Alzheimer's in 3D culture: Challenges and perspectives

An In Vitro Model for Neuroscience: Differentiation of SH-SY5Y Cells into Cells with Morphological and Biochemical Characteristics of Mature Neurons

(2017) Lotta Agholme et al.   JOURNAL OF ALZHEIMERS DISEASE

Three-dimensional brain-on-a-chip with an interstitial level of flow and its application as an in vitro model of Alzheimer's disease

(2015) JiSoo Park et al.   LAB ON A CHIP

A 3D human neural cell culture system for modeling Alzheimer's disease

(2015) Young Hye Kim et al.   Nature Protocols

APP Metabolism Regulates Tau Proteostasis in Human Cerebral Cortex Neurons

(2015) Steven Moore et al.   Cell Reports

2014 Alzheimer's disease facts and figures

(2014)   Alzheimers & Dementia

Lessons from a Failed γ-Secretase Alzheimer Trial

(2014) Bart De Strooper   CELL

Safety profile of semagacestat, a gamma-secretase inhibitor: IDENTITY trial findings

(2014) David B. Henley et al.   CURRENT MEDICAL RESEARCH AND OPINION

Human stem cell models of dementia

(2014) F. J. Livesey   HUMAN MOLECULAR GENETICS

The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons

(2014) Christina R. Muratore et al.   HUMAN MOLECULAR GENETICS

Stem cell derived basal forebrain cholinergic neurons from Alzheimer’s disease patients are more susceptible to cell death

(2014) Lishu Duan et al.   Molecular Neurodegeneration

A three-dimensional human neural cell culture model of Alzheimer’s disease

(2014) Se Hoon Choi et al.   NATURE

Characterization and Molecular Profiling of PSEN1 Familial Alzheimer's Disease iPSC-Derived Neural Progenitors

(2014) Andrew A. Sproul et al.   PLoS One

Bioengineered functional brain-like cortical tissue

(2014) M. D. Tang-Schomer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Familial Alzheimer’s disease modelling using induced pluripotent stem cell technology

(2014) Lisa Mohamet   World Journal of Stem Cells

Size-controllable networked neurospheres as a 3D neuronal tissue model for Alzheimer's disease studies

(2013) Yoon Jung Choi et al.   BIOMATERIALS

A 3D Alzheimer's disease culture model and the induction of P21-activated kinase mediated sensing in iPSC derived neurons

(2013) Dawei Zhang et al.   BIOMATERIALS

Human iPSC-Based Modeling of Late-Onset Disease via Progerin-Induced Aging

(2013) Justine D. Miller et al.   Cell Stem Cell

Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness

(2013) Takayuki Kondo et al.   Cell Stem Cell

A Transgenic Alzheimer Rat with Plaques, Tau Pathology, Behavioral Impairment, Oligomeric A , and Frank Neuronal Loss

(2013) R. M. Cohen et al.   JOURNAL OF NEUROSCIENCE

Structural and molecular interrogation of intact biological systems

(2013) Kwanghun Chung et al.   NATURE

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

The Presenilin-1 ΔE9 Mutation Results in Reduced γ-Secretase Activity, but Not Total Loss of PS1 Function, in Isogenic Human Stem Cells

(2013) Grace Woodruff et al.   Cell Reports

Drug pipeline in neurodegeneration based on transgenic mice models of Alzheimer's disease

(2012) Chaoyun Li et al.   AGEING RESEARCH REVIEWS

Presenilin-1 L166P Mutant Human Pluripotent Stem Cell–Derived Neurons Exhibit Partial Loss of γ-Secretase Activity in Endogenous Amyloid-β Generation

(2012) Philipp Koch et al.   AMERICAN JOURNAL OF PATHOLOGY

iPSCs to the Rescue in Alzheimer's Research

(2012) Se Hoon Choi et al.   Cell Stem Cell

iPSC technology to study human aging and aging-related disorders

(2012) Guang-Hui Liu et al.   CURRENT OPINION IN CELL BIOLOGY

Alzheimer's disease in a dish: promises and challenges of human stem cell models

(2012) J. E. Young et al.   HUMAN MOLECULAR GENETICS

Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues

(2012) Brendon M. Baker et al.   JOURNAL OF CELL SCIENCE

3D Differentiation of Neural Stem Cells in Macroporous Photopolymerizable Hydrogel Scaffolds

(2012) Hang Li et al.   PLoS One

Induced Tauopathy in a Novel 3D-Culture Model Mediates Neurodegenerative Processes: A Real-Time Study on Biochips

(2012) Diana Seidel et al.   PLoS One

A Human Stem Cell Model of Early Alzheimer's Disease Pathology in Down Syndrome

(2012) Y. Shi et al.   Science Translational Medicine

LRRK2 Mutant iPSC-Derived DA Neurons Demonstrate Increased Susceptibility to Oxidative Stress

(2011) Ha Nam Nguyen et al.   Cell Stem Cell

Modeling familial Alzheimer's disease with induced pluripotent stem cells

(2011) Takuya Yagi et al.   HUMAN MOLECULAR GENETICS

Self-formation of functional adenohypophysis in three-dimensional culture

(2011) Hidetaka Suga et al.   NATURE

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

Effect of 3D-scaffold formation on differentiation and survival in human neural progenitor cells

(2010) Stefanie Ortinau et al.   Biomedical Engineering Online

Matrigel: A complex protein mixture required for optimal growth of cell culture

(2010) Chris S. Hughes et al.   PROTEOMICS

A new amyloid β variant favoring oligomerization in Alzheimer's-type dementia

(2008) Takami Tomiyama et al.   ANNALS OF NEUROLOGY

Progression of Amyloid Pathology to Alzheimer's Disease Pathology in an Amyloid Precursor Protein Transgenic Mouse Model by Removal of Nitric Oxide Synthase 2

(2008) D. M. Wilcock et al.   JOURNAL OF NEUROSCIENCE

Animal models of Alzheimer's disease and frontotemporal dementia

(2008) Jürgen Götz et al.   NATURE REVIEWS NEUROSCIENCE