Optogenetic and chemogenetic techniques for neurogastroenterology

Optogenetic Demonstration of Functional Innervation of Mouse Colon by Neurons Derived From Transplanted Neural Cells

(2017) Lincon A. Stamp et al.   GASTROENTEROLOGY

The acute inhibition of enteric glial metabolism with fluoroacetate alters calcium signaling, hemichannel function, and the expression of key proteins

(2017) Jonathon L. McClain et al.   JOURNAL OF NEUROPHYSIOLOGY

Chemogenetic versus recombination-driven manipulation of enteric glia

(2017) Werend Boesmans et al.   JOURNAL OF PHYSIOLOGY-LONDON

ANO1 in intramuscular interstitial cells of Cajal plays a key role in the generation of slow waves and tone in the internal anal sphincter

(2017) C. A. Cobine et al.   JOURNAL OF PHYSIOLOGY-LONDON

Enteric glial activity regulates secretomotor function in the mouse colon but does not acutely affect gut permeability

(2017) Vladimir Grubišić et al.   JOURNAL OF PHYSIOLOGY-LONDON

Neural regulation of immunity: molecular mechanisms and clinical translation

(2017) Valentin A Pavlov et al.   NATURE NEUROSCIENCE

Lineage-dependent spatial and functional organization of the mammalian enteric nervous system

(2017) Reena Lasrado et al.   SCIENCE

Light controls cerebral blood flow in naive animals

(2017) Ravi L Rungta et al.   Nature Communications

Optogenetic activation of mechanically insensitive afferents in mouse colorectum reveals chemosensitivity

(2016) Bin Feng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Cell-Specific Targeting of Genetically Encoded Tools for Neuroscience

(2016) Lucas Sjulson et al.   Annual Review of Genetics

Neuro-immune Interactions Drive Tissue Programming in Intestinal Macrophages

(2016) Ilana Gabanyi et al.   CELL

Sensory Neurons that Detect Stretch and Nutrients in the Digestive System

(2016) Erika K. Williams et al.   CELL

White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies

(2016) Alan J. Burns et al.   DEVELOPMENTAL BIOLOGY

Enteric nervous system assembly: Functional integration within the developing gut

(2016) M.M. Hao et al.   DEVELOPMENTAL BIOLOGY

The Effect of Microbiota and the Immune System on the Development and Organization of the Enteric Nervous System

(2016) Yuuki Obata et al.   GASTROENTEROLOGY

Targeting the gastrointestinal tract with viral vectors: state of the art and possible applications in research and therapy

(2016) Roeland Buckinx et al.   HISTOCHEMISTRY AND CELL BIOLOGY

DREADD-induced activation of subfornical organ neurons stimulates thirst and salt appetite

(2016) Haley L. Nation et al.   JOURNAL OF NEUROPHYSIOLOGY

Genetically Targeted All-Optical Electrophysiology with a Transgenic Cre-Dependent Optopatch Mouse

(2016) S. Lou et al.   JOURNAL OF NEUROSCIENCE

Genetically Encoded Voltage Indicators: Opportunities and Challenges

(2016) H. H. Yang et al.   JOURNAL OF NEUROSCIENCE

Optogenetic and pharmacological evidence that somatostatin-GABA neurons are important regulators of parasympathetic outflow to the stomach

(2016) Amanda E. Lewin et al.   JOURNAL OF PHYSIOLOGY-LONDON

The intestinal cholinergic anti-inflammatory pathway

(2016) Gera Goverse et al.   JOURNAL OF PHYSIOLOGY-LONDON

Spontaneous Ca2+transients in interstitial cells of Cajal located within the deep muscular plexus of the murine small intestine

(2016) Salah A. Baker et al.   JOURNAL OF PHYSIOLOGY-LONDON

Enteric glia: the most alimentary of all glia

(2016) Vladimir Grubišić et al.   JOURNAL OF PHYSIOLOGY-LONDON

Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease

(2016) Faranak Fattahi et al.   NATURE

Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system

(2016) Michael J Workman et al.   NATURE MEDICINE

Genetically targeted magnetic control of the nervous system

(2016) Michael A Wheeler et al.   NATURE NEUROSCIENCE

Disentangling neural cell diversity using single-cell transcriptomics

(2016) Jean-Francois Poulin et al.   NATURE NEUROSCIENCE

Genetically encoded indicators of neuronal activity

(2016) Michael Z Lin et al.   NATURE NEUROSCIENCE

The bowel and beyond: the enteric nervous system in neurological disorders

(2016) Meenakshi Rao et al.   Nature Reviews Gastroenterology & Hepatology

A decade of transcription factor-mediated reprogramming to pluripotency

(2016) Kazutoshi Takahashi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

In vivo transplantation of fetal human gut-derived enteric neural crest cells

(2016) J. E. Cooper et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Signalling pathways involved in the detection of peptones by murine small intestinal enteroendocrine L-cells

(2016) Ramona Pais et al.   PEPTIDES

In Vivo Transplantation of Enteric Neural Crest Cells into Mouse Gut; Engraftment, Functional Integration and Long-Term Safety

(2016) Julie E. Cooper et al.   PLoS One

Beyond the brain: Optogenetic control in the spinal cord and peripheral nervous system

(2016) Kate L. Montgomery et al.   Science Translational Medicine

Simultaneous optical and electrical in vivo analysis of the enteric nervous system

(2016) Nikolai Rakhilin et al.   Nature Communications

A Novel Zebrafish ret Heterozygous Model of Hirschsprung Disease Identifies a Functional Role for mapk10 as a Modifier of Enteric Nervous System Phenotype Severity

(2016) Tiffany A. Heanue et al.   PLoS Genetics

Sensitive red protein calcium indicators for imaging neural activity

(2016) Hod Dana et al.   eLife

The Use of DREADDs to Deconstruct Behavior

(2016) Paul D. Whissell et al.   Frontiers in Genetics

Animal models of gastrointestinal and liver diseases. Animal models of visceral pain: pathophysiology, translational relevance, and challenges

(2015) Beverley Greenwood-Van Meerveld et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Biophysics of Channelrhodopsin

(2015) Franziska Schneider et al.   Annual Review of Biophysics

Vagal Sensory Neuron Subtypes that Differentially Control Breathing

(2015) Rui B. Chang et al.   CELL

Emerging roles of gut microbiota and the immune system in the development of the enteric nervous system

(2015) Panagiotis S. Kabouridis et al.   JOURNAL OF CLINICAL INVESTIGATION

The gut connectome: making sense of what you eat

(2015) Diego V. Bohórquez et al.   JOURNAL OF CLINICAL INVESTIGATION

Emerging roles for enteric glia in gastrointestinal disorders

(2015) Keith A. Sharkey   JOURNAL OF CLINICAL INVESTIGATION

Neuroepithelial circuit formed by innervation of sensory enteroendocrine cells

(2015) Diego V. Bohórquez et al.   JOURNAL OF CLINICAL INVESTIGATION

Single-trial imaging of spikes and synaptic potentials in single neurons in brain slices with genetically encoded hybrid voltage sensor

(2015) Nima Ghitani et al.   JOURNAL OF NEUROPHYSIOLOGY

Changes in Nicotinic Neurotransmission during Enteric Nervous System Development

(2015) J. P. P. Foong et al.   JOURNAL OF NEUROSCIENCE

Targeted Gene Delivery to the Enteric Nervous System Using AAV: A Comparison Across Serotypes and Capsid Mutants

(2015) Matthew J Benskey et al.   MOLECULAR THERAPY

Optogenetic control of organelle transport and positioning

(2015) Petra van Bergeijk et al.   NATURE

Wirelessly powered, fully internal optogenetics for brain, spinal and peripheral circuits in mice

(2015) Kate L Montgomery et al.   NATURE METHODS

Optogenetics: 10 years after ChR2 in neurons—views from the community

(2015) Antoine Adamantidis et al.   NATURE NEUROSCIENCE

Optogenetics: 10 years of microbial opsins in neuroscience

(2015) Karl Deisseroth   NATURE NEUROSCIENCE

Isogenic enteric neural progenitor cells can replace missing neurons and glia in mice with Hirschsprung disease

(2015) R. Hotta et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Proof-of-concept: neonatal intravenous injection of adeno-associated virus vectors results in successful transduction of myenteric and submucosal neurons in the mouse small and large intestine

(2015) R. Buckinx et al.   NEUROGASTROENTEROLOGY AND MOTILITY

A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior

(2015) Eyal Vardy et al.   NEURON

Natural light-gated anion channels: A family of microbial rhodopsins for advanced optogenetics

(2015) E. G. Govorunova et al.   SCIENCE

Use of Genetically Encoded Calcium Indicators (GECIs) Combined with Advanced Motion Tracking Techniques to Examine the Behavior of Neurons and Glia in the Enteric Nervous System of the Intact Murine Colon

(2015) Grant W. Hennig et al.   Frontiers in Cellular Neuroscience

Development and regulation of chloride homeostasis in the central nervous system

(2015) Miho Watanabe et al.   Frontiers in Cellular Neuroscience

Optogenetic manipulation of cGMP in cells and animals by the tightly light-regulated guanylyl-cyclase opsin CyclOp

(2015) Shiqiang Gao et al.   Nature Communications

Optical Tools to Investigate Cellular Activity in the Intestinal Wall

(2015) Werend Boesmans et al.   Journal of Neurogastroenterology and Motility

Optical Neural Interfaces

(2014) Melissa R. Warden et al.   Annual Review of Biomedical Engineering

Chemogenetic Tools to Interrogate Brain Functions

(2014) Scott M. Sternson et al.   Annual Review of Neuroscience

Heterogeneity and phenotypic plasticity of glial cells in the mammalian enteric nervous system

(2014) Werend Boesmans et al.   GLIA

Deep-tissue light delivery via optrode arrays

(2014) Tanya V.F. Abaya et al.   JOURNAL OF BIOMEDICAL OPTICS

LRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanism

(2014) A. M. Arranz et al.   JOURNAL OF CELL SCIENCE

An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger

(2014) Michael J. Krashes et al.   NATURE

All-optical electrophysiology in mammalian neurons using engineered microbial rhodopsins

(2014) Daniel R Hochbaum et al.   NATURE METHODS

Simultaneous all-optical manipulation and recording of neural circuit activity with cellular resolution in vivo

(2014) Adam M Packer et al.   NATURE METHODS

Medial prefrontal D1 dopamine neurons control food intake

(2014) Benjamin B Land et al.   NATURE NEUROSCIENCE

Lentiviral labeling of mouse and human enteric nervous system stem cells for regenerative medicine studies

(2014) D. Natarajan et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Central Terminal Sensitization of TRPV1 by Descending Serotonergic Facilitation Modulates Chronic Pain

(2014) Yu Shin Kim et al.   NEURON

Retinal Input Directs the Recruitment of Inhibitory Interneurons into Thalamic Visual Circuits

(2014) Bruno Golding et al.   NEURON

The astrocyte marker Aldh1L1 does not reliably label enteric glial cells

(2014) Werend Boesmans et al.   NEUROSCIENCE LETTERS

ChR2 Mutants at L132 and T159 with Improved Operational Light Sensitivity for Vision Restoration

(2014) Zhuo-Hua Pan et al.   PLoS One

Structure-Guided Transformation of Channelrhodopsin into a Light-Activated Chloride Channel

(2014) A. Berndt et al.   SCIENCE

Conversion of Channelrhodopsin into a Light-Gated Chloride Channel

(2014) J. Wietek et al.   SCIENCE

Intravenous AAV9 efficiently transduces myenteric neurons in neonate and juvenile mice

(2014) Sara E. Gombash et al.   Frontiers in Molecular Neuroscience

Optogenetic sensors and effectors: CHROMus—the Cornell Heart Lung Blood Institute Resource for Optogenetic Mouse Signaling

(2014) Bo Shui et al.   Frontiers in Physiology

Improved Orange and Red Ca2+ Indicators and Photophysical Considerations for Optogenetic Applications

(2013) Jiahui Wu et al.   ACS Chemical Neuroscience

Genetic Approaches to Neural Circuits in the Mouse

(2013) Z. Josh Huang et al.   Annual Review of Neuroscience

Genetically Targeted Optical Electrophysiology in Intact Neural Circuits

(2013) Guan Cao et al.   CELL

Optogenetic manipulation of neural and non-neural functions

(2013) Hiromu Yawo et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Cell-Specific Deletion of Nitric Oxide–Sensitive Guanylyl Cyclase Reveals a Dual Pathway for Nitrergic Neuromuscular Transmission in the Murine Fundus

(2013) Dieter Groneberg et al.   GASTROENTEROLOGY

Transplanted progenitors generate functional enteric neurons in the postnatal colon

(2013) Ryo Hotta et al.   JOURNAL OF CLINICAL INVESTIGATION

Planar cell polarity genes control the connectivity of enteric neurons

(2013) Valentina Sasselli et al.   JOURNAL OF CLINICAL INVESTIGATION

Development of myenteric cholinergic neurons inChAT-Cre;R26R-YFPmice

(2013) Marlene M. Hao et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Birthdating of myenteric neuron subtypes in the small intestine of the mouse

(2013) Annette J. Bergner et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Modulation of the autonomic nervous system and behaviour by acute glial cell Gqprotein-coupled receptor activationin vivo

(2013) Cendra Agulhon et al.   JOURNAL OF PHYSIOLOGY-LONDON

Ultrasensitive fluorescent proteins for imaging neuronal activity

(2013) Tsai-Wen Chen et al.   NATURE

ReaChR: a red-shifted variant of channelrhodopsin enables deep transcranial optogenetic excitation

(2013) John Y Lin et al.   NATURE NEUROSCIENCE

Surgical implantation of an abdominal imaging window for intravital microscopy

(2013) Laila Ritsma et al.   Nature Protocols

Neural stem cell therapies for enteric nervous system disorders

(2013) Alan J. Burns et al.   Nature Reviews Gastroenterology & Hepatology

New perspectives in the diagnosis and management of enteric neuropathies

(2013) Charles H. Knowles et al.   Nature Reviews Gastroenterology & Hepatology

Extrinsic primary afferent signalling in the gut

(2013) Simon J. H. Brookes et al.   Nature Reviews Gastroenterology & Hepatology

A Unique Population of Ventral Tegmental Area Neurons Inhibits the Lateral Habenula to Promote Reward

(2013) Alice M. Stamatakis et al.   NEURON

Inhibition of Mediodorsal Thalamus Disrupts Thalamofrontal Connectivity and Cognition

(2013) Sebastien Parnaudeau et al.   NEURON

In Vivo Imaging of Enteric Neurogenesis in the Deep Tissue of Mouse Small Intestine

(2013) Kei Goto et al.   PLoS One

Gut–brain axis: how the microbiome influences anxiety and depression

(2013) Jane A. Foster et al.   TRENDS IN NEUROSCIENCES

Imaging neuron-glia interactions in the enteric nervous system

(2013) Werend Boesmans et al.   Frontiers in Cellular Neuroscience

Interstitial cells of Cajal integrate excitatory and inhibitory neurotransmission with intestinal slow-wave activity

(2013) Sabine Klein et al.   Nature Communications

Genetically encoded calcium indicators for multi-color neural activity imaging and combination with optogenetics

(2013) Jasper Akerboom et al.   Frontiers in Molecular Neuroscience

New technologies for imaging synaptic partners

(2012) Ian R Wickersham et al.   CURRENT OPINION IN NEUROBIOLOGY

Axonal transport of adeno-associated viral vectors is serotype-dependent

(2012) E A Salegio et al.   GENE THERAPY

A Cre-Dependent GCaMP3 Reporter Mouse for Neuronal Imaging In Vivo

(2012) H. A. Zariwala et al.   JOURNAL OF NEUROSCIENCE

Crystal structure of the channelrhodopsin light-gated cation channel

(2012) Hideaki E. Kato et al.   NATURE

Two-photon optogenetics of dendritic spines and neural circuits

(2012) Adam M Packer et al.   NATURE METHODS

Two-photon optogenetic toolbox for fast inhibition, excitation and bistable modulation

(2012) Rohit Prakash et al.   NATURE METHODS

pHTomato, a red, genetically encoded indicator that enables multiplex interrogation of synaptic activity

(2012) Yulong Li et al.   NATURE NEUROSCIENCE

A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing

(2012) Linda Madisen et al.   NATURE NEUROSCIENCE

The enteric nervous system and neurogastroenterology

(2012) John B. Furness   Nature Reviews Gastroenterology & Hepatology

Nuclear pore complex composition: a new regulator of tissue-specific and developmental functions

(2012) Marcela Raices et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Visualization of spinal afferent innervation in the mouse colon by AAV8-mediated GFP expression

(2012) D. J. Schuster et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Imaging Calcium in Neurons

(2012) Christine Grienberger et al.   NEURON

Quantitative comparison of novel GCaMP-type genetically encoded Ca2+ indicators in mammalian neurons

(2012) Yoshiyuki Yamada et al.   Frontiers in Cellular Neuroscience

Expression Level of Hand2 Affects Specification of Enteric Neurons and Gastrointestinal Function in Mice

(2011) Fabien D'Autréaux et al.   GASTROENTEROLOGY

Tamoxifen Induces Rapid, Reversible Atrophy, and Metaplasia in Mouse Stomach

(2011) Won Jae Huh et al.   GASTROENTEROLOGY

Stem cell transplantation in neurodegenerative disorders of the gastrointestinal tract: future or fiction?

(2011) Subhash Kulkarni et al.   GUT

Glial cells in the mouse enteric nervous system can undergo neurogenesis in response to injury

(2011) Catia Laranjeira et al.   JOURNAL OF CLINICAL INVESTIGATION

Rapid, reversible activation of AgRP neurons drives feeding behavior in mice

(2011) Michael J. Krashes et al.   JOURNAL OF CLINICAL INVESTIGATION

Early Emergence of Neural Activity in the Developing Mouse Enteric Nervous System

(2011) M. M. Hao et al.   JOURNAL OF NEUROSCIENCE

Cell type–specific channelrhodopsin-2 transgenic mice for optogenetic dissection of neural circuitry function

(2011) Shengli Zhao et al.   NATURE METHODS

Principles for applying optogenetic tools derived from direct comparative analysis of microbial opsins

(2011) Joanna Mattis et al.   NATURE METHODS

Ultra light-sensitive and fast neuronal activation with the Ca2+-permeable channelrhodopsin CatCh

(2011) Sonja Kleinlogel et al.   NATURE NEUROSCIENCE

Gut feelings: the emerging biology of gut–brain communication

(2011) Emeran A. Mayer   NATURE REVIEWS NEUROSCIENCE

Optogenetics in Neural Systems

(2011) Ofer Yizhar et al.   NEURON

Remote Control of Neuronal Signaling

(2011) S. C. Rogan et al.   PHARMACOLOGICAL REVIEWS

High Cleavage Efficiency of a 2A Peptide Derived from Porcine Teschovirus-1 in Human Cell Lines, Zebrafish and Mice

(2011) Jin Hee Kim et al.   PLoS One

Electrical Spiking in Escherichia coli Probed with a Fluorescent Voltage-Indicating Protein

(2011) Joel M. Kralj et al.   SCIENCE

Transcripts expressed using a bicistronic vector pIREShyg2 are sensitized to nonsense-mediated mRNA decay

(2010) Yayoi Shikama et al.   BMC MOLECULAR BIOLOGY

High-performance genetically targetable optical neural silencing by light-driven proton pumps

(2010) Brian Y. Chow et al.   NATURE

Ultrafast optogenetic control

(2010) Lisa A Gunaydin et al.   NATURE NEUROSCIENCE

Two-photon single-cell optogenetic control of neuronal activity by sculpted light

(2010) B. K. Andrasfalvy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of signal transduction of the LOV2-Jα photosensor from Avena sativa

(2010) Emanuel Peter et al.   Nature Communications

Identification of neuron types in the submucosal ganglia of the mouse ileum

(2009) Caterina Mongardi Fantaguzzi et al.   CELL AND TISSUE RESEARCH

Purinergic Neuron-to-Glia Signaling in the Enteric Nervous System

(2009) Brian D. Gulbransen et al.   GASTROENTEROLOGY

Parvalbumin neurons and gamma rhythms enhance cortical circuit performance

(2009) Vikaas S. Sohal et al.   NATURE

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

(2009) Linda Madisen et al.   NATURE NEUROSCIENCE

Remote Control of Neuronal Activity in Transgenic Mice Expressing Evolved G Protein-Coupled Receptors

(2009) Georgia M. Alexander et al.   NEURON

Glu 87 of Channelrhodopsin-1 Causes pH-dependent Color Tuning and Fast Photocurrent Inactivation

(2009) Satoshi P. Tsunoda et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

A chemical-genetic approach to study G protein regulation of β cell function in vivo

(2009) Jean-Marc Guettier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Optogenetic Catechism

(2009) G. Miesenbock   SCIENCE

Use of the viral 2A peptide for bicistronic expression in transgenic mice

(2008) Georgios Trichas et al.   BMC BIOLOGY

Pirt, a Phosphoinositide-Binding Protein, Functions as a Regulatory Subunit of TRPV1

(2008) Andrew Y. Kim et al.   CELL

Immunohistochemical analysis of neuron types in the mouse small intestine

(2008) Zheng-Dong Qu et al.   CELL AND TISSUE RESEARCH

Enteric nervous system: reflexes, pattern generators and motility

(2008) Jackie D Wood   CURRENT OPINION IN GASTROENTEROLOGY

Highlighting Synaptic Communication in the Enteric Nervous System

(2008) Pieter Vanden Berghe et al.   GASTROENTEROLOGY

The transcriptome of retinal Müller glial cells

(2008) Karin Roesch et al.   JOURNAL OF COMPARATIVE NEUROLOGY

A FLEX Switch Targets Channelrhodopsin-2 to Multiple Cell Types for Imaging and Long-Range Circuit Mapping

(2008) D. Atasoy et al.   JOURNAL OF NEUROSCIENCE

The role of endocytosis in regulating the strength of hippocampal synapses

(2008) Björn Granseth et al.   JOURNAL OF PHYSIOLOGY-LONDON

Engineering GPCR signaling pathways with RASSLs

(2008) Bruce R Conklin et al.   NATURE METHODS

Red-shifted optogenetic excitation: a tool for fast neural control derived from Volvox carteri

(2008) Feng Zhang et al.   NATURE NEUROSCIENCE

Engineered GPCRs as Tools to Modulate Signal Transduction

(2008) Ying Pei et al.   PHYSIOLOGY

Channelrhodopsin-1 Initiates Phototaxis and Photophobic Responses in Chlamydomonas by Immediate Light-Induced Depolarization

(2008) P. Berthold et al.   PLANT CELL

High-Resolution Labeling and Functional Manipulation of Specific Neuron Types in Mouse Brain by Cre-Activated Viral Gene Expression

(2008) Sandra J. Kuhlman et al.   PLoS One

Gal4/UAS Transgenic Tools and Their Application to Zebrafish

(2008) Marnie E. Halpern et al.   Zebrafish