Targeting the gastrointestinal tract with viral vectors: state of the art and possible applications in research and therapy

rAAV-CFTRΔR Rescues the Cystic Fibrosis Phenotype in Human Intestinal Organoids and Cystic Fibrosis Mice

(2016) Dragana Vidović et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Sensory Neurons that Detect Stretch and Nutrients in the Digestive System

(2016) Erika K. Williams et al.   CELL

Adeno-Associated Virus-Based Gene Therapy for CNS Diseases

(2016) Michaël Hocquemiller et al.   HUMAN GENE THERAPY

Viral vector-based tools advance knowledge of basal ganglia anatomy and physiology

(2016) Rachel J. Sizemore et al.   JOURNAL OF NEUROPHYSIOLOGY

Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain

(2016) Benjamin E Deverman et al.   NATURE BIOTECHNOLOGY

A multifunctional AAV–CRISPR–Cas9 and its host response

(2016) Wei Leong Chew et al.   NATURE METHODS

CRISPR genome engineering and viral gene delivery: A case of mutual attraction

(2015) Florian Schmidt et al.   Biotechnology Journal

Targeted Gene Delivery to the Enteric Nervous System Using AAV: A Comparison Across Serotypes and Capsid Mutants

(2015) Matthew J Benskey et al.   MOLECULAR THERAPY

In vivo genome editing using Staphylococcus aureus Cas9

(2015) F. Ann Ran et al.   NATURE

Isogenic enteric neural progenitor cells can replace missing neurons and glia in mice with Hirschsprung disease

(2015) R. Hotta et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Proof-of-concept: neonatal intravenous injection of adeno-associated virus vectors results in successful transduction of myenteric and submucosal neurons in the mouse small and large intestine

(2015) R. Buckinx et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Nontoxicity of lentiviral vector infection to viability, migration, apoptosis, and differentiation of postnatal rat enteric neural crest-derived cells

(2015) Hui Yu et al.   NEUROREPORT

Surface-Engineered Viral Vectors for Selective and Cell Type-Specific Gene Delivery

(2015) Christian J. Buchholz et al.   TRENDS IN BIOTECHNOLOGY

Neuroanatomy goes viral!

(2015) Jonathan J. Nassi et al.   Frontiers in Neuroanatomy

CRISPR genome engineering and viral gene delivery: A case of mutual attraction

(2015) Florian Schmidt et al.   Biotechnology Journal

CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling

(2014) Randall J. Platt et al.   CELL

In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9

(2014) Lukasz Swiech et al.   NATURE BIOTECHNOLOGY

Lentiviral labeling of mouse and human enteric nervous system stem cells for regenerative medicine studies

(2014) D. Natarajan et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Adenovirus-Mediated Efficient Gene Transfer into Cultured Three-Dimensional Organoids

(2014) Ning Wang et al.   PLoS One

Biodistribution of adeno-associated virus serotype 9 (AAV9) vector after intrathecal and intravenous delivery in mouse

(2014) Daniel J. Schuster et al.   Frontiers in Neuroanatomy

Intravenous AAV9 efficiently transduces myenteric neurons in neonate and juvenile mice

(2014) Sara E. Gombash et al.   Frontiers in Molecular Neuroscience

Treatment of Aganglionic Megacolon Mice via Neural Stem Cell Transplantation

(2013) Xiaogang Shu et al.   MOLECULAR NEUROBIOLOGY

Regulation of Epithelial Differentiation in Rat Intestine by Intraluminal Delivery of an Adenoviral Vector or Silencing RNA Coding for Schlafen 3

(2013) Pavlo L. Kovalenko et al.   PLoS One

Visualization of spinal afferent innervation in the mouse colon by AAV8-mediated GFP expression

(2012) D. J. Schuster et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Identification of adeno-associated viral vectors suitable for intestinal gene delivery and modulation of experimental colitis

(2011) Steven Polyak et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Adeno-Associated Virus (AAV) Vectors in the CNS

(2011) Thomas J. McCown   CURRENT GENE THERAPY

Intravenous administration of AAV2/9 to the fetal and neonatal mouse leads to differential targeting of CNS cell types and extensive transduction of the nervous system

(2011) Ahad A. Rahim et al.   FASEB JOURNAL

Correction of Neurological Disease of Mucopolysaccharidosis IIIB in Adult Mice by rAAV9 Trans-Blood–Brain Barrier Gene Delivery

(2011) Haiyan Fu et al.   MOLECULAR THERAPY

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

(2011) Wim de Lau et al.   NATURE

Controlled gene expression in primary Lgr5 organoid cultures

(2011) Bon-Kyoung Koo et al.   NATURE METHODS

Viral vectors for gene delivery to the central nervous system

(2011) Thomas B. Lentz et al.   NEUROBIOLOGY OF DISEASE

Effective in vivo and ex vivogene transfer to intestinal mucosa by VSV-G-pseudotyped lentiviral vectors

(2010) Hiroshi Matsumoto et al.   BMC GASTROENTEROLOGY

Adenoviral Transduction of Enterocytes and M-Cells Usingin VitroModels Based on Caco-2 Cells: The Coxsackievirus and Adenovirus Receptor (CAR) Mediates Both Apical and Basolateral Transduction

(2010) Filippos Kesisoglou et al.   MOLECULAR PHARMACEUTICS

Developmental determinants of the independence and complexity of the enteric nervous system

(2010) Michael D. Gershon   TRENDS IN NEUROSCIENCES

The developmental stage determines the distribution and duration of gene expression after early intra-amniotic gene transfer using lentiviral vectors

(2009) M Endo et al.   GENE THERAPY

In Vitro and In Vivo Gene Therapy Vector Evolution via Multispecies Interbreeding and Retargeting of Adeno-Associated Viruses

(2008) D. Grimm et al.   JOURNAL OF VIROLOGY