L-type Ca2+ channels in mood, cognition and addiction: integrating human and rodent studies with a focus on behavioural endophenotypes

Common Polymorphisms in the Age of Research Domain Criteria (RDoC): Integration and Translation

(2016) Charles E. Glatt et al.   BIOLOGICAL PSYCHIATRY

Bidirectional modulation of anxiety-related and social behaviors by amygdala projections to the medial prefrontal cortex

(2016) A.C. Felix-Ortiz et al.   NEUROSCIENCE

CACNA1D De Novo Mutations in Autism Spectrum Disorders Activate Cav1.3 L-Type Calcium Channels

(2015) Alexandra Pinggera et al.   BIOLOGICAL PSYCHIATRY

Telencephalic neurocircuitry and synaptic plasticity in rodent spatial learning and memory

(2015) Tine Pooters et al.   BRAIN RESEARCH

Reward processing dysfunction in major depression, bipolar disorder and schizophrenia

(2015) Alexis E. Whitton et al.   CURRENT OPINION IN PSYCHIATRY

Prevalence of comorbid substance use, anxiety and mood disorders in epidemiological surveys, 1990–2014: A systematic review and meta-analysis

(2015) Harry Man Xiong Lai et al.   DRUG AND ALCOHOL DEPENDENCE

The effects of the CACNA1C rs1006737 A/G on affective startle modulation in healthy males

(2015) E. Pasparakis et al.   EUROPEAN PSYCHIATRY

L-type Ca2+ channel blockade with antihypertensive medication disrupts VTA synaptic plasticity and drug-associated contextual memory

(2015) M Degoulet et al.   MOLECULAR PSYCHIATRY

From circuits to behaviour in the amygdala

(2015) Patricia H. Janak et al.   NATURE

Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways

(2015)   NATURE NEUROSCIENCE

Medial prefrontal pathways for the contextual regulation of extinguished fear in humans

(2015) Fredrik Åhs et al.   NEUROIMAGE

Pharmacology of cognitive enhancers for exposure-based therapy of fear, anxiety and trauma-related disorders

(2015) N. Singewald et al.   PHARMACOLOGY & THERAPEUTICS

Schizophrenia Related Variants in CACNA1C also Confer Risk of Autism

(2015) Jun Li et al.   PLoS One

Rare variants in neuronal excitability genes influence risk for bipolar disorder

(2015) Seth A. Ament et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic disruption of voltage-gated calcium channels in psychiatric and neurological disorders

(2015) Samuel Heyes et al.   PROGRESS IN NEUROBIOLOGY

Ventral hippocampal afferents to the nucleus accumbens regulate susceptibility to depression

(2015) Rosemary C. Bagot et al.   Nature Communications

Compensatory T-type Ca2+ channel activity alters D2-autoreceptor responses of Substantia nigra dopamine neurons from Cav1.3 L-type Ca2+ channel KO mice

(2015) Christina Poetschke et al.   Scientific Reports

The NIMH Research Domain Criteria (RDoC) Project: Precision Medicine for Psychiatry

(2014) Thomas R. Insel   AMERICAN JOURNAL OF PSYCHIATRY

Natural Neural Projection Dynamics Underlying Social Behavior

(2014) Lisa A. Gunaydin et al.   CELL

The role of L-type voltage-gated calcium channels Cav1.2 and Cav1.3 in normal and pathological brain function

(2014) Stefan M. Berger et al.   CELL AND TISSUE RESEARCH

Lesions to the CA2 region of the hippocampus impair social memory in mice

(2014) Erica L. Stevenson et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Amygdala Inputs to the Ventral Hippocampus Bidirectionally Modulate Social Behavior

(2014) A. C. Felix-Ortiz et al.   JOURNAL OF NEUROSCIENCE

Genetic variation in CACNA1C affects neural processing in major depression

(2014) Heidelore Backes et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons

(2014) T Yoshimizu et al.   MOLECULAR PSYCHIATRY

The hippocampal CA2 region is essential for social memory

(2014) Frederick L. Hitti et al.   NATURE

REDD1 is essential for stress-induced synaptic loss and depressive behavior

(2014) Kristie T Ota et al.   NATURE MEDICINE

Pathological circuit function underlying addiction and anxiety disorders

(2014) Andreas Lüthi et al.   NATURE NEUROSCIENCE

Replication of brain function effects of a genome-wide supported psychiatric risk variant in the CACNA1C gene and new multi-locus effects

(2014) Susanne Erk et al.   NEUROIMAGE

Neuronal Voltage-Gated Calcium Channels: Structure, Function, and Dysfunction

(2014) Brett A. Simms et al.   NEURON

Hippocampal–Prefrontal BDNF and Memory for Fear Extinction

(2014) Luis E Rosas-Vidal et al.   NEUROPSYCHOPHARMACOLOGY

A Role for Noncoding Variation in Schizophrenia

(2014) Panos Roussos et al.   Cell Reports

CACNA1C risk variant affects reward responsiveness in healthy individuals

(2014) T M Lancaster et al.   Translational Psychiatry

TheCACNA1Crisk allele selectively impacts on executive function in bipolar type I disorder

(2013) M. G. Soeiro-de-Souza et al.   ACTA PSYCHIATRICA SCANDINAVICA

Hippocampal and Frontolimbic Function as Intermediate Phenotype for Psychosis: Evidence from Healthy Relatives and a Common Risk Variant in CACNA1C

(2013) Susanne Erk et al.   BIOLOGICAL PSYCHIATRY

Bipolar disorder and substance misuse: pathological and therapeutic implications of their comorbidity and cross-sensitisation

(2013) Robert M. Post et al.   BRITISH JOURNAL OF PSYCHIATRY

Translational value of startle modulations

(2013) Markus Fendt et al.   CELL AND TISSUE RESEARCH

Spatial memory tasks in rodents: what do they model?

(2013) Fabio Morellini   CELL AND TISSUE RESEARCH

A genome-wide supported variant in CACNA1C influences hippocampal activation during episodic memory encoding and retrieval

(2013) Axel Krug et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Association of rs1006737 inCACNA1Cwith alterations in prefrontal activation and fronto-hippocampal connectivity

(2013) Frieder M. Paulus et al.   HUMAN BRAIN MAPPING

Prefrontal Activity Links Nonoverlapping Events in Memory

(2013) M. R. Gilmartin et al.   JOURNAL OF NEUROSCIENCE

Blunted reward responsiveness in remitted depression

(2013) Pia Pechtel et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis

(2013)   LANCET

A rare mutation of CACNA1C in a patient with bipolar disorder and decreased gene expression associated with a bipolar-associated common SNP of CACNA1C in brain

(2013) E S Gershon et al.   MOLECULAR PSYCHIATRY

The brain reward circuitry in mood disorders

(2013) Scott J. Russo et al.   NATURE REVIEWS NEUROSCIENCE

The contextual brain: implications for fear conditioning, extinction and psychopathology

(2013) Stephen Maren et al.   NATURE REVIEWS NEUROSCIENCE

From Pavlov to PTSD: The extinction of conditioned fear in rodents, humans, and anxiety disorders

(2013) Michael B. VanElzakker et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

The impact of a CACNA1C gene polymorphism on learning and hippocampal formation in healthy individuals: A diffusion tensor imaging study

(2013) Bruno Dietsche et al.   NEUROIMAGE

CACNA1C Risk Variant and Amygdala Activity in Bipolar Disorder, Schizophrenia and Healthy Controls

(2013) Martin Tesli et al.   PLoS One

Structural and Functional Neuroimaging Studies in Major Depressive Disorder With Psychotic Features: A Critical Review

(2013) G. F. Busatto   SCHIZOPHRENIA BULLETIN

Independent Modulation of Engagement and Connectivity of the Facial Network During Affect Processing byCACNA1CandANK3Risk Genes for Bipolar Disorder

(2013) Danai Dima et al.   JAMA Psychiatry

Exploring the dominant role of Cav1 channels in signalling to the nucleus

(2012) Huan Ma et al.   BIOSCIENCE REPORTS

Cav1.3 L-type Ca2+channels mediate long-term adaptation in dopamine D2L-mediated GluA1 trafficking in the dorsal striatum following cocaine exposure

(2012) Kathryn Schierberl et al.   Channels

L-Type Voltage-Gated Calcium Channels in the Basolateral Amygdala Are Necessary for Fear Extinction

(2012) S. E. Davis et al.   JOURNAL OF NEUROSCIENCE

The impact of CACNA1C allelic variation on effective connectivity during emotional processing in bipolar disorder

(2012) J Radua et al.   MOLECULAR PSYCHIATRY

Forebrain elimination of cacna1c mediates anxiety-like behavior in mice

(2012) A S Lee et al.   MOLECULAR PSYCHIATRY

Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations

(2012) Brian J. O’Roak et al.   NATURE

Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy

(2012) Mark J. Millan et al.   NATURE REVIEWS DRUG DISCOVERY

Gating of Fear in Prelimbic Cortex by Hippocampal and Amygdala Inputs

(2012) Francisco Sotres-Bayon et al.   NEURON

CACNA1C (Cav1.2) in the pathophysiology of psychiatric disease

(2012) Shambhu Bhat et al.   PROGRESS IN NEUROBIOLOGY

Evidence for the impact of the CACNA1C risk allele rs1006737 on 2-year cognitive functioning in bipolar disorder

(2012) Baer Arts et al.   PSYCHIATRIC GENETICS

The social brain in psychiatric and neurological disorders

(2012) Daniel P. Kennedy et al.   TRENDS IN COGNITIVE SCIENCES

Effects of the CACNA1C risk allele on neurocognition in patients with schizophrenia and healthy individuals

(2012) Hiroaki Hori et al.   Scientific Reports

Brain-Specific Disruption of the eIF2α Kinase PERK Decreases ATF4 Expression and Impairs Behavioral Flexibility

(2012) Mimi A. Trinh et al.   Cell Reports

The CACNA1C and ANK3 risk alleles impact on affective personality traits and startle reactivity but not on cognition or gating in healthy males

(2011) Panos Roussos et al.   BIPOLAR DISORDERS

The association of genetic variation in CACNA1C with structure and function of a frontotemporal system

(2011) Fei Wang et al.   BIPOLAR DISORDERS

Initial evidence for the role of CACNA1C on subcortical brain morphology in patients with bipolar disorder

(2011) E. Perrier et al.   EUROPEAN PSYCHIATRY

Cav1.2 L-Type Ca2+ Channels Mediate Cocaine-Induced GluA1 Trafficking in the Nucleus Accumbens, a Long-Term Adaptation Dependent on Ventral Tegmental Area Cav1.3 Channels

(2011) K. Schierberl et al.   JOURNAL OF NEUROSCIENCE

The impact of the CACNA1C gene polymorphism on frontolimbic function in bipolar disorder

(2011) J Jogia et al.   MOLECULAR PSYCHIATRY

Neocortical excitation/inhibition balance in information processing and social dysfunction

(2011) Ofer Yizhar et al.   NATURE

Amygdala circuitry mediating reversible and bidirectional control of anxiety

(2011) Kay M. Tye et al.   NATURE

Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4

(2011)   NATURE GENETICS

The Effects of CACNA1C Gene Polymorphism on Spatial Working Memory in Both Healthy Controls and Patients with Schizophrenia or Bipolar Disorder

(2011) Qiumei Zhang et al.   NEUROPSYCHOPHARMACOLOGY

Mouse model of Timothy syndrome recapitulates triad of autistic traits

(2011) P. L. Bader et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

L-type calcium channels and psychiatric disorders: A brief review

(2010) Francesco Casamassima et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Genetic Variation in CACNA1C Affects Brain Circuitries Related to Mental Illness

(2010) Kristin L. Bigos et al.   ARCHIVES OF GENERAL PSYCHIATRY

Brain Function in Carriers of a Genome-wide Supported Bipolar Disorder Variant

(2010) Susanne Erk et al.   ARCHIVES OF GENERAL PSYCHIATRY

Mood Disorder Susceptibility Gene CACNA1C Modifies Mood-Related Behaviors in Mice and Interacts with Sex to Influence Behavior in Mice and Diagnosis in Humans

(2010) David T. Dao et al.   BIOLOGICAL PSYCHIATRY

Homeostatic Switch in Hebbian Plasticity and Fear Learning after Sustained Loss of Cav1.2 Calcium Channels

(2010) N. Langwieser et al.   JOURNAL OF NEUROSCIENCE

Ca2+-Dependent Facilitation of Cav1.3 Ca2+ Channels by Densin and Ca2+/Calmodulin-Dependent Protein Kinase II

(2010) M. A. Jenkins et al.   JOURNAL OF NEUROSCIENCE

Antidepressant Effect of Optogenetic Stimulation of the Medial Prefrontal Cortex

(2010) H. E. Covington et al.   JOURNAL OF NEUROSCIENCE

CACNA1C (rs1006737) is associated with schizophrenia

(2010) M Nyegaard et al.   MOLECULAR PSYCHIATRY

The CACNA1C risk variant for bipolar disorder influences limbic activity

(2010) M Wessa et al.   MOLECULAR PSYCHIATRY

Observational fear learning involves affective pain system and Cav1.2 Ca2+ channels in ACC

(2010) Daejong Jeon et al.   NATURE NEUROSCIENCE

Behavioural phenotyping assays for mouse models of autism

(2010) Jill L. Silverman et al.   NATURE REVIEWS NEUROSCIENCE

Dissociable Roles of Prelimbic and Infralimbic Cortices, Ventral Hippocampus and Basolateral Amygdala in the Expression and Extinction of Conditioned Fear

(2010) Demetrio Sierra-Mercado et al.   NEUROPSYCHOPHARMACOLOGY

Differences in responsiveness of mediodorsal thalamic and medial prefrontal cortical neurons to social interaction and systemically administered phencyclidine in rats

(2010) E. Jodo et al.   NEUROSCIENCE

Effects of a CACNA1C genotype on attention networks in healthy individuals

(2010) M. Thimm et al.   PSYCHOLOGICAL MEDICINE

Startle modulation by affective faces

(2009) Andrey P. Anokhin et al.   BIOLOGICAL PSYCHOLOGY

Effect of second-generation antipsychotics on cognition: current issues and future challenges

(2009) S Kristian Hill et al.   Expert Review of Neurotherapeutics

Overlapping and Distinct Neural Systems Code for Subjective Value during Intertemporal and Risky Decision Making

(2009) J. Peters et al.   JOURNAL OF NEUROSCIENCE

The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia

(2009) E K Green et al.   MOLECULAR PSYCHIATRY

Effect of CACNA1C rs1006737 on neural correlates of verbal fluency in healthy individuals

(2009) Axel Krug et al.   NEUROIMAGE

Neurocircuitry of Addiction

(2009) George F Koob et al.   NEUROPSYCHOPHARMACOLOGY

Phencyclidine affects firing activity of basolateral amygdala neurons related to social behavior in rats

(2009) T. Katayama et al.   NEUROSCIENCE

Human Fear Conditioning and Extinction in Neuroimaging: A Systematic Review

(2009) Christina Sehlmeyer et al.   PLoS One

Substance Use Disorders in Schizophrenia--Clinical Implications of Comorbidity

(2009) N. D. Volkow   SCHIZOPHRENIA BULLETIN

Psychiatric comorbidity in young cocaine users: induced versus independent disorders

(2008) M. Jesús Herrero et al.   ADDICTION

Cav1 L-type Ca2+channel signaling complexes in neurons

(2008) Irina Calin-Jageman et al.   JOURNAL OF NEUROCHEMISTRY

Stable Membrane Expression of Postsynaptic CaV1.2 Calcium Channel Clusters Is Independent of Interactions with AKAP79/150 and PDZ Proteins

(2008) V. Di Biase et al.   JOURNAL OF NEUROSCIENCE

L-type voltage-gated calcium channels in conditioned fear: A genetic and pharmacological analysis

(2008) B. C. McKinney et al.   LEARNING & MEMORY

Conditional forebrain deletion of the L-type calcium channel CaV1.2 disrupts remote spatial memories in mice

(2008) J. A. White et al.   LEARNING & MEMORY

Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder

(2008) Manuel A R Ferreira et al.   NATURE GENETICS

Psychological and neural mechanisms of relapse

(2008) J. Stewart   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Stathmin reveals dissociable roles of the basolateral amygdala in parental and social behaviors

(2008) G. Martel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Timothy syndrome mutation differentially affects voltage- and calcium-dependent inactivation of CaV1.2 L-type calcium channels

(2008) C. F. Barrett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA