Candidate Genes Expressed in Human Islets and Their Role in the Pathogenesis of Type 1 Diabetes

The role of reactive oxygen species and proinflammatory cytokines in type 1 diabetes pathogenesis

(2013) Lindsey E. Padgett et al.   Annals of the New York Academy of Sciences

Network models of genome-wide association studies uncover the topological centrality of protein interactions in complex diseases

(2013) Younghee Lee et al.   JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION

Identification of Novel Type 1 Diabetes Candidate Genes by Integrating Genome-Wide Association Data, Protein-Protein Interactions, and Human Pancreatic Islet Gene Expression

(2012) R. Bergholdt et al.   DIABETES

HERC2 rs12913832 modulates human pigmentation by attenuating chromatin-loop formation between a long-range enhancer and the OCA2 promoter

(2012) M. Visser et al.   GENOME RESEARCH

The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines

(2012) Décio L. Eizirik et al.   PLoS Genetics

Antigen presentation events in autoimmune diabetes

(2011) Boris Calderon et al.   CURRENT OPINION IN IMMUNOLOGY

PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Pancreatic  -Cell Apoptosis via Regulation of the BH3-Only Protein Bim

(2011) I. Santin et al.   DIABETES

Persistent glucose transporter expression on pancreatic beta cells from longstanding type 1 diabetic individuals

(2011) Ken T. Coppieters et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Paracrine signalling loops in adult human and mouse pancreatic islets: netrins modulate beta cell apoptosis signalling via dependence receptors

(2011) Y. H. C. Yang et al.   DIABETOLOGIA

Why is PTPN22 a good candidate susceptibility gene for autoimmune disease?

(2011) Garth L. Burn et al.   FEBS LETTERS

Processing of proglucagon to GLP-1 in pancreatic α-cells: is this a paracrine mechanism enabling GLP-1 to act on β-cells?

(2011) N M Whalley et al.   JOURNAL OF ENDOCRINOLOGY

Modulation of innate immunity in human pancreatic islets infected with enterovirus in vitro

(2011) Oskar Skog et al.   JOURNAL OF MEDICAL VIROLOGY

Understanding type 1 diabetes through genetics: advances and prospects

(2011) Constantin Polychronakos et al.   NATURE REVIEWS GENETICS

Type 1 Diabetes: Etiology, Immunology, and Therapeutic Strategies

(2011) Tom L. Van Belle et al.   PHYSIOLOGICAL REVIEWS

Huntingtin-interacting protein 14 is a type 1 diabetes candidate protein regulating insulin secretion and  -cell apoptosis

(2011) L. A. Berchtold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteins Encoded in Genomic Regions Associated with Immune-Mediated Disease Physically Interact and Suggest Underlying Biology

(2011) Elizabeth J. Rossin et al.   PLoS Genetics

Gene prioritization in Type 2 Diabetes using domain interactions and network analysis

(2010) Amitabh Sharma et al.   BMC GENOMICS

Immune Cell Populations in Nonhuman Primate Islets

(2010) Lane C. K. Coffey et al.   CELL TRANSPLANTATION

Genetics of Type 1 Diabetes: What's Next?

(2010) F. Pociot et al.   DIABETES

Residual Insulin Production and Pancreatic  -Cell Turnover After 50 Years of Diabetes: Joslin Medalist Study

(2010) H. A. Keenan et al.   DIABETES

Cross-Talk between Human Dendritic Cell Subsets Influences Expression of RNA Sensors and Inhibits Picornavirus Infection

(2010) Matthijs Kramer et al.   Journal of Innate Immunity

Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia

(2010) Daniel J Hodson et al.   NATURE IMMUNOLOGY

Reduced Expression of IFIH1 Is Protective for Type 1 Diabetes

(2010) Kate Downes et al.   PLoS One

An Integrative -omics Approach to Identify Functional Sub-Networks in Human Colorectal Cancer

(2010) Rod K. Nibbe et al.   PLoS Computational Biology

Detailed transcriptome atlas of the pancreatic beta cell

(2009) Burak Kutlu et al.   BMC Medical Genomics

PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Interferon- -Induced Pancreatic  -Cell Apoptosis

(2009) F. Moore et al.   DIABETES

Interrogating Type 2 Diabetes Genome-Wide Association Data Using a Biological Pathway-Based Approach

(2009) J. R.B. Perry et al.   DIABETES

Pancreatic beta cell function persists in many patients with chronic type 1 diabetes, but is not dramatically improved by prolonged immunosuppression and euglycaemia from a beta cell allograft

(2009) E. H. Liu et al.   DIABETOLOGIA

Using genome-wide pathway analysis to unravel the etiology of complex diseases

(2009) Clara C. Elbers et al.   GENETIC EPIDEMIOLOGY

MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic β-cell responses to the viral by-product double-stranded RNA

(2009) Maikel L. Colli et al.   HUMAN MOLECULAR GENETICS

Identification of Loss of Function Mutations in Human Genes Encoding RIG-I and MDA5

(2009) Taeko Shigemoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Network-Based Method for Predicting Disease-Causing Genes

(2009) Shaul Karni et al.   JOURNAL OF COMPUTATIONAL BIOLOGY

PTPN22 Deficiency Cooperates with the CD45 E613R Allele to Break Tolerance on a Non-Autoimmune Background

(2009) J. Zikherman et al.   JOURNAL OF IMMUNOLOGY

The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes

(2009) Chris Wallace et al.   NATURE GENETICS

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

(2009) Jeffrey C Barrett et al.   NATURE GENETICS

The role of inflammation in insulitis and β-cell loss in type 1 diabetes

(2009) Décio L. Eizirik et al.   Nature Reviews Endocrinology

Genetics of Type 1A Diabetes

(2009) Patrick Concannon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Induction of nuclear factor-κB and its downstream genes by TNF-α and IL-1β has a pro-apoptotic role in pancreatic beta cells

(2008) F. Ortis et al.   DIABETOLOGIA

Cytokines and β-Cell Biology: from Concept to Clinical Translation

(2008) Marc Y. Donath et al.   ENDOCRINE REVIEWS

Reduced CD4+T cell activation in children with type 1 diabetes carrying the PTPN22/Lyp 620Trp variant

(2008) Johanna Aarnisalo et al.   JOURNAL OF AUTOIMMUNITY