Identification and biology of α-secretase

Surface expression and limited proteolysis of ADAM10 are increased by a dominant negative inhibitor of dynamin

(2011) Robyn M Carey et al.   BMC CELL BIOLOGY

The Extracellular Regulated Kinase-1 (ERK1) Controls Regulated α-Secretase-mediated Processing, Promoter Transactivation, and mRNA Levels of the Cellular Prion Protein

(2011) Moustapha Cissé et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Crystal Structure of Death Receptor 6 (DR6): A Potential Receptor of the Amyloid Precursor Protein (APP)

(2011) Miriam Kuester et al.   JOURNAL OF MOLECULAR BIOLOGY

ERK1-independent α-secretase cut of β-amyloid precursor protein via M1 muscarinic receptors and PKCα/ε

(2011) Moustapha Cisse et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

TACE (ADAM17) inhibits Schwann cell myelination

(2011) Rosa La Marca et al.   NATURE NEUROSCIENCE

Novel Research Horizons for Presenilins and γ-Secretases in Cell Biology and Disease

(2010) Bart De Strooper et al.   Annual Review of Cell and Developmental Biology

The cytoplasmic domains of TNFα-converting enzyme (TACE/ADAM17) and L-selectin are regulated differently by p38 MAPK and PKC to promote ectodomain shedding

(2010) David J. Killock et al.   BIOCHEMICAL JOURNAL

Blocking ADAM10 synaptic trafficking generates a model of sporadic Alzheimer’s disease

(2010) Roberta Epis et al.   BRAIN

ADAM10 is the physiologically relevant, constitutive α-secretase of the amyloid precursor protein in primary neurons

(2010) Peer-Hendrik Kuhn et al.   EMBO JOURNAL

The Purinergic Receptor P2X7 Triggers α-Secretase-dependent Processing of the Amyloid Precursor Protein

(2010) Cécile Delarasse et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin-like Growth Factor-1 (IGF-1)-induced Processing of Amyloid-β Precursor Protein (APP) and APP-like Protein 2 Is Mediated by Different Metalloproteinases

(2010) Kristin T. Jacobsen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alpha-secretase in Alzheimer’s disease: molecular identity, regulation and therapeutic potential

(2010) Stefan F. Lichtenthaler   JOURNAL OF NEUROCHEMISTRY

Synaptic Localization and Activity of ADAM10 Regulate Excitatory Synapses through N-Cadherin Cleavage

(2010) M. Malinverno et al.   JOURNAL OF NEUROSCIENCE

The Disintegrin/Metalloproteinase ADAM10 Is Essential for the Establishment of the Brain Cortex

(2010) E. Jorissen et al.   JOURNAL OF NEUROSCIENCE

Amyloid Precursor Protein Cleavage-Dependent and -Independent Axonal Degeneration Programs Share a Common Nicotinamide Mononucleotide Adenylyltransferase 1-Sensitive Pathway

(2010) B. P. S. Vohra et al.   JOURNAL OF NEUROSCIENCE

sAPPα antagonizes dendritic degeneration and neuron death triggered by proteasomal stress

(2010) Ekaterini Copanaki et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Release of exosomes from differentiated neurons and its regulation by synaptic glutamatergic activity

(2010) Gaelle Lachenal et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Classification and basic pathology of Alzheimer disease

(2009) Charles Duyckaerts et al.   ACTA NEUROPATHOLOGICA

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

Targeting Aβ and tau in Alzheimer's disease, an early interim report

(2009) Todd E. Golde et al.   EXPERIMENTAL NEUROLOGY

Neuroprotective Secreted Amyloid Precursor Protein Acts by Disrupting Amyloid Precursor Protein Dimers

(2009) Matthias Gralle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ADAM10, the Rate-limiting Protease of Regulated Intramembrane Proteolysis of Notch and Other Proteins, Is Processed by ADAMS-9, ADAMS-15, and the γ-Secretase

(2009) Thomas Tousseyn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metalloprotease ADAM10 Is Required for Notch1 Site 2 Cleavage

(2009) Geert van Tetering et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A disintegrin and metalloproteinase (ADAM)-mediated ectodomain shedding of ADAM10

(2009) Edward Parkin et al.   JOURNAL OF NEUROCHEMISTRY

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

(2009) Anatoly Nikolaev et al.   NATURE

Regulation of cell–cell adhesion by the cadherin–catenin complex

(2008) W. James Nelson   BIOCHEMICAL SOCIETY TRANSACTIONS

CSF APPsα and Phosphorylated Tau Protein Levels in Mild Cognitive Impairment and Dementia of Alzheimer's Type

(2008) Andreas Fellgiebel et al.   JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY

Interleukin-1β up-regulates TACE to enhance α-cleavage of APP in neurons: resulting decrease in Aβ production

(2008) Yuriko Tachida et al.   JOURNAL OF NEUROCHEMISTRY

Effects of TNF -Converting Enzyme Inhibition on Amyloid   Production and APP Processing In Vitro and In Vivo

(2008) M. L. Kim et al.   JOURNAL OF NEUROSCIENCE

MMP-9 Sheds the β2Integrin Subunit (CD18) from Macrophages

(2008) Tomáš Vaisar et al.   MOLECULAR & CELLULAR PROTEOMICS

The ADAM metalloproteinases

(2008) D EDWARDS et al.   MOLECULAR ASPECTS OF MEDICINE

Effects of neuron-specific ADAM10 modulation in an in vivo model of acute excitotoxic stress

(2008) A.B. Clement et al.   NEUROSCIENCE

Cadherins and catenins at synapses: roles in synaptogenesis and synaptic plasticity

(2008) Jyothi Arikkath et al.   TRENDS IN NEUROSCIENCES