Review
Cell Biology
Yanguo Xin, Junli Li, Wenchao Wu, Xiaojing Liu
Summary: Cell proliferation is an essential cellular process for tissue maintenance and remodeling. Mitofusin-2 (Mfn-2) plays a crucial role in regulating cell proliferation by maintaining mitochondrial network and bioenergetics, making it a potential therapeutic target for pathological cell proliferation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Xiao-yu Wu, Wen-Wen Xu, Xiang-kun Huan, Guan-nan Wu, Gang Li, Yu-Hong Zhou, Masoud Najafi
Summary: Resistance of cancer cells to anti-tumour agents is a major challenge in cancer treatment. Metformin, an antidiabetic drug, can enhance cell death mechanisms and play a key role in inducing cell death, thereby increasing the therapeutic efficiency of anti-cancer therapy.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Cell Biology
Chen Wang, Jie Zeng, Li-Jie Li, Min Xue, Si-Li He
Summary: The study showed that Cdc25A regulates ferroptosis in cervical cancer cells by modulating the levels of PKM2 and ErbB2, affecting the response of cervical cancer cells to sorafenib treatment.
CELL DEATH & DISEASE
(2021)
Article
Genetics & Heredity
Xuming Hu, Huan Luo, Chunfeng Dou, Xujing Chen, Yi Huang, Liping Wang, Songlei Xue, Zhen Sun, Shihao Chen, Qi Xu, Tuoyu Geng, Xin Zhao, Hengmi Cui
Summary: Metformin induces apoptosis in macrophages, especially M1 macrophages, via G0S2 induction, providing a novel anti-inflammatory mechanism.
Article
Biochemistry & Molecular Biology
Suli Lv, Xuefeng Zhao, Erlei Zhang, Yingying Yan, Xianyun Ma, Neng Li, Qingli Zou, Lidong Sun, Tanjing Song
Summary: This study identifies a functional KDM1A-FKBP8-BCL2 axis in hepatocellular carcinoma (HCC), showing that KDM1A can demethylate FKBP8 to enhance the stability of BCL2, promoting HCC cell growth. The cytoplasmic localization of KDM1A is regulated by acetylation at lysine-117 by KAT8. In addition, the study reveals that KDM1A and BCL2 protein levels increase during acquired sorafenib resistance and inhibiting KDM1A can antagonize this resistance.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Marek Mentel, Miroslava Illova, Veronika Krajcovicova, Gabriela Kroupova, Zuzana Mannova, Petra Chovancikova, Peter Polcic
Summary: Permeabilization of mitochondrial membrane by BCL-2 family proteins is crucial for inducing apoptosis in mammalian cells. While yeast lacks BCL-2 family homologs, expressing these proteins in yeast affect cell survival similar to their activity in mammalian cells. Deletion of the yeast gene BXI1 suggests its involvement in modulating cell survival in response to specific forms of stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Sholpan Nurzhan, Zhibek Bekezhankyzy, Hong Ding, Nurken Berdigaliyev, Shynggys Sergazy, Alexander Gulyayev, Zarina Shulgau, Christopher R. Triggle, Mohamad Aljofan
Summary: The study reveals that the glucose-lowering drug metformin has anticancer properties, but its effectiveness and mechanism may vary depending on the glucose environment. The concentration of glucose can affect the antiproliferative potency and cellular mechanism of action of metformin.
Review
Cell Biology
Bumin Xie, Yuan Guo
Summary: Ferroptosis is a newly identified form of regulated cell death characterized by iron-dependent accumulation of lipid reactive oxygen species, closely related to various diseases and tumor treatment. Noncoding RNAs play a crucial role in regulating the molecular mechanism of ferroptosis in tumor cells.
CELL DEATH DISCOVERY
(2021)
Article
Chemistry, Medicinal
Jaemyun Kim, Seungwon Ji, Jin-Young Lee, Jean Lorquin, Barbora Orlikova-Boyer, Claudia Cerella, Aloran Mazumder, Florian Muller, Mario Dicato, Olivier Detournay, Marc Diederich
Summary: Palytoxin can induce cancer cell death at low picomolar concentrations without toxicity to normal cells. The mechanism involves downregulation of antiapoptotic proteins and upregulation of proteasomal enzymatic activity. Protein phosphatase 2A plays a critical role in the induction of apoptosis by palytoxin. Palytoxin also shows strong inhibitory effects on leukemia and tumor formation in vivo.
Article
Medicine, Research & Experimental
Jie Zhang, Junbin Zhang, Qingxia Lin, Lamei Chen, Yali Song
Summary: IL-17 interacted with the TRAF3IP2 adaptor protein to promote proliferation and inflammation, and inhibit apoptosis of HaCaT cells; Knockdown of TRAF3IP2 reduced the effects of IL-17 in HaCaT cells.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Peiyu Zhang, Martin Walko, Andrew J. Wilson
Summary: In this study, the authors demonstrate that dibromomaleimide staple scanning, using the HRK BH3 domain, can inform the design of BCL-x(L) selective peptidomimetic ligands. These HRK-inspired reagents could potentially be used as starting points for the development of therapeutics targeting BCL-x(L)-overexpressed cancers.
CHEMICAL COMMUNICATIONS
(2023)
Article
Oncology
Kirsteen J. Campbell, Hing Y. Leung
Summary: Cell death is crucial in organismal development, homeostasis, and disease response, and dysregulation can lead to disease progression; intrinsic apoptosis is defective in prostate cancer, and targeting pro-survival BCL-2 proteins with new therapeutics may improve treatment outcomes.
Article
Multidisciplinary Sciences
Hilmar Quentmeier, Robert Geffers, Vivien Hauer, Stefan Nagel, Claudia Pommerenke, Cord C. Uphoff, Margarete Zaborski, Hans G. Drexler
Summary: Overexpression of antiapoptotic BCL2 family proteins occurs in various hematologic malignancies and contributes to tumorigenesis by inhibiting the apoptotic machinery of the cells. The BH3 mimetics provide an option for medication, with venetoclax being the first drug applied for chronic lymphocytic leukemia and acute myeloid leukemia. The expression screening of cell lines using the LL-100 panel revealed that anaplastic large cell lymphoma (ALCL) and primary effusion lymphoma (PEL) showed high expression of MCL1 and low expression of BCL2. The MCL1 inhibitor AZD-5991 induced apoptosis in cell lines from both malignancies, suggesting its potential as a drug for these diseases. ALCL cell lines also expressed BCLXL and BCL2A1, contributing to cell survival. The combination of specific BH3 mimetics yielded synergistic effects, providing a novel strategy for the treatment of ALCL. The PI3K/mTOR inhibitor BEZ-235 could also be used in combination with AZD-5991, offering an alternative to avoid thrombocytopenia associated with BCLXL inhibitors.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Jia Luo, Lei Zhang, Lijuan Guo, Sen Yang
Summary: The study found that PKM2 is upregulated in OTSCC tissues and associated with higher tumor stages. Patients with high PKM2 expression had shorter overall survival and PKM2 expression was correlated with TNM staging. Additionally, PKM2 knockdown inhibited proliferation and promoted apoptosis in oral squamous carcinoma tumor cells.
Article
Cell Biology
Marika Rossini, Fernanda Martini, Elena Torreggiani, Francesca Fortini, Giorgio Aquila, Francesco Vieceli Dalla Sega, Simone Patergnani, Paolo Pinton, Pio Maniscalco, Giorgio Cavallesco, Paola Rizzo, Mauro Tognon
Summary: Malignant pleural mesothelioma is an aggressive cancer linked to asbestos exposure with poor prognosis. Dysregulation of Notch signaling may contribute to cancer progression. Metformin is an effective anti-tumor drug, showing inhibitory effects on MPM cell proliferation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)