miRNAs, Melanoma and Microenvironment: An Intricate Network

miR-216b enhances the efficacy of vemurafenib by targeting Beclin-1, UVRAG and ATG5 in melanoma

(2018) Meiying Luo et al.   CELLULAR SIGNALLING

Noncoding RNAs and immune checkpoints-clinical implications as cancer therapeutics

(2017) Maria A. Smolle et al.   FEBS Journal

Safety and activity of microRNA-loaded minicells in patients with recurrent malignant pleural mesothelioma: a first-in-man, phase 1, open-label, dose-escalation study

(2017) Nico van Zandwijk et al.   LANCET ONCOLOGY

miRNAs as Biomarkers and Therapeutic Targets in Non-Small Cell Lung Cancer: Current Perspectives

(2017) Mateusz Florczuk et al.   Targeted Oncology

PD-L1 up-regulation in melanoma increases disease aggressiveness and is mediated through miR-17-5p

(2017) Valentina Audrito et al.   Oncotarget

Myeloid-Derived Suppressor Cells

(2017) Dmitry I. Gabrilovich   Cancer Immunology Research

MiR-211 is epigenetically regulated by DNMT1 mediated methylation and inhibits EMT of melanoma cells by targeting RAB22A

(2016) Haizhou Yu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

miR-542-3p suppresses invasion and metastasis by targeting the proto-oncogene serine/threonine protein kinase, PIM1, in melanoma

(2016) Zhen Rang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Melanoma cell–derived exosomes promote epithelial–mesenchymal transition in primary melanocytes through paracrine/autocrine signaling in the tumor microenvironment

(2016) Deyi Xiao et al.   CANCER LETTERS

ZEB1‐mediated melanoma cell plasticity enhances resistance to MAPK inhibitors

(2016) Geoffrey Richard et al.   EMBO Molecular Medicine

Exosomal microRNA Biomarkers: Emerging Frontiers in Colorectal and Other Human Cancers

(2016) Oscar A. Tovar-Camargo et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

New Concepts in Cancer Biomarkers: Circulating miRNAs in Liquid Biopsies

(2016) Erika Larrea et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MicroRNA 211 Functions as a Metabolic Switch in Human Melanoma Cells

(2016) Joseph Mazar et al.   MOLECULAR AND CELLULAR BIOLOGY

miR-146a Exerts Differential Effects on Melanoma Growth and Metastatization

(2016) M. Raimo et al.   MOLECULAR CANCER RESEARCH

Melanoma miRNA trafficking controls tumour primary niche formation

(2016) Shani Dror et al.   NATURE CELL BIOLOGY

MicroRNA-18b inhibits the growth of malignant melanoma via inhibition of HIF-1α-mediated glycolysis

(2016) YAO CHEN et al.   ONCOLOGY REPORTS

The Nature of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment

(2016) Vinit Kumar et al.   TRENDS IN IMMUNOLOGY

miR-28 modulates exhaustive differentiation of T cells through silencing programmed cell death-1 and regulating cytokine secretion

(2016) Qing Li et al.   Oncotarget

Hypoxia and metabolic adaptation of cancer cells

(2016) K L Eales et al.   Oncogenesis

The Response of microRNAs to Solar UVR in Skin-Resident Melanocytes Differs between Melanoma Patients and Healthy Persons

(2016) Jingfeng Sha et al.   PLoS One

miR-33a functions as a tumor suppressor in melanoma by targeting HIF-1α

(2015) Jianda Zhou et al.   CANCER BIOLOGY & THERAPY

Epigenetic regulation in human melanoma: past and future

(2015) Debina Sarkar et al.   Epigenetics

Mitochondrial oxidative stress as a novel therapeutic target to overcome intrinsic drug resistance in melanoma cell subpopulations

(2015) Monika Cierlitza et al.   EXPERIMENTAL DERMATOLOGY

Myeloid-derived suppressor cells in the tumor microenvironment: expect the unexpected

(2015) Douglas Marvel et al.   JOURNAL OF CLINICAL INVESTIGATION

PDL1 Regulation by p53 via miR-34

(2015) Maria Angelica Cortez et al.   JNCI-Journal of the National Cancer Institute

Let-7a inhibits migration, invasion and epithelial-mesenchymal transition by targeting HMGA2 in nasopharyngeal carcinoma

(2015) Aibing Wu et al.   Journal of Translational Medicine

Progression of mouse skin carcinogenesis is associated with the orchestrated deregulation of mir-200 family members, mir-205 and their common targets

(2015) Elena Skourti et al.   MOLECULAR CARCINOGENESIS

Interactions of Melanoma Cells with Distal Keratinocytes Trigger Metastasis via Notch Signaling Inhibition of MITF

(2015) Tamar Golan et al.   MOLECULAR CELL

Reduced adenosine-to-inosine miR-455-5p editing promotes melanoma growth and metastasis

(2015) Einav Shoshan et al.   NATURE CELL BIOLOGY

Cancer mediates effector T cell dysfunction by targeting microRNAs and EZH2 via glycolysis restriction

(2015) Ende Zhao et al.   NATURE IMMUNOLOGY

A-to-I editing of coding and non-coding RNAs by ADARs

(2015) Kazuko Nishikura   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nivolumab and Ipilimumab versus Ipilimumab in Untreated Melanoma

(2015) Michael A. Postow et al.   NEW ENGLAND JOURNAL OF MEDICINE

Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma

(2015) James Larkin et al.   NEW ENGLAND JOURNAL OF MEDICINE

miR-200c/Bmi1 axis and epithelial-mesenchymal transition contribute to acquired resistance to BRAF inhibitor treatment

(2015) Shujing Liu et al.   Pigment Cell & Melanoma Research

MicroRNA-125b suppresses the epithelial–mesenchymal transition and cell invasion by targeting ITGA9 in melanoma

(2015) Jie Zhang et al.   TUMOR BIOLOGY

The epigenetic modifier EZH2 controls melanoma growth and metastasis through silencing of distinct tumour suppressors

(2015) Daniel Zingg et al.   Nature Communications

High intensity focused ultrasound enhances anti-tumor immunity by inhibiting the negative regulatory effect of miR-134 on CD86 in a murine melanoma model

(2015) Shi-Mei Yuan et al.   Oncotarget

A novel immune resistance mechanism of melanoma cells controlled by the ADAR1 enzyme

(2015) Gilli Galore-Haskel et al.   Oncotarget

Metabolic reprogramming of metastatic breast cancer and melanoma by let-7a microRNA

(2015) Anastassia Serguienko et al.   Oncotarget

Combining TGF-β1 knockdown and miR200c administration to optimize antitumor efficacy of B16F10/GPI-IL-21 vaccine

(2015) Xiaoying Wang et al.   Oncotarget

A direct plasma assay of circulating microRNA-210 of hypoxia can identify early systemic metastasis recurrence in melanoma patients

(2015) Shigeshi Ono et al.   Oncotarget

PDL1 Regulation by p53 via miR-34

(2015) Maria Angelica Cortez et al.   JNCI-Journal of the National Cancer Institute

Phenotype Switching in Melanoma: Implications for Progression and Therapy

(2015) Frederic Zhentao Li et al.   Frontiers in Oncology

microRNA-155, Induced by Interleukin-1ß, Represses the Expression of Microphthalmia-Associated Transcription Factor (MITF-M) in Melanoma Cells

(2015) Nathalie Arts et al.   PLoS One

Genetic and epigenetic loss of microRNA-31 leads to feed-forward expression of EZH2 in melanoma

(2015) Irfan A Asangani et al.   Oncotarget

Hypoxia represses microRNA biogenesis proteins in breast cancer cells

(2014) Veronika Bandara et al.   BMC CANCER

Host miR155 Promotes Tumor Growth through a Myeloid-Derived Suppressor Cell-Dependent Mechanism

(2014) S. Chen et al.   CANCER RESEARCH

Identification of a ZEB2-MITF-ZEB1 transcriptional network that controls melanogenesis and melanoma progression

(2014) G Denecker et al.   CELL DEATH AND DIFFERENTIATION

Immune Escape Mechanisms as a Guide for Cancer Immunotherapy

(2014) G. L. Beatty et al.   CLINICAL CANCER RESEARCH

E2F1 induces miR-224/452 expression to drive EMT through TXNIP downregulation

(2014) S. Knoll et al.   EMBO REPORTS

Regulation gene expression of miR200c and ZEB1 positively enhances effect of tumor vaccine B16F10/GPI-IL-21 on inhibition of melanoma growth and metastasis

(2014) Xiaoying Wang et al.   Journal of Translational Medicine

miRNA-200c inhibits invasion and metastasis of human non-small cell lung cancer by directly targeting ubiquitin specific peptidase 25

(2014) Jing Li et al.   Molecular Cancer

MUC1-C Induces the LIN28B→LET-7→HMGA2 Axis to Regulate Self-Renewal in NSCLC

(2014) Maroof Alam et al.   MOLECULAR CANCER RESEARCH

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

CSF1-ETS2-induced microRNA in myeloid cells promote metastatic tumor growth

(2014) H Mathsyaraja et al.   ONCOGENE

Distinct microRNA expression signatures are associated with melanoma subtypes and are regulated by HIF1A

(2014) Hun-Way Hwang et al.   Pigment Cell & Melanoma Research

miR-155 augments CD8+T-cell antitumor activity in lymphoreplete hosts by enhancing responsiveness to homeostatic γccytokines

(2014) Yun Ji et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression

(2014) Rajesha Rupaimoole et al.   Nature Communications

A Melanoma Cell State Distinction Influences Sensitivity to MAPK Pathway Inhibitors

(2014) D. J. Konieczkowski et al.   Cancer Discovery

miR-146a promotes the initiation and progression of melanoma by activating Notch signaling

(2014) Matteo Forloni et al.   eLife

A non-canonical landscape of the microRNA system

(2014) Gabriel A. Cipolla   Frontiers in Genetics

Melanoma Cells Revive an Embryonic Transcriptional Network to Dictate Phenotypic Heterogeneity

(2014) Niels Vandamme et al.   Frontiers in Oncology

A Switch in the Expression of Embryonic EMT-Inducers Drives the Development of Malignant Melanoma

(2013) Julie Caramel et al.   CANCER CELL

MiR-101 inhibits melanoma cell invasion and proliferation by targeting MITF and EZH2

(2013) Chonglin Luo et al.   CANCER LETTERS

miR-214 Coordinates Melanoma Progression by Upregulating ALCAM through TFAP2 and miR-148b Downmodulation

(2013) Elisa Penna et al.   CANCER RESEARCH

Autophagy regulation by nutrient signaling

(2013) Ryan C Russell et al.   CELL RESEARCH

MicroRNA-155 Is Required for Effector CD8+ T Cell Responses to Virus Infection and Cancer

(2013) Jan C. Dudda et al.   IMMUNITY

miR-155: an ancient regulator of the immune system

(2013) Elena Vigorito et al.   IMMUNOLOGICAL REVIEWS

MicroRNA-mediated loss of ADAR1 in metastatic melanoma promotes tumor growth

(2013) Yael Nemlich et al.   JOURNAL OF CLINICAL INVESTIGATION

The microRNA miR-155 controls CD8+ T cell responses by regulating interferon signaling

(2013) Donald T Gracias et al.   NATURE IMMUNOLOGY

miR in melanoma development: miRNAs and acquired hallmarks of cancer in melanoma

(2013) Paige E. Bennett et al.   PHYSIOLOGICAL GENOMICS

Lin28 Induces Epithelial-to-Mesenchymal Transition and Stemness via Downregulation of Let-7a in Breast Cancer Cells

(2013) Yujie Liu et al.   PLoS One

miR-200c Inhibits Melanoma Progression and Drug Resistance through Down-Regulation of Bmi-1

(2012) Shujing Liu et al.   AMERICAN JOURNAL OF PATHOLOGY

miR-143, miR-222, and miR-452 Are Useful as Tumor Stratification and Noninvasive Diagnostic Biomarkers for Bladder Cancer

(2012) Patricia Puerta-Gil et al.   AMERICAN JOURNAL OF PATHOLOGY

Enhanced stability of microRNA expression facilitates classification of FFPE tumour samples exhibiting near total mRNA degradation

(2012) J S Hall et al.   BRITISH JOURNAL OF CANCER

Polycomb-Mediated Loss of miR-31 Activates NIK-Dependent NF-κB Pathway in Adult T Cell Leukemia and Other Cancers

(2012) Makoto Yamagishi et al.   CANCER CELL

Hypoxia-Inducible miR-210 Regulates the Susceptibility of Tumor Cells to Lysis by Cytotoxic T Cells

(2012) M. Z. Noman et al.   CANCER RESEARCH

Convergent Multi-miRNA Targeting of ApoE Drives LRP1/LRP8-Dependent Melanoma Metastasis and Angiogenesis

(2012) Nora Pencheva et al.   CELL

A Landscape of Driver Mutations in Melanoma

(2012) Eran Hodis et al.   CELL

Upregulation of microRNA-224 confers a poor prognosis in glioma patients

(2012) S. Lu et al.   Clinical & Translational Oncology

MicroRNA-200c modulates epithelial-to-mesenchymal transition (EMT) in human colorectal cancer metastasis

(2012) Keun Hur et al.   GUT

Involvement of microRNA-224 in cell proliferation, migration, invasion, and anti-apoptosis in hepatocellular carcinoma

(2012) Yizhou Zhang et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

MicroRNA-494 Is Required for the Accumulation and Functions of Tumor-Expanded Myeloid-Derived Suppressor Cells via Targeting of PTEN

(2012) Y. Liu et al.   JOURNAL OF IMMUNOLOGY

miR-137 Inhibits the Invasion of Melanoma Cells through Downregulation of Multiple Oncogenic Target Genes

(2012) Chonglin Luo et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The Epithelial-Mesenchymal Transition (EMT) Regulatory Factor SLUG (SNAI2) Is a Downstream Target of SPARC and AKT in Promoting Melanoma Cell Invasion

(2012) Nina Fenouille et al.   PLoS One

Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation

(2011) Sophia Y. Lunt et al.   Annual Review of Cell and Developmental Biology

miR-30b/30d Regulation of GalNAc Transferases Enhances Invasion and Immunosuppression during Metastasis

(2011) Avital Gaziel-Sovran et al.   CANCER CELL

Tumor Suppressive MicroRNAs miR-34a/c Control Cancer Cell Expression of ULBP2, a Stress-Induced Ligand of the Natural Killer Cell Receptor NKG2D

(2011) A. Heinemann et al.   CANCER RESEARCH

The code within the code: microRNAs target coding regions

(2011) Joshua J. Forman et al.   CELL CYCLE

Principles and Current Strategies for Targeting Autophagy for Cancer Treatment

(2011) R. K. Amaravadi et al.   CLINICAL CANCER RESEARCH

microRNA-214 contributes to melanoma tumour progression through suppression of TFAP2C

(2011) Elisa Penna et al.   EMBO JOURNAL

Distinctive microRNA signature of medulloblastomas associated with the WNT signaling pathway

(2011) NeelamVishwanath Shirsat et al.   Journal of Cancer Research and Therapeutics

MicroRNA-9 up-regulates E-cadherin through inhibition of NF-κB1-Snail1 pathway in melanoma

(2011) Shujing Liu et al.   JOURNAL OF PATHOLOGY

The Polycomb complex PRC2 and its mark in life

(2011) Raphaël Margueron et al.   NATURE

miR-221/222 Targeting of Trichorhinophalangeal 1 (TRPS1) Promotes Epithelial-to-Mesenchymal Transition in Breast Cancer

(2011) S. Stinson et al.   Science Signaling

Identifying mRNA targets of microRNA dysregulated in cancer: with application to clear cell Renal Cell Carcinoma

(2010) Huiqing Liu et al.   BMC Systems Biology

Signatures of MicroRNAs and Selected MicroRNA Target Genes in Human Melanoma

(2010) D. Philippidou et al.   CANCER RESEARCH

MicroRNA miR-210 modulates cellular response to hypoxia through the MYC antagonist MNT

(2010) Zhan Zhang et al.   CELL CYCLE

Differential Mechanisms of Shedding of the Glycosylphosphatidylinositol (GPI)-anchored NKG2D Ligands

(2010) Lola Fernández-Messina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Characterization of global microRNA expression reveals oncogenic potential of miR-145 in metastatic colorectal cancer

(2009) Greg M Arndt et al.   BMC CANCER

New class of microRNA targets containing simultaneous 5'-UTR and 3'-UTR interaction sites

(2009) I. Lee et al.   GENOME RESEARCH

CRM1 mediates nuclear-cytoplasmic shuttling of mature microRNAs

(2009) D. Castanotto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNAs with a nucleolar location

(2009) J. C. Ritland Politz et al.   RNA

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

In vivo Switching of Human Melanoma Cells between Proliferative and Invasive States

(2008) K. S. Hoek et al.   CANCER RESEARCH

miRNA and piRNA localization in the male mammalian meiotic nucleus

(2008) E. Marcon et al.   CHROMOSOME RESEARCH

The miR-200 Family Inhibits Epithelial-Mesenchymal Transition and Cancer Cell Migration by Direct Targeting of E-cadherin Transcriptional RepressorsZEB1andZEB2

(2008) Manav Korpal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrin β3 expression is regulated by let-7a miRNA in malignant melanoma

(2008) D W Müller et al.   ONCOGENE