Human tissues in a dish: The research and ethical implications of organoid technology

Organoids as Models for Neoplastic Transformation

(2016) James T. Neal et al.   Annual Review of Pathology-Mechanisms of Disease

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

(2016) Xuyu Qian et al.   CELL

Zika Virus Depletes Neural Progenitors in Human Cerebral Organoids through Activation of the Innate Immune Receptor TLR3

(2016) Jason Dang et al.   Cell Stem Cell

Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth

(2016) Hengli Tang et al.   Cell Stem Cell

Expression Analysis Highlights AXL as a Candidate Zika Virus Entry Receptor in Neural Stem Cells

(2016) Tomasz J. Nowakowski et al.   Cell Stem Cell

Organoid biobanking: identifying the ethics

(2016) Sarah N Boers et al.   EMBO REPORTS

Big Data in medical research and EU data protection law: challenges to the consent or anonymise approach

(2016) Menno Mostert et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Organoid Models of Human Gastrointestinal Development and Disease

(2016) Priya H. Dedhia et al.   GASTROENTEROLOGY

One Size Fits All?: Ethical Considerations for Examining Efficacy in First-in-Human Pluripotent Stem Cell Studies

(2016) Michelle GJL Habets et al.   MOLECULAR THERAPY

FDA should stand firm on stem-cell treatments

(2016)   NATURE

Embryology policy: Revisit the 14-day rule

(2016) Insoo Hyun et al.   NATURE

The Brazilian Zika virus strain causes birth defects in experimental models

(2016) Fernanda R. Cugola et al.   NATURE

Acetate mediates a microbiome–brain–β-cell axis to promote metabolic syndrome

(2016) Rachel J. Perry et al.   NATURE

Self-organization of the in vitro attached human embryo

(2016) Alessia Deglincerti et al.   NATURE

Organoids as an in vitro model of human development and disease

(2016) Aliya Fatehullah et al.   NATURE CELL BIOLOGY

Self-organization of the human embryo in the absence of maternal tissues

(2016) Marta N. Shahbazi et al.   NATURE CELL BIOLOGY

New company aims to broaden researchers' access to organoids

(2016) Shraddha Chakradhar   NATURE MEDICINE

Confronting stem cell hype

(2016) T. Caulfield et al.   SCIENCE

Characterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosis

(2016) Johanna F. Dekkers et al.   Science Translational Medicine

Generation and characterization of rat liver stem cell lines and their engraftment in a rat model of liver failure

(2016) Ewart W. Kuijk et al.   Scientific Reports

Broad Consent Is Consent for Governance

(2015) Sarah N. Boers et al.   AMERICAN JOURNAL OF BIOETHICS

Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver

(2015) Meritxell Huch et al.   CELL

Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients

(2015) Marc van de Wetering et al.   CELL

Organoid Models of Human and Mouse Ductal Pancreatic Cancer

(2015) Sylvia F. Boj et al.   CELL

Human stem cell-based disease modeling: prospects and challenges

(2015) Joshua Z Johnson et al.   CURRENT OPINION IN CELL BIOLOGY

Organs from the lab

(2015) Vivien Marx   NATURE

Societal impacts of regenerative medicine: reflections on the views of orthopedic professionals

(2015) Sophie L Niemansburg et al.   Regenerative Medicine

Drug discovery through stem cell-based organoid models

(2014) Adrian Ranga et al.   ADVANCED DRUG DELIVERY REVIEWS

Critical analysis of 3-D organoid in vitro cell culture models for high-throughput drug candidate toxicity assessments

(2014) Anna Astashkina et al.   ADVANCED DRUG DELIVERY REVIEWS

Bioengineering approaches to guide stem cell-based organogenesis

(2014) Nikolche Gjorevski et al.   DEVELOPMENT

Organogenesis in a dish: Modeling development and disease using organoid technologies

(2014) M. A. Lancaster et al.   SCIENCE

Successful therapies for Alzheimer’s disease: why so many in animal models and none in humans?

(2014) Rafael Franco et al.   Frontiers in Pharmacology

Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients

(2013) Gerald Schwank et al.   Cell Stem Cell

A functional CFTR assay using primary cystic fibrosis intestinal organoids

(2013) Johanna F Dekkers et al.   NATURE MEDICINE

Stem Cell Trials for Cardiovascular Medicine: Ethical Rationale

(2013) Sophie L. Niemansburg et al.   TISSUE ENGINEERING PART A

Animal Experiments in Biomedical Research: A Historical Perspective

(2013) Nuno Franco   Animals

Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell

(2012) Shiro Yui et al.   NATURE MEDICINE

Inclusion of Residual Tissue in Biobanks: Opt-In or Opt-Out?

(2012) Noor A. A. Giesbertz et al.   PLOS BIOLOGY

The Singapore Statement on Research Integrity

(2011) David B. Resnik et al.   Accountability in Research-Policies and Quality Assurance

ETHICS, AMBIGUITY AVERSION, AND THE REVIEW OF COMPLEX TRANSLATIONAL CLINICAL TRIALS

(2011) JONATHAN KIMMELMAN   BIOETHICS

From consent to institutions: Designing adaptive governance for genomic biobanks

(2011) Kieran C. O’Doherty et al.   SOCIAL SCIENCE & MEDICINE

Neurogenic radial glia in the outer subventricular zone of human neocortex

(2010) David V. Hansen et al.   NATURE

The Meaning of Translational Research and Why It Matters

(2008) Steven H. Woolf   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION