqiong Fu, Bin Liu, Xueyu Wang, Junkui Li, Peili Zhu, Xiaodi Niu, Jingxuan Bai, Yuxi Liu, Xinshan Lu, Zhi-Ling Yu
Summary: This study demonstrates that luteolin has both in vitro and in vivo anti-melanoma effects. It reduces melanoma cell viability, induces apoptosis, and suppresses migration and invasion. Luteolin inhibits STAT3 signaling and promotes STAT3 protein degradation, thereby regulating the expression of genes involved in cell survival and invasion. These findings provide a pharmacological basis for developing luteolin as a chemopreventive agent against melanoma.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Oncology
Yanzhao Ji, Yanting You, Yifen Wu, Min Wang, Qiuxing He, Xinghong Zhou, Liqian Chen, Xiaomin Sun, Yanyan Liu, Xiuqiong Fu, Hiu Yee Kwan, Qiang Zuo, Ren Luo, Xiaoshan Zhao
Summary: This study found that miR-328-5p promotes proliferation and migration of NSCLC cells by targeted regulation of LOXL4.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Article
Plant Sciences
Aftab Amin, Muhammad Jahangir Hossen, Xiu-Qiong Fu, Ji-Yao Chou, Jia-Ying Wu, Xiao-Qi Wang, Ying-Jie Chen, Ying Wu, Cheng-Le Yin, Xiao-Bing Dou, Chun Liang, Gui-Xin Chou, Zhi-Ling Yu
Summary: The ethanolic extract of Atractylodes macrocephala Koidz. (Asteraceae) suppresses inflammation by inhibiting the Akt/I kappa B alpha/NF-kappa B pathway. These findings provide a pharmacological basis for the clinical use of A. macrocephala rhizome in the treatment and prevention of gastritis and gastric cancer.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Liqian Chen, Xinghong Zhou, Yijian Deng, Ying Yang, Xiaohu Chen, Qinghong Chen, Yanyan Liu, Xiuqiong Fu, Hiu Yee Kwan, Yanting You, Wen Jin, Xiaoshan Zhao
Summary: This study aimed to confirm the protective effects of ZWD on cardiac hypertrophy and explore the underlying mechanisms. The results showed that ZWD reduces oxidative stress and inflammation and exerts cardioprotective effects by activating the sGC-cGMP-PKG signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Plant Sciences
Yu-Xi Liu, Ying-Jie Chen, Bo-Wen Xu, Xiu-Qiong Fu, Wen-Jun Ding, Sze-Man Amy Li, Xiao-Qi Wang, Jia-Ying Wu, Ying Wu, Xiaobing Dou, Bin Liu, Zhi-Ling Yu
Summary: This study demonstrates for the first time that chrysoeriol has anti-melanoma effects, partially through inhibiting STAT3 signaling. The results show that chrysoeriol can inhibit proliferation, migration, and survival of melanoma cells and induce apoptosis. Mouse studies also show that chrysoeriol can restrain melanoma growth, tumor-related angiogenesis, and alter the composition of immune cells in the melanoma microenvironment. These findings suggest that chrysoeriol has the potential to be developed as an anti-melanoma agent.
Article
Plant Sciences
Lingpeng Xie, Chuying Zhou, Yuting Wu, Xiuqiong Fu, Guoyong Zhang, Xin Han, Shuwen Xie, Guanghong Chen, Honglin Xu, Bo Deng, Bin Liu, Yingchun Zhou, Aimin Li
Summary: The therapeutic efficacy and potential mechanism of action of Wenqingyin (WQY) in sepsis-induced liver injury were investigated in this study. The results demonstrated that WQY attenuated sepsis-mediated liver injury by suppressing ferroptosis in hepatocytes through the activation of Nrf2.
Article
Plant Sciences
Wei Chen, Yu-Yi Deng, Jun-Wen Yu, Yuk-Tung Leung, Jing-Xuan Bai, Ying-Jie Chen, Ying Wu, Li Wang, Xiao-Yun Fan, Xiao-Qi Wang, Jinhui Hu, Wen-Hua Chen, Xiaobing Dou, Kelvin Sze-Yin Leung, Xiu-Qiong Fu, Zhi-Ling Yu
Summary: This study investigated the liver protective effects and mechanisms of action of a tri-herb formulation in mice. The results showed that the formulation protected mice from ethanol-induced liver injury by regulating the MKP1/MAPK pathway, providing pharmacological justifications for its use in treating liver injury.
Article
Medicine, Research & Experimental
Alexis Shiying Huang, Benjamin Chun -Kit Tong, Harry Chun-Hin Hung, Aston Jiaxi Wu, Olivia Ka-Yi Ho, Anna Hau-Yee Kong, Maggie Ming-Ki Leung, Jingxuan Bai, Xiuqiong Fu, Zhiling Yu, Min Li, Ting Fan Leung, Judith Choi-Wo Mak, George Pak-Heng Leung, King -Ho Cheung
Summary: Asthma is a chronic inflammatory disease characterized by airway hypersensitivity and remodeling. Houttuynia cordata, a traditional Chinese herb, may modulate intracellular Ca2+ signaling and be a potential alternative treatment choice for asthma. The upregulation of inositol trisphosphate receptors (IP3Rs) and enhanced intracellular Ca2+ release contribute to airway remodeling, while pretreatment with H. cordata essential oil rectifies Ca2+ signaling disruption and mitigates asthma development. Houttuynin/2-undecanone could be the bioactive component in H. cordata essential oil and directly inhibits IP3R expression.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Integrative & Complementary Medicine
Shakeel Ahmad Khan, Ying Wu, Amy Sze-Man Li, Xiu-Qiong Fu, Zhi-Ling Yu
Summary: This study evaluated the active compounds and molecular targets of Cnidii Fructus (CF) in treating atopic dermatitis (AD). It identified 19 active compounds in CF, predicted 532 potential targets, and collected 1540 genes related to AD. GO enrichment analysis showed that CF affects biological processes and molecular functions associated with inflammation and steroid hormone receptor activity. KEGG pathway analysis indicated that PI3K-Akt signaling, calcium signaling, Rap1 signaling, and cAMP signaling pathways are involved in the anti-AD effects of CF. Molecular docking analysis revealed the binding of key active compounds in CF with therapeutic targets.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)
Article
Integrative & Complementary Medicine
Jia-Ying Wu, Ying-Jie Chen, Xiu-Qiong Fu, Jun-Kui Li, Ji-Yao Chou, Cheng-Le Yin, Jing-Xuan Bai, Ying Wu, Xiao-Qi Wang, Amy Sze-man Li, Lut Yi Wong, Zhi-Ling Yu
Summary: The study demonstrates that chrysoeriol suppresses the hyperproliferation of RA-FLS and induces apoptosis. This is achieved by inhibiting the JAK2/STAT3 signaling pathway and downregulating the expression of Bcl-2 and Mcl-1.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)
Article
Medicine, General & Internal
Xinghong Zhou, Xiaoyu Liu, Qiuxing He, Ming Wang, Hanqi Lu, Yanting You, Liqian Chen, Jingru Cheng, Fei Li, Xiuqiong Fu, Hiu Yee Kwan, Lin Zhou, Xiaoshan Zhao
Summary: Ginger extract has a protective effect against colitis in mice exposed to antibiotics early in life, potentially modulating gut microbiota structure and composition to prevent inflammation.
FRONTIERS IN MEDICINE
(2022)
Article
Plant Sciences
Jia-Ying Wu, Jian-Hua Xie, Ying-Jie Chen, Xiu-Qiong Fu, Rui-Jun Wang, Yu-Yi Deng, Shuo Wang, Hai-Xia Yu, Chun Liang, Zhi-Ling Yu
Summary: The study investigates the anti-inflammatory effects of an ethanolic extract of Vernonia amygdalina (VA) leaves, demonstrating that the extract ameliorates TPA-induced mouse ear edema by suppressing ERK/STAT3 (Ser727) signaling and reducing inflammatory protein expression.