Checkpoint-dependent and independent roles of the Werner syndrome protein in preserving genome integrity in response to mild replication stress

Stepwise Activation of the ATR Signaling Pathway upon Increasing Replication Stress Impacts Fragile Site Integrity

(2013) Stéphane Koundrioukoff et al.   PLoS Genetics

Perturbed replication induced genome wide or at common fragile sites is differently managed in the absence of WRN

(2012) I. Murfuni et al.   CARCINOGENESIS

Distinct functions of human RECQ helicases WRN and BLM in replication fork recovery and progression after hydroxyurea-induced stalling

(2012) Julia M. Sidorova et al.   DNA REPAIR

An N-terminal acidic region of Sgs1 interacts with Rpa70 and recruits Rad53 kinase to stalled forks

(2012) Anna Maria Hegnauer et al.   EMBO JOURNAL

The RAD9–RAD1–HUS1 (9.1.1) complex interacts with WRN and is crucial to regulate its response to replication fork stalling

(2011) P Pichierri et al.   ONCOGENE

Roles of Werner syndrome protein in protection of genome integrity

(2010) Marie L. Rossi et al.   DNA REPAIR

ATR and ATM differently regulate WRN to prevent DSBs at stalled replication forks and promote replication fork recovery

(2010) Francesca Ammazzalorso et al.   EMBO JOURNAL

Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis

(2010) Yoshitami Hashimoto et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Chk1 promotes replication fork progression by controlling replication initiation

(2010) E. Petermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA structure and the Werner protein modulate human DNA polymerase delta-dependent replication dynamics within the common fragile site FRA16D

(2009) Sandeep N. Shah et al.   NUCLEIC ACIDS RESEARCH

Werner syndrome helicase activity is essential in maintaining fragile site stability

(2008) Livia Maria Pirzio et al.   JOURNAL OF CELL BIOLOGY

Replication fork stalling in WRN-deficient cells is overcome by prompt activation of a MUS81-dependent pathway

(2008) Annapaola Franchitto et al.   JOURNAL OF CELL BIOLOGY