Microbioreactor Systems for Accelerated Bioprocess Development

Molecular mechanisms and in vitro antioxidant effects of Lactobacillus plantarum MA2

(2017) Wei Tang et al.   FOOD CHEMISTRY

The linkage between nutrient supply, intracellular enzyme abundances and bacterial growth: New evidences from the central carbon metabolism of Corynebacterium glutamicum

(2017) Stephan Noack et al.   JOURNAL OF BIOTECHNOLOGY

High-performance recombinant protein production with Escherichia coli in continuously operated cascades of stirred-tank reactors

(2017) Andreas Schmideder et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Integration and application of optical chemical sensors in microbioreactors

(2017) Pia Gruber et al.   LAB ON A CHIP

Erratum to: Enhanced biosurfactant production through cloning of three genes and role of esterase in biosurfactant release

(2017) Kamaljeet Kaur Sekhon et al.   Microbial Cell Factories

Optimizing recombinant protein expression via automated induction profiling in microtiter plates at different temperatures

(2017) Martina Mühlmann et al.   Microbial Cell Factories

CASCADE, a platform for controlled gene amplification for high, tunable and selection-free gene expression in yeast

(2017) Tomas Strucko et al.   Scientific Reports

Leaf LIMS: A Flexible Laboratory Information Management System with a Synthetic Biology Focus

(2017) Thomas Craig et al.   ACS Synthetic Biology

The Experiment Data Depot: A Web-Based Software Tool for Biological Experimental Data Storage, Sharing, and Visualization

(2017) William C. Morrell et al.   ACS Synthetic Biology

Prediction of Escherichia coli expression performance in microtiter plates by analyzing only the temporal development of scattered light during culture

(2017) Tobias Ladner et al.   Journal of Biological Engineering

Cellulolytic RoboLector – towards an automated high-throughput screening platform for recombinant cellulase expression

(2017) Martina Mühlmann et al.   Journal of Biological Engineering

Bioprocess microfluidics: applying microfluidic devices for bioprocessing

(2017) Marco PC Marques et al.   Current Opinion in Chemical Engineering

Rational modular design of metabolic network for efficient production of plant polyphenol pinosylvin

(2017) Junjun Wu et al.   Scientific Reports

High-throughput strategies for the discovery and engineering of enzymes for biocatalysis

(2016) Philippe Jacques et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

An improvement of surfactin production by B. subtilis BBG131 using design of experiments in microbioreactors and continuous process in bubbleless membrane bioreactor

(2016) Luiz Fernando Motta Dos Santos et al.   BIORESOURCE TECHNOLOGY

Online optimal experimental re-design in robotic parallel fed-batch cultivation facilities

(2016) M.N. Cruz Bournazou et al.   BIOTECHNOLOGY AND BIOENGINEERING

Fully automatized high-throughput enzyme library screening using a robotic platform

(2016) Mark Dörr et al.   BIOTECHNOLOGY AND BIOENGINEERING

Mixing at the microscale: Power input in shaken microtiter plates

(2016) Astrid Dürauer et al.   Biotechnology Journal

Lessons learned in building high-throughput process development capabilities

(2016) Jennifer Pollard et al.   ENGINEERING IN LIFE SCIENCES

Framework for Kriging-based iterative experimental analysis and design: Optimization of secretory protein production inCorynebacterium glutamicum

(2016) Lars Freier et al.   ENGINEERING IN LIFE SCIENCES

Fast-track development of a lactase production process with Kluyveromyces lactis by a progressive parameter-control workflow

(2016) Wenzel Wellenbeck et al.   ENGINEERING IN LIFE SCIENCES

Downstream process development strategies for effective bioprocesses: Trends, progress, and combinatorial approaches

(2016) Pascal Baumann et al.   ENGINEERING IN LIFE SCIENCES

Design of experiments-based high-throughput strategy for development and optimization of efficient cell disruption protocols

(2016) Florian Glauche et al.   ENGINEERING IN LIFE SCIENCES

Quasi-continuous parallel online scattered light, fluorescence and dissolved oxygen tension measurement combined with monitoring of the oxygen transfer rate in each well of a shaken microtiter plate

(2016) Tobias Ladner et al.   Microbial Cell Factories

Use of a Sec signal peptide library from Bacillus subtilis for the optimization of cutinase secretion in Corynebacterium glutamicum

(2016) Johannes Hemmerich et al.   Microbial Cell Factories

High-cell-density cultivation and recombinant protein production with Komagataella pastoris in stirred-tank bioreactors from milliliter to cubic meter scale

(2016) Andreas Schmideder et al.   PROCESS BIOCHEMISTRY

When Wavelengths Collide: Bias in Cell Abundance Measurements Due to Expressed Fluorescent Proteins

(2016) Ariel Hecht et al.   ACS Synthetic Biology

Corynebacterium glutamicum Metabolic Engineering with CRISPR Interference (CRISPRi)

(2016) Sara Cleto et al.   ACS Synthetic Biology

Mixing at the microscale: Power input in shaken microtiter plates

(2016) Astrid Dürauer et al.   Biotechnology Journal

Respiration activity monitoring system for any individual well of a 48-well microtiter plate

(2016) David Flitsch et al.   Journal of Biological Engineering

High-throughput micro-scale cultivations and chromatography modeling: Powerful tools for integrated process development

(2015) Pascal Baumann et al.   BIOTECHNOLOGY AND BIOENGINEERING

How to measure metabolic fluxes: a taxonomic guide for 13 C fluxomics

(2015) Sebastian Niedenführ et al.   CURRENT OPINION IN BIOTECHNOLOGY

Determination of protein phase diagrams by microbatch experiments: Exploring the influence of precipitants and pH

(2015) Kai Baumgartner et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Integrated development of up- and downstream processes supported by the Cherry-Tag™ for real-time tracking of stability and solubility of proteins

(2015) Pascal Baumann et al.   JOURNAL OF BIOTECHNOLOGY

A novel milliliter-scale chemostat system for parallel cultivation of microorganisms in stirred-tank bioreactors

(2015) Andreas Schmideder et al.   JOURNAL OF BIOTECHNOLOGY

Biorefineries for the production of top building block chemicals and their derivatives

(2015) Sol Choi et al.   METABOLIC ENGINEERING

Transient overexpression of DNA adenine methylase enables efficient and mobile genome engineering with reduced off-target effects

(2015) Rebecca M. Lennen et al.   NUCLEIC ACIDS RESEARCH

Seven gene deletions in seven days: Fast generation of Escherichia coli strains tolerant to acetate and osmotic stress

(2015) Sheila I. Jensen et al.   Scientific Reports

High-throughput preparation methods of crude extract for robust cell-free protein synthesis

(2015) Yong-Chan Kwon et al.   Scientific Reports

Parallel use of shake flask and microtiter plate online measuring devices (RAMOS and BioLector) reduces the number of experiments in laboratory-scale stirred tank bioreactors

(2015) S. J. Wewetzer et al.   Journal of Biological Engineering

A CRISPR-Cas9 System for Genetic Engineering of Filamentous Fungi

(2015) Christina S. Nødvig et al.   PLoS One

Rapid assessment of oxygen transfer impact for Corynebacterium glutamicum

(2014) Friedrich Käß et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Feeding strategies enhance high cell density cultivation and protein expression in milliliter scale bioreactors

(2014) Georg Faust et al.   Biotechnology Journal

Chassis organism fromCorynebacterium glutamicum- a top-down approach to identify and delete irrelevant gene clusters

(2014) Simon Unthan et al.   Biotechnology Journal

High-throughput miniaturized bioreactors for cell culture process development: Reproducibility, scalability, and control

(2014) Shahid Rameez et al.   BIOTECHNOLOGY PROGRESS

Single-cell microfluidics: opportunity for bioprocess development

(2014) Alexander Grünberger et al.   CURRENT OPINION IN BIOTECHNOLOGY

Looking for the pick of the bunch: high-throughput screening of producing microorganisms with biosensors

(2014) Marcus Schallmey et al.   CURRENT OPINION IN BIOTECHNOLOGY

The fraction of cells that resume growth after acetic acid addition is a strain-dependent parameter of acetic acid tolerance inSaccharomyces cerevisiae

(2014) Steve Swinnen et al.   FEMS YEAST RESEARCH

The development and application of high throughput cultivation technology in bioprocess development

(2014) Quan Long et al.   JOURNAL OF BIOTECHNOLOGY

A novel platform for automated high-throughput fluxome profiling of metabolic variants

(2014) Stéphanie Heux et al.   METABOLIC ENGINEERING

Pitfalls in optical on-line monitoring for high-throughput screening of microbial systems

(2014) Martin Kunze et al.   Microbial Cell Factories

Comprehensive clone screening and evaluation of fed-batch strategies in a microbioreactor and lab scale stirred tank bioreactor system: application on Pichia pastoris producing Rhizopus oryzae lipase

(2014) Johannes Hemmerich et al.   Microbial Cell Factories

Application of a Genetically Encoded Biosensor for Live Cell Imaging of L-Valine Production in Pyruvate Dehydrogenase Complex-Deficient Corynebacterium glutamicum Strains

(2014) Nurije Mustafi et al.   PLoS One

Quantitative metabolomics: a phantom?

(2014) Stephan Noack et al.   TRENDS IN BIOTECHNOLOGY

A Computational Method for Automated Characterization of Genetic Components

(2014) Boyan Yordanov et al.   ACS Synthetic Biology

Cross-section perimeter is a suitable parameter to describe the effects of different baffle geometries in shaken microtiter plates

(2014) Clemens Lattermann et al.   Journal of Biological Engineering

Impact of aeration strategies on fed-batch cell culture kinetics in a single-use 24-well miniature bioreactor

(2013) J.P.J. Betts et al.   BIOCHEMICAL ENGINEERING JOURNAL

Re-evaluation of glycerol utilization in Saccharomyces cerevisiae: characterization of an isolate that grows on glycerol without supporting supplements

(2013) Steve Swinnen et al.   Biotechnology for Biofuels

Consistent development of bioprocesses from microliter cultures to the industrial scale

(2013) Peter Neubauer et al.   ENGINEERING IN LIFE SCIENCES

A chemostat array enables the spatio-temporal analysis of the yeast proteome

(2013) N. Denervaud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microbials for the production of monoclonal antibodies and antibody fragments

(2013) Oliver Spadiut et al.   TRENDS IN BIOTECHNOLOGY

Using Synthetic Biological Parts and Microbioreactors to Explore the Protein Expression Characteristics of Escherichia coli

(2013) Thomas E. Gorochowski et al.   ACS Synthetic Biology

Characterization of stirrers for screening studies of enzymatic biomass hydrolyses on a milliliter scale

(2012) Peter Riedlberger et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Oxygen transfer characteristics of miniaturized bioreactor systems

(2012) Timothy V. Kirk et al.   BIOTECHNOLOGY AND BIOENGINEERING

Monitoring and control of microbioreactors: An expert opinion on development needs

(2012) Krist V. Gernaey et al.   Biotechnology Journal

Fed-batch CHO cell t-PA production and feed glutamine replacement to reduce ammonia production

(2012) Do Yun Kim et al.   BIOTECHNOLOGY PROGRESS

Advanced microscale bioreactor system: a representative scale-down model for bench-top bioreactors

(2012) Wei-Ting Hsu et al.   CYTOTECHNOLOGY

A novel automated bioreactor for scalable process optimisation of haematopoietic stem cell culture

(2012) E. Ratcliffe et al.   JOURNAL OF BIOTECHNOLOGY

Metabolic responses to recombinant bioprocesses in Escherichia coli

(2012) Sónia Carneiro et al.   JOURNAL OF BIOTECHNOLOGY

Growth independent rhamnolipid production from glucose using the non-pathogenic Pseudomonas putida KT2440

(2012) Andreas Wittgens et al.   Microbial Cell Factories

Systems metabolic engineering, industrial biotechnology and microbial cell factories

(2012) Sang-Yup Lee et al.   Microbial Cell Factories

An automated workflow for enhancing microbial bioprocess optimization on a novel microbioreactor platform

(2012) Peter Rohe et al.   Microbial Cell Factories

A high-throughput approach to identify genomic variants of bacterial metabolite producers at the single-cell level

(2012) Stephan Binder et al.   GENOME BIOLOGY

TECHNOLOGY PROSPECTING ON ENZYMES: APPLICATION, MARKETING AND ENGINEERING

(2012) Shuang Li et al.   Computational and Structural Biotechnology Journal

Perspective on opportunities in industrial biotechnology in renewable chemicals

(2011) Brent Erickson et al.   Biotechnology Journal

A new microfluidic concept for parallel operated milliliter-scale stirred tank bioreactors

(2011) Gabi Gebhardt et al.   BIOTECHNOLOGY PROGRESS

Rapid throughput analysis of filamentous fungal growth using turbidimetric measurements with the Bioscreen C: a tool for screening antifungal compounds

(2011) Angel Medina et al.   Fungal Biology

Improved antimicrobial efficacy with nitric oxide releasing nanoparticle generated S-nitrosoglutathione

(2011) Adam J. Friedman et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Microfluidic biolector-microfluidic bioprocess control in microtiter plates

(2010) Matthias Funke et al.   BIOTECHNOLOGY AND BIOENGINEERING

A review of advanced small-scale parallel bioreactor technology for accelerated process development: Current state and future need

(2010) Rachel Bareither et al.   BIOTECHNOLOGY PROGRESS

Scale-down simulators for metabolic analysis of large-scale bioprocesses

(2010) Peter Neubauer et al.   CURRENT OPINION IN BIOTECHNOLOGY

Bioprocess scale-up: quest for the parameters to be used as criterion to move from microreactors to lab-scale

(2010) Marco P. C. Marques et al.   JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

Bioprocess Control in Microscale: Scalable Fermentations in Disposable and User-Friendly Microfluidic Systems

(2010) Matthias Funke et al.   Microbial Cell Factories

Novel approach of high cell density recombinant bioprocess development: Optimisation and scale-up from microlitre to pilot scales while maintaining the fed-batch cultivation mode of E. coli cultures

(2010) Juozas Šiurkus et al.   Microbial Cell Factories

The baffled microtiter plate: Increased oxygen transfer and improved online monitoring in small scale fermentations

(2009) Matthias Funke et al.   BIOTECHNOLOGY AND BIOENGINEERING

Review: Microscale methods for high-throughput chromatography development in the pharmaceutical industry

(2009) Sunil Chhatre et al.   JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

Robo-Lector – a novel platform for automated high-throughput cultivations in microtiter plates with high information content

(2009) Robert Huber et al.   Microbial Cell Factories

Scale-up from microtiter plate to laboratory fermenter: evaluation by online monitoring techniques of growth and protein expression in Escherichia coli and Hansenula polymorpha fermentations

(2009) Frank Kensy et al.   Microbial Cell Factories

High throughput, non-invasive and dynamic toxicity screening on adherent cells using respiratory measurements

(2009) Simone Beckers et al.   TOXICOLOGY IN VITRO

Twenty-four well plate miniature bioreactor system as a scale-down model for cell culture process development

(2008) Aaron Chen et al.   BIOTECHNOLOGY AND BIOENGINEERING

Bioprocess optimization using design-of-experiments methodology

(2008) Carl-Fredrik Mandenius et al.   BIOTECHNOLOGY PROGRESS

Time-series measurements of oxygen consumption of copepod nauplii

(2008) M Köster et al.   MARINE ECOLOGY PROGRESS SERIES

Scale-up ofEscherichia coli growth and recombinant protein expression conditions from microwell to laboratory and pilot scale based on matchedkLa

(2007) R.S. Islam et al.   BIOTECHNOLOGY AND BIOENGINEERING