Chk1 inhibits replication factory activation but allows dormant origin firing in existing factories

Clusters, factories and domains

(2010) Peter J. Gillespie et al.   CELL CYCLE

Cdc25 Phosphatases Are Required for Timely Assembly of CDK1-Cyclin B at the G2/M Transition

(2010) Oleg Timofeev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Replication factory activation can be decoupled from the replication timing program by modulating Cdk levels

(2010) Alexander M. Thomson et al.   JOURNAL OF CELL BIOLOGY

DNA damage response and tumorigenesis in Mcm2-deficient mice

(2010) D Kunnev et al.   ONCOGENE

Cdk2 Is Required for p53-Independent G2/M Checkpoint Control

(2010) Jon H. Chung et al.   PLoS Genetics

Analysis of replication factories in human cells by super-resolution light microscopy

(2009) Zoltan Cseresnyes et al.   BMC CELL BIOLOGY

Replicon Dynamics, Dormant Origin Firing, and Terminal Fork Integrity after Double-Strand Break Formation

(2009) Ylli Doksani et al.   CELL

Defining replication origin efficiency using DNA fiber assays

(2009) Sandie Tuduri et al.   CHROMOSOME RESEARCH

A model for DNA replication showing how dormant origins safeguard against replication fork failure

(2009) J Julian Blow et al.   EMBO REPORTS

DNA damage induces Chk1-dependent threonine-160 phosphorylation and activation of Cdk2

(2009) E Bourke et al.   ONCOGENE

Cdk1 and Cdk2 activity levels determine the efficiency of replication origin firing in Xenopus

(2008) Liliana Krasinska et al.   EMBO JOURNAL

Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication

(2008) Arkaitz Ibarra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global Reorganization of Replication Domains During Embryonic Stem Cell Differentiation

(2008) Ichiro Hiratani et al.   PLOS BIOLOGY