Targeting voltage-gated calcium channels in neurological and psychiatric diseases

CACNA1D De Novo Mutations in Autism Spectrum Disorders Activate Cav1.3 L-Type Calcium Channels

(2015) Alexandra Pinggera et al.   BIOLOGICAL PSYCHIATRY

L-type calcium channels contribute to 5-HT3-receptor-evoked CaMKIIα and ERK activation and induction of emesis in the least shrew (Cryptotis parva)

(2015) Tarun E. Hutchinson et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Small Organic Molecule Disruptors of Cav3.2 - USP5 Interactions Reverse Inflammatory and Neuropathic Pain

(2015) Vinicius M Gadotti et al.   Molecular Pain

Erratum: Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons

(2015) T Yoshimizu et al.   MOLECULAR PSYCHIATRY

A randomized double-blind, placebo-, and active-controlled study of T-type calcium channel blocker ABT-639 in patients with diabetic peripheral neuropathic pain

(2015) Dan Ziegler et al.   PAIN

Rare variants in neuronal excitability genes influence risk for bipolar disorder

(2015) Seth A. Ament et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Experience from therapeutic drug monitoring and gender aspects of gabapentin and pregabalin in clinical practice

(2015) Cecilie Johannessen Landmark et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Extending the amygdala in theories of threat processing

(2015) Andrew S. Fox et al.   TRENDS IN NEUROSCIENCES

Abnormal cortical synaptic transmission in CaV2.1 knockin mice with the S218L missense mutation which causes a severe familial hemiplegic migraine syndrome in humans

(2015) Dania Vecchia et al.   Frontiers in Cellular Neuroscience

Characterization of Novel Cannabinoid Based T-Type Calcium Channel Blockers with Analgesic Effects

(2014) Chris Bladen et al.   ACS Chemical Neuroscience

Evaluating State Dependence and Subtype Selectivity of Calcium Channel Modulators in Automated Electrophysiology Assays

(2014) Yuri A. Kuryshev et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Cav1.3 channels control D2-autoreceptor responses via NCS-1 in substantia nigra dopamine neurons

(2014) Elena Dragicevic et al.   BRAIN

In vivoprofiling of seven common opioids for antinociception, constipation and respiratory depression: no two opioids have the same profile

(2014) A Kuo et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Paths to Neurodegeneration in Genetic Parkinson's Disease

(2014) Omar Abdel-Salam   CNS & Neurological Disorders-Drug Targets

Pharmacotherapy of focal epilepsy

(2014) Anand Iyer et al.   EXPERT OPINION ON PHARMACOTHERAPY

CACNA1B mutation is linked to unique myoclonus-dystonia syndrome

(2014) J. L. Groen et al.   HUMAN MOLECULAR GENETICS

Pharmacological Treatment of Parkinson Disease

(2014) Barbara S. Connolly et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Episodic ataxia type 2: phenotype characteristics of a novel CACNA1A mutation and review of the literature

(2014) Wolfgang Nachbauer et al.   JOURNAL OF NEUROLOGY

Cav1.2 and Cav1.3 L-type calcium channels regulate dopaminergic firing activity in the mouse ventral tegmental area

(2014) Yudan Liu et al.   JOURNAL OF NEUROPHYSIOLOGY

Distinct roles for Cav2.1–2.3 in activity-dependent synaptic dynamics

(2014) Ulises M. Ricoy et al.   JOURNAL OF NEUROPHYSIOLOGY

Z944: A first in class T-type calcium channel modulator for the treatment of pain

(2014) M Lee   JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM

NMP-7 Inhibits Chronic Inflammatory and Neuropathic Pain via Block of Cav3.2 T-type Calcium Channels and Activation of CB2 Receptors

(2014) N Daniel Berger et al.   Molecular Pain

Regulating excitability of peripheral afferents: emerging ion channel targets

(2014) Stephen G Waxman et al.   NATURE NEUROSCIENCE

Replication of brain function effects of a genome-wide supported psychiatric risk variant in the CACNA1C gene and new multi-locus effects

(2014) Susanne Erk et al.   NEUROIMAGE

The Deubiquitinating Enzyme USP5 Modulates Neuropathic and Inflammatory Pain by Enhancing Cav3.2 Channel Activity

(2014) Agustin García-Caballero et al.   NEURON

Pharmacological Correction of Gating Defects in the Voltage-Gated Ca v 2.1 Ca 2+ Channel due to a Familial Hemiplegic Migraine Mutation

(2014) Akira Inagaki et al.   NEURON

Age-Related Homeostatic Midchannel Proteolysis of Neuronal L-type Voltage-Gated Ca2+ Channels

(2014) Ioannis E. Michailidis et al.   NEURON

Neuronal Voltage-Gated Calcium Channels: Structure, Function, and Dysfunction

(2014) Brett A. Simms et al.   NEURON

Postherpetic Neuralgia

(2014) Robert W. Johnson et al.   NEW ENGLAND JOURNAL OF MEDICINE

T-type Ca2+ channels in absence epilepsy

(2014) Eunji Cheong et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

1,4-Dihydropyridine derivatives with T-type calcium channel blocking activity attenuate inflammatory and neuropathic pain

(2014) Chris Bladen et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Calcium-Permeable Ion Channels in Pain Signaling

(2014) Emmanuel Bourinet et al.   PHYSIOLOGICAL REVIEWS

Rare Mutations of CACNB2 Found in Autism Spectrum Disease-Affected Families Alter Calcium Channel Function

(2014) Alexandra F. S. Breitenkamp et al.   PLoS One

Rebound burst firing in the reticular thalamus is not essential for pharmacological absence seizures in mice

(2014) S. E. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional exofacially tagged N-type calcium channels elucidate the interaction with auxiliary  2 -1 subunits

(2014) J. S. Cassidy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pyrimidine-2,4,6-triones are a new class of voltage-gated L-type Ca2+ channel activators

(2014) Nadine J. Ortner et al.   Nature Communications

Alteration in basal and depolarization induced transcriptional network in iPSC derived neurons from Timothy syndrome

(2014) Yuan Tian et al.   Genome Medicine

Pilot investigation of isradipine in the treatment of bipolar depression motivated by genome-wide association

(2013) Michael J Ostacher et al.   BIPOLAR DISORDERS

Parkinson’s disease is associated with altered expression of CaV1 channels and calcium-binding proteins

(2013) Michael J. Hurley et al.   BRAIN

Retracted: Cav2.3 (R-type) calcium channels are critical for mediating anticonvulsive and neuroprotective properties of lamotrigine in vivo

(2013) Maxine Dibué et al.   EPILEPSIA

Association of rs1006737 inCACNA1Cwith alterations in prefrontal activation and fronto-hippocampal connectivity

(2013) Frieder M. Paulus et al.   HUMAN BRAIN MAPPING

Temperature-Sensitive Cav1.2 Calcium Channels Support Intrinsic Firing of Pyramidal Neurons and Provide a Target for the Treatment of Febrile Seizures

(2013) D. Radzicki et al.   JOURNAL OF NEUROSCIENCE

Mechanisms by which aCACNA1Hmutation in epilepsy patients increases seizure susceptibility

(2013) Veit-Simon Eckle et al.   JOURNAL OF PHYSIOLOGY-LONDON

Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis

(2013)   LANCET

Spinal Morphine but not Ziconotide or Gabapentin Analgesia is Affected by Alternative Splicing of Voltage-Gated Calcium Channel Cav2.2 Pre-mRNA

(2013) Yu-Qiu Jiang et al.   Molecular Pain

Analgesic Effect of a Mixed T-Type Channel Inhibitor/CB2 Receptor Agonist

(2013) Vinicius M Gadotti et al.   Molecular Pain

A rare mutation of CACNA1C in a patient with bipolar disorder and decreased gene expression associated with a bipolar-associated common SNP of CACNA1C in brain

(2013) E S Gershon et al.   MOLECULAR PSYCHIATRY

Neuronal vulnerability, pathogenesis, and Parkinson's disease

(2013) David Sulzer et al.   MOVEMENT DISORDERS

Phase II safety, tolerability, and dose selection study of isradipine as a potential disease-modifying intervention in early Parkinson's disease (STEADY-PD)

(2013)   MOVEMENT DISORDERS

Timothy syndrome is associated with activity-dependent dendritic retraction in rodent and human neurons

(2013) Jocelyn F Krey et al.   NATURE NEUROSCIENCE

BLA to vHPC Inputs Modulate Anxiety-Related Behaviors

(2013) Ada C. Felix-Ortiz et al.   NEURON

Intrathecal P/Q- and R-type calcium channel blockade of spinal substance P release and c-Fos expression

(2013) Tetsuji Terashima et al.   NEUROPHARMACOLOGY

Synthesis and Evaluation of 1,4-Dihydropyridine Derivatives with Calcium Channel Blocking Activity

(2013) Chris Bladen et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Association between Genetic Polymorphisms in Cav2.3 (R-type) Ca2+ Channels and Fentanyl Sensitivity in Patients Undergoing Painful Cosmetic Surgery

(2013) Soichiro Ide et al.   PLoS One

A Mutation in CABP2 , Expressed in Cochlear Hair Cells, Causes Autosomal-Recessive Hearing Impairment

(2012) Isabelle Schrauwen et al.   AMERICAN JOURNAL OF HUMAN GENETICS

α-Synuclein oligomers and clinical implications for Parkinson disease

(2012) Lorraine V. Kalia et al.   ANNALS OF NEUROLOGY

T-type calcium channels in burst-firing, network synchrony, and epilepsy

(2012) Stuart M. Cain et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The α2δ subunits of voltage-gated calcium channels

(2012) Annette C. Dolphin   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Alternative splicing: Functional diversity among voltage-gated calcium channels and behavioral consequences

(2012) Diane Lipscombe et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Discovery and evaluation of selective N-type calcium channel blockers: 6-Unsubstituted-1,4-dihydropyridine-5-carboxylic acid derivatives

(2012) Takashi Yamamoto et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A novel series of pyrazolylpiperidine N-type calcium channel blockers

(2012) Nalin L. Subasinghe et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Inhibition of human recombinant T-type calcium channels byN-arachidonoyl 5-HT

(2012) Andrew J Gilmore et al.   BRITISH JOURNAL OF PHARMACOLOGY

CaV1 and CaV2 Channels Engage Distinct Modes of Ca2+ Signaling to Control CREB-Dependent Gene Expression

(2012) Damian G. Wheeler et al.   CELL

Cav1.3 L-type Ca2+channels mediate long-term adaptation in dopamine D2L-mediated GluA1 trafficking in the dorsal striatum following cocaine exposure

(2012) Kathryn Schierberl et al.   Channels

Chronic pregabalin inhibits synaptic transmission between rat dorsal root ganglion and dorsal horn neurons in culture

(2012) Janek Hendrich et al.   Channels

Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy: Initial monotherapy outcomes at 12 months

(2012) Tracy A. Glauser et al.   EPILEPSIA

Aminopiperidine Sulfonamide Cav2.2 Channel Inhibitors for the Treatment of Chronic Pain

(2012) Pengcheng P. Shao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Exposure to predator odor and resulting anxiety enhances the expression of the α2δ subunit of voltage-sensitive calcium channels in the amygdala

(2012) Carla Nasca et al.   JOURNAL OF NEUROCHEMISTRY

Dual Control of Dopamine Synthesis and Release by Presynaptic and Postsynaptic Dopamine D2 Receptors

(2012) A. Anzalone et al.   JOURNAL OF NEUROSCIENCE

Antiepileptic Drugs 2012: Recent Advances and Trends

(2012) Joseph I. Sirven et al.   MAYO CLINIC PROCEEDINGS

Forebrain elimination of cacna1c mediates anxiety-like behavior in mice

(2012) A S Lee et al.   MOLECULAR PSYCHIATRY

Erratum: Calcium channel auxiliary α2δ and β subunits: trafficking and one step beyond

(2012) Annette C. Dolphin   NATURE REVIEWS NEUROSCIENCE

Cilnidipine, an L/N-type calcium channel blocker prevents acquisition and expression of ethanol-induced locomotor sensitization in mice

(2012) Pravinkumar Bhutada et al.   NEUROSCIENCE LETTERS

Functional Upregulation of Ca2+ -Activated K+ Channels in the Development of Substantia Nigra Dopamine Neurons

(2012) José A. Ramírez-Latorre   PLoS One

T-Type Calcium Channel Blockers That Attenuate Thalamic Burst Firing and Suppress Absence Seizures

(2012) E. Tringham et al.   Science Translational Medicine

CaV1.3-selective L-type calcium channel antagonists as potential new therapeutics for Parkinson's disease

(2012) Soosung Kang et al.   Nature Communications

Support for calcium channel gene defects in autism spectrum disorders

(2012) Ake Tzu-Hui Lu et al.   Molecular Autism

Surviving Drug Addiction: The Effect of Treatment and Abstinence on Mortality

(2011) Christy K. Scott et al.   AMERICAN JOURNAL OF PUBLIC HEALTH

A-1048400 is a novel, orally active, state-dependent neuronal calcium channel blocker that produces dose-dependent antinociception without altering hemodynamic function in rats

(2011) Victoria E. Scott et al.   BIOCHEMICAL PHARMACOLOGY

The association of genetic variation in CACNA1C with structure and function of a frontotemporal system

(2011) Fei Wang et al.   BIPOLAR DISORDERS

Spontaneous epileptiform discharges in a mouse model of Alzheimer's disease are suppressed by antiepileptic drugs that block sodium channels

(2011) Sofya Ziyatdinova et al.   EPILEPSY RESEARCH

A Cav3.2/Syntaxin-1A Signaling Complex Controls T-type Channel Activity and Low-threshold Exocytosis

(2011) Norbert Weiss et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modulation of subthalamic T-type Ca2+ channels remedies locomotor deficits in a rat model of Parkinson disease

(2011) Chun-Hwei Tai et al.   JOURNAL OF CLINICAL INVESTIGATION

Cav1.2 L-Type Ca2+ Channels Mediate Cocaine-Induced GluA1 Trafficking in the Nucleus Accumbens, a Long-Term Adaptation Dependent on Ventral Tegmental Area Cav1.3 Channels

(2011) K. Schierberl et al.   JOURNAL OF NEUROSCIENCE

Minimal alterations in T-type calcium channel gating markedly modify physiological firing dynamics

(2011) A. Tscherter et al.   JOURNAL OF PHYSIOLOGY-LONDON

Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca2+ channel complex

(2011) Joel M Brittain et al.   NATURE MEDICINE

CaV2.3 Channels Are Critical for Oscillatory Burst Discharges in the Reticular Thalamus and Absence Epilepsy

(2011) Tariq Zaman et al.   NEURON

A novel slow-inactivation-specific ion channel modulator attenuates neuropathic pain

(2011) Michael E. Hildebrand et al.   PAIN

The CaV3.3 calcium channel is the major sleep spindle pacemaker in thalamus

(2011) S. Astori et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T-type calcium channels contribute to colonic hypersensitivity in a rat model of irritable bowel syndrome

(2011) F. Marger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Voltage-Gated Calcium Channels

(2011) W. A. Catterall   Cold Spring Harbor Perspectives in Biology

Synaptic plasticity in the mesolimbic system

(2010) Billy T. Chen et al.   Annals of the New York Academy of Sciences

The anti-allodynic α2δ ligand pregabalin inhibits the trafficking of the calcium channel α2δ-1 subunit to presynaptic terminalsin vivo: Figure 1

(2010) Claudia S. Bauer et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Mood Disorder Susceptibility Gene CACNA1C Modifies Mood-Related Behaviors in Mice and Interacts with Sex to Influence Behavior in Mice and Diagnosis in Humans

(2010) David T. Dao et al.   BIOLOGICAL PSYCHIATRY

Contributions of T-type calcium channel isoforms to neuronal firing

(2010) Stuart M. Cain et al.   Channels

Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update

(2010) Karen Nuytemans et al.   HUMAN MUTATION

Molecular Switch from L-Type Cav1.3 to Cav1.2 Ca2+ Channel Signaling Underlies Long-Term Psychostimulant-Induced Behavioral and Molecular Plasticity

(2010) T. P. Giordano et al.   JOURNAL OF NEUROSCIENCE

The  2  Ligand Gabapentin Inhibits the Rab11-Dependent Recycling of the Calcium Channel Subunit  2 -2

(2010) A. Tran-Van-Minh et al.   JOURNAL OF NEUROSCIENCE

A molecular basis for the increased vulnerability of substantia nigra dopamine neurons in aging and Parkinson's disease

(2010) C. Savio Chan et al.   MOVEMENT DISORDERS

Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1

(2010) Jaime N. Guzman et al.   NATURE

The Cavβ subunit prevents RFP2-mediated ubiquitination and proteasomal degradation of L-type channels

(2010) Christophe Altier et al.   NATURE NEUROSCIENCE

Loss of Cav1.3 (CACNA1D) function in a human channelopathy with bradycardia and congenital deafness

(2010) Shahid M Baig et al.   NATURE NEUROSCIENCE

Ion Channel Voltage Sensors: Structure, Function, and Pathophysiology

(2010) William A. Catterall   NEURON

Review: The neuropathology of drug abuse

(2010) A. Büttner   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

KST5468, a new T-type calcium channel antagonist, has an antinociceptive effect on inflammatory and neuropathic pain models

(2010) Min Ju Lee et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Safety and efficacy of intrathecal ziconotide in the management of severe chronic pain

(2010) Howard Howard Smith   Therapeutics and Clinical Risk Management

A novel Nav1.7 mutation producing carbamazepine-responsive erythromelalgia

(2009) Tanya Z. Fischer et al.   ANNALS OF NEUROLOGY

A Fluorescence-Based High-Throughput Screening Assay for the Identification of T-Type Calcium Channel Blockers

(2009) Francesco Belardetti et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Scaffold-based design and synthesis of potent N-type calcium channel blockers

(2009) Gerald W. Zamponi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Cellular and Molecular Mechanisms of Pain

(2009) Allan I. Basbaum et al.   CELL

Pathophysiology and Treatment of Psychosis in Parkinson’s Disease

(2009) Laura B Zahodne et al.   DRUGS & AGING

Zonisamide block of cloned human T-type voltage-gated calcium channels

(2009) Nora Matar et al.   EPILEPSY RESEARCH

Five different profiles of dihydropyridines in blocking T-type Ca2+ channel subtypes (Cav3.1 (α1G), Cav3.2 (α1H), and Cav3.3 (α1I)) expressed in Xenopus oocytes

(2009) Taiji Furukawa et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

CaV1.3 L-type Ca2+ channels modulate depression-like behaviour in mice independent of deaf phenotype

(2009) Perrine Busquet et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Robust Pacemaking in Substantia Nigra Dopaminergic Neurons

(2009) J. N. Guzman et al.   JOURNAL OF NEUROSCIENCE

Cav1.3 Channel Voltage Dependence, Not Ca2+ Selectivity, Drives Pacemaker Activity and Amplifies Bursts in Nigral Dopamine Neurons

(2009) I. Putzier et al.   JOURNAL OF NEUROSCIENCE

A Cav3.2 T-Type Calcium Channel Point Mutation Has Splice-Variant-Specific Effects on Function and Segregates with Seizure Expression in a Polygenic Rat Model of Absence Epilepsy

(2009) K. L. Powell et al.   JOURNAL OF NEUROSCIENCE

Genetic Enhancement of Thalamocortical Network Activity by Elevating  1G-Mediated Low-Voltage-Activated Calcium Current Induces Pure Absence Epilepsy

(2009) W. L. Ernst et al.   JOURNAL OF NEUROSCIENCE

The Increased Trafficking of the Calcium Channel Subunit  2 -1 to Presynaptic Terminals in Neuropathic Pain Is Inhibited by the  2  Ligand Pregabalin

(2009) C. S. Bauer et al.   JOURNAL OF NEUROSCIENCE

Neurocircuitry of Addiction

(2009) George F Koob et al.   NEUROPSYCHOPHARMACOLOGY

Role of voltage-gated calcium channels in epilepsy

(2009) Gerald W. Zamponi et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Intrathecal Ziconotide for Neuropathic Pain: A Review

(2009) Richard L. Rauck et al.   Pain Practice

Optimization of Cav1.2 screening with an automated planar patch clamp platform

(2009) Bharathi Balasubramanian et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

A High-Throughput Assay for Evaluating State Dependence and Subtype Selectivity of Cav2 Calcium Channel Inhibitors

(2008) Ge Dai et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Upregulation of the T-Type Calcium Current in Small Rat Sensory Neurons After Chronic Constrictive Injury of the Sciatic Nerve

(2008) Miljen M. Jagodic et al.   JOURNAL OF NEUROPHYSIOLOGY

A Blocker of N- and T-type Voltage-Gated Calcium Channels Attenuates Ethanol-Induced Intoxication, Place Preference, Self-Administration, and Reinstatement

(2008) P. M. Newton et al.   JOURNAL OF NEUROSCIENCE

Zonisamide Suppresses Pain Symptoms of Formalin-Induced Inflammatory and Streptozotocin-Induced Diabetic Neuropathy

(2008) Mitsuo Tanabe et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Expression and 1,4-Dihydropyridine-Binding Properties of Brain L-Type Calcium Channel Isoforms

(2008) M. J. Sinnegger-Brauns et al.   MOLECULAR PHARMACOLOGY

Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder

(2008) Manuel A R Ferreira et al.   NATURE GENETICS