Journal
JOURNAL OF BIOMEDICAL OPTICS
Volume 19, Issue 1, Pages -Publisher
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.JBO.19.1.015006
Keywords
optrode; optogenetics; infrared; neural stimulation; waveguide array; neural probe; tissue optics
Funding
- University of Utah Research Foundation
- NSF [ECCS 1310654]
- NSF MRSEC grant [DMR 1121252]
- Directorate For Engineering
- Div Of Electrical, Commun & Cyber Sys [1310654] Funding Source: National Science Foundation
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We establish performance characteristics of needle-type waveguides in three-dimensional array architectures as light delivery interfaces into deep tissue for applications, such as optogenetic and infrared (IR) neural stimulation. A single optrode waveguide achieves as high as 90% transmission efficiency, even at tissue depths >1 mm. Throughout the visible and near-IR spectrum, the effective light attenuation through the waveguide is similar to 3 orders of magnitude smaller than attenuation in tissue/water, as confirmed by both simulation and experimental results. Light emission profiles from the optrode tips into tissue were also measured. Beam widths of 70 to 150 mu m and full-angle divergence ranging from 13 to 40 deg in tissue can be achieved. These beam characteristics satisfy a wide range of requirements for targeted illumination in neural stimulation. (C) 2014 Society of Photo-Optical Instrumentation Engineers (SPIE)
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