Beyond the brain: Optogenetic control in the spinal cord and peripheral nervous system

Epidural optogenetics for controlled analgesia

(2016) Robert P Bonin et al.   Molecular Pain

Biophysical constraints of optogenetic inhibition at presynaptic terminals

(2016) Mathias Mahn et al.   NATURE NEUROSCIENCE

Controlling the Origins of Inflammation with a Photoactive Lipopeptide Immunopotentiator

(2015) Rock J. Mancini et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Synthetic Erectile Optogenetic Stimulator Enabling Blue-Light-Inducible Penile Erection

(2015) Taeuk Kim et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

DREADDs (Designer Receptors Exclusively Activated by Designer Drugs): Chemogenetic Tools with Therapeutic Utility

(2015) Daniel J. Urban et al.   Annual Review of Pharmacology and Toxicology

A novel analgesic approach to optogenetically and specifically inhibit pain transmission using TRPV1 promoter

(2015) Bei Li et al.   BRAIN RESEARCH

Systemic gene transfer enables optogenetic pacing of mouse hearts

(2015) C. C. Vogt et al.   CARDIOVASCULAR RESEARCH

Vagal Sensory Neuron Subtypes that Differentially Control Breathing

(2015) Rui B. Chang et al.   CELL

Sympathetic Neuro-adipose Connections Mediate Leptin-Driven Lipolysis

(2015) Wenwen Zeng et al.   CELL

Wireless Optofluidic Systems for Programmable In Vivo Pharmacology and Optogenetics

(2015) Jae-Woong Jeong et al.   CELL

Optogenetic control of insulin secretion by pancreatic β-cells in vitro and in vivo

(2015) T Kushibiki et al.   GENE THERAPY

Novel method to assess axonal excitability using channelrhodopsin-based photoactivation

(2015) Yi Zhu et al.   JOURNAL OF NEUROPHYSIOLOGY

Corticospinal Tract Development and Spinal Cord Innervation Differ between Cervical and Lumbar Targets

(2015) T. Kamiyama et al.   JOURNAL OF NEUROSCIENCE

Acute off-target effects of neural circuit manipulations

(2015) Timothy M. Otchy et al.   NATURE

Optogenetics for in vivo cardiac pacing and resynchronization therapies

(2015) Udi Nussinovitch et al.   NATURE BIOTECHNOLOGY

Soft, stretchable, fully implantable miniaturized optoelectronic systems for wireless optogenetics

(2015) Sung Il Park et al.   NATURE BIOTECHNOLOGY

Multifunctional fibers for simultaneous optical, electrical and chemical interrogation of neural circuits in vivo

(2015) Andres Canales et al.   NATURE BIOTECHNOLOGY

Wirelessly powered, fully internal optogenetics for brain, spinal and peripheral circuits in mice

(2015) Kate L Montgomery et al.   NATURE METHODS

Optogenetics and the future of neuroscience

(2015) Edward S Boyden   NATURE NEUROSCIENCE

Optogenetics: 10 years after ChR2 in neurons—views from the community

(2015) Antoine Adamantidis et al.   NATURE NEUROSCIENCE

Optogenetics: 10 years of microbial opsins in neuroscience

(2015) Karl Deisseroth   NATURE NEUROSCIENCE

Targeted Ablation, Silencing, and Activation Establish Glycinergic Dorsal Horn Neurons as Key Components of a Spinal Gate for Pain and Itch

(2015) Edmund Foster et al.   NEURON

Brains, Genes, and Primates

(2015) Juan Carlos Izpisua Belmonte et al.   NEURON

Closed-Loop and Activity-Guided Optogenetic Control

(2015) Logan Grosenick et al.   NEURON

Optoactivation of parvalbumin neurons in the spinal dorsal horn evokes GABA release that is regulated by presynaptic GABAB receptors

(2015) Kun Yang et al.   NEUROSCIENCE LETTERS

Long-Term Effect of Gene Therapy on Leber’s Congenital Amaurosis

(2015) James W.B. Bainbridge et al.   NEW ENGLAND JOURNAL OF MEDICINE

Presynaptic inhibition of optogenetically identified VGluT3+ sensory fibres by opioids and baclofen

(2015) Silke D. Honsek et al.   PAIN

Optogenetic determination of the myocardial requirements for extrasystoles by cell type-specific targeting of ChannelRhodopsin-2

(2015) Tania Zaglia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural foundations of optogenetics: Determinants of channelrhodopsin ion selectivity

(2015) Andre Berndt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A prudent path forward for genomic engineering and germline gene modification

(2015) D. Baltimore et al.   SCIENCE

Wireless magnetothermal deep brain stimulation

(2015) R. Chen et al.   SCIENCE

Refining deep brain stimulation to emulate optogenetic treatment of synaptic pathology

(2015) M. Creed et al.   SCIENCE

Effects of Electrical Stimulation in Spastic Muscles After Stroke

(2015) Cinara Stein et al.   STROKE

“Beauty is a light in the heart”: The transformative potential of optogenetics for clinical applications in cardiovascular medicine1

(2015) Patrick M. Boyle et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Optogenetic approach for functional assays of the cardiovascular system by light activation of the vascular smooth muscle

(2015) Yang Wu et al.   VASCULAR PHARMACOLOGY

Optogenetic intervention to the vascular endothelium

(2015) Shuang Zhang et al.   VASCULAR PHARMACOLOGY

Direct optical activation of skeletal muscle fibres efficiently controls muscle contraction and attenuates denervation atrophy

(2015) Philippe Magown et al.   Nature Communications

Optogenetic control of contractile function in skeletal muscle

(2015) Tobias Bruegmann et al.   Nature Communications

Sonogenetics is a non-invasive approach to activating neurons in Caenorhabditis elegans

(2015) Stuart Ibsen et al.   Nature Communications

Inhibitory luminopsins: genetically-encoded bioluminescent opsins for versatile, scalable and hardware-independent optogenetic inhibition

(2015) Jack K. Tung et al.   Scientific Reports

Optogenetic induction of contractile ability in immature C2C12 myotubes

(2015) Toshifumi Asano et al.   Scientific Reports

Controlling fertilization and cAMP signaling in sperm by optogenetics

(2015) Vera Jansen et al.   eLife

Keratinocytes can modulate and directly initiate nociceptive responses

(2015) Kyle M Baumbauer et al.   eLife

Self-Tracking Energy Transfer for Neural Stimulation in Untethered Mice

(2015) John S. Ho et al.   Physical Review Applied

Adeno-Associated Viral Vectors at the Frontier between Tolerance and Immunity

(2015) Federico Mingozzi et al.   Frontiers in Immunology

Modified toolbox for optogenetics in the nonhuman primate

(2015) Ji Dai et al.   Neurophotonics

Polymer Fiber Probes Enable Optical Control of Spinal Cord and Muscle Function In Vivo

(2014) Chi Lu et al.   ADVANCED FUNCTIONAL MATERIALS

Optical Neural Interfaces

(2014) Melissa R. Warden et al.   Annual Review of Biomedical Engineering

Chemogenetic Tools to Interrogate Brain Functions

(2014) Scott M. Sternson et al.   Annual Review of Neuroscience

Optogenetic release of norepinephrine from cardiac sympathetic neurons alters mechanical and electrical function

(2014) Anastasia M. Wengrowski et al.   CARDIOVASCULAR RESEARCH

Systematic review and individual patient data meta-analysis of diagnosis of heart failure, with modelling of implications of different diagnostic strategies in primary care

(2014) J Mant et al.   HEALTH TECHNOLOGY ASSESSMENT

VGluT3+ Primary Afferents Play Distinct Roles in Mechanical and Cold Hypersensitivity Depending on Pain Etiology

(2014) P. Draxler et al.   JOURNAL OF NEUROSCIENCE

Preclinical Toxicity Evaluation of AAV for Pain: Evidence from Human AAV Studies and from the Pharmacology of Analgesic Drugs

(2014) Josef Pleticha et al.   Molecular Pain

Skilled reaching relies on a V2a propriospinal internal copy circuit

(2014) Eiman Azim et al.   NATURE

Epidermal Merkel cells are mechanosensory cells that tune mammalian touch receptors

(2014) Srdjan Maksimovic et al.   NATURE

Virally mediated optogenetic excitation and inhibition of pain in freely moving nontransgenic mice

(2014) Shrivats Mohan Iyer et al.   NATURE BIOTECHNOLOGY

Independent optical excitation of distinct neural populations

(2014) Nathan C Klapoetke et al.   NATURE METHODS

A spinal analog of memory reconsolidation enables reversal of hyperalgesia

(2014) Robert P Bonin et al.   NATURE NEUROSCIENCE

Normal and abnormal coding of somatosensory stimuli causing pain

(2014) Steven A Prescott et al.   NATURE NEUROSCIENCE

Noninvasive optical inhibition with a red-shifted microbial rhodopsin

(2014) Amy S Chuong et al.   NATURE NEUROSCIENCE

Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing

(2014) Dmitry Usoskin et al.   NATURE NEUROSCIENCE

Bioelectronic medicines: a research roadmap

(2014) Karen Birmingham et al.   NATURE REVIEWS DRUG DISCOVERY

Engineering adeno-associated viruses for clinical gene therapy

(2014) Melissa A. Kotterman et al.   NATURE REVIEWS GENETICS

Mapping Sensory Circuits by Anterograde Transsynaptic Transfer of Recombinant Rabies Virus

(2014) Niccolò Zampieri et al.   NEURON

Fast-conducting mechanoreceptors contribute to withdrawal behavior in normal and nerve injured rats

(2014) Danilo M. Boada et al.   PAIN

Rac1-Dependent Lamellipodial Motility in Prostate Cancer PC-3 Cells Revealed by Optogenetic Control of Rac1 Activity

(2014) Takuma Kato et al.   PLoS One

Rostro-Caudal Inhibition of Hindlimb Movements in the Spinal Cord of Mice

(2014) Vittorio Caggiano et al.   PLoS One

Optogenetic Patterning of Whisker-Barrel Cortical System in Transgenic Rat Expressing Channelrhodopsin-2

(2014) Tatsuya Honjoh et al.   PLoS One

Wireless power transfer to deep-tissue microimplants

(2014) J. S. Ho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure-Guided Transformation of Channelrhodopsin into a Light-Activated Chloride Channel

(2014) A. Berndt et al.   SCIENCE

Optical Control of Muscle Function by Transplantation of Stem Cell-Derived Motor Neurons in Mice

(2014) J. B. Bryson et al.   SCIENCE

Channelrhodopsin-2-Expressed Dorsal Root Ganglion Neurons Activates Calcium Channel Currents and Increases Action Potential in Spinal Cord

(2014) Yi Zhang et al.   SPINE

Optogenetic control of insulin secretion in intact pancreatic islets with β-cell-specific expression of Channelrhodopsin-2

(2014) Thomas M Reinbothe et al.   Islets

Optogenetic inhibition of neurons by internal light production

(2014) Benjamin B. Land et al.   Frontiers in Behavioral Neuroscience

Nociception and pain: lessons from optogenetics

(2014) Fiona B. Carr et al.   Frontiers in Behavioral Neuroscience

Cell type-specific and time-dependent light exposure contribute to silencing in neurons expressing Channelrhodopsin-2

(2014) Alexander M Herman et al.   eLife

Immune responses to AAV vectors: overcoming barriers to successful gene therapy

(2013) F. Mingozzi et al.   BLOOD

Optogenetic and Electrical Microstimulation Systematically Bias Visuospatial Choice in Primates

(2013) Ji Dai et al.   CURRENT BIOLOGY

Gene therapy clinical trials worldwide to 2012 - an update

(2013) Samantha L. Ginn et al.   JOURNAL OF GENE MEDICINE

Fatal Neurological Respiratory Insufficiency Is Common Among Viral Encephalitides

(2013) Hong Wang, Venkatraman Siddharthan, Kyle K. Kesler, Jeffery O. Hall, Neil E. Motter, Justin G. Julander, John D. Morrey   JOURNAL OF INFECTIOUS DISEASES

Remote Optogenetic Activation and Sensitization of Pain Pathways in Freely Moving Mice

(2013) I. Daou et al.   JOURNAL OF NEUROSCIENCE

Saccade Modulation by Optical and Electrical Stimulation in the Macaque Frontal Eye Field

(2013) S. Ohayon et al.   JOURNAL OF NEUROSCIENCE

Covert Warfare Against the Immune System: Decoy Capsids, Stealth Genomes, and Suppressors

(2013) Brad E Hoffman et al.   MOLECULAR THERAPY

Photochemical activation of TRPA1 channels in neurons and animals

(2013) David Kokel et al.   Nature Chemical Biology

ReaChR: a red-shifted variant of channelrhodopsin enables deep transcranial optogenetic excitation

(2013) John Y Lin et al.   NATURE NEUROSCIENCE

Targeting neurons and photons for optogenetics

(2013) Adam M Packer et al.   NATURE NEUROSCIENCE

The Sensory Neurons of Touch

(2013) Victoria E. Abraira et al.   NEURON

Locomotor Rhythm Generation Linked to the Output of Spinal Shox2 Excitatory Interneurons

(2013) Kimberly J. Dougherty et al.   NEURON

Light-Emitting Channelrhodopsins for Combined Optogenetic and Chemical-Genetic Control of Neurons

(2013) Ken Berglund et al.   PLoS One

Intraganglionic AAV6 Results in Efficient and Long-Term Gene Transfer to Peripheral Sensory Nervous System in Adult Rats

(2013) Hongwei Yu et al.   PLoS One

Optogenetic Control of Targeted Peripheral Axons in Freely Moving Animals

(2013) Chris Towne et al.   PLoS One

Optogenetic dissection reveals multiple rhythmogenic modules underlying locomotion

(2013) M. Hagglund et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Injectable, Cellular-Scale Optoelectronics with Applications for Wireless Optogenetics

(2013) T.-i. Kim et al.   SCIENCE

Optogenetics and Translational Medicine

(2013) B. Y. Chow et al.   Science Translational Medicine

From Optogenetic Technologies to Neuromodulation Therapies

(2013) J. C. Williams et al.   Science Translational Medicine

Light-controlled inhibition of malignant glioma by opsin gene transfer

(2013) F Yang et al.   Cell Death & Disease

Optical control of neuronal excitation and inhibition using a single opsin protein, ChR2

(2013) Holly Liske et al.   Scientific Reports

Lessons Learned from the Clinical Development and Market Authorization of Glybera

(2013) Laura M. Bryant et al.   Human Gene Therapy Clinical Development

Optogenetically Induced Behavioral and Functional Network Changes in Primates

(2012) Annelies Gerits et al.   CURRENT BIOLOGY

Interfacing the Somatosensory System to Restore Touch and Proprioception: Essential Considerations

(2012) Douglas J. Weber et al.   JOURNAL OF MOTOR BEHAVIOR

Formation and optogenetic control of engineered 3D skeletal muscle bioactuators

(2012) Mahmut Selman Sakar et al.   LAB ON A CHIP

The AAV Vector Toolkit: Poised at the Clinical Crossroads

(2012) Aravind Asokan et al.   MOLECULAR THERAPY

Optical inhibition of motor nerve and muscle activityin vivo

(2012) Holly Liske et al.   MUSCLE & NERVE

Rapid optical control of nociception with an ion-channel photoswitch

(2012) Alexandre Mourot et al.   NATURE METHODS

A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing

(2012) Linda Madisen et al.   NATURE NEUROSCIENCE

Saccadic eye movements evoked by optogenetic activation of primate V1

(2012) Mehrdad Jazayeri et al.   NATURE NEUROSCIENCE

The vagus nerve and the inflammatory reflex—linking immunity and metabolism

(2012) Valentin A. Pavlov et al.   Nature Reviews Endocrinology

Optogenetic Inactivation Modifies Monkey Visuomotor Behavior

(2012) James Cavanaugh et al.   NEURON

Light-evoked Somatosensory Perception of Transgenic Rats That Express Channelrhodopsin-2 in Dorsal Root Ganglion Cells

(2012) Zhi-Gang Ji et al.   PLoS One

Optically controlled contraction of photosensitive skeletal muscle cells

(2011) Toshifumi Asano et al.   BIOTECHNOLOGY AND BIOENGINEERING

Stimulating Cardiac Muscle by Light

(2011) Zhiheng Jia et al.   Circulation-Arrhythmia and Electrophysiology

Spinal Cord Stimulation: A Review

(2011) Aaron K. Compton et al.   Current Pain and Headache Reports

Comparison of Adeno-Associated Viral Vector Serotypes for Spinal Cord and Motor Neuron Gene Delivery

(2011) Brooke R. Snyder et al.   HUMAN GENE THERAPY

A wirelessly powered and controlled device for optical neural control of freely-behaving animals

(2011) Christian T Wentz et al.   Journal of Neural Engineering

Cell type–specific channelrhodopsin-2 transgenic mice for optogenetic dissection of neural circuitry function

(2011) Shengli Zhao et al.   NATURE METHODS

An optogenetic toolbox designed for primates

(2011) Ilka Diester et al.   NATURE NEUROSCIENCE

Therapeutic in vivo gene transfer for genetic disease using AAV: progress and challenges

(2011) Federico Mingozzi et al.   NATURE REVIEWS GENETICS

Recombinase-Driver Rat Lines: Tools, Techniques, and Optogenetic Application to Dopamine-Mediated Reinforcement

(2011) Ilana B. Witten et al.   NEURON

A Synthetic Optogenetic Transcription Device Enhances Blood-Glucose Homeostasis in Mice

(2011) H. Ye et al.   SCIENCE

Enhancing the clinical potential of AAV vectors by capsid engineering to evade pre-existing immunity

(2011) Melissa Bartel   Frontiers in Microbiology

Immune responses to adeno-associated virus type 2 encoding channelrhodopsin-2 in a genetically blind rat model for gene therapy

(2010) E Sugano et al.   GENE THERAPY

Comparison of AAV Serotypes for Gene Delivery to Dorsal Root Ganglion Neurons

(2010) Matthew RJ Mason et al.   MOLECULAR THERAPY

Orderly recruitment of motor units under optical control in vivo

(2010) Michael E Llewellyn et al.   NATURE MEDICINE

Optogenetic control of heart muscle in vitro and in vivo

(2010) Tobias Bruegmann et al.   NATURE METHODS

Activation of groups of excitatory neurons in the mammalian spinal cord or hindbrain evokes locomotion

(2010) Martin Hägglund et al.   NATURE NEUROSCIENCE

Optogenetic interrogation of neural circuits: technology for probing mammalian brain structures

(2010) Feng Zhang et al.   Nature Protocols

Implanted Neural Interfaces: Biochallenges and Engineered Solutions

(2009) Warren M. Grill et al.   Annual Review of Biomedical Engineering

AAV for pain: steps towards clinical translation

(2009) A S Beutler et al.   GENE THERAPY

Mrgprd-Expressing Polymodal Nociceptive Neurons Innervate Most Known Classes of Substantia Gelatinosa Neurons

(2009) H. Wang et al.   JOURNAL OF NEUROSCIENCE

Recombinant Adeno-Associated Virus Serotype 6 (rAAV2/6)-Mediated Gene Transfer to Nociceptive Neurons through Different Routes of Delivery

(2009) Chris Towne et al.   Molecular Pain

Effect of Genome Size on AAV Vector Packaging

(2009) Zhijian Wu et al.   MOLECULAR THERAPY

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

(2009) Linda Madisen et al.   NATURE NEUROSCIENCE

Animal models of pain: progress and challenges

(2009) Jeffrey S. Mogil   NATURE REVIEWS NEUROSCIENCE

Millisecond-Timescale Optical Control of Neural Dynamics in the Nonhuman Primate Brain

(2009) Xue Han et al.   NEURON

Optical Deconstruction of Parkinsonian Neural Circuitry

(2009) V. Gradinaru et al.   SCIENCE

Light-Induced Rescue of Breathing after Spinal Cord Injury

(2008) W. J. Alilain et al.   JOURNAL OF NEUROSCIENCE

Transgenic primate models inch forward

(2008)   NATURE NEUROSCIENCE