Advances in Proteomic Techniques for Cytokine Analysis: Focus on Melanoma Research

Chromatin organization as an indicator of glucocorticoid induced natural killer cell dysfunction

(2018) Michael S. Misale et al.   BRAIN BEHAVIOR AND IMMUNITY

Functional interplay between secreted ligands and receptors in melanoma

(2018) Cecilia Herraiz et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The role of the tumour microenvironment in immune therapy

(2017) Stephan Gasser et al.   ENDOCRINE-RELATED CANCER

Peripheral CD8 effector-memory type 1 T-cells correlate with outcome in ipilimumab-treated stage IV melanoma patients

(2017) Kilian Wistuba-Hamprecht et al.   EUROPEAN JOURNAL OF CANCER

The proportion of circulating CD45RO + CD8 + memory T cells is correlated with clinical response in melanoma patients treated with ipilimumab

(2017) Julia K. Tietze et al.   EUROPEAN JOURNAL OF CANCER

Adjuvant interferon-α for the treatment of high-risk melanoma: An individual patient data meta-analysis

(2017) Natalie J. Ives et al.   EUROPEAN JOURNAL OF CANCER

Identification of Nidogen 1 as a lung metastasis protein through secretome analysis

(2017) Maša Alečković et al.   GENES & DEVELOPMENT

Development of an epitope panel for consistent identification of antigen-specific T-cells in humans

(2017) Andreas Fløe et al.   IMMUNOLOGY

miRNAs, Melanoma and Microenvironment: An Intricate Network

(2017) Gabriele Romano et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Assessing basophil activation by using flow cytometry and mass cytometry in blood stored 24 hours before analysis

(2017) Kaori Mukai et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mass cytometry identifies a distinct monocyte cytokine signature shared by clinically heterogeneous pediatric SLE patients

(2017) W.E. O'Gorman et al.   JOURNAL OF AUTOIMMUNITY

Precise role of dermal fibroblasts on melanocyte pigmentation

(2017) Yinjuan Wang et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

An optimized protocol for the generation and functional analysis of human mast cells from CD34 + enriched cell populations

(2017) Yuzhi Yin et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Melanoma antigen-specific effector T cell cytokine secretion patterns in patients treated with ipilimumab

(2017) Yana G. Najjar et al.   Journal of Translational Medicine

Regression in primary cutaneous melanoma: etiopathogenesis and clinical significance

(2017) Phyu P Aung et al.   LABORATORY INVESTIGATION

How Signaling Molecules Regulate Tumor Microenvironment: Parallels to Wound Repair

(2017) Peter Gál et al.   MOLECULES

Targeted agents and immunotherapies: optimizing outcomes in melanoma

(2017) Jason J. Luke et al.   Nature Reviews Clinical Oncology

Low molecular weight heparins prevent the induction of autophagy of activated neutrophils and the formation of neutrophil extracellular traps

(2017) Angelo A. Manfredi et al.   PHARMACOLOGICAL RESEARCH

Role for extracellular vesicles in the tumour microenvironment

(2017) Ana O'Loghlen   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

drLumi: An open-source package to manage data, calibrate, and conduct quality control of multiplex bead-based immunoassays data analysis

(2017) Hector Sanz et al.   PLoS One

SWATH-MS as a tool for biomarker discovery: From basic research to clinical applications

(2017) Sandra Isabel Anjo et al.   PROTEOMICS

Emerging Cytokine Biosensors with Optical Detection Modalities and Nanomaterial-Enabled Signal Enhancement

(2017) Manpreet Singh et al.   SENSORS

Ultrasensitive bioanalysis: current status and future trends

(2017) Stéphanie Simon et al.   Bioanalysis

Multi-laboratory assessment of reproducibility, qualitative and quantitative performance of SWATH-mass spectrometry

(2017) Ben C. Collins et al.   Nature Communications

Ipilimumab treatment decreases monocytic MDSCs and increases CD8 effector memory T cells in long-term survivors with advanced melanoma

(2017) Yago Pico de Coana et al.   Oncotarget

Plasma Levels of Aβ42 and Tau Identified Probable Alzheimer’s Dementia: Findings in Two Cohorts

(2017) Lih-Fen Lue et al.   Frontiers in Aging Neuroscience

Immunomodulatory Monoclonal Antibodies in Combined Immunotherapy Trials for Cutaneous Melanoma

(2017) Mariana Aris et al.   Frontiers in Immunology

B cells and the humoral response in melanoma: The overlooked players of the tumor microenvironment

(2017) Giulia Chiaruttini et al.   OncoImmunology

The MeLiM Minipig: An Original Spontaneous Model to Explore Cutaneous Melanoma Genetic Basis

(2017) Emmanuelle Bourneuf   Frontiers in Genetics

Single-cell profiling of dynamic cytokine secretion and the phenotype of immune cells

(2017) Xingyue An et al.   PLoS One

Emerging techniques for ultrasensitive protein analysis

(2016) Xiaolong Yang et al.   ANALYST

Immuno-PCR: An ultrasensitive immunoassay for biomolecular detection

(2016) Le Chang et al.   ANALYTICA CHIMICA ACTA

Multiplex single molecule counting technology used to generate interleukin 4, interleukin 6, and interleukin 10 reference limits

(2016) Michele Gilbert et al.   ANALYTICAL BIOCHEMISTRY

Ultrasensitive Detection of α-Fetoprotein by Total Internal Reflection Scattering-Based Super-Resolution Microscopy for Superlocalization of Nano-Immunoplasmonics

(2016) Sujin Ahn et al.   ANALYTICAL CHEMISTRY

Protein Chips Compatible with MALDI Mass Spectrometry Prepared by Ambient Ion Landing

(2016) Petr Pompach et al.   ANALYTICAL CHEMISTRY

Digital Bioassays: Theory, Applications, and Perspectives

(2016) Yi Zhang et al.   ANALYTICAL CHEMISTRY

Immuno-PCR: achievements and perspectives

(2016) D. Y. Ryazantsev et al.   BIOCHEMISTRY-MOSCOW

Recent advances in cytokine detection by immunosensing

(2016) Guozhen Liu et al.   BIOSENSORS & BIOELECTRONICS

Enzyme-linked immunosorbent assay (ELISA): the basics

(2016) Karishma Shah et al.   BRITISH JOURNAL OF HOSPITAL MEDICINE

Systematic review of the use of granulocyte–macrophage colony-stimulating factor in patients with advanced melanoma

(2016) Christoph Hoeller et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

HMGB1, IL-1α, IL-33 and S100 proteins: dual-function alarmins

(2016) Damien Bertheloot et al.   Cellular & Molecular Immunology

Phenotypic and functional characterization of neutrophils and monocytes from patients with myelodysplastic syndrome by flow cytometry

(2016) Cornelia S. Schmidt et al.   CELLULAR IMMUNOLOGY

The CXCL8-CXCR1/2 pathways in cancer

(2016) Qian Liu et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Combination of IL-6, IL-10, and MCP-1 with traditional serum tumor markers in lung cancer diagnosis and prognosis

(2016) Y.W. Pan et al.   GENETICS AND MOLECULAR RESEARCH

Simultaneous blocking of IL-6 and IL-8 is sufficient to fully inhibit CAF-induced human melanoma cell invasiveness

(2016) Njainday Pulo Jobe et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Immunomagnetic Reduction Assay on Des-Gamma-Carboxy Prothrombin for Screening of Hepatocellular Carcinoma

(2016) Jen-Jie Chieh et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

Predictors of tumor-infiltrating lymphocyte efficacy in melanoma

(2016) Dragoslav Zikich et al.   Immunotherapy

Macrophage secretion heterogeneity in engineered microenvironments revealed using a microwell platform

(2016) Frances Y. McWhorter et al.   Integrative Biology

Tumor immune profiling predicts response to anti–PD-1 therapy in human melanoma

(2016) Adil I. Daud et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumor-associated macrophages in skin: How to treat their heterogeneity and plasticity

(2016) Taku Fujimura et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Plasmacytoid dendritic cell role in cutaneous malignancies

(2016) Dana Saadeh et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Evaluation of highly sensitive immunoassay technologies for quantitative measurements of sub-pg/mL levels of cytokines in human serum

(2016) David Yeung et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Exogenous IL-2 Induces FoxP3+ Th17 Cells In Vivo in Melanoma Patients

(2016) Maggie L. Diller et al.   JOURNAL OF IMMUNOTHERAPY

Revelation of the IFNα, IL-10, IL-8 and IL-1β as promising biomarkers reflecting immuno-pathological mechanisms in porcine Huntington's disease model

(2016) Ivona Valekova et al.   JOURNAL OF NEUROIMMUNOLOGY

The secretome signature of malignant mesothelioma cell lines

(2016) Marcello Manfredi et al.   Journal of Proteomics

A multiplex immunoassay for the non-invasive detection of bladder cancer

(2016) Yoshiko Shimizu et al.   Journal of Translational Medicine

Complete response to high-dose IL-2 and enhanced IFNγ+Th17 

(2016) Maggie L. Diller et al.   MELANOMA RESEARCH

Application of immuno-PCR for the detection of early stage cancer

(2016) Amjad Hayat Khan et al.   MOLECULAR AND CELLULAR PROBES

Metabolic rewiring in melanoma

(2016) B I Ratnikov et al.   ONCOGENE

Chemokines, cytokines and exosomes help tumors to shape inflammatory microenvironment

(2016) K.-S.N. Atretkhany et al.   PHARMACOLOGY & THERAPEUTICS

Intercellular crosstalk in human malignant melanoma

(2016) Barbora Dvořánková et al.   PROTOPLASMA

Immuno-PCR in cancer and non-cancer related diseases: a review

(2016) Anna Luiza F. V. Assumpção et al.   VETERINARY QUARTERLY

PD-1 Blockade Expands Intratumoral Memory T Cells

(2016) A. Ribas et al.   Cancer Immunology Research

Natural Killer Cell Recognition of Melanoma: New Clues for a More Effective Immunotherapy

(2016) Raquel Tarazona et al.   Frontiers in Immunology

Role of IL-2 in cancer immunotherapy

(2016) Tao Jiang et al.   OncoImmunology

Label-free cytokine micro- and nano-biosensing towards personalized medicine of systemic inflammatory disorders

(2015) Pengyu Chen et al.   ADVANCED DRUG DELIVERY REVIEWS

Single molecule array (Simoa) assay with optimal antibody pairs for cytokine detection in human serum samples

(2015) Danlu Wu et al.   ANALYST

Bioanalytical chemistry of cytokines – A review

(2015) Julie A. Stenken et al.   ANALYTICA CHIMICA ACTA

Biosensors for Cell Analysis

(2015) Qing Zhou et al.   Annual Review of Biomedical Engineering

Planar Functionalized Surfaces for Direct Immunoaffinity Desorption/Ionization Mass Spectrometry

(2015) P. Pompach et al.   CLINICAL CHEMISTRY

Plasma immune analytes in patients with epithelial ovarian cancer

(2015) Matthew S. Block et al.   CYTOKINE

Cancer Microenvironment: What Can We Learn from the Stem Cell Niche

(2015) Lukas Lacina et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Fibroblasts isolated from the malignant melanoma influence phenotype of normal human keratinocytes

(2015) Jan Kučera et al.   Journal of Applied Biomedicine

A fully-automated, six-plex single molecule immunoassay for measuring cytokines in blood

(2015) Andrew J. Rivnak et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Cross-species models of human melanoma

(2015) Louise van der Weyden et al.   JOURNAL OF PATHOLOGY

The HGF-cMET signaling pathway in conferring stromal-induced BRAF-inhibitor resistance in melanoma

(2015) Dan C. Filitis et al.   MELANOMA RESEARCH

Spontaneous cellular and humoral tumor antigen responses in patients with uveal melanoma

(2015) Pierre L. Triozzi et al.   MELANOMA RESEARCH

Melanoma cells influence the differentiation pattern of human epidermal keratinocytes

(2015) Ondřej Kodet et al.   Molecular Cancer

Pro-Inflammatory Cytokines Predict Relapse-Free Survival after One Month of Interferon-α but Not Observation in Intermediate Risk Melanoma Patients

(2015) Ahmad A. Tarhini et al.   PLoS One

Highly multiplexed profiling of single-cell effector functions reveals deep functional heterogeneity in response to pathogenic ligands

(2015) Yao Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of colorectal cancer glyco-secretome identifies laminin β-1 (LAMB1) as a potential serological biomarker for colorectal cancer

(2015) Qifeng Lin et al.   PROTEOMICS

Digital detection of biomarkers assisted by nanoparticles: application to diagnostics

(2015) Marina Cretich et al.   TRENDS IN BIOTECHNOLOGY

Regulatory T cells in the immunotherapy of melanoma

(2015) Zhengxiao Ouyang et al.   TUMOR BIOLOGY

The prognostic impact of specific CD4 T-cell responses is critically dependent on the target antigen in melanoma

(2015) Henning Zelba et al.   OncoImmunology

Emerging Technologies to Increase Ligand Binding Assay Sensitivity

(2014) Saloumeh K. Fischer et al.   AAPS Journal

Serum Interleukin-8 Reflects Tumor Burden and Treatment Response across Malignancies of Multiple Tissue Origins

(2014) M. F. Sanmamed et al.   CLINICAL CANCER RESEARCH

Circulating CD4+ T Cells That Produce IL4 or IL17 When Stimulated by Melan-A but Not by NY-ESO-1 Have Negative Impacts on Survival of Patients with Stage IV Melanoma

(2014) H. Zelba et al.   CLINICAL CANCER RESEARCH

Effects of serum and plasma matrices on multiplex immunoassays

(2014) Yael Rosenberg-Hasson et al.   IMMUNOLOGIC RESEARCH

A Combined Prognostic Serum Interleukin-8 and Interleukin-6 Classifier for Stage 1 Lung Cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial

(2014) Bríd M. Ryan et al.   Journal of Thoracic Oncology

Melanoma brain metastasis globally reconfigures chemokine and cytokine profiles in patient cerebrospinal fluid

(2014) Edwin Lok et al.   MELANOMA RESEARCH

Mass spectrometry based biomarker discovery, verification, and validation - Quality assurance and control of protein biomarker assays

(2014) Carol E. Parker et al.   Molecular Oncology

Single-cell technologies for monitoring immune systems

(2014) Pratip K Chattopadhyay et al.   NATURE IMMUNOLOGY

Mass Spectrometric Immunoassay for the qualitative and quantitative analysis of the cytokine Macrophage Migration Inhibitory Factor (MIF)

(2014) Nisha D Sherma et al.   Proteome Science

The melanoma revolution: From UV carcinogenesis to a new era in therapeutics

(2014) J. A. Lo et al.   SCIENCE

Development of antibody functionalized magnetic nanoparticles for the immunoassay of carcinoembryonic antigen: a feasibility study for clinical use

(2014) Che-Chuan Yang et al.   JOURNAL OF NANOBIOTECHNOLOGY

A repository of assays to quantify 10,000 human proteins by SWATH-MS

(2014) George Rosenberger et al.   Scientific Data

High-Throughput Secretomic Analysis of Single Cells to Assess Functional Cellular Heterogeneity

(2013) Yao Lu et al.   ANALYTICAL CHEMISTRY

Plasma Cytokine Analysis in Patients with Advanced Extremity Melanoma Undergoing Isolated Limb Infusion

(2013) Gina Shetty et al.   ANNALS OF SURGICAL ONCOLOGY

Advances in multiplexed MRM-based protein biomarker quantitation toward clinical utility

(2013) Andrew J. Percy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Current management of melanoma

(2013) Erik M. Dunki-Jacobs et al.   CURRENT PROBLEMS IN SURGERY

Melanoma epidemiology, biology and prognosis

(2013) Z. Ali et al.   EJC SUPPLEMENTS

Immunotherapy of melanoma

(2013) John B.A.G. Haanen   EJC SUPPLEMENTS

Cancer incidence and mortality patterns in Europe: Estimates for 40 countries in 2012

(2013) J. Ferlay et al.   EUROPEAN JOURNAL OF CANCER

UV Radiation and the Skin

(2013) John D'Orazio et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Multiplexed single molecule immunoassays

(2013) David M. Rissin et al.   LAB ON A CHIP

Enhancement of Tumor-Reactive Cytotoxic CD4+ T-cell Responses after Ipilimumab Treatment in Four Advanced Melanoma Patients

(2013) S. Kitano et al.   Cancer Immunology Research

Melanoma as a model tumour for immuno-oncology

(2012) M. Maio   ANNALS OF ONCOLOGY

Upregulation of IL-6, IL-8 and CXCL-1 production in dermal fibroblasts by normal/malignant epithelial cellsin vitro: Immunohistochemical and transcriptomic analyses

(2012) Michal Kolář et al.   BIOLOGY OF THE CELL

Analysis of nuclear localization of interleukin-1 family cytokines by flow cytometry

(2012) Ralf Ross et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Interleukin-6 and melanoma

(2012) Lise Hoejberg et al.   MELANOMA RESEARCH

Phase 1 Study of Stereotactic Body Radiotherapy and Interleukin-2--Tumor and Immunological Responses

(2012) S. K. Seung et al.   Science Translational Medicine

A Dynamic Inflammatory Cytokine Network in the Human Ovarian Cancer Microenvironment

(2011) H. Kulbe et al.   CANCER RESEARCH

ELISpot for measuring human immune responses to vaccines

(2011) Meredith Slota et al.   Expert Review of Vaccines

Exploration of the Relationship Between the Tumor Burden and the Concentration of Vascular Endothelial Growth Factor in Liver-Cancer-Bearing Animals Using Immunomagnetic Reduction Assay

(2011) K. W. Huang et al.   Journal of Biomedical Nanotechnology

Multiplex measurement of proinflammatory cytokines in human serum: Comparison of the Meso Scale Discovery electrochemiluminescence assay and the Cytometric Bead Array

(2011) Djeneba Dabitao et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Proteomic Profiling of Human Melanoma Metastatic Cell Line Secretomes

(2011) Micaela Rocco et al.   JOURNAL OF PROTEOME RESEARCH

Electrochemiluminescence of tris(2,2′-bipyridyl)ruthenium and its applications in bioanalysis: a review

(2011) Hui Wei et al.   LUMINESCENCE

Interlaboratory Evaluation of Automated, Multiplexed Peptide Immunoaffinity Enrichment Coupled to Multiple Reaction Monitoring Mass Spectrometry for Quantifying Proteins in Plasma

(2011) Eric Kuhn et al.   MOLECULAR & CELLULAR PROTEOMICS

A clinical microchip for evaluation of single immune cells reveals high functional heterogeneity in phenotypically similar T cells

(2011) Chao Ma et al.   NATURE MEDICINE

gp100 Peptide Vaccine and Interleukin-2 in Patients with Advanced Melanoma

(2011) Douglas J. Schwartzentruber et al.   NEW ENGLAND JOURNAL OF MEDICINE

Polyfunctional responses by human T cells result from sequential release of cytokines

(2011) Q. Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum

(2011) S. C. Bendall et al.   SCIENCE

The soluble Interleukin 6 receptor: Generation and role in inflammation and cancer

(2010) Athena Chalaris et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Single-molecule enzyme-linked immunosorbent assay detects serum proteins at subfemtomolar concentrations

(2010) David M Rissin et al.   NATURE BIOTECHNOLOGY

Mass spectrometry in high-throughput proteomics: ready for the big time

(2010) Tommy Nilsson et al.   NATURE METHODS

Antibody array-based technologies for cancer protein profiling and functional proteomic analyses using serum and tissue specimens

(2010) Marta Sanchez-Carbayo   TUMOR BIOLOGY

Detecting Cytokine Release from Single T-cells

(2009) He Zhu et al.   ANALYTICAL CHEMISTRY

Mass Cytometry: Technique for Real Time Single Cell Multitarget Immunoassay Based on Inductively Coupled Plasma Time-of-Flight Mass Spectrometry

(2009) Dmitry R. Bandura et al.   ANALYTICAL CHEMISTRY

Comparison of Multiplex Immunoassay Platforms

(2009) Q. Fu et al.   CLINICAL CHEMISTRY

Novel Strategies and Tools for Enhanced Sensitivity in Routine Biomolecule Analytics

(2009) Michael Adler et al.   Current Pharmaceutical Analysis

CXCL8 and its cognate receptors in melanoma progression and metastasis

(2009) Seema Singh et al.   Future Oncology

Entering a New Era of Rational Biomarker Discovery for Early Detection of Melanoma Metastases: Secretome Analysis of Associated Stroma Cells

(2009) Verena Paulitschke et al.   JOURNAL OF PROTEOME RESEARCH

Spontaneous regression of metastases from melanoma: review of the literature

(2009) Louise Vennegaard Kalialis et al.   MELANOMA RESEARCH

Multi-site assessment of the precision and reproducibility of multiple reaction monitoring–based measurements of proteins in plasma

(2009) Terri A Addona et al.   NATURE BIOTECHNOLOGY

Electrochemiluminescence in bioanalysis

(2009) Paul W Rhyne et al.   Bioanalysis

Biological and Technical Variables Affecting Immunoassay Recovery of Cytokines from Human Serum and Simulated Vaginal Fluid: A Multicenter Study

(2008) Raina N. Fichorova et al.   ANALYTICAL CHEMISTRY

Concurrent detection of secreted products from human lymphocytes by microengraving: Cytokines and antigen-reactive antibodies

(2008) Elizabeth M. Bradshaw et al.   CLINICAL IMMUNOLOGY

Three Phase II Cytokine Working Group Trials of gp100 (210M) Peptide Plus High-Dose Interleukin-2 in Patients With HLA-A2–Positive Advanced Melanoma

(2008) Jeffrey A. Sosman et al.   JOURNAL OF CLINICAL ONCOLOGY

Phase III Trial Comparing Concurrent Biochemotherapy With Cisplatin, Vinblastine, Dacarbazine, Interleukin-2, and Interferon Alfa-2b With Cisplatin, Vinblastine, and Dacarbazine Alone in Patients With Metastatic Malignant Melanoma (E3695): A Trial Coordinated by the Eastern Cooperative Oncology Group

(2008) Michael B. Atkins et al.   JOURNAL OF CLINICAL ONCOLOGY

Validation and comparison of two multiplex technologies, Luminex® and Mesoscale Discovery, for human cytokine profiling

(2008) Ferdousi Chowdhury et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Macrophage Inhibitory Cytokine-1 Is Overexpressed in Malignant Melanoma and Is Associated with Tumorigenicity

(2008) Glen M. Boyle et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Quantification of human insulin-like growth factor-1 and qualitative detection of its analogues in plasma using liquid chromatography/electrospray ionisation tandem mass spectrometry

(2008) Michael Bredehöft et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY