Kurarinone promotes TRAIL-induced apoptosis by inhibiting NF-κB-dependent cFLIP expression in HeLa cells

Targeting IAP proteins for therapeutic intervention in cancer

(2012) Simone Fulda et al.   NATURE REVIEWS DRUG DISCOVERY

Attenuation of ERK/RSK2-Driven NFκB Gene Expression and Cancer Cell Proliferation by Kurarinone, a Lavandulyl Flavanone Isolated from Sophora flavescens Ait. Roots

(2012) Wim Vanden Berghe et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

Mitochondria in Apoptosis: Bcl-2 Family Members and Mitochondrial Dynamics

(2011) Jean-Claude Martinou et al.   DEVELOPMENTAL CELL

Bisphosphonate enhances TRAIL sensitivity to human osteosarcoma cellsviadeath receptor 5 upregulation

(2011) Myung-Hee Moon et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Paxilline enhances TRAIL-mediated apoptosis of glioma cellsviamodulation of c-FLIP, survivin and DR5

(2011) You Jung Kang et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Cellular FLICE-inhibitory Protein (cFLIP) Isoforms Block CD95- and TRAIL Death Receptor-induced Gene Induction Irrespective of Processing of Caspase-8 or cFLIP in the Death-inducing Signaling Complex

(2011) Shyam M. Kavuri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bortezomib Sensitizes Malignant Human Glioma Cells to TRAIL, Mediated by Inhibition of the NF- B Signaling Pathway

(2011) E. P. Jane et al.   MOLECULAR CANCER THERAPEUTICS

Sensitization of human bladder tumor cells to TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis with a small molecule IAP antagonist

(2010) Thomas S. Griffith et al.   APOPTOSIS

Lavandulyl Flavonoids from Sophora flavescens Suppress Lipopolysaccharide-Induced Activation of Nuclear Factor-κB and Mitogen-Activated Protein Kinases in RAW264.7 Cells

(2010) Jong-Min Han et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Nimbolide Sensitizes Human Colon Cancer Cells to TRAIL through Reactive Oxygen Species- and ERK-dependent Up-regulation of Death Receptors, p53, and Bax

(2010) Subash C. Gupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of NF-κB Signaling by Quinacrine Is Cytotoxic to Human Colon Carcinoma Cell Lines and Is Synergistic in Combination with Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) or Oxaliplatin

(2010) Tanvi S. Jani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Is There a Role for Nuclear Factor κB in Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Resistance?

(2009) Amandine Plantivaux et al.   Annals of the New York Academy of Sciences

Suppression of cFLIP by Lupeol, a Dietary Triterpene, Is Sufficient to Overcome Resistance to TRAIL-Mediated Apoptosis in Chemoresistant Human Pancreatic Cancer Cells

(2009) I. Murtaza et al.   CANCER RESEARCH

Withaferin A sensitizes TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of death receptor 5 and down-regulation of c-FLIP

(2009) Tae-Jin Lee et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effects of cIAP-1, cIAP-2 and XIAP triple knockdown on prostate cancer cell susceptibility to apoptosis, cell survival and proliferation

(2009) Catherine Gill et al.   Molecular Cancer

cFLIP Regulates Death Receptor-mediated Apoptosis in an Ovarian Granulosa Cell Line by Inhibiting Procaspase-8 Cleavage

(2008) Fuko MATSUDA et al.   JOURNAL OF REPRODUCTION AND DEVELOPMENT

NF-κB-dependent expression of the antiapoptotic factor c-FLIP is regulated by calpain 3, the protein involved in limb-girdle muscular dystrophy type 2A

(2007) Béatrice Benayoun et al.   FASEB JOURNAL

Apoptosis: controlled demolition at the cellular level

(2007) Rebecca C. Taylor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY