From Gene to Behavior: L-Type Calcium Channel Mechanisms Underlying Neuropsychiatric Symptoms

Reduced levels of Cacna1c attenuate mesolimbic dopamine system function

(2017) C. E. Terrillion et al.   GENES BRAIN AND BEHAVIOR

Enhancing VTA Cav1.3 L-type Ca2+ channel activity promotes cocaine and mood-related behaviors via overlapping AMPA receptor mechanisms in the nucleus accumbens

(2017) A Martínez-Rivera et al.   MOLECULAR PSYCHIATRY

Rescue of impaired sociability and anxiety-like behavior in adult cacna1c-deficient mice by pharmacologically targeting eIF2α

(2017) Z D Kabir et al.   MOLECULAR PSYCHIATRY

A Brief History of Long-Term Potentiation

(2017) Roger A. Nicoll   NEURON

The neural underpinnings of cognitive flexibility and their disruption in psychotic illness

(2017) James A. Waltz   NEUROSCIENCE

Accumulated quiescent neural stem cells in adult hippocampus of the mouse model for the MECP2 duplication syndrome

(2017) Zhifang Chen et al.   Scientific Reports

Common variants inCACNA1Cand MDD susceptibility: A comprehensive meta-analysis

(2016) Shuquan Rao et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Essential Role of Mesolimbic Brain-Derived Neurotrophic Factor in Chronic Social Stress–Induced Depressive Behaviors

(2016) Ja Wook Koo et al.   BIOLOGICAL PSYCHIATRY

Stress and Cocaine Trigger Divergent and Cell Type–Specific Regulation of Synaptic Transmission at Single Spines in Nucleus Accumbens

(2016) Lena A. Khibnik et al.   BIOLOGICAL PSYCHIATRY

Activity-dependent signaling: influence on plasticity in circuits controlling fear-related behavior

(2016) Julia L Hill et al.   CURRENT OPINION IN NEUROBIOLOGY

BAZ1B in Nucleus Accumbens Regulates Reward-Related Behaviors in Response to Distinct Emotional Stimuli

(2016) H. Sun et al.   JOURNAL OF NEUROSCIENCE

L-type Ca2+ channels in mood, cognition and addiction: integrating human and rodent studies with a focus on behavioural endophenotypes

(2016) Z. D. Kabir et al.   JOURNAL OF PHYSIOLOGY-LONDON

A systematic review of calcium channel antagonists in bipolar disorder and some considerations for their future development

(2016) A Cipriani et al.   MOLECULAR PSYCHIATRY

Synaptic mechanisms underlying persistent cocaine craving

(2016) Marina E. Wolf   NATURE REVIEWS NEUROSCIENCE

Unifying Views of Autism Spectrum Disorders: A Consideration of Autoregulatory Feedback Loops

(2016) Caitlin Mullins et al.   NEURON

Differential Roles for L-Type Calcium Channel Subtypes in Alcohol Dependence

(2016) Stefanie Uhrig et al.   NEUROPSYCHOPHARMACOLOGY

Splice variants of the CaV1.3 L-type calcium channel regulate dendritic spine morphology

(2016) Ruslan Stanika et al.   Scientific Reports

An autism-associated mutation in CaV1.3 channels has opposing effects on voltage- and Ca2+-dependent regulation

(2016) Worawan B. Limpitikul et al.   Scientific Reports

Everolimus improves neuropsychiatric symptoms in a patient with tuberous sclerosis carrying a novel TSC2 mutation

(2016) Su-Kyeong Hwang et al.   Molecular Brain

MEF2C regulates cortical inhibitory and excitatory synapses and behaviors relevant to neurodevelopmental disorders

(2016) Adam J Harrington et al.   eLife

Proteomic analysis of the postsynaptic density implicates synaptic function and energy pathways in bipolar disorder

(2016) M Föcking et al.   Translational Psychiatry

Consistently altered expression of gene sets in postmortem brains of individuals with major psychiatric disorders

(2016) M M Darby et al.   Translational Psychiatry

Pathway Network Analyses for Autism Reveal Multisystem Involvement, Major Overlaps with Other Diseases and Convergence upon MAPK and Calcium Signaling

(2016) Ya Wen et al.   PLoS One

Functional Characterization of Schizophrenia-Associated Variation in CACNA1C

(2016) Nicole Eckart et al.   PLoS One

Ethanol and corticotropin releasing factor receptor modulation of central amygdala neurocircuitry: An update and future directions

(2015) Yuval Silberman et al.   ALCOHOL

Evolutionary and functional perspectives on signaling from neuronal surface to nucleus

(2015) Samuel M. Cohen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Distinct roles of multiple isoforms of CaMKII in signaling to the nucleus

(2015) Huan Ma et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

CACNA1D De Novo Mutations in Autism Spectrum Disorders Activate Cav1.3 L-Type Calcium Channels

(2015) Alexandra Pinggera et al.   BIOLOGICAL PSYCHIATRY

The L-type calcium channel Cav1.3 is required for proper hippocampal neurogenesis and cognitive functions

(2015) Julia Marschallinger et al.   CELL CALCIUM

L-type calcium channels as drug targets in CNS disorders

(2015) Nadine J Ortner et al.   Channels

Hippocampal Neurogenesis, Neurotrophic Factors and Depression: Possible Therapeutic Targets?

(2015) Gianluca Serafini et al.   CNS & Neurological Disorders-Drug Targets

Common Mechanisms of Excitatory and Inhibitory Imbalance in Schizophrenia and Autism Spectrum Disorders

(2015) R. Gao et al.   CURRENT MOLECULAR MEDICINE

Altered voltage-gated calcium channels in rat inferior colliculus neurons contribute to alcohol withdrawal seizures

(2015) Prosper N’Gouemo   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Non-coding genetic variants in human disease: Figure 1.

(2015) Feng Zhang et al.   HUMAN MOLECULAR GENETICS

MECP2 disorders: from the clinic to mice and back

(2015) Laura Marie Lombardi et al.   JOURNAL OF CLINICAL INVESTIGATION

L-type Ca2+ channel blockade with antihypertensive medication disrupts VTA synaptic plasticity and drug-associated contextual memory

(2015) M Degoulet et al.   MOLECULAR PSYCHIATRY

Targeting voltage-gated calcium channels in neurological and psychiatric diseases

(2015) Gerald W. Zamponi   NATURE REVIEWS DRUG DISCOVERY

L-type calcium channel blockers and substance P induce angiogenesis of cortical vessels associated with beta-amyloid plaques in an Alzheimer mouse model

(2015) Nina Daschil et al.   NEUROBIOLOGY OF AGING

Sufficiency of Mesolimbic Dopamine Neuron Stimulation for the Progression to Addiction

(2015) Vincent Pascoli et al.   NEURON

Excitatory/Inhibitory Balance and Circuit Homeostasis in Autism Spectrum Disorders

(2015) Sacha B. Nelson et al.   NEURON

Forkhead box O transcription factors as possible mediators in the development of major depression

(2015) Haitao Wang et al.   NEUROPHARMACOLOGY

Increasing Adult Hippocampal Neurogenesis is Sufficient to Reduce Anxiety and Depression-Like Behaviors

(2015) Alexis S Hill et al.   NEUROPSYCHOPHARMACOLOGY

Pharmacologic rescue of motor and sensory function by the neuroprotective compound P7C3 following neonatal nerve injury

(2015) S.W.P. Kemp et al.   NEUROSCIENCE

Pharmacology of cognitive enhancers for exposure-based therapy of fear, anxiety and trauma-related disorders

(2015) N. Singewald et al.   PHARMACOLOGY & THERAPEUTICS

Schizophrenia Related Variants in CACNA1C also Confer Risk of Autism

(2015) Jun Li et al.   PLoS One

Rare variants in neuronal excitability genes influence risk for bipolar disorder

(2015) Seth A. Ament et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic disruption of voltage-gated calcium channels in psychiatric and neurological disorders

(2015) Samuel Heyes et al.   PROGRESS IN NEUROBIOLOGY

What is the impact of genome-wide supported risk variants for schizophrenia and bipolar disorder on brain structure and function? A systematic review

(2015) R. Gurung et al.   PSYCHOLOGICAL MEDICINE

Integration of gene expression and GWAS results supports involvement of calcium signaling in Schizophrenia

(2015) L. Hertzberg et al.   SCHIZOPHRENIA RESEARCH

Evaluation of genetic susceptibility of common variants in CACNA1D with schizophrenia in Han Chinese

(2015) Fanglin Guan et al.   Scientific Reports

A new perspective on the role of the CREB family of transcription factors in memory consolidation via adult hippocampal neurogenesis

(2015) Sylvia Ortega-Martínez   Frontiers in Molecular Neuroscience

Pharmacology of L-type Calcium Channels: Novel Drugs for Old Targets?

(2015) Jorg Striessnig et al.   Current Molecular Pharmacology

Convergence of Genes and Cellular Pathways Dysregulated in Autism Spectrum Disorders

(2014) Dalila Pinto et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Natural Neural Projection Dynamics Underlying Social Behavior

(2014) Lisa A. Gunaydin et al.   CELL

γCaMKII Shuttles Ca2+/CaM to the Nucleus to Trigger CREB Phosphorylation and Gene Expression

(2014) Huan Ma et al.   CELL

P7C3 and an unbiased approach to drug discovery for neurodegenerative diseases

(2014) Andrew A. Pieper et al.   CHEMICAL SOCIETY REVIEWS

Regulation of later neurogenic stages of adult-derived neural stem/progenitor cells by L-type Ca2+channels

(2014) Daniel B. L. Teh et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Involvement of prefrontal AMPA receptors in encounter stimulation-induced hyperactivity in isolation-reared mice

(2014) Ryota Araki et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Early Detection of Subclinical Visual Damage After Blast-Mediated TBI Enables Prevention of Chronic Visual Deficit by Treatment With P7C3-S243

(2014) L. M. Dutca et al.   INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Discovery of a Neuroprotective Chemical, (S)-N-(3-(3,6-Dibromo-9H-carbazol-9-yl)-2-fluoropropyl)-6-methoxypyridin-2-amine [(−)-P7C3-S243], with Improved Druglike Properties

(2014) Jacinth Naidoo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cav1.2 and Cav1.3 L-type calcium channels regulate dopaminergic firing activity in the mouse ventral tegmental area

(2014) Yudan Liu et al.   JOURNAL OF NEUROPHYSIOLOGY

Proteomic and genomic evidence implicates the postsynaptic density in schizophrenia

(2014) M Föcking et al.   MOLECULAR PSYCHIATRY

Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons

(2014) T Yoshimizu et al.   MOLECULAR PSYCHIATRY

The P7C3 class of neuroprotective compounds exerts antidepressant efficacy in mice by increasing hippocampal neurogenesis

(2014) A K Walker et al.   MOLECULAR PSYCHIATRY

The contribution of de novo coding mutations to autism spectrum disorder

(2014) Ivan Iossifov et al.   NATURE

REDD1 is essential for stress-induced synaptic loss and depressive behavior

(2014) Kristie T Ota et al.   NATURE MEDICINE

Pathological circuit function underlying addiction and anxiety disorders

(2014) Andreas Lüthi et al.   NATURE NEUROSCIENCE

Improving cognition in schizophrenia with antipsychotics that elicit neurogenesis through 5-HT1A receptor activation

(2014) Rudy Schreiber et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Replication of brain function effects of a genome-wide supported psychiatric risk variant in the CACNA1C gene and new multi-locus effects

(2014) Susanne Erk et al.   NEUROIMAGE

Neuronal Voltage-Gated Calcium Channels: Structure, Function, and Dysfunction

(2014) Brett A. Simms et al.   NEURON

The heterogeneity of ventral tegmental area neurons: Projection functions in a mood-related context

(2014) J.J. Walsh et al.   NEUROSCIENCE

Transcriptional Regulation of L-Type Calcium Channel Subtypes Cav1.2 and Cav1.3 by Nicotine and Their Potential Role in Nicotine Sensitization

(2014) R. E. Bernardi et al.   NICOTINE & TOBACCO RESEARCH

Illicit dopamine transients: Reconciling actions of abused drugs

(2014) Dan P. Covey et al.   TRENDS IN NEUROSCIENCES

How voltage-gated calcium channels gate forms of homeostatic synaptic plasticity

(2014) C. Andrew Frank   Frontiers in Cellular Neuroscience

Cell cycle-linked MeCP2 phosphorylation modulates adult neurogenesis involving the Notch signalling pathway

(2014) Hongda Li et al.   Nature Communications

A Role for Noncoding Variation in Schizophrenia

(2014) Panos Roussos et al.   Cell Reports

P7C3 Neuroprotective Chemicals Block Axonal Degeneration and Preserve Function after Traumatic Brain Injury

(2014) Terry C. Yin et al.   Cell Reports

AKAP-Anchored PKA Maintains Neuronal L-type Calcium Channel Activity and NFAT Transcriptional Signaling

(2014) Jonathan G. Murphy et al.   Cell Reports

Optogenetic insights on the relationship between anxiety-related behaviors and social deficits

(2014) Stephen A. Allsop et al.   Frontiers in Behavioral Neuroscience

Alteration in basal and depolarization induced transcriptional network in iPSC derived neurons from Timothy syndrome

(2014) Yuan Tian et al.   Genome Medicine

Identification of Pathways for Bipolar Disorder

(2014) John I. Nurnberger et al.   JAMA Psychiatry

CACNA1C risk variant affects reward responsiveness in healthy individuals

(2014) T M Lancaster et al.   Translational Psychiatry

Acute and chronic effects of ethanol on learning-related synaptic plasticity

(2013) Charles F. Zorumski et al.   ALCOHOL

Bipolar disorder and substance misuse: pathological and therapeutic implications of their comorbidity and cross-sensitisation

(2013) Robert M. Post et al.   BRITISH JOURNAL OF PSYCHIATRY

DISC1-related signaling pathways in adult neurogenesis of the hippocampus

(2013) Qian Wu et al.   GENE

The UPF3B gene, implicated in intellectual disability, autism, ADHD and childhood onset schizophrenia regulates neural progenitor cell behaviour and neuronal outgrowth

(2013) Lachlan A. Jolly et al.   HUMAN MOLECULAR GENETICS

 FosB Induction in Striatal Medium Spiny Neuron Subtypes in Response to Chronic Pharmacological, Emotional, and Optogenetic Stimuli

(2013) M. K. Lobo et al.   JOURNAL OF NEUROSCIENCE

Calcium-Permeable AMPA Receptors in the Nucleus Accumbens Regulate Depression-Like Behaviors in the Chronic Neuropathic Pain State

(2013) Y. Goffer et al.   JOURNAL OF NEUROSCIENCE

Neuroprotective Efficacy of a Proneurogenic Compound after Traumatic Brain Injury

(2013) Meghan O. Blaya et al.   JOURNAL OF NEUROTRAUMA

Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis

(2013)   LANCET

A rare mutation of CACNA1C in a patient with bipolar disorder and decreased gene expression associated with a bipolar-associated common SNP of CACNA1C in brain

(2013) E S Gershon et al.   MOLECULAR PSYCHIATRY

Activity-dependent neuronal signalling and autism spectrum disorder

(2013) Daniel H. Ebert et al.   NATURE

Timothy syndrome is associated with activity-dependent dendritic retraction in rodent and human neurons

(2013) Jocelyn F Krey et al.   NATURE NEUROSCIENCE

mTOR complexes in neurodevelopmental and neuropsychiatric disorders

(2013) Mauro Costa-Mattioli et al.   NATURE NEUROSCIENCE

The brain reward circuitry in mood disorders

(2013) Scott J. Russo et al.   NATURE REVIEWS NEUROSCIENCE

mTORC1-dependent protein synthesis underlying rapid antidepressant effect requires GABABR signaling

(2013) E.R. Workman et al.   NEUROPHARMACOLOGY

The Central Amygdala and Alcohol: Role of  -Aminobutyric Acid, Glutamate, and Neuropeptides

(2013) M. Roberto et al.   Cold Spring Harbor Perspectives in Medicine

Synaptosomal-associated protein 25 mutation induces immaturity of the dentate granule cells of adult mice

(2013) Koji Ohira et al.   Molecular Brain

Pharmacological brake-release of mRNA translation enhances cognitive memory

(2013) Carmela Sidrauski et al.   eLife

Independent Modulation of Engagement and Connectivity of the Facial Network During Affect Processing byCACNA1CandANK3Risk Genes for Bipolar Disorder

(2013) Danai Dima et al.   JAMA Psychiatry

Rare Genomic Variants Link Bipolar Disorder with Anxiety Disorders to CREB-Regulated Intracellular Signaling Pathways

(2013) Berit Kerner et al.   Frontiers in Psychiatry

Do ATP-Binding Cassette Transporters Cause Pharmacoresistance in Epilepsy? Problems and Approaches in Determining which Antiepileptic Drugs are Affected

(2012) Wolfgang Loscher et al.   CURRENT PHARMACEUTICAL DESIGN

The effect of nimodipine on memory impairment during spontaneous morphine withdrawal in mice: Corticosterone interaction

(2012) Golnaz Vaseghi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

L-Type Voltage-Gated Calcium Channels in the Basolateral Amygdala Are Necessary for Fear Extinction

(2012) S. E. Davis et al.   JOURNAL OF NEUROSCIENCE

Synaptic Refinement of an Inhibitory Topographic Map in the Auditory Brainstem Requires Functional CaV1.3 Calcium Channels

(2012) J. J. Hirtz et al.   JOURNAL OF NEUROSCIENCE

Pten Deletion in Adult Hippocampal Neural Stem/Progenitor Cells Causes Cellular Abnormalities and Alters Neurogenesis

(2012) A. Amiri et al.   JOURNAL OF NEUROSCIENCE

Forebrain elimination of cacna1c mediates anxiety-like behavior in mice

(2012) A S Lee et al.   MOLECULAR PSYCHIATRY

Autism-related deficits via dysregulated eIF4E-dependent translational control

(2012) Christos G. Gkogkas et al.   NATURE

Anhedonia requires MC4R-mediated synaptic adaptations in nucleus accumbens

(2012) Byung Kook Lim et al.   NATURE

Exaggerated translation causes synaptic and behavioural aberrations associated with autism

(2012) Emanuela Santini et al.   NATURE

Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons

(2012) Dipesh Chaudhury et al.   NATURE

Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations

(2012) Brian J. O’Roak et al.   NATURE

Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy

(2012) Mark J. Millan et al.   NATURE REVIEWS DRUG DISCOVERY

Chronic d-amphetamine administered from childhood to adulthood dose-dependently increases the survival of new neurons in the hippocampus of male C57BL/6J mice

(2012) E.C. Dabe et al.   NEUROSCIENCE

Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis

(2012) R. Tesla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of Parkinson disease

(2012) H. De Jesus-Cortes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CACNA1C (Cav1.2) in the pathophysiology of psychiatric disease

(2012) Shambhu Bhat et al.   PROGRESS IN NEUROBIOLOGY

The social brain in psychiatric and neurological disorders

(2012) Daniel P. Kennedy et al.   TRENDS IN COGNITIVE SCIENCES

Rapamycin reverses impaired social interaction in mouse models of tuberous sclerosis complex

(2012) Atsushi Sato et al.   Nature Communications

Long QT, syndactyly, joint contractures, stroke and novel CACNA1C mutation: Expanding the spectrum of Timothy syndrome

(2011) Jane Gillis et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

GRIK4/KA1 protein expression in human brain and correlation with bipolar disorder risk variant status

(2011) Helen M. Knight et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Reward, Addiction, Withdrawal to Nicotine

(2011) Mariella De Biasi et al.   Annual Review of Neuroscience

The CACNA1C and ANK3 risk alleles impact on affective personality traits and startle reactivity but not on cognition or gating in healthy males

(2011) Panos Roussos et al.   BIPOLAR DISORDERS

The association of genetic variation in CACNA1C with structure and function of a frontotemporal system

(2011) Fei Wang et al.   BIPOLAR DISORDERS

Progress in defining the biological causes of schizophrenia

(2011) Benjamin Pickard   EXPERT REVIEWS IN MOLECULAR MEDICINE

Reduced AKT/mTOR signaling and protein synthesis dysregulation in a Rett syndrome animal model

(2011) Sara Ricciardi et al.   HUMAN MOLECULAR GENETICS

Genetic variations in FOXO3A are associated with Bipolar Disorder without confering vulnerability for suicidal behavior

(2011) Luiz Alexandre V. Magno et al.   JOURNAL OF AFFECTIVE DISORDERS

Decreased cardiac L-type Ca2+ channel activity induces hypertrophy and heart failure in mice

(2011) Sanjeewa A. Goonasekera et al.   JOURNAL OF CLINICAL INVESTIGATION

Cav1.2 L-Type Ca2+ Channels Mediate Cocaine-Induced GluA1 Trafficking in the Nucleus Accumbens, a Long-Term Adaptation Dependent on Ventral Tegmental Area Cav1.3 Channels

(2011) K. Schierberl et al.   JOURNAL OF NEUROSCIENCE

Postsynaptic BDNF signalling regulates long-term potentiation at thalamo-amygdala afferents

(2011) S. Meis et al.   JOURNAL OF PHYSIOLOGY-LONDON

Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation

(2011) Amar Sahay et al.   NATURE

Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome

(2011) Sergiu P Paşca et al.   NATURE MEDICINE

A Role for Repressive Histone Methylation in Cocaine-Induced Vulnerability to Stress

(2011) Herbert E. Covington et al.   NEURON

Regulation of Brain-Derived Neurotrophic Factor Exon IV Transcription through Calcium Responsive Elements in Cortical Neurons

(2011) Fei Zheng et al.   PLoS One

Mouse model of Timothy syndrome recapitulates triad of autistic traits

(2011) P. L. Bader et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

L-type calcium channels and psychiatric disorders: A brief review

(2010) Francesco Casamassima et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Genetic Variation in CACNA1C Affects Brain Circuitries Related to Mental Illness

(2010) Kristin L. Bigos et al.   ARCHIVES OF GENERAL PSYCHIATRY

Brain Function in Carriers of a Genome-wide Supported Bipolar Disorder Variant

(2010) Susanne Erk et al.   ARCHIVES OF GENERAL PSYCHIATRY

Participation of L-type calcium channels in ethanol-induced behavioral stimulation and motor incoordination: Effects of diltiazem and verapamil

(2010) Pablo Baliño et al.   BEHAVIOURAL BRAIN RESEARCH

Mood Disorder Susceptibility Gene CACNA1C Modifies Mood-Related Behaviors in Mice and Interacts with Sex to Influence Behavior in Mice and Diagnosis in Humans

(2010) David T. Dao et al.   BIOLOGICAL PSYCHIATRY

Discovery of a Proneurogenic, Neuroprotective Chemical

(2010) Andrew A. Pieper et al.   CELL

Up-regulation of Cav1.2 subunit via facilitating trafficking induced by Vps34 on morphine-induced place preference in mice

(2010) Masahiro Shibasaki et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Molecular Switch from L-Type Cav1.3 to Cav1.2 Ca2+ Channel Signaling Underlies Long-Term Psychostimulant-Induced Behavioral and Molecular Plasticity

(2010) T. P. Giordano et al.   JOURNAL OF NEUROSCIENCE

Homeostatic Switch in Hebbian Plasticity and Fear Learning after Sustained Loss of Cav1.2 Calcium Channels

(2010) N. Langwieser et al.   JOURNAL OF NEUROSCIENCE

Verapamil Block of T-Type Calcium Channels

(2010) P. Bergson et al.   MOLECULAR PHARMACOLOGY

CACNA1C (rs1006737) is associated with schizophrenia

(2010) M Nyegaard et al.   MOLECULAR PSYCHIATRY

ΔFosB in brain reward circuits mediates resilience to stress and antidepressant responses

(2010) Vincent Vialou et al.   NATURE NEUROSCIENCE

Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens

(2010) Quincey LaPlant et al.   NATURE NEUROSCIENCE

New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?

(2010) Wei Deng et al.   NATURE REVIEWS NEUROSCIENCE

Fragile X Mental Retardation Protein Is Required for Synapse Elimination by the Activity-Dependent Transcription Factor MEF2

(2010) Brad E. Pfeiffer et al.   NEURON

Plastic Synaptic Networks of the Amygdala for the Acquisition, Expression, and Extinction of Conditioned Fear

(2010) Hans-Christian Pape et al.   PHYSIOLOGICAL REVIEWS

Cell Type-Specific Loss of BDNF Signaling Mimics Optogenetic Control of Cocaine Reward

(2010) M. K. Lobo et al.   SCIENCE

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

(2010) N. Li et al.   SCIENCE

Upregulation of L-type Cav1 channels in the development of psychological dependence

(2010) Masahiro Shibasaki et al.   SYNAPSE

The addicted synapse: mechanisms of synaptic and structural plasticity in nucleus accumbens

(2010) Scott J. Russo et al.   TRENDS IN NEUROSCIENCES

The Role of Genes Involved in Neuroplasticity and Neurogenesis in the Observation of a Gene-Environment Interaction (GxE) in Schizophrenia

(2009) Yann Strat et al.   CURRENT MOLECULAR MEDICINE

CaV1.3 L-type Ca2+ channels modulate depression-like behaviour in mice independent of deaf phenotype

(2009) Perrine Busquet et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Blocking L-type Voltage-gated Ca2+Channels with Dihydropyridines Reduces γ-Aminobutyric Acid Type A Receptor Expression and Synaptic Inhibition

(2009) Richard S. Saliba et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N Terminus Is Key to the Dominant Negative Suppression of CaV2 Calcium Channels

(2009) Karen M. Page et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Estradiol Reverses a Calcium-Related Biomarker of Brain Aging in Female Rats

(2009) L. D. Brewer et al.   JOURNAL OF NEUROSCIENCE

L-Type Calcium Channels and Calcium/Calmodulin-Dependent Kinase II Differentially Mediate Behaviors Associated with Nicotine Withdrawal in Mice

(2009) K. J. Jackson et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Impaired long-term potentiation and enhanced neuronal excitability in the amygdala of CaV1.3 knockout mice

(2009) Brandon C. McKinney et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

The yin and yang of MeCP2 phosphorylation

(2009) H.-T. Chao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function

(2009) J. Tao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Forkhead Box, Class O Transcription Factors in Brain: Regulation and Behavioral Manifestation

(2008) Abigail Polter et al.   BIOLOGICAL PSYCHIATRY

Verapamil augmentation of lithium treatment improves outcome in mania unresponsive to lithium alone: preliminary findings and a discussion of therapeutic mechanisms

(2008) Alan G Mallinger et al.   BIPOLAR DISORDERS

CaMKII locally encodes L-type channel activity to signal to nuclear CREB in excitation–transcription coupling

(2008) Damian G. Wheeler et al.   JOURNAL OF CELL BIOLOGY

Cav1 L-type Ca2+channel signaling complexes in neurons

(2008) Irina Calin-Jageman et al.   JOURNAL OF NEUROCHEMISTRY

A Destructive Interaction Mechanism Accounts for Dominant-Negative Effects of Misfolded Mutants of Voltage-Gated Calcium Channels

(2008) A. Mezghrani et al.   JOURNAL OF NEUROSCIENCE

Repolarizing Responses of BKCa-Cav Complexes Are Distinctly Shaped by Their Cav Subunits

(2008) H. Berkefeld et al.   JOURNAL OF NEUROSCIENCE

Role of L-type Ca2+ channel isoforms in the extinction of conditioned fear

(2008) P. Busquet et al.   LEARNING & MEMORY

Selective and protracted effect of nifedipine on fear memory extinction correlates with induced stress response

(2008) R. Waltereit et al.   LEARNING & MEMORY

L-type voltage-gated calcium channels in conditioned fear: A genetic and pharmacological analysis

(2008) B. C. McKinney et al.   LEARNING & MEMORY

Conditional forebrain deletion of the L-type calcium channel CaV1.2 disrupts remote spatial memories in mice

(2008) J. A. White et al.   LEARNING & MEMORY

Failure of neuronal homeostasis results in common neuropsychiatric phenotypes

(2008) Melissa B. Ramocki et al.   NATURE

CaMKII: a biochemical bridge linking accumbens dopamine and glutamate systems in cocaine seeking

(2008) Sharon M Anderson et al.   NATURE NEUROSCIENCE

Psychological and neural mechanisms of relapse

(2008) J. Stewart   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Chronic morphine treatment decreases the Cav1.3 subunit of the L-type calcium channel

(2007) Victoria L. Haller et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Differential Effects of Corticosterone on the Slow Afterhyperpolarization in the Basolateral Amygdala and CA1 Region: Possible Role of Calcium Channel Subunits

(2007) Lutz Liebmann et al.   JOURNAL OF NEUROPHYSIOLOGY