Genes Affecting β-Cell Function in Type 1 Diabetes

Understanding type 2 diabetes: from genetics to epigenetics

(2015) Gregory Alexander Raciti et al.   ACTA DIABETOLOGICA

Horizontal transfer of exosomal microRNAs transduce apoptotic signals between pancreatic beta-cells

(2015) Claudiane Guay et al.   Cell Communication and Signaling

TYK2, a Candidate Gene for Type 1 Diabetes, Modulates Apoptosis and the Innate Immune Response in Human Pancreatic β-Cells

(2015) Laura Marroqui et al.   DIABETES

Reduced Expression of the MDA5 GeneIFIH1Prevents Autoimmune Diabetes

(2015) Pamela J. Lincez et al.   DIABETES

Shared Genetic Basis for Type 1 Diabetes, Islet Autoantibodies, and Autoantibodies Associated With Other Immune-Mediated Diseases in Families With Type 1 Diabetes

(2015) Caroline A. Brorsson et al.   DIABETES CARE

INS-gene mutations: From genetics and beta cell biology to clinical disease

(2015) Ming Liu et al.   MOLECULAR ASPECTS OF MEDICINE

Structural imprints in vivo decode RNA regulatory mechanisms

(2015) Robert C. Spitale et al.   NATURE

Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers

(2015) Suna Onengut-Gumuscu et al.   NATURE GENETICS

Thinking bedside at the bench: the NOD mouse model of T1DM

(2015) James C. Reed et al.   Nature Reviews Endocrinology

Long non-coding RNAs as regulators of the endocrine system

(2015) Marko Knoll et al.   Nature Reviews Endocrinology

Role of non-coding RNAs in pancreatic beta-cell development and physiology

(2014) L. Eliasson et al.   Acta Physiologica

The transcriptional landscape of mouse beta cells compared to human beta cells reveals notable species differences in long non-coding RNA and protein-coding gene expression

(2014) Christopher Benner et al.   BMC GENOMICS

BACH2, a Candidate Risk Gene for Type 1 Diabetes, Regulates Apoptosis in Pancreatic  -Cells via JNK1 Modulation and Crosstalk With the Candidate Gene PTPN2

(2014) L. Marroqui et al.   DIABETES

A Method for Gene-Based Pathway Analysis Using Genomewide Association Study Summary Statistics Reveals Nine New Type 1 Diabetes Associations

(2014) Marina Evangelou et al.   GENETIC EPIDEMIOLOGY

Temporal profiling of cytokine-induced genes in pancreatic β-cells by meta-analysis and network inference

(2014) Miguel Lopes et al.   GENOMICS

RNA-seq methods for identifying differentially expressed gene in human pancreatic islet cells treated with pro-inflammatory cytokines

(2014) Bo Li et al.   MOLECULAR BIOLOGY REPORTS

Minireview: MicroRNA Function in Pancreatic β Cells

(2014) Sabire Özcan   MOLECULAR ENDOCRINOLOGY

A comparative encyclopedia of DNA elements in the mouse genome

(2014) Feng Yue et al.   NATURE

Evolutionary dynamics of coding and non-coding transcriptomes

(2014) Anamaria Necsulea et al.   NATURE REVIEWS GENETICS

Effects of GWAS-Associated Genetic Variants on lncRNAs within IBD and T1D Candidate Loci

(2014) Aashiq H. Mirza et al.   PLoS One

Insulitis in human type 1 diabetes: a comparison between patients and animal models

(2014) Peter In’t Veld   Seminars in Immunopathology

Modules, networks and systems medicine for understanding disease and aiding diagnosis

(2014) Mika Gustafsson et al.   Genome Medicine

Type 2 diabetes mellitus-related genetic polymorphisms in microRNAs and microRNA target sites (MicroRNAs中与2型糖尿病相关的基因多态性及microRNA靶位)

(2014) Weijing Gong et al.   Journal of Diabetes

Genome-Wide Associations between Genetic and Epigenetic Variation Influence mRNA Expression and Insulin Secretion in Human Pancreatic Islets

(2014) Anders H. Olsson et al.   PLoS Genetics

Developmental and environmental epigenetic programming of the endocrine pancreas: consequences for type 2 diabetes

(2013) Ionel Sandovici et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Candidate Genes Expressed in Human Islets and Their Role in the Pathogenesis of Type 1 Diabetes

(2013) Joachim Storling et al.   Current Diabetes Reports

Candidate genes for type 1 diabetes modulate pancreatic islet inflammation andβ-cell apoptosis

(2013) I. Santin et al.   DIABETES OBESITY & METABOLISM

Cell-type, allelic, and genetic signatures in the human pancreatic beta cell transcriptome

(2013) A. C. Nica et al.   GENOME RESEARCH

RNAsnp: Efficient Detection of Local RNA Secondary Structure Changes Induced by SNPs

(2013) Radhakrishnan Sabarinathan et al.   HUMAN MUTATION

Genetics of diabetes – Are we missing the genes or the disease?

(2013) Leif Groop et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Integrative approaches for finding modular structure in biological networks

(2013) Koyel Mitra et al.   NATURE REVIEWS GENETICS

Bringing genome-wide association findings into clinical use

(2013) Teri A. Manolio   NATURE REVIEWS GENETICS

Diversifying microRNA sequence and function

(2013) Stefan L. Ameres et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

NONCODEv4: exploring the world of long non-coding RNA genes

(2013) Chaoyong Xie et al.   NUCLEIC ACIDS RESEARCH

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human β Cell Transcriptome Analysis Uncovers lncRNAs That Are Tissue-Specific, Dynamically Regulated, and Abnormally Expressed in Type 2 Diabetes

(2012) Ignasi Morán et al.   Cell Metabolism

Inhibition of Histone Deacetylase 3 Protects Beta Cells from Cytokine-Induced Apoptosis

(2012) Danny Hung-Chieh Chou et al.   CHEMISTRY & BIOLOGY

Identification of Novel Type 1 Diabetes Candidate Genes by Integrating Genome-Wide Association Data, Protein-Protein Interactions, and Human Pancreatic Islet Gene Expression

(2012) R. Bergholdt et al.   DIABETES

 -Cell Mass and Turnover in Humans: Effects of obesity and aging

(2012) Y. Saisho et al.   DIABETES CARE

Emerging roles of non-coding RNAs in pancreatic β-cell function and dysfunction

(2012) C. Guay et al.   DIABETES OBESITY & METABOLISM

Sustained expression of the transcription factor GLIS3 is required for normal beta cell function in adults

(2012) Yisheng Yang et al.   EMBO Molecular Medicine

Epigenetics: The missing link to understanding β-cell dysfunction in the pathogenesis of type 2 diabetes

(2012) Elizabeth R. Gilbert et al.   Epigenetics

Post-transcriptional control of candidate risk genes for type 1 diabetes by rare genetic variants

(2012) V M de Jong et al.   GENES AND IMMUNITY

Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients

(2012) Ken T. Coppieters et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines

(2012) Décio L. Eizirik et al.   PLoS Genetics

Concise Review: In Search of Unlimited Sources of Functional Human Pancreatic Beta Cells

(2012) Raphael Scharfmann et al.   Stem Cells Translational Medicine

The Therapeutic Potential of Epigenetics in Autoimmune Diseases

(2011) Maria De Santis et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Association of Genetic Loci With Glucose Levels in Childhood and Adolescence: A Meta-Analysis of Over 6,000 Children

(2011) A. Barker et al.   DIABETES

PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Pancreatic  -Cell Apoptosis via Regulation of the BH3-Only Protein Bim

(2011) I. Santin et al.   DIABETES

miRNAs control insulin content in pancreatic β-cells via downregulation of transcriptional repressors

(2011) Tal Melkman-Zehavi et al.   EMBO JOURNAL

Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses

(2011) M. N. Cabili et al.   GENES & DEVELOPMENT

Modulation of innate immunity in human pancreatic islets infected with enterovirus in vitro

(2011) Oskar Skog et al.   JOURNAL OF MEDICAL VIROLOGY

Molecular Mechanisms of Long Noncoding RNAs

(2011) Kevin C. Wang et al.   MOLECULAR CELL

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(2011) Eli Lewis et al.   MOLECULAR MEDICINE

Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians

(2011) Yoon Shin Cho et al.   NATURE GENETICS

Type 1 Diabetes: Etiology, Immunology, and Therapeutic Strategies

(2011) Tom L. Van Belle et al.   PHYSIOLOGICAL REVIEWS

Beta-Cell Specific Deletion of Dicer1 Leads to Defective Insulin Secretion and Diabetes Mellitus

(2011) Martins Kalis et al.   PLoS One

Huntingtin-interacting protein 14 is a type 1 diabetes candidate protein regulating insulin secretion and  -cell apoptosis

(2011) L. A. Berchtold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Genome-Wide Meta-Analysis of Six Type 1 Diabetes Cohorts Identifies Multiple Associated Loci

(2011) Jonathan P. Bradfield et al.   PLoS Genetics

Integrating Pathway Analysis and Genetics of Gene Expression for Genome-wide Association Studies

(2010) Hua Zhong et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genetics of Type 1 Diabetes: What's Next?

(2010) F. Pociot et al.   DIABETES

Residual Insulin Production and Pancreatic  -Cell Turnover After 50 Years of Diabetes: Joslin Medalist Study

(2010) H. A. Keenan et al.   DIABETES

Dimorphic histopathology of long-standing childhood-onset diabetes

(2010) R. Gianani et al.   DIABETOLOGIA

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

(2010) Josée Dupuis et al.   NATURE GENETICS

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Interferon- -Induced Pancreatic  -Cell Apoptosis

(2009) F. Moore et al.   DIABETES

Pancreatic beta cell function persists in many patients with chronic type 1 diabetes, but is not dramatically improved by prolonged immunosuppression and euglycaemia from a beta cell allograft

(2009) E. H. Liu et al.   DIABETOLOGIA

MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic β-cell responses to the viral by-product double-stranded RNA

(2009) Maikel L. Colli et al.   HUMAN MOLECULAR GENETICS

Transcription Factor Glis3, a Novel Critical Player in the Regulation of Pancreatic  -Cell Development and Insulin Gene Expression

(2009) H. S. Kang et al.   MOLECULAR AND CELLULAR BIOLOGY

The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes

(2009) Chris Wallace et al.   NATURE GENETICS

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

(2009) Jeffrey C Barrett et al.   NATURE GENETICS

The role of inflammation in insulitis and β-cell loss in type 1 diabetes

(2009) Décio L. Eizirik et al.   Nature Reviews Endocrinology

The Krüppel-like zinc finger protein Glis3 directly and indirectly activates insulin gene transcription

(2009) Yisheng Yang et al.   NUCLEIC ACIDS RESEARCH

Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

(2009) L. A. Hindorff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rare Variants of IFIH1, a Gene Implicated in Antiviral Responses, Protect Against Type 1 Diabetes

(2009) S. Nejentsev et al.   SCIENCE

Prediction and Interaction in Complex Disease Genetics: Experience in Type 1 Diabetes

(2009) David G. Clayton   PLoS Genetics

Analysis of islet inflammation in human type 1 diabetes

(2008) A. Willcox et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci

(2008) Jason D Cooper et al.   NATURE GENETICS