Online optimal experimental re-design in robotic parallel fed-batch cultivation facilities

Online bioprocess data generation, analysis, and optimization for parallel fed-batch fermentations in milliliter scale

(2016) David Benjamin Nickel et al.   ENGINEERING IN LIFE SCIENCES

Design of experiments-based high-throughput strategy for development and optimization of efficient cell disruption protocols

(2016) Florian Glauche et al.   ENGINEERING IN LIFE SCIENCES

Nonlinear ill-posed problem analysis in model-based parameter estimation and experimental design

(2015) Diana C. López C. et al.   COMPUTERS & CHEMICAL ENGINEERING

Heading in the right direction: thermodynamics-based network analysis and pathway engineering

(2015) Meric Ataman et al.   CURRENT OPINION IN BIOTECHNOLOGY

Quantitative high-throughput screening data analysis: challenges and recent advances

(2015) Keith R. Shockley   DRUG DISCOVERY TODAY

Limits to the reliability of size-based fishing status estimation for data-poor stocks

(2015) Alexandros Kokkalis et al.   FISHERIES RESEARCH

An approach to mechanistic event recognition applied on monitoring organic matter depletion in SBRs

(2014) Mariano N. Cruz Bournazou et al.   AICHE JOURNAL

Sliding-Window Optimal Experimental Re-Design in Parallel Microbioreactors

(2014) M. N. Cruz Bournazou et al.   CHEMIE INGENIEUR TECHNIK

Mixed integer optimal control of an intermittently aerated sequencing batch reactor for wastewater treatment

(2014) Juan Antonio Delgado San Martín et al.   COMPUTERS & CHEMICAL ENGINEERING

The development and application of high throughput cultivation technology in bioprocess development

(2014) Quan Long et al.   JOURNAL OF BIOTECHNOLOGY

Model-based identifiable parameter determination applied to a simultaneous saccharification and fermentation process model for bio-ethanol production

(2013) Diana C. López C. et al.   BIOTECHNOLOGY PROGRESS

Consistent development of bioprocesses from microliter cultures to the industrial scale

(2013) Peter Neubauer et al.   ENGINEERING IN LIFE SCIENCES

Model based optimization of the intermittent aeration profile for SBRs under partial nitrification

(2013) M.N. Cruz Bournazou et al.   WATER RESEARCH

Experimental evaluation of an approach to online redesign of experiments for parameter determination

(2012) Tilman Barz et al.   AICHE JOURNAL

Automated dynamic fed-batch process and media optimization for high productivity cell culture process development

(2012) Franklin Lu et al.   BIOTECHNOLOGY AND BIOENGINEERING

ASM3 extended for two-step nitrification-denitrification: a model reduction for sequencing batch reactors

(2012) M. N. Cruz Bournazou et al.   JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

Computational tools for the synthetic design of biochemical pathways

(2012) Marnix H. Medema et al.   NATURE REVIEWS MICROBIOLOGY

Integrating computational methods to retrofit enzymes to synthetic pathways

(2011) Elizabeth Brunk et al.   BIOTECHNOLOGY AND BIOENGINEERING

Modeling and design of optimal flow perfusion bioreactors for tissue engineering applications

(2011) L. Araida Hidalgo-Bastida et al.   BIOTECHNOLOGY AND BIOENGINEERING

Online model-based redesign of experiments with erratic models: A disturbance estimation approach

(2011) Federico Galvanin et al.   COMPUTERS & CHEMICAL ENGINEERING

Constrained receding-horizon experiment design and parameter estimation in the presence of poor initial conditions

(2010) Yijia Zhu et al.   AICHE JOURNAL

An optimal experimental design approach to model discrimination in dynamic biochemical systems

(2010) Dominik Skanda et al.   BIOINFORMATICS

Systems biology approach reveals that overflow metabolism of acetate in Escherichia coli is triggered by carbon catabolite repression of acetyl-CoA synthetase

(2010) Kaspar Valgepea et al.   BMC Systems Biology

Scale-down simulators for metabolic analysis of large-scale bioprocesses

(2010) Peter Neubauer et al.   CURRENT OPINION IN BIOTECHNOLOGY

Optimal design of clinical tests for the identification of physiological models of type 1 diabetes in the presence of model mismatch

(2010) Federico Galvanin et al.   MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING

Application of microbioreactors in fermentation process development: a review

(2009) Daniel Schäpper et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

A predictive high-throughput scale-down model of monoclonal antibody production in CHO cells

(2009) Rachel Legmann et al.   BIOTECHNOLOGY AND BIOENGINEERING

Systems biology: experimental design

(2009) Clemens Kreutz et al.   FEBS Journal

Mechanistic kinetic model for symmetric carboligations using benzaldehyde lyase

(2008) Michael Zavrel et al.   BIOTECHNOLOGY AND BIOENGINEERING

Model-based design of experiments for parameter precision: State of the art

(2007) Gaia Franceschini et al.   CHEMICAL ENGINEERING SCIENCE