Omega-3 fatty acids, lipids, and apoE lipidation in Alzheimer’s disease: a rationale for multi-nutrient dementia prevention

The Isoform-Specific Pathological Effects of ApoE4 in vivo are Prevented by a Fish Oil (DHA) Diet and are Modified by Cholesterol

(2018) Zehavit Kariv-Inbal et al.   JOURNAL OF ALZHEIMERS DISEASE

Increased Ceramide in Brains with Alzheimer's and Other Neurodegenerative Diseases

(2018) Valery Filippov et al.   JOURNAL OF ALZHEIMERS DISEASE

Increased intermediate M1-M2 macrophage polarization and improved cognition in mild cognitive impairment patients on ω-3 supplementation

(2017) Sam Famenini et al.   FASEB JOURNAL

Anomalies occurring in lipid profiles and protein distribution in frontal cortex lipid rafts in dementia with Lewy bodies disclose neurochemical traits partially shared by Alzheimer's and Parkinson's diseases

(2017) Raquel Marin et al.   NEUROBIOLOGY OF AGING

Association of Docosahexaenoic Acid Supplementation With Alzheimer Disease Stage in Apolipoprotein E ε4 Carriers

(2017) Hussein N. Yassine et al.   JAMA Neurology

APP Function and Lipids: A Bidirectional Link

(2017) Marcus O. W. Grimm et al.   Frontiers in Molecular Neuroscience

Profiling Brain and Plasma Lipids in Human APOE ε2, ε3, and ε4 Knock-in Mice Using Electrospray Ionization Mass Spectrometry

(2017) Matthew J. Sharman et al.   JOURNAL OF ALZHEIMERS DISEASE

Eicosapentaenoic acid and docosahexaenoic acid increase the degradation of amyloid-β by affecting insulin-degrading enzyme

(2016) Marcus O.W. Grimm et al.   Biochemistry and Cell Biology

Dietary DHA supplementation causes selective changes in phospholipids from different brain regions in both wild type mice and the Tg2576 mouse model of Alzheimer's disease

(2016) Cécile Bascoul-Colombo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Plasma Phospholipid and Sphingolipid Alterations in Presenilin1 Mutation Carriers: A Pilot Study

(2016) Pratishtha Chatterjee et al.   JOURNAL OF ALZHEIMERS DISEASE

ABCA1 Agonist Reverses the ApoE4-Driven Cognitive and Brain Pathologies

(2016) Anat Boehm-Cagan et al.   JOURNAL OF ALZHEIMERS DISEASE

Effect Size Analyses of Souvenaid in Patients with Alzheimer’s Disease

(2016) Jeffrey Cummings et al.   JOURNAL OF ALZHEIMERS DISEASE

Omega-3 Fatty Acid Status Enhances the Prevention of Cognitive Decline by B Vitamins in Mild Cognitive Impairment

(2016) Abderrahim Oulhaj et al.   JOURNAL OF ALZHEIMERS DISEASE

Docosahexaenoic Acid Promotes Axon Outgrowth by Translational Regulation of Tau and Collapsin Response Mediator Protein 2 Expression

(2016) Toshinari Mita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Brain omega-3 polyunsaturated fatty acids modulate microglia cell number and morphology in response to intracerebroventricular amyloid-β 1-40 in mice

(2016) Kathryn E. Hopperton et al.   Journal of Neuroinflammation

Apolipoprotein E Genotype Affects Size of ApoE Complexes in Cerebrospinal Fluid

(2016) Nicolette Mary Heinsinger et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Neutral Sphingomyelinase-2 Deficiency Ameliorates Alzheimer's Disease Pathology and Improves Cognition in the 5XFAD Mouse

(2016) Michael B. Dinkins et al.   JOURNAL OF NEUROSCIENCE

The pleiotropic effects of omega-3 docosahexaenoic acid on the hallmarks of Alzheimer's disease

(2016) Mounir Belkouch et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Analysis of Plasmalogen Species in Foodstuffs

(2016) Shinji Yamashita et al.   LIPIDS

Loss of ceramide synthase 2 activity, necessary for myelin biosynthesis, precedes tau pathology in the cortical pathogenesis of Alzheimer's disease

(2016) Timothy A. Couttas et al.   NEUROBIOLOGY OF AGING

APOEε4 and the associations of seafood and long-chain omega-3 fatty acids with cognitive decline

(2016) Ondine van de Rest et al.   NEUROLOGY

N-3 long chain polyunsaturated fatty acids increase the expression of PPARγ-target genes and resistance of isolated heart and cultured cardiomyocytes to ischemic injury

(2016) Angela M. Shysh et al.   Pharmacological Reports

The role of omega-3 polyunsaturated fatty acids eicosapentaenoic and docosahexaenoic acids in the treatment of major depression and Alzheimer's disease: Acting separately or synergistically?

(2016) Cai Song et al.   PROGRESS IN LIPID RESEARCH

Fingolimod modulates multiple neuroinflammatory markers in a mouse model of Alzheimer’s disease

(2016) Nurgul Aytan et al.   Scientific Reports

The effect of APOE genotype on the delivery of DHA to cerebrospinal fluid in Alzheimer’s disease

(2016) Hussein N. Yassine et al.   Alzheimers Research & Therapy

Association of Serum Docosahexaenoic Acid With Cerebral Amyloidosis

(2016) Hussein N. Yassine et al.   JAMA Neurology

A Dietary Treatment Improves Cerebral Blood Flow and Brain Connectivity in Aging apoE4 Mice

(2016) Maximilian Wiesmann et al.   NEURAL PLASTICITY

Network Analysis of a Comprehensive Knowledge Repository Reveals a Dual Role for Ceramide in Alzheimer’s Disease

(2016) Satoshi Mizuno et al.   PLoS One

Non-targeted lipidomics of CSF and frontal cortex grey and white matter in control, mild cognitive impairment, and Alzheimer’s disease subjects

(2015) Paul L. Wood et al.   ACTA NEUROPSYCHIATRICA

Loss-of-function mutation in ABCA1 and risk of Alzheimer's disease and cerebrovascular disease

(2015) Liv Tybjærg Nordestgaard et al.   Alzheimers & Dementia

Brain atrophy in cognitively impaired elderly: the importance of long-chain ω-3 fatty acids and B vitamin status in a randomized controlled trial

(2015) Fredrik Jernerén et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Intakes of fish and polyunsaturated fatty acids and mild-to-severe cognitive impairment risks: a dose-response meta-analysis of 21 cohort studies1–3

(2015) Yu Zhang et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

The binding of Aβ1–42 to lipid rafts of RBC is enhanced by dietary docosahexaenoic acid in rats: Implicates to Alzheimer's disease

(2015) Michio Hashimoto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Marine omega-3 fatty acids and inflammatory processes: Effects, mechanisms and clinical relevance

(2015) Philip C. Calder   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Erythrocyte phospholipid molecular species and fatty acids of Down syndrome children compared with non-affected siblings

(2015) Allain A. Bueno et al.   BRITISH JOURNAL OF NUTRITION

Lipid-Based Diets Improve Muscarinic Neurotransmission in the Hippocampus of Transgenic APPswe/PS1dE9 Mice

(2015) Helena Janickova et al.   Current Alzheimer Research

Socio-economic Aspects of Alzheimer's Disease

(2015) Petra Maresova et al.   Current Alzheimer Research

Docosahexaenoic Acid-Phosphatidylcholine Improves Cognitive Deficits in an A?23-35-Induced Alzheimer's Disease Rat Model

(2015) Mei-Hua Qu et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

ω-3 Supplementation increases amyloid-β phagocytosis and resolvin D1 in patients with minor cognitive impairment

(2015) Milan Fiala et al.   FASEB JOURNAL

GM1 ganglioside and Alzheimer’s disease

(2015) Katsuhiko Yanagisawa   GLYCOCONJUGATE JOURNAL

Abnormal cortical lysosomal β-hexosaminidase and β-galactosidase activity at post-synaptic sites during Alzheimer's disease progression

(2015) Alessandro Magini et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Neurite outgrowth stimulation by n-3 and n-6 PUFAs of phospholipids in apoE-containing lipoproteins secreted from glial cells

(2015) Mitsuhiro Nakato et al.   JOURNAL OF LIPID RESEARCH

Hippocampal Endosomal, Lysosomal, and Autophagic Dysregulation in Mild Cognitive Impairment

(2015) Sylvia E. Perez et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Omega-3 Fatty Acids Augment the Actions of Nuclear Receptor Agonists in a Mouse Model of Alzheimer's Disease

(2015) B. T. Casali et al.   JOURNAL OF NEUROSCIENCE

Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and Aβ metabolism in apoE4-targeted replacement mice

(2015) Jin Hu et al.   Molecular Neurodegeneration

A specific multi-nutrient enriched diet enhances hippocampal cholinergic transmission in aged rats

(2015) Mehmet Cansev et al.   NEUROBIOLOGY OF AGING

Dietary DHA supplementation in an APP/PS1 transgenic rat model of AD reduces behavioral and Aβ pathology and modulates Aβ oligomerization

(2015) Edmond Teng et al.   NEUROBIOLOGY OF DISEASE

Oxidized Docosahexaenoic Acid Species and Lipid Peroxidation Products Increase Amyloidogenic Amyloid Precursor Protein Processing

(2015) Marcus O.W. Grimm et al.   Neurodegenerative Diseases

Altered lysosomal proteins in neural-derived plasma exosomes in preclinical Alzheimer disease

(2015) Edward J. Goetzl et al.   NEUROLOGY

Ceramides in Alzheimer’s Disease: Key Mediators of Neuronal Apoptosis Induced by Oxidative Stress and AβAccumulation

(2015) Maja Jazvinšćak Jembrek et al.   Oxidative Medicine and Cellular Longevity

Phospholipid dysregulation contributes to ApoE4-associated cognitive deficits in Alzheimer’s disease pathogenesis

(2015) Li Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dementia risk estimates associated with measures of depression: a systematic review and meta-analysis

(2015) Nicolas Cherbuin et al.   BMJ Open

APP intracellular domain derived from amyloidogenic β- and γ-secretase cleavage regulates neprilysin expression

(2015) Marcus O. W. Grimm et al.   Frontiers in Aging Neuroscience

Non-targeted lipidomics of CSF and frontal cortex grey and white matter in control, mild cognitive impairment, and Alzheimer’s disease subjects

(2015) Paul L. Wood et al.   ACTA NEUROPSYCHIATRICA

The Role of Oxidative Stress in Neurodegenerative Diseases

(2015) Geon Ha Kim et al.   Experimental Neurobiology

Novel Apo E-Derived ABCA1 Agonist Peptide (CS-6253) Promotes Reverse Cholesterol Transport and Induces Formation of preβ-1 HDL In Vitro

(2015) Anouar Hafiane et al.   PLoS One

APOE ε4: The most prevalent yet understudied risk factor for Alzheimer's disease

(2014) Daniel M. Michaelson   Alzheimers & Dementia

Region-specific metabolic alterations in the brain of the APP/PS1 transgenic mice of Alzheimer's disease

(2014) Raúl González-Domínguez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

PS Dependent APP Cleavage Regulates Glucosylceramide Synthase and is Affected in Alzheimer's Disease

(2014) Marcus O.W. Grimm et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Sphingosine-1-Phosphate: Boon and Bane for the Brain

(2014) Gerhild van Echten-Deckert et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Phosphatidylethanolamine plasmalogen enhances the inhibiting effect of phosphatidylethanolamine on  -secretase activity

(2014) T. Onodera et al.   JOURNAL OF BIOCHEMISTRY

Deficiency of Sphingosine-1-phosphate Lyase Impairs Lysosomal Metabolism of the Amyloid Precursor Protein

(2014) Ilker Karaca et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acid sphingomyelinase modulates the autophagic process by controlling lysosomal biogenesis in Alzheimer’s disease

(2014) Jong Kil Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Reversal of apoE4-Driven Brain Pathology and Behavioral Deficits by Bexarotene

(2014) A. Boehm-Cagan et al.   JOURNAL OF NEUROSCIENCE

Sphingosine-1-Phosphate and Its Effect on Glucose Deprivation/Glucose Reload Stress: From Gene Expression to Neuronal Survival

(2014) Kinga Czubowicz et al.   MOLECULAR NEUROBIOLOGY

Evidence that small molecule enhancement of β-hexosaminidase activity corrects the behavioral phenotype in Dutch APPE693Q mice through reduction of ganglioside-bound Aβ

(2014) E M Knight et al.   MOLECULAR PSYCHIATRY

Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid

(2014) Long N. Nguyen et al.   NATURE

The Effect of Souvenaid on Functional Brain Network Organisation in Patients with Mild Alzheimer’s Disease: A Randomised Controlled Study

(2014) Hanneke de Waal et al.   PLoS One

Loss of the neuroprotective factor Sphingosine 1-phosphate early in Alzheimer’s disease pathogenesis

(2014) Timothy A Couttas et al.   Acta Neuropathologica Communications

Upregulation of PGC-1α expression by Alzheimer's disease-associated pathway: presenilin 1/amyloid precursor protein (APP)/intracellular domain of APP

(2013) Ari Robinson et al.   AGING CELL

Systematic Review: Factors Associated With Risk for and Possible Prevention of Cognitive Decline in Later Life

(2013) Brenda L. Plassman   ANNALS OF INTERNAL MEDICINE

Brain Gangliosides of a Transgenic Mouse Model of Alzheimer's Disease with Deficiency in GD3-Synthase: Expression of Elevated Levels of a Cholinergic-Specific Ganglioside, GT1aα

(2013) Toshio Ariga et al.   ASN Neuro

Effect of Different Phospholipids on α-Secretase Activity in the Non-Amyloidogenic Pathway of Alzheimer’s Disease

(2013) Marcus Grimm et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Phospholipids and Alzheimer’s Disease: Alterations, Mechanisms and Potential Biomarkers

(2013) Marko Kosicek et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Relationship between diet and plasma long-chain n-3 PUFAs in older people: impact of apolipoprotein E genotype

(2013) Cécilia Samieri et al.   JOURNAL OF LIPID RESEARCH

Specific changes of sulfatide levels in individuals with pre-clinical Alzheimer's disease: an early event in disease pathogenesis

(2013) Hua Cheng et al.   JOURNAL OF NEUROCHEMISTRY

Plant Sterols the Better Cholesterol in Alzheimer's Disease? A Mechanistical Study

(2013) V. K. Burg et al.   JOURNAL OF NEUROSCIENCE

A randomized controlled Alzheimer’s disease prevention trial’s evolution into an exposure trial: The preadvise trial

(2013) R. J. Kryscio et al.   Journal of Nutrition Health & Aging

Special lipid-based diets alleviate cognitive deficits in the APPswe/PS1dE9 transgenic mouse model of Alzheimer's disease independent of brain amyloid deposition

(2013) Hennariikka Koivisto et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

EPA but Not DHA Appears To Be Responsible for the Efficacy of Omega-3 Long Chain Polyunsaturated Fatty Acid Supplementation in Depression: Evidence from a Meta-Analysis of Randomized Controlled Trials

(2013) Julian G Martins   JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION

ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice

(2013) Ori Liraz et al.   Molecular Neurodegeneration

Multinutrient diets improve cerebral perfusion and neuroprotection in a murine model of Alzheimer's disease

(2013) Valerio Zerbi et al.   NEUROBIOLOGY OF AGING

Effects of Specific Multi-Nutrient Enriched Diets on Cerebral Metabolism, Cognition and Neuropathology in AβPPswe-PS1dE9 Mice

(2013) Diane Jansen et al.   PLoS One

ApoE influences amyloid-  (A ) clearance despite minimal apoE/A  association in physiological conditions

(2013) P. B. Verghese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preventing Alzheimer’s disease-related gray matter atrophy by B-vitamin treatment

(2013) Gwenaëlle Douaud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The S-Connect study: results from a randomized, controlled trial of Souvenaid in mild-to-moderate Alzheimer’s disease

(2013) Raj C Shah et al.   Alzheimers Research & Therapy

Apolipoprotein E and Apolipoprotein E Receptors: Normal Biology and Roles in Alzheimer Disease

(2013) D. M. Holtzman et al.   Cold Spring Harbor Perspectives in Medicine

Neprilysin and Aβ Clearance: Impact of the APP Intracellular Domain in NEP Regulation and Implications in Alzheimer’s Disease

(2013) Marcus O. W. Grimm et al.   Frontiers in Aging Neuroscience

Effect of Apolipoprotein E Genotype and Diet on Apolipoprotein E Lipidation and Amyloid Peptides

(2013) Angela J. Hanson et al.   JAMA Neurology

Reprint of “Alzheimer’s disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein”

(2012) George G. Glenner   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Alpha-Secretase Cleavage of the Amyloid Precursor Protein: Proteolysis Regulated by Signaling Pathways and Protein Trafficking

(2012) Stefan F. Lichtenthaler   Current Alzheimer Research

Serum ceramides increase the risk of Alzheimer disease: The Women's Health and Aging Study II

(2012) M. M. Mielke et al.   NEUROLOGY

Elevated cerebrospinal fluid sphingomyelin levels in prodromal Alzheimer's disease

(2012) M. Kosicek et al.   NEUROSCIENCE LETTERS

DHA supplementation: Current implications in pregnancy and childhood

(2012) Lynette K. Rogers et al.   PHARMACOLOGICAL RESEARCH

Amyloid Precursor Protein (APP) Mediated Regulation of Ganglioside Homeostasis Linking Alzheimer's Disease Pathology with Ganglioside Metabolism

(2012) Marcus O. W. Grimm et al.   PLoS One

Plasmalogens Inhibit APP Processing by Directly Affectingγ-Secretase Activity in Alzheimer’s Disease

(2012) Tatjana L. Rothhaar et al.   TheScientificWorldJOURNAL

Sphingosine-1-phosphate links glycosphingolipid metabolism to neurodegeneration via a calpain-mediated mechanism

(2011) N Hagen et al.   CELL DEATH AND DIFFERENTIATION

Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial

(2011) Celeste A. Jager et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

β-Amyloid Peptide Variants in Brains and Cerebrospinal Fluid from Amyloid Precursor Protein (APP) Transgenic Mice

(2011) Heinke Schieb et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Docosahexaenoic Acid Reduces Amyloid β Production via Multiple Pleiotropic Mechanisms

(2011) Marcus O. W. Grimm et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

From brain to food: Analysis of phosphatidylcholins, lyso-phosphatidylcholins and phosphatidylcholin–plasmalogens derivates in Alzheimer's disease human post mortem brains and mice model via mass spectrometry

(2011) Marcus O.W. Grimm et al.   JOURNAL OF CHROMATOGRAPHY A

Plasmalogen synthesis is regulated via alkyl-dihydroxyacetonephosphate-synthase by amyloid precursor protein processing and is affected in Alzheimer’s disease

(2011) Marcus O. W. Grimm et al.   JOURNAL OF NEUROCHEMISTRY

Pathological significance of ganglioside clusters in Alzheimer’s disease

(2011) Katsuhiko Yanagisawa   JOURNAL OF NEUROCHEMISTRY

Identification and biology of α-secretase

(2011) Valérie Vingtdeux et al.   JOURNAL OF NEUROCHEMISTRY

The physiology of the β-amyloid precursor protein intracellular domain AICD

(2011) Raphaëlle Pardossi-Piquard et al.   JOURNAL OF NEUROCHEMISTRY

A specific multi-nutrient formulation enhances M1 muscarinic acetylcholine receptor responses in vitro

(2011) Paul J. M. Savelkoul et al.   JOURNAL OF NEUROCHEMISTRY

BACE1 Activity Is Modulated by Cell-Associated Sphingosine-1-Phosphate

(2011) N. Takasugi et al.   JOURNAL OF NEUROSCIENCE

Intraneuronal amyloid β oligomers cause cell death via endoplasmic reticulum stress, endosomal/lysosomal leakage, and mitochondrial dysfunction in vivo

(2011) Tomohiro Umeda et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Trans fatty acids enhance amyloidogenic processing of the Alzheimer amyloid precursor protein (APP)

(2011) Marcus O.W. Grimm et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Neuroprotectin D1 Induces Neuronal Survival and Downregulation of Amyloidogenic Processing in Alzheimer’s Disease Cellular Models

(2011) David T. Stark et al.   MOLECULAR NEUROBIOLOGY

The effects of 90-day supplementation with the Omega-3 essential fatty acid docosahexaenoic acid (DHA) on cognitive function and visual acuity in a healthy aging population

(2011) Con Stough et al.   NEUROBIOLOGY OF AGING

A randomized, double-blind, placebo-controlled trial of simvastatin to treat Alzheimer disease

(2011) M. Sano et al.   NEUROLOGY

Oxidative Stress and β-Amyloid Protein in Alzheimer’s Disease

(2011) Zhiyou Cai et al.   NEUROMOLECULAR MEDICINE

Metabolomics in Early Alzheimer's Disease: Identification of Altered Plasma Sphingolipidome Using Shotgun Lipidomics

(2011) Xianlin Han et al.   PLoS One

Membrane Organization and Lipid Rafts

(2011) K. Simons et al.   Cold Spring Harbor Perspectives in Biology

What was lost in translation in the DHA trial is whom you should intend to treat

(2011) Sally A Frautschy et al.   Alzheimers Research & Therapy

Efficacy of a medical food in mild Alzheimer's disease: A randomized, controlled trial

(2010) Philip Scheltens et al.   Alzheimers & Dementia

Beneficial effects of docosahexaenoic acid on cognition in age-related cognitive decline

(2010) Karin Yurko-Mauro et al.   Alzheimers & Dementia

Ectodomain shedding of the Notch ligand Jagged1 is mediated by ADAM17, but is not a lipid-raft-associated event

(2010) Catherine A. Parr-Sturgess et al.   BIOCHEMICAL JOURNAL

Lipids in Alzheimer's disease: A century-old story

(2010) Paul Foley   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Clathrin-dependent APP endocytosis and Aβ secretion are highly sensitive to the level of plasma membrane cholesterol

(2010) Jack-Christophe Cossec et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Docosahexaenoic Acid Supplementation and Cognitive Decline in Alzheimer Disease

(2010) Joseph F. Quinn et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Ganglioside-mediated aggregation of amyloid β-proteins (Aβ): comparison between Aβ-(1-42) and Aβ-(1-40)

(2010) Mariko Ogawa et al.   JOURNAL OF NEUROCHEMISTRY

Fibrillar Amyloid- -Activated Human Astroglia Kill Primary Human Neurons via Neutral Sphingomyelinase: Implications for Alzheimer's Disease

(2010) A. Jana et al.   JOURNAL OF NEUROSCIENCE

Effects of fatty acid unsaturation numbers on membrane fluidity and α-secretase-dependent amyloid precursor protein processing

(2010) Xiaoguang Yang et al.   NEUROCHEMISTRY INTERNATIONAL

Randomized controlled trial of atorvastatin in mild to moderate Alzheimer disease: LEADe

(2010) H. H. Feldman et al.   NEUROLOGY

Homocysteine-Lowering by B Vitamins Slows the Rate of Accelerated Brain Atrophy in Mild Cognitive Impairment: A Randomized Controlled Trial

(2010) A. David Smith et al.   PLoS One

Deficient Liver Biosynthesis of Docosahexaenoic Acid Correlates with Cognitive Impairment in Alzheimer's Disease

(2010) Giuseppe Astarita et al.   PLoS One

Genetic Evidence Implicates the Immune System and Cholesterol Metabolism in the Aetiology of Alzheimer's Disease

(2010) Lesley Jones et al.   PLoS One

Lipid Rafts As a Membrane-Organizing Principle

(2010) D. Lingwood et al.   SCIENCE

Dietary fish and meat intake and dementia in Latin America, China, and India: a 10/66 Dementia Research Group population-based study

(2009) Emiliano Albanese et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Use of Phosphatide Precursors to Promote Synaptogenesis

(2009) Richard J. Wurtman et al.   Annual Review of Nutrition

Mediterranean Diet and Mild Cognitive Impairment

(2009) Nikolaos Scarmeas et al.   ARCHIVES OF NEUROLOGY

Effects of docosahexaenoic acid on in vitro amyloid beta peptide 25–35 fibrillation

(2009) Michio Hashimoto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The reliability of three depression rating scales in a general population of Dutch older persons

(2009) Ondine van de Rest et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Mechanism of docosahexaenoic acid-induced inhibition ofin vitroAβ1-42fibrillation and Aβ1-42-induced toxicity in SH-S5Y5 cells

(2009) Shahdat Hossain et al.   JOURNAL OF NEUROCHEMISTRY

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

(2009) Denise Harold et al.   NATURE GENETICS

Diffusion of docosahexaenoic and eicosapentaenoic acids through the blood–brain barrier: An in situ cerebral perfusion study

(2009) Melissa Ouellet et al.   NEUROCHEMISTRY INTERNATIONAL

The Role of Apolipoprotein E in Alzheimer's Disease

(2009) Jungsu Kim et al.   NEURON

Structural Studies of the Transmembrane C-Terminal Domain of the Amyloid Precursor Protein (APP): Does APP Function as a Cholesterol Sensor?†‡

(2008) Andrew J. Beel et al.   BIOCHEMISTRY

Age-dependent high-density clustering of GM1 ganglioside at presynaptic neuritic terminals promotes amyloid β-protein fibrillogenesis

(2008) Naoki Yamamoto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Independent Inhibition of Alzheimer Disease β- and γ-Secretase Cleavage by Lowered Cholesterol Levels

(2008) Marcus O. W. Grimm et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane microdomain switching: a regulatory mechanism of amyloid precursor protein processing

(2008) Takashi Sakurai et al.   JOURNAL OF CELL BIOLOGY

Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease

(2008) Suzanne E. Wahrle et al.   JOURNAL OF CLINICAL INVESTIGATION

Neuroprotectin D1-mediated anti-inflammatory and survival signaling in stroke, retinal degenerations, and Alzheimer's disease

(2008) Nicolas G. Bazan   JOURNAL OF LIPID RESEARCH

Formation of Toxic Aβ(1–40) Fibrils on GM1 Ganglioside-Containing Membranes Mimicking Lipid Rafts: Polymorphisms in Aβ(1–40) Fibrils

(2008) Takuma Okada et al.   JOURNAL OF MOLECULAR BIOLOGY

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Elimination of GD3 synthase improves memory and reduces amyloid-β plaque load in transgenic mice

(2008) Alexandra Bernardo et al.   NEUROBIOLOGY OF AGING

Apolipoprotein E mediates sulfatide depletion in animal models of Alzheimer's disease

(2008) Hua Cheng et al.   NEUROBIOLOGY OF AGING

Deregulation of sphingolipid metabolism in Alzheimer's disease

(2008) Xingxuan He et al.   NEUROBIOLOGY OF AGING

Oral administration of circulating precursors for membrane phosphatides can promote the synthesis of new brain synapses

(2007) Mehmet Cansev et al.   Alzheimers & Dementia

Behavioral Deficits Associated with Dietary Induction of Decreased Brain Docosahexaenoic Acid Concentration

(2003) Toru Moriguchi et al.   JOURNAL OF NEUROCHEMISTRY