γ-Secretase modulators reduce endogenous amyloid β42 levels in human neural progenitor cells without altering neuronal differentiation

Notch Signaling Regulates Motor Neuron Differentiation of Human Embryonic Stem Cells

(2015) Etti Ben-Shushan et al.   STEM CELLS

Soluble γ-Secretase Modulators Selectively Inhibit the Production of the 42-Amino Acid Amyloid β Peptide Variant and Augment the Production of Multiple Carboxy-Truncated Amyloid β Species

(2014) Steven L. Wagner et al.   BIOCHEMISTRY

Safety profile of semagacestat, a gamma-secretase inhibitor: IDENTITY trial findings

(2014) David B. Henley et al.   CURRENT MEDICAL RESEARCH AND OPINION

A three-dimensional human neural cell culture model of Alzheimer’s disease

(2014) Se Hoon Choi et al.   NATURE

2013 Alzheimer's disease facts and figures

(2013)   Alzheimers & Dementia

Has inhibition of Aβ production adequately been tested as therapeutic approach in mild AD? A model-based meta-analysis of γ-secretase inhibitor data

(2013) Camilla Niva et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Caspase-2 and caspase-8 trigger caspase-3 activation following 6-OHDA-induced stress in human dopaminergic neurons differentiated from ReNVM stem cells

(2013) Zohara L Chaudhry et al.   NEUROLOGICAL RESEARCH

A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease

(2013) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

γ-Secretase Inhibitors Prevent Overgrowth of Transplanted Neural Progenitors Derived from Human-Induced Pluripotent Stem Cells

(2012) Aya Ogura et al.   STEM CELLS AND DEVELOPMENT

Regulated Intramembrane Cleavage of the EGF Receptor

(2012) Hong-Jun Liao et al.   TRAFFIC

Notch signaling contributes to the maintenance of both normal neural stem cells and patient-derived glioma stem cells

(2011) Yi-Yang Hu et al.   BMC CANCER

Presenilin-1 Regulates Neural Progenitor Cell Differentiation in the Adult Brain

(2011) A. Gadadhar et al.   JOURNAL OF NEUROSCIENCE

Presenilin 1 Mutants Impair the Self-Renewal and Differentiation of Adult Murine Subventricular Zone-Neuronal Progenitors via Cell-Autonomous Mechanisms Involving Notch Signaling

(2010) K. Veeraraghavalu et al.   JOURNAL OF NEUROSCIENCE

Key Alzheimer's findings questioned

(2010) Heidi Ledford   NATURE

Modulation of γ-Secretase Reduces β-Amyloid Deposition in a Transgenic Mouse Model of Alzheimer's Disease

(2010) Maria Z. Kounnas et al.   NEURON

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibition of Notch Signaling in Human Embryonic Stem Cell-Derived Neural Stem Cells Delays G1/S Phase Transition and Accelerates Neuronal Differentiation In Vitro and In Vivo

(2010) Lodovica Borghese et al.   STEM CELLS

Protection of neurons derived from human neural progenitor cells by veratridine

(2009) Peter J. Morgan et al.   NEUROREPORT

Phase 2 Safety Trial Targeting Amyloid β Production With a γ-Secretase Inhibitor in Alzheimer Disease

(2008) Adam S. Fleisher et al.   ARCHIVES OF NEUROLOGY

Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage

(2008) Y. Elkabetz et al.   GENES & DEVELOPMENT

Presenilins are required for maintenance of neural stem cells in the developing brain

(2008) Woo-Young Kim et al.   Molecular Neurodegeneration