L-type calcium channels as drug targets in CNS disorders

CACNA1D De Novo Mutations in Autism Spectrum Disorders Activate Cav1.3 L-Type Calcium Channels

(2015) Alexandra Pinggera et al.   BIOLOGICAL PSYCHIATRY

Targeting the schizophrenia genome: a fast track strategy from GWAS to clinic

(2015) T Lencz et al.   MOLECULAR PSYCHIATRY

Cav1.3 channels control D2-autoreceptor responses via NCS-1 in substantia nigra dopamine neurons

(2014) Elena Dragicevic et al.   BRAIN

Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons

(2014) T Yoshimizu et al.   MOLECULAR PSYCHIATRY

Synaptic, transcriptional and chromatin genes disrupted in autism

(2014) Silvia De Rubeis et al.   NATURE

Mitochondrial oxidant stress in locus coeruleus is regulated by activity and nitric oxide synthase

(2014) Javier Sanchez-Padilla et al.   NATURE NEUROSCIENCE

Antihypertensive Agents and Risk of Parkinson's Disease: A Nationwide Cohort Study

(2014) Yen-Chieh Lee et al.   PLoS One

Basal and β-adrenergic regulation of the cardiac calcium channel CaV1.2 requires phosphorylation of serine 1700

(2014) Ying Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pyrimidine-2,4,6-triones are a new class of voltage-gated L-type Ca2+ channel activators

(2014) Nadine J. Ortner et al.   Nature Communications

Structure–Activity Relationship of N,N′-Disubstituted Pyrimidinetriones as CaV1.3 Calcium Channel-Selective Antagonists for Parkinson’s Disease

(2013) Soosung Kang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Temperature-Sensitive Cav1.2 Calcium Channels Support Intrinsic Firing of Pyramidal Neurons and Provide a Target for the Treatment of Febrile Seizures

(2013) D. Radzicki et al.   JOURNAL OF NEUROSCIENCE

Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis

(2013)   LANCET

Side pockets provide the basis for a new mechanism of Kv channel–specific inhibition

(2013) Stefanie Marzian et al.   Nature Chemical Biology

Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension

(2013) Elena A B Azizan et al.   NATURE GENETICS

Somatic and germline CACNA1D calcium channel mutations in aldosterone-producing adenomas and primary aldosteronism

(2013) Ute I Scholl et al.   NATURE GENETICS

Genome-wide association analysis identifies 13 new risk loci for schizophrenia

(2013) Stephan Ripke et al.   NATURE GENETICS

Phosphorylation sites required for regulation of cardiac calcium channels in the fight-or-flight response

(2013) Y. Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Use of Calcium Channel Blockers and Parkinson’s Disease

(2012) Björn Pasternak et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Exploring the dominant role of Cav1 channels in signalling to the nucleus

(2012) Huan Ma et al.   BIOSCIENCE REPORTS

Structural determinants of CaV1.3 L-type calcium channel gating

(2012) Andreas Lieb et al.   Channels

Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations

(2012) Brian J. O’Roak et al.   NATURE

De Novo Gene Disruptions in Children on the Autistic Spectrum

(2012) Ivan Iossifov et al.   NEURON

CaV1.3-selective L-type calcium channel antagonists as potential new therapeutics for Parkinson's disease

(2012) Soosung Kang et al.   Nature Communications

Long QT, syndactyly, joint contractures, stroke and novel CACNA1C mutation: Expanding the spectrum of Timothy syndrome

(2011) Jane Gillis et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

The L-type channel antagonist isradipine is neuroprotective in a mouse model of Parkinson's disease

(2011) E. Ilijic et al.   NEUROBIOLOGY OF DISEASE

The Origins of Oxidant Stress in Parkinson's Disease and Therapeutic Strategies

(2010) Dalton James Surmeier et al.   ANTIOXIDANTS & REDOX SIGNALING

Mood Disorder Susceptibility Gene CACNA1C Modifies Mood-Related Behaviors in Mice and Interacts with Sex to Influence Behavior in Mice and Diagnosis in Humans

(2010) David T. Dao et al.   BIOLOGICAL PSYCHIATRY

Loss of Cav1.3 Channels Reveals the Critical Role of L-Type and BK Channel Coupling in Pacemaking Mouse Adrenal Chromaffin Cells

(2010) A. Marcantoni et al.   JOURNAL OF NEUROSCIENCE

L-Type Voltage-Gated Ca2+ Channels: A Single Molecular Switch for Long-Term Potentiation/Long-Term Depression-Like Plasticity and Activity-Dependent Metaplasticity in Humans

(2010) K. Wankerl et al.   JOURNAL OF NEUROSCIENCE

Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1

(2010) Jaime N. Guzman et al.   NATURE

L-Type Calcium Channel C Terminus Autoregulates Transcription

(2009) Elizabeth Schroder et al.   CIRCULATION RESEARCH

CaV1.3 L-type Ca2+ channels modulate depression-like behaviour in mice independent of deaf phenotype

(2009) Perrine Busquet et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Robust Pacemaking in Substantia Nigra Dopaminergic Neurons

(2009) J. N. Guzman et al.   JOURNAL OF NEUROSCIENCE

Modulation of Voltage- and Ca2+-dependent Gating of CaV1.3 L-type Calcium Channels by Alternative Splicing of a C-terminal Regulatory Domain

(2008) Anamika Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantification of isradipine in human plasma using LC–MS/MS for pharmacokinetic and bioequivalence study

(2008) Jin-Hee Park et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Role of L-type Ca2+ channel isoforms in the extinction of conditioned fear

(2008) P. Busquet et al.   LEARNING & MEMORY

Selective and protracted effect of nifedipine on fear memory extinction correlates with induced stress response

(2008) R. Waltereit et al.   LEARNING & MEMORY

L-type voltage-gated calcium channels in conditioned fear: A genetic and pharmacological analysis

(2008) B. C. McKinney et al.   LEARNING & MEMORY

Use of antihypertensives and the risk of Parkinson disease

(2008) C. Becker et al.   NEUROLOGY

The Timothy syndrome mutation differentially affects voltage- and calcium-dependent inactivation of CaV1.2 L-type calcium channels

(2008) C. F. Barrett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA