Type 1 Diabetes: Etiology, Immunology, and Therapeutic Strategies

Impact of Protective IL-2 Allelic Variants on CD4+Foxp3+ Regulatory T Cell Function In Situ and Resistance to Autoimmune Diabetes in NOD Mice

(2014) E. Sgouroudis et al.   JOURNAL OF IMMUNOLOGY

Soluble IL-2RA Levels in Multiple Sclerosis Subjects and the Effect of Soluble IL-2RA on Immune Responses

(2014) L. M. Maier et al.   JOURNAL OF IMMUNOLOGY

Inconsistent formation and nonfunction of insulin-positive cells from pancreatic endoderm derived from human embryonic stem cells in athymic nude rats

(2010) Aleksey V. Matveyenko et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Immunological efficacy of heat shock protein 60 peptide DiaPep277TM therapy in clinical type I diabetes

(2010) V. A. L. Huurman et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Infiltration of forkhead box P3-expressing cells in small intestinal mucosa in coeliac disease but not in type 1 diabetes

(2010) M. Tiittanen et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Developing combination immunotherapies for type 1 diabetes: recommendations from the ITN-JDRF Type 1 Diabetes Combination Therapy Assessment Group

(2010) J. B. Matthews et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Failure to Preserve  -Cell Function With Mycophenolate Mofetil and Daclizumab Combined Therapy in Patients With New- Onset Type 1 Diabetes

(2010) P. A. Gottlieb et al.   DIABETES CARE

Induction and Inhibition of Type I Interferon Responses by Distinct Components of Lymphocytic Choriomeningitis Virus

(2010) S. Zhou et al.   JOURNAL OF VIROLOGY

Anti-TNFα therapy—killing two birds with one stone?

(2010) Sefina Arif et al.   LANCET

Long-Term Controlled Normoglycemia in Diabetic Non-Human Primates After Transplantation with hCD46 Transgenic Porcine Islets

(2009) D. J. van der Windt et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Exendin-4 Therapy in NOD Mice with New-Onset Diabetes Increases Regulatory T Cell Frequency

(2009) Song Xue et al.   Annals of the New York Academy of Sciences

Persistence of Residual Beta Cells and Islet Autoimmunity during Increasing Duration of Diabetes in NOD Mice and Experimental Approaches toward Reversing New-Onset Disease with Bioactive Peptides

(2009) Shiva Reddy et al.   Annals of the New York Academy of Sciences

The interleukin 1 inhibitor rilonacept in treatment of chronic gouty arthritis: results of a placebo-controlled, monosequence crossover, non-randomised, single-blind pilot study

(2009) R Terkeltaub et al.   ANNALS OF THE RHEUMATIC DISEASES

Transient Epstein-Barr virus reactivation in CD3 monoclonal antibody-treated patients

(2009) B. Keymeulen et al.   BLOOD

Monitoring of antigen-specific CD8 T cells in patients with type 1 diabetes treated with antiCD3 monoclonal antibodies

(2009) Simona Cernea et al.   CLINICAL IMMUNOLOGY

Dipeptidyl Peptidase-4 (CD26): Knowing the Function before Inhibiting the Enzyme

(2009) E. Matteucci et al.   CURRENT MEDICINAL CHEMISTRY

Immune Depletion With Cellular Mobilization Imparts Immunoregulation and Reverses Autoimmune Diabetes in Nonobese Diabetic Mice

(2009) M. J. Parker et al.   DIABETES

Interleukin-21 Is Required for the Development of Type 1 Diabetes in NOD Mice

(2009) A. P.R. Sutherland et al.   DIABETES

Validity and Reproducibility of Measurement of Islet Autoreactivity by T-Cell Assays in Subjects With Early Type 1 Diabetes

(2009) K. C. Herold et al.   DIABETES

Current Advances and Travails in Islet Transplantation

(2009) D. M. Harlan et al.   DIABETES

Enterovirus Infection, CXC Chemokine Ligand 10 (CXCL10), and CXCR3 Circuit: A Mechanism of Accelerated  -Cell Failure in Fulminant Type 1 Diabetes

(2009) S. Tanaka et al.   DIABETES

Differences in Baseline Lymphocyte Counts and Autoreactivity Are Associated With Differences in Outcome of Islet Cell Transplantation in Type 1 Diabetic Patients

(2009) R. Hilbrands et al.   DIABETES

Effects of Exenatide Alone and in Combination With Daclizumab on  -Cell Function in Long-Standing Type 1 Diabetes

(2009) K. I. Rother et al.   DIABETES CARE

Etanercept Treatment in Children With New-Onset Type 1 Diabetes: Pilot Randomized, Placebo-Controlled, Double-Blind Study: Response to Peters

(2009) L. Mastrandrea et al.   DIABETES CARE

Effect of Ingested Interferon-  on  -Cell Function in Children With New-Onset Type 1 Diabetes

(2009) K. I. Rother et al.   DIABETES CARE

Autologous Umbilical Cord Blood Transfusion in Very Young Children With Type 1 Diabetes

(2009) M. J. Haller et al.   DIABETES CARE

No Effect of the Altered Peptide Ligand NBI-6024 on  -Cell Residual Function and Insulin Needs in New-Onset Type 1 Diabetes

(2009) M. Walter et al.   DIABETES CARE

Pancreatic Islet Autoantibodies as Predictors of Type 1 Diabetes in the Diabetes Prevention Trial-Type 1

(2009) T. Orban et al.   DIABETES CARE

Beneficial effects of K-ATP channel openers in diabetes: an update on mechanisms and clinical experiences

(2009) V. Grill et al.   DIABETES OBESITY & METABOLISM

Effects of therapy in type 1 and type 2 diabetes mellitus with a peptide derived from islet neogenesis associated protein (INGAP)

(2009) Kathleen M. Dungan et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Therapy with GAD in diabetes

(2009) Johnny Ludvigsson   DIABETES-METABOLISM RESEARCH AND REVIEWS

The anti-interleukin-1 in type 1 diabetes action trial-background and rationale

(2009) Linda M.S. Pickersgill et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Role of enteroviruses in the pathogenesis of type 1 diabetes

(2009) M. Roivainen et al.   DIABETOLOGIA

Development of type 1 diabetes in a patient treated with anti-TNF-α therapy for active rheumatoid arthritis

(2009) C. J. Tack et al.   DIABETOLOGIA

Combination therapy with a dipeptidyl peptidase-4 inhibitor and a proton pump inhibitor restores normoglycaemia in non-obese diabetic mice

(2009) W. L. Suarez-Pinzon et al.   DIABETOLOGIA

GAD65 vaccination: 5 years of follow-up in a randomised dose-escalating study in adult-onset autoimmune diabetes

(2009) C.-D. Agardh et al.   DIABETOLOGIA

The prevalence of enteroviral capsid protein vp1 immunostaining in pancreatic islets in human type 1 diabetes

(2009) S. J. Richardson et al.   DIABETOLOGIA

Liraglutide

(2009) Katherine F. Croom et al.   DRUGS

Thymus-specific deletion of insulin induces autoimmune diabetes

(2009) Yong Fan et al.   EMBO JOURNAL

Remodeling rodent models to mimic human type 1 diabetes

(2009) Matthias von Herrath et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Giessen-Bad Oeynhausen family study: Improved prediction of type I diabetes in a low incidence population of relatives using combinations of islet autoantibodies in a dual step model

(2009) C. Jaeger et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Prevalence of vitamin D receptor gene polymorphisms FokI and BsmI in Brazilian individuals with type 1 diabetes and their relation to β-cell autoimmunity and to remaining β-cell function

(2009) Denise B. Mory et al.   HUMAN IMMUNOLOGY

Pioglitazone Might Prevent the Progression of Slowly Progressive Type 1 Diabetes

(2009) Yoshinaga Kawano et al.   INTERNAL MEDICINE

C-Peptide Levels and Insulin Independence Following Autologous Nonmyeloablative Hematopoietic Stem Cell Transplantation in Newly Diagnosed Type 1 Diabetes Mellitus

(2009) Carlos E. B. Couri   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Interplay between PTPN22 C1858T polymorphism and cow's milk formula exposure in type 1 diabetes

(2009) Johanna Lempainen et al.   JOURNAL OF AUTOIMMUNITY

Pre-existing autoimmunity determines type 1 diabetes outcome after Flt3-ligand treatment

(2009) Tom L. Van Belle et al.   JOURNAL OF AUTOIMMUNITY

Autoantigen-specific regulatory T cells induced in patients with type 1 diabetes mellitus by insulin B-chain immunotherapy

(2009) Tihamer Orban et al.   JOURNAL OF AUTOIMMUNITY

Identification of Loss of Function Mutations in Human Genes Encoding RIG-I and MDA5

(2009) Taeko Shigemoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Realistic Expectations and Practical Use of Continuous Glucose Monitoring for the Endocrinologist

(2009) Irl B. Hirsch   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

How can we improve the translational landscape for a faster cure of type 1 diabetes?

(2009) Matthias von Herrath et al.   JOURNAL OF CLINICAL INVESTIGATION

A cis-Acting Regulatory Variant in the IL2RA Locus

(2009) H.-Q. Qu et al.   JOURNAL OF IMMUNOLOGY

MDA5 and MAVS Mediate Type I Interferon Responses to Coxsackie B Virus

(2009) J. P. Wang et al.   JOURNAL OF VIROLOGY

Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)

(2009) John B Buse et al.   LANCET

Incidence trends for childhood type 1 diabetes in Europe during 1989–2003 and predicted new cases 2005–20: a multicentre prospective registration study

(2009) Christopher C Patterson et al.   LANCET

Genetic-induced Variations in the GAD65 T-cell Repertoire Governs Efficacy of Anti-CD3/GAD65 Combination Therapy in New-onset Type 1 Diabetes

(2009) Damien Bresson et al.   MOLECULAR THERAPY

The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes

(2009) Chris Wallace et al.   NATURE GENETICS

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

(2009) Jeffrey C Barrett et al.   NATURE GENETICS

Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

(2009) Xuyu Zhou et al.   NATURE IMMUNOLOGY

Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis

(2009) Masako Murai et al.   NATURE IMMUNOLOGY

The Diabetes Control and Complications Trial: the gift that keeps giving

(2009) Eric S. Kilpatrick et al.   Nature Reviews Endocrinology

Genetics of Type 1A Diabetes

(2009) Patrick Concannon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rituximab, B-Lymphocyte Depletion, and Preservation of Beta-Cell Function

(2009) Mark D. Pescovitz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Common Genetic Variation and Human Traits

(2009) David B. Goldstein   NEW ENGLAND JOURNAL OF MEDICINE

Association Between Adherence and Glycemic Control in Pediatric Type 1 Diabetes: A Meta-analysis

(2009) K. K. Hood et al.   PEDIATRICS

Specific Immunoassays Confirm Association of Mycobacterium avium Subsp. paratuberculosis with Type-1 but Not Type-2 Diabetes Mellitus

(2009) Valentina Rosu et al.   PLoS One

Interaction of Vitamin D Receptor with HLA DRB1*0301 in Type 1 Diabetes Patients from North India

(2009) Neetu Israni et al.   PLoS One

Human Induced Pluripotent Stem Cells Free of Vector and Transgene Sequences

(2009) J. Yu et al.   SCIENCE

Rare Variants of IFIH1, a Gene Implicated in Antiviral Responses, Protect Against Type 1 Diabetes

(2009) S. Nejentsev et al.   SCIENCE

Real-Time Bioluminescence Imaging of Macroencapsulated Fibroblasts Reveals Allograft Protection in Rhesus Monkeys (Macaca mulatta)

(2009) Alice F. Tarantal et al.   TRANSPLANTATION

Human β-cell Precursors Mature Into Functional Insulin-producing Cells in an Immunoisolation Device: Implications for Diabetes Cell Therapies

(2009) Seung-Hee Lee et al.   TRANSPLANTATION

Stem cell therapy for type 1 diabetes mellitus: a review of recent clinical trials

(2009) Carlos Couri et al.   Diabetology & Metabolic Syndrome

Stem cell transplantation for type 1 diabetes mellitus

(2009) Júlio C Voltarelli et al.   Diabetology & Metabolic Syndrome

IL2RA Genetic Heterogeneity in Multiple Sclerosis and Type 1 Diabetes Susceptibility and Soluble Interleukin-2 Receptor Production

(2009) Lisa M. Maier et al.   PLoS Genetics

Prolonged Insulin Independence After Islet Allotransplants in Recipients with Type 1 Diabetes

(2008) M. D. Bellin et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Ocrelizumab, a humanized anti-CD20 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase I/II randomized, blinded, placebo-controlled, dose-ranging study

(2008) Mark C. Genovese et al.   ARTHRITIS AND RHEUMATISM

Autoimmune manifestations in primary immune deficiencies

(2008) Guillaume Bussone et al.   AUTOIMMUNITY REVIEWS

Combination Therapy with Glucagon-Like Peptide-1 and Gastrin Induces β-Cell Neogenesis from Pancreatic Duct Cells in Human Islets Transplanted in Immunodeficient Diabetic Mice

(2008) Wilma L. Suarez-Pinzon et al.   CELL TRANSPLANTATION

Analysis of islet inflammation in human type 1 diabetes

(2008) A. Willcox et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Islet antigen specific IL-10+ immune responses but not CD4+CD25+FoxP3+ cells at diagnosis predict glycemic control in type 1 diabetes

(2008) Srinath Sanda et al.   CLINICAL IMMUNOLOGY

Postnatal Expansion of the Pancreatic  -Cell Mass Is Dependent on Survivin

(2008) Y. Jiang et al.   DIABETES

Idd Loci Synergize to Prolong Islet Allograft Survival Induced by Costimulation Blockade in NOD Mice

(2008) J. Mangada et al.   DIABETES

Slc11a1 Enhances the Autoimmune Diabetogenic T-Cell Response by Altering Processing and Presentation of Pancreatic Islet Antigens

(2008) Y. D. Dai et al.   DIABETES

Inhibition of Dipeptidyl Peptidase IV With Sitagliptin (MK0431) Prolongs Islet Graft Survival in Streptozotocin-Induced Diabetic Mice

(2008) S.-J. Kim et al.   DIABETES

Combination Therapy With Glucagon-Like Peptide-1 and Gastrin Restores Normoglycemia in Diabetic NOD Mice

(2008) W. L. Suarez-Pinzon et al.   DIABETES

A Novel Susceptibility Locus for Type 1 Diabetes on Chr12q13 Identified by a Genome-Wide Association Study

(2008) H. Hakonarson et al.   DIABETES

Follow-Up Analysis of Genome-Wide Association Data Identifies Novel Loci for Type 1 Diabetes

(2008) S. F.A. Grant et al.   DIABETES

The "Perfect Storm" for Type 1 Diabetes: The Complex Interplay Between Intestinal Microbiota, Gut Permeability, and Mucosal Immunity

(2008) O. Vaarala et al.   DIABETES

Expansion of Human Regulatory T-Cells From Patients With Type 1 Diabetes

(2008) A. L. Putnam et al.   DIABETES

Dipeptidyl Peptidase IV Inhibition With MK0431 Improves Islet Graft Survival in Diabetic NOD Mice Partially via T-Cell Modulation

(2008) S.-J. Kim et al.   DIABETES

The Frequency and Immunodominance of Islet-Specific CD8+ T-cell Responses Change after Type 1 Diabetes Diagnosis and Treatment

(2008) E. Martinuzzi et al.   DIABETES

mTOR Inhibition by Rapamycin Prevents  -Cell Adaptation to Hyperglycemia and Exacerbates the Metabolic State in Type 2 Diabetes

(2008) M. Fraenkel et al.   DIABETES

 -Cell Mass and Type 1 Diabetes: Going, Going, Gone?

(2008) E. Akirav et al.   DIABETES

HLA DR-DQ Haplotypes and Genotypes and Type 1 Diabetes Risk: Analysis of the Type 1 Diabetes Genetics Consortium Families

(2008) H. Erlich et al.   DIABETES

Viral Trigger for Type 1 Diabetes: Pros and Cons

(2008) C. M. Filippi et al.   DIABETES

Taking a closer look at the pancreas

(2008) K. Coppieters et al.   DIABETOLOGIA

Congenital rubella and diabetes mellitus

(2008) M. A. Burgess et al.   DIABETOLOGIA

Congenital rubella: citation virus or viral cause of type 1 diabetes?

(2008) E. A. M. Gale   DIABETOLOGIA

The association between ultraviolet B irradiance, vitamin D status and incidence rates of type 1 diabetes in 51 regions worldwide

(2008) S. B. Mohr et al.   DIABETOLOGIA

A Case of Fulminant Type 1 Diabetes Associated With Significant Elevation of Mumps Titers

(2008) Atsushi GOTO et al.   ENDOCRINE JOURNAL

Liraglutide, a Long-Acting Human Glucagon-Like Peptide 1 Analog, Improves Glucose Homeostasis in Marginal Mass Islet Transplantation in Mice

(2008) S. Merani et al.   ENDOCRINOLOGY

Clinical application of regulatory T cells for treatment of type 1 diabetes and transplantation

(2008) Todd Brusko et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Maternal Enterovirus Infection during Pregnancy as a Risk Factor in Offspring Diagnosed with Type 1 Diabetes between 15 and 30 Years of Age

(2008) Maria Elfving et al.   Experimental Diabetes Research

IFIH1 polymorphisms are significantly associated with type 1 diabetes and IFIH1 gene expression in peripheral blood mononuclear cells

(2008) S. Liu et al.   HUMAN MOLECULAR GENETICS

Central Role of Defective Interleukin-2 Production in the Triggering of Islet Autoimmune Destruction

(2008) Qizhi Tang et al.   IMMUNITY

Human regulatory T cells: role in autoimmune disease and therapeutic opportunities

(2008) Todd M. Brusko et al.   IMMUNOLOGICAL REVIEWS

How to Interpret a Genome-wide Association Study

(2008) Thomas A. Pearson   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A new role for an old player: Do B cells unleash the self-reactive CD8+ T cell storm necessary for the development of type 1 diabetes?

(2008) Eliana Mariño et al.   JOURNAL OF AUTOIMMUNITY

Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes

(2008) Matej Orešič et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Relationship between pancreatic vesicular monoamine transporter 2 (VMAT2) and insulin expression in human pancreas

(2008) Yoshifumi Saisho et al.   JOURNAL OF MOLECULAR HISTOLOGY

Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: a double-blind, randomised controlled trial

(2008) Kirsti Näntö-Salonen et al.   LANCET

In vivo reprogramming of adult pancreatic exocrine cells to β-cells

(2008) Qiao Zhou et al.   NATURE

Innate immunity and intestinal microbiota in the development of Type 1 diabetes

(2008) Li Wen et al.   NATURE

Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo

(2008) Evert Kroon et al.   NATURE BIOTECHNOLOGY

Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci

(2008) Jason D Cooper et al.   NATURE GENETICS

The Foxp3+ regulatory T cell: a jack of all trades, master of regulation

(2008) Qizhi Tang et al.   NATURE IMMUNOLOGY

Concordance for Islet Autoimmunity among Monozygotic Twins

(2008) Maria J. Redondo et al.   NEW ENGLAND JOURNAL OF MEDICINE

GAD Treatment and Insulin Secretion in Recent-Onset Type 1 Diabetes

(2008) Johnny Ludvigsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Prevention of diabetes: effect of mycophenolate mofetil and anti-CD25 on onset of diabetes in the DRBB rat

(2008) Figen Ugrasbul et al.   PEDIATRIC DIABETES

Selective death of autoreactive T cells in human diabetes by TNF or TNF receptor 2 agonism

(2008) L. Ban et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combination Therapy With Epidermal Growth Factor and Gastrin Delays Autoimmune Diabetes Recurrence in Nonobese Diabetic Mice Transplanted With Syngeneic Islets

(2008) W.L. Suarez-Pinzon et al.   TRANSPLANTATION PROCEEDINGS

Exendin-4 Modulates Diabetes Onset in Nonobese Diabetic Mice

(2007) Irene Hadjiyanni et al.   ENDOCRINOLOGY