Activation of the ATR kinase by the RPA-binding protein ETAA1

Probing the Mec1ATRCheckpoint Activation Mechanism with Small Peptides

(2015) Paulina H. Wanrooij et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphoproteomics Reveals Distinct Modes of Mec1/ATR Signaling during DNA Replication

(2015) Francisco Meirelles Bastos de Oliveira et al.   MOLECULAR CELL

High-throughput phosphoproteomics reveals in vivo insulin signaling dynamics

(2015) Sean J Humphrey et al.   NATURE BIOTECHNOLOGY

Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer

(2015) Erica J Childs et al.   NATURE GENETICS

Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links

(2015) M. Raschle et al.   SCIENCE

Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ

(2014) Jürgen Cox et al.   MOLECULAR & CELLULAR PROTEOMICS

ProteomeXchange provides globally coordinated proteomics data submission and dissemination

(2014) Juan A Vizcaíno et al.   NATURE BIOTECHNOLOGY

Targeting ATR in DNA damage response and cancer therapeutics

(2013) Emmanouil Fokas et al.   CANCER TREATMENT REVIEWS

ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA

(2013) Luis Ignacio Toledo et al.   CELL

Lagging strand maturation factor Dna2 is a component of the replication checkpoint initiation machinery

(2013) S. Kumar et al.   GENES & DEVELOPMENT

ATR phosphorylates SMARCAL1 to prevent replication fork collapse

(2013) F. B. Couch et al.   GENES & DEVELOPMENT

A Role for the MRN Complex in ATR Activation via TOPBP1 Recruitment

(2013) Anja M. Duursma et al.   MOLECULAR CELL

Causes and consequences of replication stress

(2013) Michelle K. Zeman et al.   NATURE CELL BIOLOGY

The ATM protein kinase: regulating the cellular response to genotoxic stress and more

(2013) Yosef Shiloh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

DNA Damage Sensing by the ATM and ATR Kinases

(2013) A. Marechal et al.   Cold Spring Harbor Perspectives in Biology

Two Distinct Modes of ATR Activation Orchestrated by Rad17 and Nbs1

(2013) Bunsyo Shiotani et al.   Cell Reports

An Essential Function for the ATR-Activation-Domain (AAD) of TopBP1 in Mouse Development and Cellular Senescence

(2013) Zhong-Wei Zhou et al.   PLoS Genetics

Human RNF169 is a negative regulator of the ubiquitin-dependent response to DNA double-strand breaks

(2012) Maria Poulsen et al.   JOURNAL OF CELL BIOLOGY

Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response

(2012) Petra Beli et al.   MOLECULAR CELL

DVC1 (C1orf124) is a DNA damage–targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks

(2012) Anna Mosbech et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Double-Strand Break End Resection and Repair Pathway Choice

(2011) Lorraine S. Symington et al.   Annual Review of Genetics

53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress

(2011) Claudia Lukas et al.   NATURE CELL BIOLOGY

Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations

(2011) Chen Wu et al.   NATURE GENETICS

A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations

(2011) Luis I Toledo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A DNA Damage Response Screen Identifies RHINO, a 9-1-1 and TopBP1 Interacting Protein Required for ATR Signaling

(2011) C. Cotta-Ramusino et al.   SCIENCE

The ATR barrier to replication-born DNA damage

(2010) Andrés J. López-Contreras et al.   DNA REPAIR

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

ATM-Dependent and -Independent Dynamics of the Nuclear Phosphoproteome After DNA Damage

(2010) A. Bensimon et al.   Science Signaling

The SIOD disorder protein SMARCAL1 is an RPA-interacting protein involved in replication fork restart

(2009) A. Ciccia et al.   GENES & DEVELOPMENT

The Unstructured C-Terminal Tail of the 9-1-1 Clamp Subunit Ddc1 Activates Mec1/ATR via Two Distinct Mechanisms

(2009) Vasundhara M. Navadgi-Patil et al.   MOLECULAR CELL

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

TopBP1 activates ATR through ATRIP and a PIKK regulatory domain

(2008) D. A. Mordes et al.   GENES & DEVELOPMENT

ATR signaling can drive cells into senescence in the absence of DNA breaks

(2008) L. I. Toledo et al.   GENES & DEVELOPMENT

The Basic Cleft of RPA70N Binds Multiple Checkpoint Proteins, Including RAD9, To Regulate ATR Signaling

(2008) X. Xu et al.   MOLECULAR AND CELLULAR BIOLOGY

ATR: an essential regulator of genome integrity

(2008) Karlene A. Cimprich et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY