Highly multiplexed profiling of single-cell effector functions reveals deep functional heterogeneity in response to pathogenic ligands

Conversion of Danger Signals into Cytokine Signals by Hematopoietic Stem and Progenitor Cells for Regulation of Stress-Induced Hematopoiesis

(2014) Jimmy L. Zhao et al.   Cell Stem Cell

Single-cell technologies for monitoring immune systems

(2014) Pratip K Chattopadhyay et al.   NATURE IMMUNOLOGY

Glioblastoma cellular architectures are predicted through the characterization of two-cell interactions

(2014) N. Kravchenko-Balasha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-Throughput Secretomic Analysis of Single Cells to Assess Functional Cellular Heterogeneity

(2013) Yao Lu et al.   ANALYTICAL CHEMISTRY

Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells

(2013) Alex K. Shalek et al.   NATURE

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

viSNE enables visualization of high dimensional single-cell data and reveals phenotypic heterogeneity of leukemia

(2013) El-ad David Amir et al.   NATURE BIOTECHNOLOGY

Cytometry by Time-of-Flight Shows Combinatorial Cytokine Expression and Virus-Specific Cell Niches within a Continuum of CD8+ T Cell Phenotypes

(2012) Evan W. Newell et al.   IMMUNITY

Defining GM-CSF- and Macrophage-CSF-Dependent Macrophage Responses by In Vitro Models

(2012) D. C. Lacey et al.   JOURNAL OF IMMUNOLOGY

Quantitating Cell–Cell Interaction Functions with Applications to Glioblastoma Multiforme Cancer Cells

(2012) Jun Wang et al.   NANO LETTERS

Next-generation proteomics: towards an integrative view of proteome dynamics

(2012) A. F. Maarten Altelaar et al.   NATURE REVIEWS GENETICS

Rapid, efficient functional characterization and recovery of HIV-specific human CD8+ T cells using microengraving

(2012) N. Varadarajan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A clinical microchip for evaluation of single immune cells reveals high functional heterogeneity in phenotypically similar T cells

(2011) Chao Ma et al.   NATURE MEDICINE

Single-cell proteomic chip for profiling intracellular signaling pathways in single tumor cells

(2011) Q. Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polyfunctional responses by human T cells result from sequential release of cytokines

(2011) Q. Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum

(2011) S. C. Bendall et al.   SCIENCE

Cellular Heterogeneity: Do Differences Make a Difference?

(2010) Steven J. Altschuler et al.   CELL

Multidimensional analysis of the frequencies and rates of cytokine secretion from single cells by quantitative microengraving

(2010) Qing Han et al.   LAB ON A CHIP

Non-genetic cell-to-cell variability and the consequences for pharmacology

(2009) Mario Niepel et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Cytokine secretion in macrophages and other cells: Pathways and mediators

(2009) Jennifer L. Stow et al.   IMMUNOBIOLOGY

Cancer Cells Display Profound Intra- and Interline Variation following Prolonged Exposure to Antimitotic Drugs

(2008) Karen E. Gascoigne et al.   CANCER CELL

Concurrent detection of secreted products from human lymphocytes by microengraving: Cytokines and antigen-reactive antibodies

(2008) Elizabeth M. Bradshaw et al.   CLINICAL IMMUNOLOGY

Integrated barcode chips for rapid, multiplexed analysis of proteins in microliter quantities of blood

(2008) Rong Fan et al.   NATURE BIOTECHNOLOGY

What is principal component analysis?

(2008) Markus Ringnér   NATURE BIOTECHNOLOGY

Dynamic Proteomics of Individual Cancer Cells in Response to a Drug

(2008) A. A. Cohen et al.   SCIENCE