Rescue of impaired sociability and anxiety-like behavior in adult cacna1c-deficient mice by pharmacologically targeting eIF2α

L-type Ca2+ channels in mood, cognition and addiction: integrating human and rodent studies with a focus on behavioural endophenotypes

(2016) Z. D. Kabir et al.   JOURNAL OF PHYSIOLOGY-LONDON

Understanding how non-coding genomic polymorphisms affect gene expression

(2016) S E Koester et al.   MOLECULAR PSYCHIATRY

Energy deficit in parvalbumin neurons leads to circuit dysfunction, impaired sensory gating and social disability

(2016) Melis Inan et al.   NEUROBIOLOGY OF DISEASE

Unifying Views of Autism Spectrum Disorders: A Consideration of Autoregulatory Feedback Loops

(2016) Caitlin Mullins et al.   NEURON

Functional Characterization of Schizophrenia-Associated Variation in CACNA1C

(2016) Nicole Eckart et al.   PLoS One

Mechanisms of Functional Hypoconnectivity in the Medial Prefrontal Cortex ofMecp2Null Mice

(2015) Michael P. Sceniak et al.   CEREBRAL CORTEX

Common Mechanisms of Excitatory and Inhibitory Imbalance in Schizophrenia and Autism Spectrum Disorders

(2015) R. Gao et al.   CURRENT MOLECULAR MEDICINE

Conditional neuroligin-2 knockout in adult medial prefrontal cortex links chronic changes in synaptic inhibition to cognitive impairments

(2015) J Liang et al.   MOLECULAR PSYCHIATRY

Resolving the neural circuits of anxiety

(2015) Gwendolyn G Calhoon et al.   NATURE NEUROSCIENCE

Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways

(2015)   NATURE NEUROSCIENCE

eIF4E/ Fmr1 double mutant mice display cognitive impairment in addition to ASD-like behaviors

(2015) Thu N. Huynh et al.   NEUROBIOLOGY OF DISEASE

Excitatory/Inhibitory Balance and Circuit Homeostasis in Autism Spectrum Disorders

(2015) Sacha B. Nelson et al.   NEURON

Schizophrenia Related Variants in CACNA1C also Confer Risk of Autism

(2015) Jun Li et al.   PLoS One

Genetic disruption of voltage-gated calcium channels in psychiatric and neurological disorders

(2015) Samuel Heyes et al.   PROGRESS IN NEUROBIOLOGY

Parvalbumin-positive interneurons of the prefrontal cortex support working memory and cognitive flexibility

(2015) Andrew J. Murray et al.   Scientific Reports

Autism-like Deficits in Shank3-Deficient Mice Are Rescued by Targeting Actin Regulators

(2015) Lara J. Duffney et al.   Cell Reports

Specific Downregulation of Hippocampal ATF4 Reveals a Necessary Role in Synaptic Plasticity and Memory

(2015) Silvia Pasini et al.   Cell Reports

Decreased mTOR signaling pathway in human idiopathic autism and in rats exposed to valproic acid

(2015) Chiara Nicolini et al.   Acta Neuropathologica Communications

Translational Control in Synaptic Plasticity and Cognitive Dysfunction

(2014) Shelly A. Buffington et al.   Annual Review of Neuroscience

Loss of MeCP2 From Forebrain Excitatory Neurons Leads to Cortical Hyperexcitation and Seizures

(2014) W. Zhang et al.   JOURNAL OF NEUROSCIENCE

The eIF2  kinase PERK limits the expression of hippocampal metabotropic glutamate receptor-dependent long-term depression

(2014) M. A. Trinh et al.   LEARNING & MEMORY

Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons

(2014) T Yoshimizu et al.   MOLECULAR PSYCHIATRY

Translational control of mGluR-dependent long-term depression and object-place learning by eIF2α

(2014) Gonzalo Viana Di Prisco et al.   NATURE NEUROSCIENCE

Replication of brain function effects of a genome-wide supported psychiatric risk variant in the CACNA1C gene and new multi-locus effects

(2014) Susanne Erk et al.   NEUROIMAGE

Loss of mTOR-Dependent Macroautophagy Causes Autistic-like Synaptic Pruning Deficits

(2014) Guomei Tang et al.   NEURON

Neuronal Voltage-Gated Calcium Channels: Structure, Function, and Dysfunction

(2014) Brett A. Simms et al.   NEURON

A Role for Noncoding Variation in Schizophrenia

(2014) Panos Roussos et al.   Cell Reports

Optogenetic insights on the relationship between anxiety-related behaviors and social deficits

(2014) Stephen A. Allsop et al.   Frontiers in Behavioral Neuroscience

The Dyslexia-Associated Gene Dcdc2 Is Required for Spike-Timing Precision in Mouse Neocortex

(2013) Alicia Che et al.   BIOLOGICAL PSYCHIATRY

Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis

(2013)   LANCET

A rare mutation of CACNA1C in a patient with bipolar disorder and decreased gene expression associated with a bipolar-associated common SNP of CACNA1C in brain

(2013) E S Gershon et al.   MOLECULAR PSYCHIATRY

mTOR complexes in neurodevelopmental and neuropsychiatric disorders

(2013) Mauro Costa-Mattioli et al.   NATURE NEUROSCIENCE

The translation of translational control by FMRP: therapeutic targets for FXS

(2013) Jennifer C Darnell et al.   NATURE NEUROSCIENCE

The impact of a CACNA1C gene polymorphism on learning and hippocampal formation in healthy individuals: A diffusion tensor imaging study

(2013) Bruno Dietsche et al.   NEUROIMAGE

Molecular Mechanisms Mediating a Deficit in Recall of Fear Extinction in Adult Mice Exposed to Cocaine In Utero

(2013) Zeeba D. Kabir et al.   PLoS One

Pharmacological brake-release of mRNA translation enhances cognitive memory

(2013) Carmela Sidrauski et al.   eLife

Female Mecp2+/− mice display robust behavioral deficits on two different genetic backgrounds providing a framework for pre-clinical studies

(2012) Rodney C. Samaco et al.   HUMAN MOLECULAR GENETICS

Forebrain elimination of cacna1c mediates anxiety-like behavior in mice

(2012) A S Lee et al.   MOLECULAR PSYCHIATRY

Autistic-like behaviour in Scn1a +/− mice and rescue by enhanced GABA-mediated neurotransmission

(2012) Sung Han et al.   NATURE

Autism-related deficits via dysregulated eIF4E-dependent translational control

(2012) Christos G. Gkogkas et al.   NATURE

Exaggerated translation causes synaptic and behavioural aberrations associated with autism

(2012) Emanuela Santini et al.   NATURE

Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy

(2012) Mark J. Millan et al.   NATURE REVIEWS DRUG DISCOVERY

CACNA1C (Cav1.2) in the pathophysiology of psychiatric disease

(2012) Shambhu Bhat et al.   PROGRESS IN NEUROBIOLOGY

Effects of the CACNA1C risk allele on neurocognition in patients with schizophrenia and healthy individuals

(2012) Hiroaki Hori et al.   Scientific Reports

Brain-Specific Disruption of the eIF2α Kinase PERK Decreases ATF4 Expression and Impairs Behavioral Flexibility

(2012) Mimi A. Trinh et al.   Cell Reports

The CACNA1C and ANK3 risk alleles impact on affective personality traits and startle reactivity but not on cognition or gating in healthy males

(2011) Panos Roussos et al.   BIPOLAR DISORDERS

The association of genetic variation in CACNA1C with structure and function of a frontotemporal system

(2011) Fei Wang et al.   BIPOLAR DISORDERS

Reduced AKT/mTOR signaling and protein synthesis dysregulation in a Rett syndrome animal model

(2011) Sara Ricciardi et al.   HUMAN MOLECULAR GENETICS

The Anterior Piriform Cortex Is Sufficient for Detecting Depletion of an Indispensable Amino Acid, Showing Independent Cortical Sensory Function

(2011) J. B. Rudell et al.   JOURNAL OF NEUROSCIENCE

Neocortical excitation/inhibition balance in information processing and social dysfunction

(2011) Ofer Yizhar et al.   NATURE

Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome

(2011) Sergiu P Paşca et al.   NATURE MEDICINE

Rapid Synthesis of the X-Linked Mental Retardation Protein OPHN1 Mediates mGluR-Dependent LTD through Interaction with the Endocytic Machinery

(2011) Nael Nadif Kasri et al.   NEURON

Fear-Conditioning Mechanisms Associated with Trait Vulnerability to Anxiety in Humans

(2011) Iole Indovina et al.   NEURON

Enhanced Fear Expression in a Psychopathological Mouse Model of Trait Anxiety: Pharmacological Interventions

(2011) Simone B. Sartori et al.   PLoS One

Regulation of Brain-Derived Neurotrophic Factor Exon IV Transcription through Calcium Responsive Elements in Cortical Neurons

(2011) Fei Zheng et al.   PLoS One

Mouse model of Timothy syndrome recapitulates triad of autistic traits

(2011) P. L. Bader et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Akt Determines Cell Fate Through Inhibition of the PERK-eIF2  Phosphorylation Pathway

(2011) Z. Mounir et al.   Science Signaling

Enhanced Dopamine D1 and BDNF Signaling in the Adult Dorsal Striatum but not Nucleus Accumbens of Prenatal Cocaine Treated Mice

(2011) Thomas F. Tropea et al.   Frontiers in Psychiatry

Genetic Variation in CACNA1C Affects Brain Circuitries Related to Mental Illness

(2010) Kristin L. Bigos et al.   ARCHIVES OF GENERAL PSYCHIATRY

Brain Function in Carriers of a Genome-wide Supported Bipolar Disorder Variant

(2010) Susanne Erk et al.   ARCHIVES OF GENERAL PSYCHIATRY

Behavioural phenotyping assays for mouse models of autism

(2010) Jill L. Silverman et al.   NATURE REVIEWS NEUROSCIENCE

The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia

(2009) E K Green et al.   MOLECULAR PSYCHIATRY

SUnSET, a nonradioactive method to monitor protein synthesis

(2009) Enrico K Schmidt et al.   NATURE METHODS

Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function

(2009) J. Tao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The contribution of failing adult hippocampal neurogenesis to psychiatric disorders

(2008) Gerd Kempermann et al.   CURRENT OPINION IN PSYCHIATRY

Stable Membrane Expression of Postsynaptic CaV1.2 Calcium Channel Clusters Is Independent of Interactions with AKAP79/150 and PDZ Proteins

(2008) V. Di Biase et al.   JOURNAL OF NEUROSCIENCE

Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder

(2008) Manuel A R Ferreira et al.   NATURE GENETICS