Hyperthermia restores apoptosis induced by death receptors through aggregation-induced c-FLIP cytosolic depletion

CD40 Ligand Protects from TRAIL-Induced Apoptosis in Follicular Lymphomas through NF- B Activation and Up-Regulation of c-FLIP and Bcl-xL

(2014) M. Travert et al.   JOURNAL OF IMMUNOLOGY

XIAP-targeting drugs re-sensitize PIK3CA-mutated colorectal cancer cells for death receptor-induced apoptosis

(2014) M Ehrenschwender et al.   Cell Death & Disease

Differential affinity of FLIP and procaspase 8 for FADD’s DED binding surfaces regulates DISC assembly

(2014) J. Majkut et al.   Nature Communications

Death receptors as targets in cancer

(2013) O Micheau et al.   BRITISH JOURNAL OF PHARMACOLOGY

Novel Phosphorylation and Ubiquitination Sites Regulate Reactive Oxygen Species-dependent Degradation of Anti-apoptotic c-FLIP Protein

(2013) Rachel P. Wilkie-Grantham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evidence for Two Modes of Synergistic Induction of Apoptosis by Mapatumumab and Oxaliplatin in Combination with Hyperthermia in Human Colon Cancer Cells

(2013) Xinxin Song et al.   PLoS One

Hyperthermia enhances mapatumumab-induced apoptotic death through ubiquitin-mediated degradation of cellular FLIP(long) in human colon cancer cells

(2013) X Song et al.   Cell Death & Disease

Prognostic and therapeutic relevance of FLIP and procaspase-8 overexpression in non-small cell lung cancer

(2013) J S Riley et al.   Cell Death & Disease

Hyperthermic Pelvic Perfusion With Tumor Necrosis Factor-α for Locally Advanced Cancers

(2012) Sylvie Bonvalot et al.   ANNALS OF SURGERY

Prognostic and therapeutic relevance of c-FLIP in acute myeloid leukaemia

(2012) Donal McLornan et al.   BRITISH JOURNAL OF HAEMATOLOGY

A Death Effector Domain Chain DISC Model Reveals a Crucial Role for Caspase-8 Chain Assembly in Mediating Apoptotic Cell Death

(2012) Laura S. Dickens et al.   MOLECULAR CELL

Stoichiometry of the CD95 Death-Inducing Signaling Complex: Experimental and Modeling Evidence for a Death Effector Domain Chain Model

(2012) Kolja Schleich et al.   MOLECULAR CELL

Regulation of CD95/Fas signaling at the DISC

(2011) I N Lavrik et al.   CELL DEATH AND DIFFERENTIATION

Targeting c-FLIP in cancer

(2010) Sarah Shirley et al.   CANCER LETTERS

Chemotherapy overcomes TRAIL-R4-mediated TRAIL resistance at the DISC level

(2010) A Morizot et al.   CELL DEATH AND DIFFERENTIATION

Prognostic Significance of TRAIL Signaling Molecules in Stage II and III Colorectal Cancer

(2010) D. P. McLornan et al.   CLINICAL CANCER RESEARCH

Proapoptotic DR4 and DR5 signaling in cancer cells: toward clinical translation

(2010) Annie Yang et al.   CURRENT OPINION IN CELL BIOLOGY

Hyperthermic Isolated Limb Perfusion in Locally Advanced Soft Tissue Sarcoma and Progressive Desmoid-Type Fibromatosis with TNF 1 mg and Melphalan (T1-M HILP) Is Safe and Efficient

(2009) Sylvie Bonvalot et al.   ANNALS OF SURGICAL ONCOLOGY

A Novel PTEN-Dependent Link to Ubiquitination Controls FLIPS Stability and TRAIL Sensitivity in Glioblastoma Multiforme

(2009) A. Panner et al.   CANCER RESEARCH

PKC-mediated phosphorylation regulates c-FLIP ubiquitylation and stability

(2009) A Kaunisto et al.   CELL DEATH AND DIFFERENTIATION

Predicting melting temperature directly from protein sequences

(2009) Tienhsiung Ku et al.   COMPUTATIONAL BIOLOGY AND CHEMISTRY

Resistance of Cutaneous Anaplastic Large-Cell Lymphoma Cells to Apoptosis by Death Ligands Is Enhanced by CD30-Mediated Overexpression of c-FLIP

(2009) Frank K. Braun et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A TNF- and c-Cbl-dependent FLIPS-degradation pathway and its function in Mycobacterium tuberculosis–induced macrophage apoptosis

(2009) Manikuntala Kundu et al.   NATURE IMMUNOLOGY

Mutational analyses of c-FLIPR, the only murine short FLIP isoform, reveal requirements for DISC recruitment

(2008) N Ueffing et al.   CELL DEATH AND DIFFERENTIATION

Caspases activation in hyperthermia-induced stimulation of TRAIL apoptosis

(2008) Maryline Moulin et al.   CELL STRESS & CHAPERONES