The Dimeric Architecture of Checkpoint Kinases Mec1ATRand Tel1ATMReveal a Common Structural Organization

Structure of the human dimeric ATM kinase

(2016) Wilson C. Y. Lau et al.   CELL CYCLE

Molecular Basis of the Rapamycin Insensitivity of Target Of Rapamycin Complex 2

(2015) Christl Gaubitz et al.   MOLECULAR CELL

A network of SMG-8, SMG-9 and SMG-1 C-terminal insertion domain regulates UPF1 substrate recruitment and phosphorylation

(2015) Aurélien Deniaud et al.   NUCLEIC ACIDS RESEARCH

Architecture of human mTOR complex 1

(2015) C. H. S. Aylett et al.   SCIENCE

Structures of SMG1-UPFs Complexes: SMG1 Contributes to Regulate UPF2-Dependent Activation of UPF1 in NMD

(2014) Roberto Melero et al.   STRUCTURE

Lagging strand maturation factor Dna2 is a component of the replication checkpoint initiation machinery

(2013) S. Kumar et al.   GENES & DEVELOPMENT

mTOR kinase structure, mechanism and regulation

(2013) Haijuan Yang et al.   NATURE

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

Prevention of overfitting in cryo-EM structure determination

(2012) Sjors H W Scheres et al.   NATURE METHODS

Dpb11 coordinates Mec1 kinase activation with cell cycle-regulated Rad9 recruitment

(2011) Boris Pfander et al.   EMBO JOURNAL

Regulation of Rad51 function by phosphorylation

(2011) Sonja Flott et al.   EMBO REPORTS

The nonsense-mediated mRNA decay SMG-1 kinase is regulated by large-scale conformational changes controlled by SMG-8

(2011) E. Arias-Palomo et al.   GENES & DEVELOPMENT

The Unstructured C-terminal Tail of Yeast Dpb11 (Human TopBP1) Protein Is Dispensable for DNA Replication and the S Phase Checkpoint but Required for the G2/M Checkpoint

(2011) Vasundhara M. Navadgi-Patil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Bayesian View on Cryo-EM Structure Determination

(2011) Sjors H.W. Scheres   JOURNAL OF MOLECULAR BIOLOGY

ATR Autophosphorylation as a Molecular Switch for Checkpoint Activation

(2011) Shizhou Liu et al.   MOLECULAR CELL

Tel1ATM and Rad3ATR kinases promote Ccq1-Est1 interaction to maintain telomeres in fission yeast

(2011) Bettina A Moser et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the Human mTOR Complex I and Its Implications for Rapamycin Inhibition

(2010) Calvin K. Yip et al.   MOLECULAR CELL

ATM Activation by Oxidative Stress

(2010) Z. Guo et al.   SCIENCE

A tale of two tails: Activation of DNA damage checkpoint kinase Mec1/ATR by the 9-1-1 clamp and by Dpb11/TopBP1

(2009) Vasundhara M. Navadgi-Patil et al.   DNA REPAIR

Emerging common themes in regulation of PIKKs and PI3Ks

(2009) Harri Lempiäinen et al.   EMBO JOURNAL

mTOR Ser-2481 Autophosphorylation Monitors mTORC-specific Catalytic Activity and Clarifies Rapamycin Mechanism of Action

(2009) Ghada A. Soliman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats

(2009) Bancinyane L. Sibanda et al.   NATURE

SPIDER image processing for single-particle reconstruction of biological macromolecules from electron micrographs

(2009) Tanvir R Shaikh et al.   Nature Protocols

TopBP1 activates ATR through ATRIP and a PIKK regulatory domain

(2008) D. A. Mordes et al.   GENES & DEVELOPMENT

Yeast DNA Replication Protein Dpb11 Activates the Mec1/ATR Checkpoint Kinase

(2008) Vasundhara M. Navadgi-Patil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Tel1/ATM N-Terminal Motif, TAN, Is Essential for Telomere Length Maintenance and a DNA Damage Response

(2008) J. J. Seidel et al.   MOLECULAR AND CELLULAR BIOLOGY

Dpb11 activates the Mec1-Ddc2 complex

(2008) D. A. Mordes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cryo-EM Structure of the DNA-Dependent Protein Kinase Catalytic Subunit at Subnanometer Resolution Reveals α Helices and Insight into DNA Binding

(2008) Dewight R. Williams et al.   STRUCTURE